Holiday houses in Panacea

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Top-rated holiday rentals in Panacea

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Guest favourite
The living area is furnished with a large, inviting couch and features artwork on the walls, including nautical-themed pieces. A lamp beside the couch provides ambient lighting. A decorative arrangement with a wine bottle and glasses sits on a white countertop, which divides the space.
Bungalow in Panacea
4.88 out of 5 average rating, 310 reviews

Otter lake cottage

The Otter Lake Cottage is in a small fishing village with beaches 6mi. It sets on 3/4 acre with a concrete grill area out back ,plenty of parking space if you want to bring your boat canoe or bikes. Large covered porch on the front. There is beautiful rivers for canoeing or swimming, great fishing it is also less than a mile away from the Gulf. Wakulla has great Seafood restaurant'syou can dine over the water or by it. We have a park for kids and the Gulf Marine lab where they can touch and learn about sea turtles and all marine life. This is the perfect place to have a quiet get away. Otter Lake is a great place to walk it has bald eagles bird trails walking trails a great place for picnics. It's located in the national forest just down the rd.

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Top Guest favourite
Cottage in Panacea
4.99 out of 5 average rating, 231 reviews

Vintage Old Florida Charm “For The Birds”

Welcome to Natural Florida! About 30 mi from FSU’s 🏈 Stadium , 5 min from the Gulf. Vintage 1938 cottage, 2 bedrooms/2 bathrooms, under ancient mossy oaks & palms in Panacea, FL. Comfortable, eccentrically decorated w/well-equipped kitchen. Near boat ramp, top seafood markets & wonderful restaurants. Close to public National & State Parks: St. Marks Wildlife Refuge & Lighthouse, AREA X, Wakulla Springs, Florida Birding & Hiking & Bicycle Trails, Gulf, Bays, Lake, & Beach, Birdwatch, Fish, FUN!

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Top Guest favourite
A spacious waterfront home is depicted, featuring a screened porch and a metal roof. Lush greenery and golden grasses surround the base of the house, while calm waters extend across the foreground. The structure is elevated on stilts, providing an inviting appearance.
Home in Crawfordville
4.97 out of 5 average rating, 130 reviews

Fisherman’s Oceanfront Dream Home w/Dock & Kayaks

35% discount for monthly stays, 15% for weekly. Million$$ views of Oyster Bay & Gulf from every room. Only 40 minutes to the Florida Capital, FSU, FAMU, TSC & the Tallahassee International Airport. Private dock, trailer parking & boat ramp. Screened porch & 2 walkout decks. Views from any room are breathtaking! Enjoy the hammocks under the house. Kayaks, fish cleaning station & crab trap are provided. With the well appointed kitchen, gas grill & laundry you will have everything you need.

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Guest favourite
Home in Panacea
5 out of 5 average rating, 37 reviews

Coastal Cottage- on the Bay

A nature lover’s paradise, the “Coastal Cottage” has it all!  Nestled on the edge of Dickerson Bay, it's located in a gated community with a pool, a pool house, a gazebo and a fishing pier. This stylish circular-shaped home comes with an open floor plan, lots of windows and natural light, many new upgrades, and the views are absolutely phenomenal! The home is within walking distance to waterfront restaurants and the Gulf Specimen Aquarium. A new home is being prepared for occupancy next door.

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Top Guest favourite
Three horses graze peacefully in a lush green field, surrounded by a wooden fence. A spacious barn with a light-colored exterior and green roof stands in the background, framed by tall trees offering a serene, natural setting.
Barn in Panacea
4.94 out of 5 average rating, 235 reviews

Enjoy a Weekend in a Barn near the Refuge.

Experience Country Life, in a barn loft nestled in the the woods, close to the St Marks Refuge & the Gulf. Its secluded & private, close to several local beaches. View Florida's breath taking sunsets. Great for family get a ways or some R&R. Fish, kayak, bike alonfg our nice trails & do some hiking, along the Coast. There is Fresh & Salt Water fishing for the fishermen. So bring the boat, bikes, kayaks, kids, pets, even grandma! Enjoy a fire & do some star gazing. Make family memories!

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Top Guest favourite
A shaded deck features a single rocking chair facing a serene pond, surrounded by lush greenery. The inviting space offers a peaceful view of the water and natural landscape, providing an ideal setting for relaxation and reflection.
Home in Panacea
5 out of 5 average rating, 18 reviews

Refuge on the Water

A private bit of paradise! Visitors to the Refuge on the Water gaze upon the Saint Mark's Wildlife Refuge from across a beautiful pond. Every space in the home has a tranquil water view. You'll enjoy the play of sun and clouds on the pond from inside or on the huge deck as the sun crosses the sky each day-followed by pure darkness and moonlight. This cottage is a birders, stargazers and wildlife lovers dream come true. Otters, osprey, bears and eagles await you at the Refuge on the Water.

