House holiday rentals in Pickens County

Find and book unique houses on Airbnb

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Popular amenities for Pickens County house rentals

House rentals with a pool

Home in Pendleton
4.67 out of 5 average rating, 18 reviews

The Hawks Nest

BridgetRating, 5 stars9 months ago
Exactly what I was looking for! I was in-town for parent's weekend and looking for a place with a great kitchen to prepare home cooked meals for my daughters as well as great location. Instantly felt like home and we knew an amazing family lived there. The host went out of her way to make sure we were comfortable and had everything we expected. I hope it is available for my future trips!!
Home in Salem
5 out of 5 average rating, 14 reviews

Lakefront, Dog Friendly, Golf Resort Amenities

PattyRating, 5 stars9 months ago
Really felt as comfortable as being home. Loved all the labels on light switches and helpful hints throughout to make the stay easy. Probably the best stocked rental on the market- everything you need for your stay. And greatly appreciated the cold waters in the mini fridge and we used them all- again thank you!!! Great place to stay and have a little view of the Lake.
Home in Salem
4.88 out of 5 average rating, 17 reviews

Lake Keowee condo by marina&pool close to Clemson

AmandaRating, 5 stars9 months ago
Annica's place was perfect for our family. We were in town for Clemson's Family weekend. Only a 23 min drive to campus. The space was easy to get to, in a private gated community and had amenity perks for staying in the community. The 2 king size beds were super comfortable. The bathrooms, kitchen, and living areas were all decorated nicely and our group had plenty of space to spread out. We rented a pontoon boat through the community for an affordable price (perks of being in the community) and had a wonderful couple days. Would love to come back for a visit our next trio to Clemson.
Superhost
Home in Six Mile
4.87 out of 5 average rating, 39 reviews

Lake Keowee Access-Dock-Pool-Grill-Clemson 17 Min

JeffRating, 5 stars4 days ago
The condo was well maintained and extremely clean. What we liked most was being outside of the city with beautiful drives in any direction. We visited Greenville, SC for a day, spent a day renting a boat on Lake Jocassee, and took a drive another day to Gorges State Park for some hiking. Everything was within an hours drive and the towns of Senaca and Clemson had anything you might need supply wise. The pool was clean and landscaping kept nice and trim. Erin was a wonderful, super responsive, host. I would highly recommend staying here.
Guest favourite
Home in Six Mile
5 out of 5 average rating, 5 reviews

Clemson football 15 minutes away. 2 night minimum.

ChipRating, 5 stars1 month ago
Rebecca was a fantastic host. Eight of stayed at her home for Clemson Graduation weekend. When we arrived Rebecca had left us a welcome basket with multiple snacks and coffee. We had plenty of space for everyone. The home was clean, and had plenty of amenities. The kids (teenagers) loved the volleyball pool, pickleball and other lawn games. The adults enjoyed sitting on the deck in the evening with a beverage while the propane fire pit provided nice ambiance. Now that our daughter has graduated we hope to return to Clemson and would absolutely rent Rebecca's home again!
Superhost
Home in Salem
4.86 out of 5 average rating, 21 reviews

Lake Keowee Home near Clemson, boating, and hiking

Leslie NunezRating, 5 stars8 months ago
Keowee Key community is great. This place is bigger than it even seems in the pictures. Very responsive host.
Top Guest favourite
Home in Salem
5 out of 5 average rating, 28 reviews

Golf view, lake access, 3 pools!

