
Holiday houses in La Mesa District
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Top-rated holiday rentals in La Mesa District
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Beachfront Family EcoParadise to Coiba lsl BunkBed
Experience authentic Panama in our family-owned 30-hectare private tropical beachfront paradise. Accessible only by boat (30-min ride from Pixvae or 1:30hr from Santa Catalina). Gateway to Coiba Island, our remote bay offers pristine jungle, diverse wildlife, and breathtaking views. Enjoy kayaking, fishing, and guided eco-tours. Spot howler monkeys, sloths, and rare birds. Savor fresh tropical fruits and local cuisine. Perfect for nature lovers, photographers, and digital nomads (WiFi available)

Casa a minutos de Santiago, U Latina, HospChichoF.
Casa amplia, cómoda y totalmente equipada en una ubicación estratégica de Santiago.Perfecta para todo tipo de huéspedes: familias, viajeros de trabajo, estudiantes, personas que vienen a citas médicas o quienes buscan un espacio tranquilo y accesible. La casa está ubicada muy cerca del Hospital Dr. Chicho Fábrega, Clínica Norte, U.Latina, Oxford School, Comercios Supermercados, farmacia, ,restaurantes, y minutos de Santiago centro. Un lugar seguro para estadías cortas y de larga estancia.

South Villa w Rooftop Fly- Drive- Coiba day tour
Fly in - charters. Rooftop w/great view! 1000ft2 Your rooftop lounge is perfect for star gazing and birdwatching. Your villa comes with a spacious bedrooms, a fully equipped kitchen (cookware, spices, blender, coffee maker etc), full living area, & your backyard grill. All surrounded by acres of gardens. Fly / drive / take a tour to Coiba Island. If you drive in, we have covered parking for you. If you fly - we have you covered as well! Message for additional information.

Country House in Olá, rivers, waterfalls, Los Picachos
Finca La Terapia lives up to its name, nestled among the mountains of the picturesque village of Olá de Penonomé, where you can disconnect from the busy day-to-day life of the city. It has 42 private hectares to explore nature. The district of Olá is characterized by having the most beautiful natural landscapes among which we can mention, Los Chorros de Olá, Chorros las Mesitas, Cerros los Picachos, Rio San Antonio, Balneario Brujas, among others, just a few minutes from the Finca.

Private Villa with private pool, in Santa Catalina
A beautiful stand-alone 60 sq mt villa, 1 King bed and 1 queen. King size bed in the master bedroom with black out drapes, Queen size bed and fold out couch in the loft area. Full kitchen, living and dining area, flat screen TV, Bathroom with soaps/shampoos, and rainfall showerhead. Large terrace with views as far as the eye can see, with BBQ, dining table and outdoor sectional sofa. Private swimming pool with seating area, pool lounge chairs, lighted gazebo and sun umbrellas.

Mountain retreat
Our beautiful, modern, comfortable house is designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and also a base to explore the area which is in a beautiful part of Panama near a cloud forest national park with amazing hiking to waterfalls and local communities. The house is large, sleeping 12, within 17 acres of forest with rivers for swimming. We can arrange tours and hosted retreats for yoga, cooking and more.

Casa Colibrí - modern house in the green
Casa Colibri is a beatiful, spacious home in the middle of nature and will make your stay in Santa Catalina perfect. It has a large terrace with a fantastic view into the green where you can relax and listen to the birds. The interior has a lot of natural light and stays cool during the day, in case you need to escape the tropical heat. It is the perfect place for a unique experience in this special town with your friends or family.

"La Moncheria" house with garden and kitchen X 2
CASA "LA MONCHERIA" is a very colorful house, hand-furnished with love. It has a large outdoor garden equipped with hammocks and sofas where you can enjoy a little relaxation in privacy. The bathroom is private and has a hot water shower. There is also a kitchen equipped with a refrigerator and dishes for cooking. The house is located right halfway between the village and Playa del Estero and a 2-minute walk from La Punta.

Santa Fe villa with a espectacular view
Spectacular contemporary style villa surrounded by local flowers and woods. The villas design enhances the relationship with the outside environment with panoramic windows which are found in the dining room and kitchen, this offers an awesome view of the mountains and green flora. The villa is located in a organic quiet farm, with abundant vegetation and great presence of birds.

k* Casa Matilde | 2BR Santa Fe Retreat by River
Escape to Casa Matilde, a renovated 100 m² home in Santa Fe de Veraguas. With 2 bedrooms and 3 beds (1 queen & 2 twins), it’s perfect for families or remote workers. Enjoy a bright living room, modern bath with hot water, A/C, and fast Starlink Wi-Fi. Relax by the private creek, explore the river just 200 m away, and take in mountain views—all with total privacy and comfort.

d'rosas apartamentos 3PB
Discover the comfort in our cozy home in the heart of Santiago, Veraguas. Just a 5 minute walk from downtown, you'll enjoy a well-equipped space that includes all the necessary amenities for a relaxing stay. Ideal for exploring local culture and resting after a day of adventure. We look forward to seeing you!

Mansion in Granja Orgánica Climatized Pool
Relax with the whole family and friends up to 30 people in this cozy house on an organic farm with animals, seedlings, tilapia fishing, coffee , rivers, we have a heated pool, roofed terrace of 120 meters to celebrate your special occasions.
Popular amenities for La Mesa District holiday rentals
Other great holiday rentals in La Mesa District

Oceanfront Getaway | Divers & Surfers Delight

2 bedroom house in Santiago

Ecolodge Deseo Bamboo - Family Villa

Accommodation in Santiago Centro

Furnished apartment in Aguadulce

Studio Hotel Gran David

tipi

Mountain retreat with hot tub and farm views
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