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Holiday houses in Santa Cruz

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness and more.

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Guest favourite
A modern living area is displayed, featuring a comfortable sofa and a green accent pouf. A dining table is situated nearby. Floor-to-ceiling windows offer a view of the greenery outside, allowing natural light to fill the space. The kitchen is equipped with sleek appliances.
Apartment in Santa Cruz de la Sierra
4.91 out of 5 average rating, 155 reviews

Studio 518 - Luxury near Everything

Automatic access, 2 Air Conditioners, Washing Machine, Kitchen, Sofa and TV perfect for working all day with a green view from an 8th floor apartment in the most sought-after neighborhood in the city, Equipetrol. If you get bored you can use the pool at no cost, social areas, BBQ. If you get bored, you'll be 2 minutes away from supermarkets, pharmacies, blocks from Equipetrol's main square with renowned restaurants, 5 minutes from the Central Plaza or 5 minutes from Bolivia's largest shopping mall, Ventura Mall.

LocationValueHeating

Top Guest favourite
A modern living area is furnished with a gray sofa and a brown accent chair. A wooden coffee table sits on a textured rug in front of the sofa. Natural light floods in through large windows, illuminating the open layout that connects to an equipped kitchen.
Apartment in Santa Cruz de la Sierra
4.98 out of 5 average rating, 55 reviews

Luxury and comfort in every detail

This apartment combines luxury, style, and comfort in every detail. Designed as a boutique hotel, it offers a unique experience with impeccable finishes, an equipped kitchen, a cozy living room, spacious bedrooms, and a beautiful balcony to relax. Located in the heart of Equipetrol and a short walk from restaurants, shops and attractions. Perfect for business trips or relaxation, this modern and elegant space is ideal for relaxing and enjoying an unforgettable stay. You'll love it! Parking is included!

FamilyValueDecor

Guest favourite
Apartment in Santa Cruz de la Sierra
5.0 out of 5 average rating, 6 reviews

Skyline Luxury • Rooftop, Piscina, Billar & Lounge

Designed for discerning guests seeking an experience superior to a 5-star hotel. Located in Equipetrol, the most exclusive and secure area of Santa Cruz, this elegant apartment on the second-to-last floor offers a double balcony with unique views! Premium amenities such as a sky pool, lounge, pool table, barbecue grills, fully equipped gym, and more! Surrounded by the best restaurants, bars, cafes, theaters, shops and business centers. Ideal for executive trips, luxury getaways or unforgettable stays.

LocationHospitalityPool

Guest favourite
Apartment in Santa Cruz de la Sierra
4.9 out of 5 average rating, 21 reviews

Luxury apartment in Equipetrol | SKY Moon

Enjoy a unique stylish experience, steps from Mall Ventura, Mz-40, Green Tower, Camino Real hotel. Elegant studio in SKY MOON, Equipetrol Norte. Furnished studio with a bed, a comfortable sofa, a desk, an equipped kitchen, a private bathroom and a balcony. Great for business trips or rest. Enjoy hotel-like amenities: swimming pool, sauna, gym, coworking, billiards, paddle tennis court and terrace with fireplace in Santa Cruz's best business area. Book and live the experience today

LocationValueAmenities

Guest favourite
A contemporary entryway featuring sleek, metallic walls and smooth marble flooring. A minimalist reception desk with soft ambient lighting displays the name 'NUU.' A large potted plant adds a touch of greenery, while well-placed lighting creates a bright atmosphere.
Apartment in Santa Cruz de la Sierra
4.92 out of 5 average rating, 76 reviews

apartment with an excellent view

Apartment located in the Equipetrol area. Located on the 13th floor, you'll enjoy stunning views in a comfortable and elegant atmosphere. This apartment has two bedrooms and two bathrooms, ideal for families or groups. It's fully equipped to make you feel at home. Among the building's amenities, you will find a cinema, a swimming pool, a barbecue area, an equipped gym, a playground, and parking for visitors. Easy access to restaurants, shops, and attractions.

LocationValueBathroom

Guest favourite
Apartment in Santa Cruz de la Sierra
5.0 out of 5 average rating, 12 reviews

Comfortable and Modern apartment in Equipetrol Fast Wifi

Stay in the best area of the city – Equipetrol Norte This studio is ideal if you're looking for comfort, style and a strategic location. 🛏️ Modern, elegant and fully equipped space 💻 Perfect for remote work and corporate stays High-Speed 📶 Internet 📍 Unbeatable location: A few minutes from Ventura Mall, Hipermaxi Steps away from the Fidalga supermarket, Green Tower and Manzano 40 Surrounded by cafes, restaurants, and business centers

LocationDecorComfort

Top Guest favourite
A comfortable sleeping area features a spacious bed adorned with soft pillows and a decorative throw. Warm bedside lamps illuminate the space, while large windows offer views of the surrounding cityscape and allow natural light to brighten the room.
Apartment in Santa Cruz de la Sierra
4.98 out of 5 average rating, 135 reviews

13° SmartLife - Luxury Equipetrol

Welcome to your sanctuary of sophistication and elegance at the top. This exceptionally cozy and stylish studio on the 13th floor invites you to experience luxury and comfort at their finest. Ready to experience the perfect combination of sophistication, comfort, and technology? Don't miss out on this unique opportunity. Book your stay at "13° SmartLife" and be seduced by the charm of this incomparable space! Your urban retreat awaits.

