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Holiday houses in La Mesa District

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in La Mesa District

Guests agree: these stays are highly rated for location, cleanliness and more.

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Top Guest favourite
Cabin in Sona
4.95 out of 5 average rating, 20 reviews

Beachfront Family EcoParadise to Coiba lsl BunkBed

Experience authentic Panama in our family-owned 30-hectare private tropical beachfront paradise. Accessible only by boat (30-min ride from Pixvae or 1:30hr from Santa Catalina). Gateway to Coiba Island, our remote bay offers pristine jungle, diverse wildlife, and breathtaking views. Enjoy kayaking, fishing, and guided eco-tours. Spot howler monkeys, sloths, and rare birds. Savor fresh tropical fruits and local cuisine. Perfect for nature lovers, photographers, and digital nomads (WiFi available)

Guest favourite
Tiny home in El Copé, La Pintada
4.95 out of 5 average rating, 22 reviews

Serena Lodge & Camping - The Cope

Escape to Serena Lodge, a cozy mountain cabin tucked among pine trees in El Copé, Panama. Wake up to birdsong, stunning valley views, and total privacy—just minutes from waterfalls (Las Yayas, Tigrero, Santa Maria, El Harino river, Rio Grande, Chorro Grande) and the Omar Torrijos National Park. Perfect for couples, families, friends, remote workers and nature lovers seeking fresh air, and a true disconnect in the mountains. 🌧️ Rainy Season (May–November) ☀️ Summer Season (December–March) por

Guest favourite
A thatched-roof gazebo provides shade over a wooden bar counter, accompanied by several wooden stools. Lush vegetation surrounds the structure, with a clear blue sky visible overhead, creating an inviting outdoor space for relaxation.
Townhouse in Santa Catalina
4.88 out of 5 average rating, 139 reviews

North Villa with Rooftop. Full Kitchen!

Fly / Drive - Tour Coiba - Relax at the North Villa! The North Villa has plenty of space. The rooftop patio has furniture, a bar and is perfect for star gazing and birdwatching. Your villa comes with ample bedrooms, fully equipped kitchen (cookware, spices, blender, coffee maker etc), full living area, charcoal grill, covered parking and dedicated Internet. We offer a free ground shuttle if you fly into the local airstrip. Feel free to message us and learn how to skip the 6hr+ drive!

Superhost
A scenic view of rolling hills under a colorful sky at sunset. Shades of orange, pink, and purple blend, creating a vibrant horizon. Lush trees are scattered across the landscape, adding a touch of greenery to the terrain.
Cottage in Olá
4.79 out of 5 average rating, 29 reviews

Country House in Olá, rivers, waterfalls, Los Picachos

Finca La Terapia lives up to its name, it is located among the mountains of the picturesque village of Olá de Penonomé, where you can disconnect from the busy day to day of the city. It has 42 private hectares to explore nature. The Olá district is characterized by having the most beautiful natural landscapes, among which we can mention Los Chorros de Olá, Chorros las Mesitas, Cerros los Picachos, Rio San Antonio, Balneario Brujas, among others, just a few minutes from the property.

Top Guest favourite
An outdoor terrace is furnished with a sectional sofa in neutral tones and a low coffee table. A potted plant with green leaves and colorful flowers adds a vibrant touch. Large glass doors provide a view into the interior space, inviting natural light.
Villa in Lagartero
5 out of 5 average rating, 73 reviews

Private Villa & Pool, in Lago Bay, Santa Catalina

A beautiful stand-alone 60 sq mt villa, 1 King bed and 1 queen. King size bed in the master bedroom with black out drapes, Queen size bed and fold out couch in the loft area. Full kitchen, living and dining area, flat screen TV, Bathroom with soaps/shampoos, and rainfall showerhead. Large terrace with views as far as the eye can see, with BBQ, dining table and outdoor sectional sofa. Private swimming pool with seating area, pool lounge chairs, lighted gazebo and sun umbrellas.