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Guest favourite
An outdoor seating area is presented beneath a wooden pergola, featuring a small round table surrounded by two chairs. A colorful patterned rug is visible on the ground, and potted plants are arranged around the space. The backdrop displays a grassy area leading to the ocean.
Bungalow in Alligator Point
4.92 out of 5 average rating, 185 reviews

"Finest Kind" - Direct Oceanfront & Bay Access

Newly renovated beachfront bungalow with a captivating direct unobstructed (100 foot) oceanfront view. (note, directly in front of house is a rock wall - not beach.) Crowd-free public beach nearby & private bay right outside your door. Great location for star-gazing at night & beautiful ocean view sunrises & sunsets. Perfect location for fishing, kayaking, boating, bicycling & other beachside activities. Catch shrimp from the gulf & hook up in the bay only footsteps away. Outdoor Shower

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Top Guest favourite
The exterior of a single-story home is presented, featuring a bright blue front door framed by two tall windows with decorative shutters. Lush green plants and landscaping enhance the entryway, and a small porch is highlighted, creating an inviting first impression.
Home in Panacea
4.98 out of 5 average rating, 43 reviews

A Pretty stay at Panacea Palms!

Bring the whole family to this peaceful place with lots of room for relaxing. With a fully fenced yard, your pup is welcome, too! Large parking pad is ideal for a two family get together or vacation, and there's room for your boat, too. Less than 1 mile from the public boat ramp makes this an ideal spot to come and have a fishing or recreational get away. Enjoy an afternoon on the comfy screened porch or a quick excursion to one of the many fine seafood restaurants or parks in the area!!

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Guest favourite
Home in Panacea
5 out of 5 average rating, 7 reviews

Panacea SeaTower (2)

No pets! 🚤 Why We Love This Spot (From Me Personally) On weekends, we come down for local festivals, launch our boat with the kids, and head out for: • Speckled trout • Redfish • scallops The public boat ramp is only about 50 feet away, making it incredibly easy to launch, park, and walk back to the house. Bring your boat, drop it in.. Panacea restaurants serving fresh local catch straight off the boat! • Trident Restaurant • Posey’s • Tropical Trader Shrimp • Angelo’s Restaurant

FamilyCheckoutRiver

Top Guest favourite
A single-story home features a welcoming front porch with green railings and a decorative entrance. A light color palette of the exterior is complemented by green shutters, and tall palm plants line the front yard, creating an inviting outdoor space surrounded by natural landscaping.
Home in Panacea
4.93 out of 5 average rating, 208 reviews

Fishermans Retreat

Fisherman's Retreat is the perfect location to get away from the stress of the city. Located in the quiet and cozy Panacea ocean community, you are close to several beaches, boat ramps, favorite local fishing spots, kids playground across the street, and the Gulf Specimen Aquarium that is fun for all ages. Don't forget the food, you can take in and enjoy several local restaurants that will satisfy every culinary appetite. So, check out of the big city and check into our relaxing home.

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Guest favourite
Home in Panacea
4.91 out of 5 average rating, 75 reviews

Paradise in Panacea- Waterfront on Ochlockonee Bay

Trailer your boat and family down to this one-of-a-kind home on the Ochlockonee Bay. This waterfront property offers a private boat slip, dock w/ seating area, fenced-in back yard, luxury kitchen with eat-in bar, game room/office, sunroom w/ 2 single beds, deck with outdoor seating, 3 bedrooms (split plan), 2.5 baths, and 2-car carport with room for a trailer. Inside, enjoy an open and comfortable floor plan, perfect for entertaining and bringing friends and family together.

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Guest favourite
A serene sunset is captured over calm waters, with soft hues of orange and pink reflecting on the surface. Silhouettes of palm trees are visible in the foreground, enhancing the tranquil coastal setting.
Condo in Carrabelle
4.88 out of 5 average rating, 144 reviews

St. James Sanctuary

This lovely condo on Florida's "Forgotten Coast" provides guest with a beautiful view and tranquility only seen in this area of Florida. Located in St. James in Franklin county, you are 44 miles from the Tallahassee airport, it is convenient to a big city, while set in a quiet, rural beach area. You are only minutes from St. James Golf club, Carrabelle (7 miles away with public beach), St. George Island, Panacea and Apalachicola. Swimming not recommended (more like a bay).

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Popular amenities for Panacea holiday rentals

When is the best time to visit Panacea?

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Frequently Asked Questions

  • What are the best places to stay in Panacea?

    Lodging options in Panacea include waterfront cabins, family houses, and rentals near the coastline. Staying around the bay or marshes lets guests enjoy scenic views and direct access to nature.