StephanieRating, 5 stars1 month ago
We had a wonderful stay at the Sail Loft over Memorial Day weekend! From the moment we arrived, we felt right at home. The space is so cozy, beautifully decorated, and full of thoughtful touches—it’s clear that every detail has been carefully considered. It’s just like the photos, only better in person! Nichole was the perfect host—kind, responsive, and welcoming. She guided us throughout our stay, making sure everything went smoothly and that we felt comfortable and cared for. We loved enjoying the Keowee Key amenities, especially the pool and dining at the club’s restaurants. It truly felt like a hidden gem! We’re already looking forward to coming back soon. Highly recommended for anyone looking for a peaceful retreat with all the comforts of home!
Home in Salem
4.74 out of 5 average rating, 27 reviews

* Keowee Key* Lake* Fireplace*Golf*Tennis*Gym*

Elisa SuttiRating, 5 stars2 months ago
Christina's house is amazing! We had a wonderful week in her home. It is spacious, comfortable and very clean. Equipped with all the necessary comforts and more. It also has a very large terrace. I highly recommend it!!

Weekly house rentals

Top Guest favourite
Home in Pendleton
4.99 out of 5 average rating, 67 reviews

Raven's Ridge

CarolRating, 5 stars2 weeks ago
One of the best airbnb's I've ever stayed in, and one of the best (the best?) hosts. My sister and I were in the area due to a death in the family, and from start to finish Esther thought about our needs, even anticipating stuff we did not! The home is sprawling with everything neat and labeled. We loved the raven and historic images all over the home. Happy to see deer out the window and I think a cow but I was out at the time! I hope my review pays forward all that Esther and her home did for us.
Guest favourite
Home in Seneca
4.95 out of 5 average rating, 93 reviews

Hanover Haven 3 BR/2 Bath

JulieRating, 5 stars3 weeks ago
Hanover was truly a haven. Our entire family was happy we could have such a lovely place to be together. The home was so lovely, roomy and clean, and well located for our time there. Jose was a wonderful host from the start of the process and we cannot thank him enough for our time there.⭐️⭐️⭐️⭐️⭐️⭐️⭐️⭐️⭐️
Guest favourite
Home in Six Mile
4.94 out of 5 average rating, 71 reviews

3 BR House Near Clemson

AmandaRating, 5 stars1 month ago
Absolutely loved it. We didn’t want to leave! Sitting on the covered porch each night was the highlight of my days.
Top Guest favourite
Home in Easley
4.96 out of 5 average rating, 55 reviews

Respite House

WilliamRating, 5 stars3 weeks ago
We were perfectly pleased with the entire experience. After 1 week, we wished we could have stayed longer. This was a peaceful loving home that we were privileged to enjoy as we got to spend time with our nearby family. We are truly grateful to Janie and her husband for providing such a beautiful experience. We look forward to visiting again.
Guest favourite
Home in Pickens
4.94 out of 5 average rating, 52 reviews

Countryside Haven

CandiceRating, 5 stars3 days ago
My family and I loved the place!! Such a great spot to spend the weekend. Place has a lot of character and is very cozy. Had everything we needed!
Guest favourite
Home in Easley
5 out of 5 average rating, 11 reviews

Farm-Style Cottage

AliceRating, 5 stars1 month ago
Beautiful home and very responsive hosts!
Guest favourite
Home in Easley
4.94 out of 5 average rating, 33 reviews

Easley/ Greenville, 7 bedrooms 3.5 bath billiards

AnnaRating, 5 stars1 month ago
Perfect house for our large family. We all had plenty of space and privacy. Close to grocery stores, shopping and event centers that we were there for. Very easy to talk to and answered questions quickly.
Guest favourite
Home in Piedmont
4.96 out of 5 average rating, 24 reviews

Farmhouse | Near Greenville & Clemson | Retreat!

KendallRating, 5 stars2 weeks ago
Very charming farmhouse. Was perfect for our long weekend stay for family get together in Greenville. Only about 15-20 minute drive to center of city. We had a toddler and this place was fabulous: had really nice high chair, pack and play, children dishes, toys, and books. Saved us from hauling a lot of stuff. We had 3 couples, so we each had our own bedroom and bath which was essential. Kitchen was beautiful. Very cute decor. Nice coffee maker/ tea varieties and basic supplies. Linens/ towels/ toiletries were very nice and high quality. There was a big storm that came through with high winds. Rosa immediately contacted us to make sure we had power and were safe. I really appreciated that. She also let us check out late so the baby could nap before we left for the airport. Would highly recommend staying there.

