Some info has been automatically translated. Show original language

Holiday houses in La Mesa District

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in La Mesa District

Guests agree: these stays are highly rated for location, cleanliness and more.

%{current} / %{total}1 / 1
Guest favourite
A view of the tranquil beachfront area reveals two boats anchored near the shore. The lush green jungle surrounds a rustic property featuring a cozy outdoor seating area under a canopy of palm trees. The calm waters reflect the greenery, creating a serene atmosphere.
Cabin in Sona
4.89 out of 5 average rating, 9 reviews

Beachfront Family EcoParadise to Coiba lsl BunkBed

Experience authentic Panama in our family-owned 30-hectare private tropical beachfront paradise. Accessible only by boat (30-min ride from Pixvae or 1:30hr from Santa Catalina). Gateway to Coiba Island, our remote bay offers pristine jungle, diverse wildlife, and breathtaking views. Enjoy kayaking, fishing, and guided eco-tours. Spot howler monkeys, sloths, and rare birds. Savor fresh tropical fruits and local cuisine. Perfect for nature lovers, photographers, and digital nomads (WiFi available)

Guest favourite
A thatched-roof gazebo provides shade over a wooden bar counter, accompanied by several wooden stools. Lush vegetation surrounds the structure, with a clear blue sky visible overhead, creating an inviting outdoor space for relaxation.
Townhouse in Santa Catalina
4.88 out of 5 average rating, 134 reviews

North Villa with Rooftop. Full Kitchen!

Fly / Drive - Tour Coiba - Relax at the North Villa! The North Villa has plenty of space. The rooftop patio has furniture, a bar and is perfect for star gazing and birdwatching. Your villa comes with ample bedrooms, fully equipped kitchen (cookware, spices, blender, coffee maker etc), full living area, charcoal grill, covered parking and dedicated Internet. We offer a free ground shuttle if you fly into the local airstrip. Feel free to message us and learn how to skip the 6hr+ drive!

Superhost
Home in Santiago
4.95 out of 5 average rating, 20 reviews

Casa a minutos de Santiago, U Latina, HospChichoF.

Casa amplia, cómoda y totalmente equipada en una ubicación estratégica de Santiago.Perfecta para todo tipo de huéspedes: familias, viajeros de trabajo, estudiantes, personas que vienen a citas médicas o quienes buscan un espacio tranquilo y accesible. La casa está ubicada muy cerca del Hospital Dr. Chicho Fábrega, Clínica Norte, U.Latina, Oxford School, Comercios Supermercados, farmacia, ,restaurantes, y minutos de Santiago centro. Un lugar seguro para estadías cortas y de larga estancia.

Guest favourite
A scenic view of rolling hills under a colorful sky at sunset. Shades of orange, pink, and purple blend, creating a vibrant horizon. Lush trees are scattered across the landscape, adding a touch of greenery to the terrain.
Cottage in Olá
4.95 out of 5 average rating, 19 reviews

Country House in Olá, rivers, waterfalls, Los Picachos

Finca La Terapia lives up to its name, nestled among the mountains of the picturesque village of Olá de Penonomé, where you can disconnect from the busy day-to-day life of the city. It has 42 private hectares to explore nature. The district of Olá is characterized by having the most beautiful natural landscapes among which we can mention, Los Chorros de Olá, Chorros las Mesitas, Cerros los Picachos, Rio San Antonio, Balneario Brujas, among others, just a few minutes from the Finca.

Top Guest favourite
An outdoor terrace is furnished with a sectional sofa in neutral tones and a low coffee table. A potted plant with green leaves and colorful flowers adds a vibrant touch. Large glass doors provide a view into the interior space, inviting natural light.
Villa in Lagartero
5 out of 5 average rating, 53 reviews

Private Villa with private pool, in Santa Catalina

A beautiful stand-alone 60 sq mt villa, 1 King bed and 1 queen. King size bed in the master bedroom with black out drapes, Queen size bed and fold out couch in the loft area. Full kitchen, living and dining area, flat screen TV, Bathroom with soaps/shampoos, and rainfall showerhead. Large terrace with views as far as the eye can see, with BBQ, dining table and outdoor sectional sofa. Private swimming pool with seating area, pool lounge chairs, lighted gazebo and sun umbrellas.