  • What are the best things to do in Panacea with kids?

    Kids can interact with marine life at the Gulf Specimen Marine Lab, hunt for shells on quiet beaches, or spot wildlife in local parks. Family-friendly hiking and fishing are also popular choices.

  • What are some of the best things to do in Panacea?

    Explore kayak trails through salt marshes, try fishing from public piers, or engage with touch tanks at the Gulf Specimen Marine Lab. Birdwatching, local dining, and small-town shops add to the experience.

  • How is the weather in Panacea?

    Panacea experiences mild winters, typically between 40–66°F (5–19°C), and hot, humid summers near 73–92°F (23–33°C) with more frequent rainfall. Spring and fall are comfortable, making them attractive times for outdoor activities.

  • When is the best time to visit Panacea?

    Spring and fall are often recommended for milder temperatures, comfortable humidity, and fewer bugs. Summer brings warmer weather and lively local events, while winter is typically quieter and cooler.

  • What are the best places to visit in Panacea?

    Panacea has coastal parks, wildlife education centers, and fishing piers where visitors can explore local nature and culture. The Gulf Specimen Marine Lab is often recommended for its interactive marine exhibits.

  • What are some hiking trails in Panacea?

    Panacea has flat, scenic trails through coastal forests and salt marshes, suitable for casual walkers and birdwatchers. Some trails connect to wildlife refuges for more extensive nature exploration.

  • What are some family activities we can do in Panacea?

    Explore marine touch tanks, walk local nature trails, or picnic near marshes where kids can spot birds and small wildlife. Guided boat rides and simple fishing outings create memorable family moments.

  • What are some of the best day trip ideas from Panacea?

    Visitors often take day trips to explore nearby lighthouses, clear springs, or coastal wildlife areas. Nature refuges and historic fishing villages around the region provide additional opportunities for outings.

  • Are there any pet friendly accommodations available in Panacea?

    Many Panacea rentals welcome pets, especially around the waterfront and quieter residential areas. Parks and natural beaches make it easy to enjoy the outdoors with dogs.

  • What are some local tips for visiting Panacea?

    Early mornings are great for spotting wildlife, and locals suggest visiting the waterfront before midday for cooler weather. Fresh seafood is often sourced directly from local docks, so sampling it is a popular choice.

  • What is Panacea known for?

    Panacea is known for its rich coastal ecosystems, small-town fishing traditions, and marine education experiences. The area often attracts visitors interested in nature, seafood, and quiet getaways.

  • What are the best hidden gems to explore in Panacea?

    Explore quiet marsh boardwalks, small local art galleries, or historic sites reflecting the town’s fishing heritage. Tucked-away nature areas often provide peaceful spots for birdwatching and photography.

  • What are the best foods to try in Panacea?

    Fresh Gulf seafood is frequently suggested in Panacea, including oysters, blue crabs, and shrimp prepared in locally rooted styles. Southern pies and regional barbecue round out many menus.

  • What should I bring for a trip to Panacea?

    Pack casual clothing, a sun hat, and sunscreen for outdoor activities, as the area is sunny and humid much of the year. Bug spray, comfortable walking shoes, and a light rain jacket are also useful.

  • What is the nightlife in Panacea like?

    Nightlife in Panacea is relaxed, with casual seafood restaurants, local bars, and occasional live music events. Evenings are often spent by the water or enjoying small community gatherings.

  • What are the most popular events or festivals in Panacea?

    Panacea frequently celebrates local traditions through seafood festivals, small-town parades, and community gatherings, often centered around the fishing season or holiday weekends. Visitors can also find outdoor markets and seasonal arts events throughout the year.

  • Are there family friendly vacation rentals in Panacea?

    Panacea has a range of family-friendly rentals, including homes with spacious yards and easy beach access. Many properties are set up to welcome children and groups looking to enjoy the outdoors together.

Quick stats about holiday rentals in Panacea

  • Total holiday rentals

    Explore 30 holiday rentals in Panacea

  • Nightly prices starting at

    Panacea holiday rentals start at $136 NZD per night before taxes and fees

  • Verified guest reviews

    Over 1,060 verified reviews to help you choose

  • Family-friendly holiday rentals

    10 properties offer extra space and kid-friendly amenities

  • Pet-friendly accommodation

    Find 10 rentals that welcome pets

  • Wi-Fi availability

    30 of Panacea holiday rentals include Wi-Fi access

  • Popular amenities for guests

    Guests love Beachfront, Gym and BBQ grill across Panacea rentals

  • 4.7 Average rating

    Panacea stays receive an average rating of 4.7 out of 5 from guests

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  2. United States
  3. Florida
  4. Wakulla County
  5. Panacea