
House holiday rentals in Picayune
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Top-rated house rentals in Picayune
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Holiday rentals for every style
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Popular amenities for Picayune house rentals
House rentals with a pool

Heated Pool, Hot Tub, Boat/Fish Dock, No pet fees!
This was exactly the right choice for our small wedding. The home and yard were ABSOLUTELY BEAUTIFUL. Everything was easy to find in the home, the home was so inviting too! Just really had the best time, everyone in the family that attended also loved it. There were nothing but compliments! And Dick was probably the best host I've ever had. He was on top of things communication-wise! I thank him so much for everything. He really made my wedding so perfect.

*Walk to Beach! Heated Pool/Spa*views & oak trees
What an awesome place to stay. Great location and convenient to restaurants, beach and Biloxi. Awesome pool and fun to have a view of the beach and water across the road while you relax poolside. Everything you need for a home away from home feel. Just what we needed for a relaxing getaway.

The Corr'al Reef - Brand New!
This was a absolutely amazing Airbnb! The pool and bar area was amazing and everything me and my wife were looking for. I 100% recommend this Airbnb for a beautiful place to cool off this summer

Coastal Serenity! Heated Pool/Hot tub!
My fiancé and I, along with our two friends, very much enjoyed our stay with Mrs. Stacey. We checked in very late due to work hours and she was very understanding. She was accommodating to our needs and wants, always quick to respond, and very kind and sweet. We will most definitely be booking with her and her beautiful home again in the future. Hands down a great first impression for our first stay in an Airbnb!

Wined Down in a cozy 2br/2ba home on water w/pool
Wanted to take a trip to visit my dad’s grave, at the Veterans National Cemetery in Biloxi, and make a fun little summer vacation trip for the kids. Wined down was located in the perfect spot. The pool and dock helped keep the kids entertained. Wined down also had plenty of entertainment for the stormy days. We felt like we were home and will definitely be back.

Waveland Beach Cottage 213
Super cute house—very clean, comfortable, and the pool and hot tub were fantastic! The only minor inconvenience was the lack of shade in the pool area, and there were only four lounge chairs and four regular chairs, which wasn’t quite enough since the space is shared by five houses. That said, the host was friendly, helpful, and very responsive, which made our stay even better. Overall, we had a great experience and are definitely planning to stay here again!

The Boat House Bay St. Louis
This was a last minute getaway trip for us. We live in New Orleans, which made the drive easy. I really just wanted to float in a pool for two days to escape the heat. This was perfect for that. I loved how the pool is surrounded by greenery, making it feel really secluded and private. The bay is across the street. There is a small beach area too. We spent Saturday wandering around Bay St. Louis and the rest of our time in the pool. The house is clean and comfortable. We ate on the front porch a lot. It's a plus that it's screened in. Overall, we had a great stay.

Gulf Moon II - Spacious Beachfront Home with Pool
From the moment we got into the house, we were completely amazed by how beautiful the inside was. Very spacious, welcoming and comfortable. We rented this beach house for our wedding party to stay in. Everyone fit comfortably and had their own space. The bridal party had the second floor to get ready, and the groom and groomsmen had the bottom to get ready. Made staying separate really easy. The pool was the cherry on top. After a long day of wedding activities, it was so nice to relax by the pool outside to end the night with our wedding party. We would definitely stay again.
Weekly house rentals

Cabin at Creekside Ranch
Creekside Cottage was a haven of peace, comfort, and tranquility. The setting provided a place for family gathering and laughter, as well as, an opportunity for healing. All of us enjoyed the Creekside Cottage and highly recommend it to anyone!

Luxury 3 bedroom home with epic views
If you are looking for a wonderful place to stay on the Mississippi Gulf Coast, look no further. The house is great and looks just like the pictures. The beds were very comfortable, and the house was very spacious. If you are looking to bring a boat, this is the perfect place. Having your personal boat ramp to launch your boat is priceless!!! The canal is plenty deep all the way out to the Gulf, and there is ample dock space for most any boat you plan to bring. Don't worry about parking. There was plenty of room for parking under the house, even with our center console boat under the house, and there was still plenty of covered room under the house for entertaining or just relaxing in the cool evening breeze. The neighbors were wonderful and provided additional recommendations for great fishing spots and where to buy bait. To say the host were amazing would be an understatement. They were very responsive and helpful even before we booked the house. Thanks for a wonderful time!!!

Beach Therapy - Beachfront Rental!
Was a great location. Clean, easy to get to, easy to get inside, great communication from Michelle. As advertised. One minute walk to the beach. The breeze was nice and the view was awesome. Short drive to BSL. The beaches were not overpopulated and very clean. Enjoyed our stay! We will be back!