Guest favourite
A spacious outdoor deck features modern furniture arranged for relaxation, overlooking a lush mountainous landscape. Verdant hills and a colorful sky at dawn create a tranquil environment, inviting guests to enjoy the natural beauty and serenity of the surroundings.
Villa in El Copé
4.92 out of 5 average rating, 190 reviews

Mountain retreat

Our beautiful, modern, comfortable house is designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and also a base to explore the area which is in a beautiful part of Panama near a cloud forest national park with amazing hiking to waterfalls and local communities. The house is large, sleeping 12, within 17 acres of forest with rivers for swimming. We can arrange tours and hosted retreats for yoga, cooking and more.

Guest favourite
Home in Canto del Llano
4.91 out of 5 average rating, 43 reviews

Santiago city, home w/ spacious living & office

Spacious and peaceful home in a safe area of Santiago. 4 bedrooms (ideal for families and groups), bright living-dining area and large kitchen to share with family or friends, plus a private office for working comfortably. High-speed Wi-Fi, air conditioning and fans in all rooms, fully equipped kitchen, washer/dryer, and safe for valuables. Self check-in with smart lock, parking for several cars, and a coffee station with board games and karaoke.

Top Guest favourite
A large kitchen is featured with a central island surrounded by modern stools. Stainless steel appliances complement the elegant design, while natural light streams through large windows opening to a garden view. Decorative pendant lights hang above the island, adding a warm ambiance.
Home in Santa Catalina
4.97 out of 5 average rating, 37 reviews

Casa Tropical- Private Home in Santa Catalina

Located in the Heart of Santa Catalina village, this newly remodeled Panamanian style home inspires comfort and relaxation. The interior is designed with an open floor plan that connects to the outdoors, so that you can truly experience tropical living. Enjoy the privacy of an entire home while being within walking distance of restaurants, shops, and town beach. Our home is perfect for Scuba Dive enthusiasts or Surfers in search of great waves.

Superhost
An inviting swimming pool is framed by natural stone, surrounded by lush greenery and flowering plants. The expansive view reveals a tranquil body of water and rolling hills under a clear blue sky, creating a serene outdoor setting.
Villa in Quebrada de Piedra
4.93 out of 5 average rating, 14 reviews

Amazing Cozy Villa Overlooking the Pacific Ocean

Disfruta de nuestra espectacular Villa, rodeada de tranquilidad con un hermoso paisaje, conectada con la naturaleza y perfecta para desconectar de la vida cotidiana; un lugar encantador para compartir con tu familia o amigos. Cuenta con todas las amenidades necesarias para que su estadía sea inolvidable y una piscina exclusiva para disfrutar de la hermosa vista al Océano Pacífico.

Guest favourite
Farm stay in Santa Fe
4.9 out of 5 average rating, 323 reviews

Sun Cabin at Finca Namuiki by the River

Spectacular contemporary style villa surrounded by local flowers and woods. The villas design enhances the relationship with the outside environment with panoramic windows which are found in the dining room and kitchen, this offers an awesome view of the mountains and green flora. The villa is located in a organic quiet farm, with abundant vegetation and great presence of birds.

Guest favourite
Cottage in Santa Fe
4.89 out of 5 average rating, 18 reviews

k* Casa Matilde | 2BR Santa Fe Retreat by River

Escape to Casa Matilde, a renovated 100 m² home in Santa Fe de Veraguas. With 2 bedrooms and 3 beds (1 queen & 2 twins), it’s perfect for families or remote workers. Enjoy a bright living room, modern bath with hot water, A/C, and fast Starlink Wi-Fi. Relax by the private creek, explore the river just 200 m away, and take in mountain views—all with total privacy and comfort.

Guest favourite
A contemporary cabana is nestled among lush greenery, showcasing a unique stone accent wall. Large windows offer expansive views of the natural surroundings, complemented by a covered terrace that invites outdoor relaxation.
Home in Las Trancas
4.91 out of 5 average rating, 32 reviews

Vergara Cabin Santa Fe

Kick back and relax on this 2 acre ( 1 hectare) private mountain side property, on the Santa Maria River. Equipped with all the amenities you will need to make your stay a home away from home!

Popular amenities for La Mesa District holiday rentals