Private house rentals

Guest favourite
Home in Brevard
5 out of 5 average rating, 66 reviews

This is the One!-Just Wow-Arrowhead Point of View

KatherineRating, 5 stars6 months ago
The views were beautiful! Pictures don’t do it justice! The location was remote and peaceful, exactly what my husband and I needed! Highly recommend if you want to get away from the hustle bustle of life.
Guest favourite
Home in Seneca
4.96 out of 5 average rating, 98 reviews

Cozy Clemson Hideaway • 5 min to Campus • Wi-Fi

MelissaRating, 5 stars3 weeks ago
Thoroughly enjoyed our stay at Christina’s. Her home was perfect! Kitchen is well stocked, beds were comfortable, very clean and felt like home! It is close to Clemson which is why we were there. We didn’t have any issues and we would recommend staying there.
Top Guest favourite
Home in Six Mile
5 out of 5 average rating, 30 reviews

Lakefront luxury home w/panoramic view & Boat Slip

LauraRating, 5 stars3 days ago
We had a fantastic stay at Chuck and Brenda’s beautiful Lake Keowee home with family and friends! The views and sunsets from the wrap-around deck were spectacular — it felt like we were right on the water. The house is spacious, comfortable, and full of fun amenities. We especially enjoyed the kayaks, tubes, and easy access to the community dock. Chuck and Brenda were great hosts and very easy to communicate with. Highly recommend!
Top Guest favourite
Home in Six Mile
5 out of 5 average rating, 28 reviews

The White House-Near Keowee and Clemson

CodyRating, 5 stars1 week ago
Renee was such a great host for my family for the last 2 weeks! She was always quickly responsive, very friendly, and went above and beyond with our accommodations! We call her cottage the “Miss Honey Cottage” from Matilda. We look forward to booking again in the near future!
Top Guest favourite
Home in Slater-Marietta
4.98 out of 5 average rating, 82 reviews

Robin’s Nest- Cottage in the Woods

KathyRating, 5 stars1 month ago
We loved staying at Michelle's. It was quiet and private but not too far from town or being able to go places. Great location and we loved the porch and the cabin feel of the home
Top Guest favourite
Home in Six Mile
5 out of 5 average rating, 11 reviews

Lake Keowee SC Lakehouse Escape

cherylRating, 5 stars1 week ago
We had a fabulous week at your lake house! the house was perfect for our 3 generations. The game room and beds upstairs was the secret hide away for grand kids. the bedrooms were extra spacious and cozy. living space great. tops was the double deck at the lake. We were gifted with new fishing poles, floats, and corn hole game. Could not have been a more pleasant home. kitchen so organized, and clean. immediate response to any questions. loved the book choices throughout the house. We had warm greating and note for a blessed week, and blessed week it was!
Superhost
Home in Brevard
5 out of 5 average rating, 9 reviews

Mountain Retreat | 7 Acres | Arcades | Hot Tub

TammyRating, 5 stars3 days ago
This was our first Airbnb experience and it was a great one! The place was beautiful and the view was amazing. Everything was as described in the listing and Heidi was very responsive. Thank you.
Superhost
Home in Brevard
5 out of 5 average rating, 5 reviews

Secluded Home | Backyard Waterfall | 3BR | events

KatieRating, 5 stars1 week ago
Holly was an excellent host. She communicated well and answered all of our questions prior to booking and before the trip. She also recommended local businesses for things we wanted to do while on our trip. The house was exactly as pictured and very clean. Plenty of room to spread out with a large group or two families. The waterfall in the backyard was beyond perfect and peaceful! We brought a 23’ wake-boat for nearby lakes. The driveway/yard of the house was tight to maneuver parking with the trailer, but we made it work! Overall a great experience and we plan to visit again!

Destinations to explore