Holiday houses in Cape Girardeau County

Guesthouse in Cape Girardeau

4.92 out of 5 average rating, 113 reviews

Cozy 1-BR guest house w/free parking on premises

Enjoy a cozy experience at this centrally, located place. Literally, a 1-4 minute walk to Mercy Hospital(formerly Southeast Hospital), less than 1 mile to Southeast University Campus, along with downtown(river). A street over is Broadway with many restaurants. Walmart Market and Dollar General are also conveniently located nearby. The kitchen is fully furnished with cooking utensils, clean towels, pots and pans for those who prefer eating in. Please no animals and no smoking in the apartment.

4.98 out of 5 average rating, 416 reviews

Beautiful Historic Boulevard District Apartment

This beautiful, private upstairs apartment is located on a favorite street in Cape Girardeau’s Historic Boulevard District. It is walking distance to SEMO University, Capaha Park, and the downtown riverfront. Recently remodeled for laundry, spacious rooms offer private bedroom spaces and a cozy den for watching movies or reading. The kitchen is fully equipped with amenities. This quiet neighborhood setting even has a front porch swing and sitting area where you can enjoy your morning coffee.

4.82 out of 5 average rating, 114 reviews

Herman's Corner Cottage.

Tucked in historic Cape Girardeau, this charming cottage offers comfort and convenience. Enjoy the cozy back deck with a privacy fence—perfect for relaxing or grilling. With ample off-street parking, your stay is stress-free. The home is equipped with essentials for a smooth, hassle-free visit. Book the entire house for added privacy, providing a peaceful retreat for you and your guests. Experience the perfect blend of comfort, affordability, and convenience during your Cape Girardeau getaway.

Guest suite in Cape Girardeau

4.97 out of 5 average rating, 151 reviews

MAINSTAY CAPE [downtown]

Nestled in the heart of the Downtown Historic District, this suite is centrally located as a prime destination for any and all travelers alike. With parking available, this space offers a unique & trendy “midwest boho” vibe. ~WALKABLE~ Our studio is 1 block from the bustling Southeast Missouri State University, 1 block from the gorgeous Capaha Park, and 2 blocks from Mercy Hospital. If you are interested in night life, this space is simply a 5-10 minute walk to all DT bars and restaurants.

4.95 out of 5 average rating, 247 reviews

Brand new 2 bedroom unit right in downtown Cape.

This special place is close to everything, making it easy to plan your visit. Walking distance to restaurants, the river and nightlife. Property includes wifi, full kitchen, laundry, deck and private parking for one. One king bed room and a twin bed room in addition to a roll out twin bed along with a 60 inch smart television. Dog bed and bowls included along with board games! Property is conveniently located across the street from "The Bar" the famous spot from the movie "Gone Girl" .

4.86 out of 5 average rating, 610 reviews

Unique Design | Walk Downtown/River | .5 mile SEMO

At our Adventurous 2 Bedroom Suite you’ll first arrive at a Brightly decorated Space with Artsy Walls and Bold Decor. Designed with its History in mind & a twist of Creativity, you will Immerse Yourself within your Stay; from our Stocked Kitchen, Reading Area with Indoor Swing to Themed & Cozy Bedrooms. Enjoy being near Downtown/the River with a short Bike Ride or Walk and when you are ready to Tuck in at night, Sink into our 10” Memory Foam mattress with Plush Pillows and feel at Ease.

Treehouse in Cape Girardeau

4.99 out of 5 average rating, 142 reviews

Twisted Sassafras Treehouse

A custom-built treehouse located on 10 acres with a water view that you can take in from the hot tub on the deck! It is nestled high in the trees and is the perfect romantic getaway for two! Feel like you are away from it all without being away from it all! This treehouse is located on a county road just minutes from Cape Girardeau. Enjoy catch and release fishing on site, local wineries, shopping in historic downtown Cape Girardeau, local restaurants, gambling, historical sites & more!

4.88 out of 5 average rating, 105 reviews

House Of Clubs- 2 Bed 1.5 Bath

The PERFECT hideway. The House of Clubs offers a quiet setting with a creek that wraps around the enitre property. Two bedrooms, each include a queen size bed. One Full bathroom. Full Laundry room that also offers a private cammode. The stylish living room offers a unique style that higlights Cape Girardeaus rich history. Enjoy your morning coffee in the four seasons room with breathtaking views of this hidden gem . Less than 5 minutes to downtown. Only 2 minutes to Cape Country Club.