Waterfront property! Private Boat Launch
We cannot begin to tell you how wonderful Malarie was. She answered in a very timely manner and offered suggestions for whatever we asked for. She told us it was about 9 miles from the camp to the beach and that was very accurate. She also gave us suggestions on restaurants and we sent them one as well. The layout is amazing and it has a good atmosphere, with very comfortable furniture in every room. The kids had a great time fishing and crabbing, and every day they did not want to stop. There were more than enough games inside for the family to play together and both TVs worked very well giving us family movie night with no issue. They had enough supplies to get us through the first few days and plenty of dishes. The coffee pot was broken and when I told Malarie she immediately had one brought to us by way of DoorDash. She even included donuts for the kids and coffee. They do have several stairs to get into the camp, but it is well lit and they are in great condition. Highly recommend

NEW!Modern, Cozy, 3BR FarmhouseW/ Private Hot Tub
My wife and I stayed in this Air BNB in Slidell for our anniversary trip in May of 2025. We had an awesome time! We’ve stayed in a lot of places and this one hands down has been the most at home we’ve ever felt. The house was clean, welcoming and so peaceful. Stephanie was wonderful to interact with. She was prompt and made sure we had anything we needed while there. We will definitely be back. Thanks Stephanie!

Cottage in Diamondhead
Great host! The home had everything we needed for a vacation that still felt like home. Traveled with my two kids (ages 8 and 9), we loved the house and the quiet, friendly neighborhood. Would definitely book again. 10/10!

New, "Old Mandeville" cottage 30 miles to NOLA
We had a wonderful experience! The home was beautiful, spacious, and exactly as described. Haley was incredibly friendly, responsive, and made sure we had everything we needed during our stay. Great communication throughout, and we felt very well taken care of. Highly recommend!

Woodland House Nature Retreat
This house was perfect for our group! My family of 3 stayed in the master bed which gave our baby somewhere to play on the 1st floor without being in everyone’s way. Everyone else got their own room upstairs. We felt right at home and appreciated how well stocked everything was. The swing was great, the location was peaceful, and we will definitely book again if we’re ever in the area!
Private house rentals

Coastal Retreat
Phillip's place was perfect! The house looked new and had modern finishes. The neighborhood is quiet, but still very close to everything! The level of cleanliness was immaculate. I was also pleasantly surprised by how well stocked the Airbnb was with essentials like paper towels, toilet paper, shampoo, conditioner, coffee, creamer, etc. The cost was very affordable especially compared to other Airbnbs in the area. I would love to stay here again if back in the area!

The Yellow Birdie
A wonderfully warm home! Spacious for our family to spend time together. Conveniently located and in a peaceful location. Jacque was friendly and responded quickly. Our dogs loved the backyard.

On The Point Family Fish Camp
Place is wonderful. Thanks to Dean and Kim for being awesome hosts. Highly recommend and look forward to making more lasting memories here.

Luxury home 20 min from NOLA
The home was spotless and in a great neighborhood. However it’s about 35 minutes from Bourbon Street if that matters to you. But, the home was great, worked for my family, easy to check in, the host was very responsive. I have no complaints. I’d stay here again.

The Salty Dawg Fish Camp
We loved everything about the cabin! The location, the privacy, the items offered in the kitchen to cook with (although we didn’t use any), the games both upstairs and down (again we didn’t have time to use). Our visit was to attend Jeepin the Coast so we were wiped out when we returned each evening. We plan to return again! Thank you so much for opening up your cabin! ❤️

Cute Coast Camp~Pet Friendly-Dock BIG Water Access
I can’t say enough nice words for Amy! We arrived early to check in and she graciously allowed us to use an outside refrigerator for my daughter’s birthday cake because they were still there finishing up the cleaning. When we arrived back she had left my daughter a birthday happy!! The home was spotless and well stocked! She gave us so many recommendations we didn’t have time to visit them all!! I can assure you we will be back to this property!!!!!

Relax @ Waterfront *fishing*kayaks & private dock
Beth was the most AMAZING host we have ever had! She’s professional, courteous and so accommodating. Made me feel right at home with a friend I had known forever! Thank you my lady for having us and can’t wait to be back💜

Boating, Fishing and Big Porch to Relax
The house was immaculate! Loved the location and the peacefulness. We will definitely be staying there again.
Quick stats about house rentals in Picayune
Total rentals
20 properties
Nightly prices starting at
$50 NZD before taxes and fees
Total number of reviews
260 reviews
Family-friendly rentals
10 properties are a good fit for families
Pet-friendly rentals
10 properties allow pets
Rentals with dedicated workspaces
10 properties have a dedicated workspace
Destinations to explore
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- Biloxi Beach
- Tulane University
- Smoothie King Center
- Get Wet
- Mardi Gras World
- The National WWII Museum
- Mississippi Aquarium
- Fontainebleau State Park
- Gulf Island National Seashore
- Saenger Theatre
- English Turn Golf & Country Club
- Gulfport Beach, MS
- Buccaneer State Park
- Grand Bear Golf Club
- Louis Armstrong Park
- Milićević Family Vineyards
- Fallen Oak Golf
- Henderson Point Beach
- Amatos Winery
- St. Louis Cemetery No. 1
- New Orleans Jazz Museum
- Long Beach Pavilion
- Money Hill Golf & Country Club
- Harrison County Sand Beach