Top Guest favourite
A spacious outdoor deck features modern furniture arranged for relaxation, overlooking a lush mountainous landscape. Verdant hills and a colorful sky at dawn create a tranquil environment, inviting guests to enjoy the natural beauty and serenity of the surroundings.
Villa in El Copé
4.92 out of 5 average rating, 183 reviews

Mountain retreat

Our beautiful, modern, comfortable house is designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and also a base to explore the area which is in a beautiful part of Panama near a cloud forest national park with amazing hiking to waterfalls and local communities. The house is large, sleeping 12, within 17 acres of forest with rivers for swimming. We can arrange tours and hosted retreats for yoga, cooking and more.

Superhost
A tranquil garden scene is depicted, featuring a winding pathway of smooth stones and pebbles. Surrounding areas are adorned with various flowering plants and a small pond, enhancing the peaceful ambiance. Lush greenery is visible in the background, contributing to the serene atmosphere.
Farm stay in Santa Fe
4.89 out of 5 average rating, 301 reviews

Santa Fe villa with a espectacular view

Spectacular contemporary style villa surrounded by local flowers and woods. The villas design enhances the relationship with the outside environment with panoramic windows which are found in the dining room and kitchen, this offers an awesome view of the mountains and green flora. The villa is located in a organic quiet farm, with abundant vegetation and great presence of birds.

Guest favourite
Cottage in Santa Fe
5 out of 5 average rating, 6 reviews

k* Casa Matilde | 2BR Santa Fe Retreat by River

Escape to Casa Matilde, a renovated 100 m² home in Santa Fe de Veraguas. With 2 bedrooms and 3 beds (1 queen & 2 twins), it’s perfect for families or remote workers. Enjoy a bright living room, modern bath with hot water, A/C, and fast Starlink Wi-Fi. Relax by the private creek, explore the river just 200 m away, and take in mountain views—all with total privacy and comfort.

Superhost
Cabin in Calobre
4.71 out of 5 average rating, 24 reviews

La Yeguada - Forest Point Cabin

Lleva a toda la familia a este fantástico lugar con muchas zonas para divertirse, totalmente equipada cabaña de campo con cocina amplia, sala de estar con acceso a televisión, hamacas, refrigerador, estufa, agua caliente y todo lo que necesitas para pasar un buen momento alejado del ruido y convivir con la naturaleza.

Superhost
A small dining area is featured with a round table and two folding chairs. Large windows offer views of lush greenery outside, while sheer white curtains partially filter natural light.
Apartment in Santiago
4.88 out of 5 average rating, 8 reviews

d'rosas apartamentos 3PB

Discover the comfort in our cozy home in the heart of Santiago, Veraguas. Just a 5 minute walk from downtown, you'll enjoy a well-equipped space that includes all the necessary amenities for a relaxing stay. Ideal for exploring local culture and resting after a day of adventure. We look forward to seeing you!

Guest favourite
A spacious living area is surrounded by large windows, offering panoramic views of the lush landscape. Comfortable seating is arranged in a circular layout, adorned with colorful cushions. A central coffee table is complemented by decorative plants and a warm wooden floor enhances the inviting ambiance.
Farm stay in Santa Fe
5 out of 5 average rating, 9 reviews

Mansion in Granja Orgánica Climatized Pool

Relax with the whole family and friends up to 30 people in this cozy house on an organic farm with animals, seedlings, tilapia fishing, coffee , rivers, we have a heated pool, roofed terrace of 120 meters to celebrate your special occasions.

Guest favourite
A contemporary cabana is nestled among lush greenery, showcasing a unique stone accent wall. Large windows offer expansive views of the natural surroundings, complemented by a covered terrace that invites outdoor relaxation.
Home in Las Trancas
4.91 out of 5 average rating, 22 reviews

Cabana Vergara Santa Fe

Kick back and relax on this 2 acre ( 1 hectare) private mountain side property, on the Santa Maria River. Equipped with all the amenities you will need to make your stay a home away from home!

Popular amenities for La Mesa District holiday rentals