LocationValueBarbecue

Guest favourite
Apartment in Santa Cruz de la Sierra
4.92 out of 5 average rating, 26 reviews

POX: Green Tower 16th floor | Luxury and elegance - 2H

Live the POX experience! We present our largest apartment in the iconic Green Tower, the most exclusive and luxurious building in Santa Cruz. A fully equipped apartment for you to live a unique experience with your family or friends. Be dazzled by the best view of the city, 24/7 service and close to banks, restaurants, shopping malls, everything you need meters away. We'll make sure you have a great stay, welcome to POX!

LocationAmenitiesBathroom

Superhost
Apartment in Santa Cruz de la Sierra
4.84 out of 5 average rating, 107 reviews

new and modern apartment

Welcome to your new home in Equipetrol, the best area of Santa Cruz! This new and modern apartment offers you a cozy and comfortable space, ideal for you to enjoy your stay, whether for work or rest. Located in the heart of Equipetrol, you'll be surrounded by everything you need: supermarkets, banks, shops, pharmacies, cafes, restaurants, church and the Ventura Mall. We invite you to enjoy an unforgettable stay.

LocationValueNearby

Superhost
Cottage in Samaipata
4.96 out of 5 average rating, 25 reviews

EcoHouse · Pool · Nature · Tranquility · Samaipata

A Living Earth Sanctuary on Samaipata Mountain Handcrafted with natural materials and a Bolivian soul. Welcome to CASA CACTUS — fully equipped and personalized for a stay surrounded by natural luxuries. 🏊 Pool · 🛜 Starlink · 🌿 Nature · Weekly and monthly DEALS *see below or contact us*. A place to really rest. To write. For slow cooking. To work online and offline. To look at the mountains without rushing.

FamilyLocationCleanliness

Top Guest favourite
Apartment in Santa Cruz de la Sierra
5.0 out of 5 average rating, 39 reviews

Green Tower* 27th Floor Stunning views & Luxury

Truly the highest floor in the building, this modern luxury retreat soars above the city with breathtaking panoramic views. Sleek finishes, stylish decor, and plush comforts create a refined, high-end ambiance. Whether you’re sipping wine at sunset or waking up in the clouds, this stunning high-rise sanctuary delivers an unforgettable, elevated stay.

FamilyLocationDecor

Guest favourite
Apartment in Santa Cruz de la Sierra
5.0 out of 5 average rating, 19 reviews

Luxury apartment across from the Hotel Yotaú

Enjoy a unique stay in the heart of Equipetrol, the best area in the city. Located on the 13th floor, this modern apartment offers a wonderful view and a private balcony for relaxing. Fully equipped for short or long stays, designed for your maximum comfort. Plus, enjoy exclusive luxury social areas that will make your experience even more special.

LocationWalkabilityComfort

Popular amenities for Santa Cruz holiday rentals

Other great holiday rentals in Santa Cruz

Guest favourite
Apartment in Santa Cruz de la Sierra
5.0 out of 5 average rating, 25 reviews

Work and relax in Equipetrol, accessible and practical

ValueLocationHospitality

Guest favourite
An outdoor terrace features sleek wooden decking, complemented by low seating arrangements and lush greenery. A tranquil water feature runs along one side, reflecting the surrounding cityscape. Modern buildings rise in the background under a clear, blue sky.
Apartment in Santa Cruz de la Sierra
4.96 out of 5 average rating, 55 reviews

Elegant family apartment in Equipetrol

ValueLocationAir conditioning

Top Guest favourite
Apartment in Santa Cruz de la Sierra
4.97 out of 5 average rating, 79 reviews

Premium 3-Bedroom Apartment | Pool | Macororo.

FamilyLocationGetting around

Superhost
Apartment in Santa Cruz de la Sierra
4.67 out of 5 average rating, 6 reviews

Balcony on the 17th Floor / Desk / Pool / Gym

LocationValueAmenities

Guest favourite
An open living area is displayed, featuring a modern design with light-toned floor tiles. A comfortable seating area includes a large gray sofa, black accent chairs, and an entertainment unit with a large TV. A kitchen bar with stools adds functionality to the space.
Apartment in Santa Cruz de la Sierra
4.92 out of 5 average rating, 13 reviews

Unique apartment in the best area!

LocationAmenitiesView

Top Guest favourite
Apartment in Santa Cruz de la Sierra
5.0 out of 5 average rating, 9 reviews

Beautiful view, vacation-friendly & worker-friendly, lounge area, Wi-Fi (350 MB)

LocationValueCleanliness

Guest favourite
Apartment in Santa Cruz de la Sierra
5.0 out of 5 average rating, 14 reviews

Separate Luxury Elite 507

LocationCleanlinessAccess

Superhost
A modern outdoor pathway is flanked by sleek buildings and lush greenery. Soft, natural light filters through the space, illuminating the smooth stone finish of the walkway. Curved steps lead up to elevated garden areas, creating a harmonious blend of nature and architecture.
Apartment in Santa Cruz de la Sierra
4.89 out of 5 average rating, 72 reviews

Luxury 18th-Floor Apt | City View, Pools & Netflix

LocationFamilyAccess