4.96 out of 5 average rating, 196 reviews

Barn in Cape Girardeau

Under the Stars - Farmhouse

Enjoy the tranquility of this modern farmhouse charmer! Custom built minutes from downtown Cape. Relax outside around the fire pit, roast marshmallows and watch the sunset. Finish the night with a long soak in the hot tub. Start the morning on the front porch rocking chairs and take in a sunrise. Open concept, fully equipped kitchen, 3 Bd. including King master/full bath, 2 Queens with full guest bath. Near Trail of Tears and walking distance to classic dive bar/burger joint

Guesthouse in Cape Girardeau

4.93 out of 5 average rating, 518 reviews

Downtown Guesthouse- Romantic Getaway

The guesthouse seamlessly blends modern amenities with historic charm in a cozy, compact space. The antique claw foot tub/shower combo offers a charming, yet snug, spot for a relaxing soak—true to its historic roots, the bathroom could be best described as a quaint water closet. After a day of exploring unwind in the patio. Play a favorite record, and savor your coffee while daydreaming about new experiences. Despite its small size, it provides all the modern comforts you need.

4.88 out of 5 average rating, 100 reviews

Visit the "Gone Girl" neighborhood

Living rm/bedrm, full kitchen, ADA bath, and walk in closet. Fully equipped with dishes,linens, refig, micro,stove, keurig, dishwasher and welcome home snacks. Double Murphy bed, queen hide a bed couch convert the living room to bedroom. Space is good for up to 3 adults, 2 adults and 2 children or a single guest. We accept well mannered dogs up to 50 pounds. We do not accept CATS. Like cats but they cause additional clean up. See pets section for dog guest guidelines.

4.77 out of 5 average rating, 100 reviews

Historic Blvd District Home in Cape Girardeau

This beautiful, private home is located on a favorite street in Cape Girardeau’s Historic Boulevard District. It is walking distance to SEMO University, Capaha Park, and the downtown riverfront. With large bedrooms, spacious living room and separate dining room you will have all the room you need! The kitchen is fully equipped with amenities. This quiet neighborhood setting with a big front porch sitting area where you can enjoy your morning coffee.

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Other great holiday rentals in Cape Girardeau County

4.95 out of 5 average rating, 43 reviews

Cabin in Jackson

The Cabin at Timber Creek

Susan DeniseRating, 5 stars2 weeks ago

Beautiful home and property. Very peaceful. The owners don't mind if you fish the ponds, walk the creek and enjoy the outdoors. I can't begin to tell you how I've NEVER had such a responsive host. Any question I had was answered within a few minutes if not sooner. They are on the property but the distance between you and them is enough to feel like you are by yourself there. We will stay here again. Highly recommend.

4.75 out of 5 average rating, 20 reviews

3 Bedroom home

JohnRating, 5 stars2 days ago

Greta place to stay while I was in town for work. I will definitely be back.

Guest suite in Cape Girardeau

4.82 out of 5 average rating, 85 reviews

[*Charming Cozy Suite*]

YvonneRating, 5 stars1 month ago

Exactly as described. The bed was amazing!! Very peaceful setting.

4.9 out of 5 average rating, 10 reviews

Cape Charm: 3 BR Close to SEMO & Mercy! CLEAN!

StephanieRating, 5 stars2 weeks ago

Great stay, beautiful home. Only feedback would be to add another tv in one of the other bedrooms. 3 bedroom house and only one of the bedrooms has a tv.

Guest suite in Cape Girardeau

4.73 out of 5 average rating, 40 reviews

Private Downtown Apartment

RogerRating, 5 stars8 months ago

This was the perfect place for Homecoming weekend at SEMO. We were able to walk to and from the stadium. Everything was clean and comfortable. Thanks for the stay!

Cottage in Cape Girardeau

5 out of 5 average rating, 22 reviews

Beautiful Sunset Cottage with amazing views

JenniferRating, 5 stars9 months ago

This property is located in the country on a beautiful estate. If you are looking for a relaxing and peaceful stay, where you can see the stars at night and watch a stunning sunset…this is the place. I can’t say enough about Dru, she is a wonderful host and cooks some amazing home cooked meals. We were there for a retreat with friends and to celebrate birthdays, she did a great job making our stay memorable. She can arrange horseback riding or relaxing massages if that’s what you are looking for. This property is located about a two hour drive south of St. Louis; however it’s an easy drive mostly highway. I am already looking forward to my next visit! Thanks Dru, for being an amazing host.

5 out of 5 average rating, 8 reviews

Farm stay in Jackson

The Cabins 1

LanceRating, 5 stars1 week ago

Great place to visit very clean and beautiful cabin we will definitely be back in the future