Holiday houses in Florence County

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Top-rated holiday rentals in Florence County

Guests agree: these stays are highly rated for location, cleanliness and more.

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The charming facade of Kuker Cottage is framed by lush greenery and trees, featuring a covered porch with colorful seating. Large windows are positioned symmetrically, and the brick columns add character to the entrance, inviting guests to relax in a tranquil outdoor space.
Home in Florence

Kuker Cottage Downtown Florence-Near I95 & I20

Kuker Cottage is a beautifully restored Florence home in the heart of downtown. Perfectly situated halfway between New York and Florida, it is an ideal overnight stopping point. Plenty of space to spread out, offering families room to unwind after a long day of traveling. This home has been beautifully updated and is ready to host you, whether for a short or an extended stay. 2 queen beds, one twin bed, full bath, kitchen, wifi and TV. Walkable to parks and restaurants. 4 miles from I95 and I20

4.86 out of 5 average rating, 644 reviews
Top Guest favourite
A charming tree house is surrounded by snow-covered trees, showcasing a wraparound deck with wooden stairs leading to the entrance. Large windows allow views into the inviting interior, while snow blankets the ground, highlighting the natural setting.
Treehouse in Marion

Enchanting Treehouse with Modern Amenities

Perched on 20 acres along Catfish Creek, this enchanting tree house allows you to appreciate nature from a birds eye view. Whether it’s kayaking, canoeing, feeding our goats or exploring along the creek; relaxing in the hammocks and swings; engaging in a board game; or roasting marshmallows at the fire pit, Amenities include a full kitchen with full bath, outdoor shower, booth seating in dining table for up to 8, 2 bunk beds and loft style sleeping. Conveniently located 20 minutes from I-95.

5.0 out of 5 average rating, 342 reviews
Guest favourite
Home in Florence

Cozy 2BR Near McLeod & MUSC | Pet-Friendly

Perfect for traveling professionals or vacationers, this 2BR/1BA home is quiet, comfortable and minutes from the heart of Florence. Enjoy fast Wi-Fi, on-site parking, and a fully furnished pet-friendly space in a layout ideal for solo travelers or shared stays. Unwind on the spacious front porch or private deck in a space set up to support your stay. The central location of this home and nearby amenities make it perfect for short stays or extended assignments. Please inquire about pet fees.

4.96 out of 5 average rating, 27 reviews
Top Guest favourite
The exterior of the hermitage is seen at dusk, highlighted by a warm glow from outdoor lights. The rich orange facade contrasts with the pink and purple hues of the sunset sky. Nearby trees frame the scene, and a landscaped area features decorative plants.
Place to stay in Effingham

Gated and Private Catholic Hermitage house

Saint Michael Hermitage and retreat is a serene, gated, private home that is for 1-3 guests looking for a quiet stay while traveling or as a retreat destination. You will self check into your Hermitage after you obtain a gate code. There is a prayer chapel close by on the property. It is pet friendly for a well trained pet. There is Catholic iconography throughout the home. It is warm and inviting. There is a full kitchen, washer/dryer for your convenience and complementary coffee/tea.

4.98 out of 5 average rating, 179 reviews
Top Guest favourite
Cottage in Timmonsville

“Feels Like Home” Near I-95, King Bed

Located just 5 mins from I-95 , this quaint cottage sits on 6 acres with private deck, firepit & large back yard in a peaceful, country location. Your pets are welcome (max of 2, pls) but are not allowed on our beds. King bed in master, 3 TV's, coffee bar with Keurig, strong WiFi. We use 100% cotton sheets and quilts for your maximum sleeping comfort. NOTE- OUR COTTAGE IS NOT TO BE USED AS A VENUE FOR GATHERINGS OF ANY KIND. ABSOLUTELY NO SMOKING OR VAPING ON OUR PROPERTY ($200 fine!)

4.97 out of 5 average rating, 1117 reviews
Superhost
Home in Florence

Charming Home in Florence, SC

Welcome to Florence, South Carolina! This inviting 3-bedroom, 2-bathroom home is a haven of comfort and convenience. With four queen beds, it comfortably accommodates a group of friends or family. Step into the fully stocked kitchen, relax in the cozy living space, equipped with smart TVs for entertainment. The fenced backyard offers both privacy and a secure play area for your furry friends. Enjoy outdoor gatherings at the picnic table. Convenient amenities include a washer and dryer.

