Experience Prague as if you were a local!
The Lesser Town is on the side of the river not as spoiled with mass tourism as the Old Town, yet within the walking distance to all major sightseeings, pubs, cafes and restaurants.
Calm, but still very central location of the apartment is something unique when visiting Prague these days. I live here myself and would never ever consider moving somewhere else. This location is simply the best to get around the city and explore it in a proper way!