4.9 out of 5 average rating, 126 reviews
Top Guest favourite
The cozy interior features rustic wooden beams and a blend of warm tones. A spacious bed is positioned against a wall with a peacock artwork. A kitchenette area is visible, alongside a small dining table and a television, providing a comfortable, multifunctional living space.
Farm stay in Timmonsville

The Cottage at Dream Acres & Petting Zoo I-95/I-20

The Cottage at Dream Acres is situated with its own private drive on our 8 acre working horse farm located near Florence SC at the I-20/ I-95 corridor, 5 mins off the highway. We are the 1/2 way point between NY & FL. Relax and unwind from a long roadtrip or take a weekend farm-stay getaway. All the amenities of a larger home with the convenience of a smaller studio space! Family Friendly; sleeps up to 4, newly renovated in 2020, petting zoo, outdoor fire pit, tree swing, picnic table!

4.95 out of 5 average rating, 782 reviews
Top Guest favourite
Farm stay in Hemingway

Quiet farmhouse near the beach

The best memories are made on the farm. Life is just better away from the hustle and bustle of city lights and busy schedules. Come stay in this recently renovated fourth generation 1950s farmhouse on an 80 acre working farm. Unwind on the porch, walk trails, find millions of years old sharks teeth, build a bonfire, pick blackberries, swim in the ponds, collect walnuts, or just relax while you’re here but don’t forget to wish on a dandelion or a shooting star before you leave.

4.96 out of 5 average rating, 251 reviews
Top Guest favourite
A comfortable living area features a dark gray sofa complemented by two accent pillows. A coffee table is positioned in front of the seating, and two standing lamps provide soft lighting. A simple wall art above the sofa adds a touch of elegance to the space.
Home in Florence

Renovated 2 BR/2 B Townhouse Cozy & Clean

Keep it simple at this peaceful, centrally-located, and renovated townhouse close by I-95 and I-20 and within 15 mins. to the Florence Center, downtown Florence, many restaurants, and McLeod and MUSC Florence. House is located in a safe neighborhood. Enjoy being outdoors? Relax outdoors on your own private patio, go on a walk around the neighborhood, or go on an adventure. The Rail Trail & Ebenezer Park are minutes away. Utilities included.

4.99 out of 5 average rating, 148 reviews
Top Guest favourite
A charming poolside cottage is surrounded by lush palm trees and vibrant plants. The outdoor space features a dining set on a paved patio, providing a tranquil area for relaxation. The entrance to the cottage is easily accessible, enhancing the inviting ambiance.
Guesthouse in Florence

Cottage by the Pool: Close to Interstates

Palm Trees, colorful flowers, hammocks and quiet space await in this tropic-like oasis just minutes from I-95/20. Hundreds of reviews acknowledge this idyllic setting. We are a Florence Airbnb favorite for travelers. We offer a queen bed, full bathroom, full sleeper sofa, strong wifi and TV. We even provide breakfast bars and coffee to help you jump start your day as you set off for the next journey. We look forward to hosting you.

4.94 out of 5 average rating, 1011 reviews
Top Guest favourite
The exterior of the house features a cozy entrance with wooden double doors. The façade displays a blend of light brick and dark shutters. A driveway leads to two garages on the side, while the front yard is landscaped with minimal vegetation.
Home in Florence County

Highway Oasis in Florence, Darlington & Hartsville

Welcome to this charming new house ideally situated close to both a major highway i 95 and i20 and the serene Myrtle beach, offering the perfect blend of convenience . Nestled in a great neighborhood, this residence boasts easy access to shopping center, ensuring that all your daily needs are just moments away. Very close to Florence Civic Center, 15 minutes to Buc-ee's Myrtle beach in 1 hr of a drive and shopping amenities.

4.98 out of 5 average rating, 250 reviews
Guest favourite
A private guest house is nestled among trees, featuring a small porch with a table and chairs. Pathways lined with stepping stones lead to the entrance. Surrounding greenery and shrubs create a serene atmosphere that complements the charm of the outdoor space.
Guesthouse in Florence

Midtown Retreat - Guest House in heart of Florence

A private, relaxing place to stay right in the middle of town. Conveniently located close to all Florence has to offer, this 1-bedroom guest house is nestled among the trees behind the main house. Located in a beautiful, quiet neighborhood, yet within a few minutes to restaurants, grocery stores, fitness centers, McLeod and MUSC Medical Centers, and more.

4.89 out of 5 average rating, 250 reviews

Popular amenities for Florence County holiday rentals