
Holiday houses in Santa Cruz
Find and book unique accommodation on Airbnb
Top-rated holiday rentals in Santa Cruz
Guests agree: these stays are highly rated for location, cleanliness and more.

Designer Penthouse | Huge Terrace | Pool & Gym
🏙️ 🌟 Luxury 3-Bedroom Penthouse Duplex with huge private terrace and panoramic view. Premium amenities include a gym, pool, steam room, kids’ playroom, EV charger, and rooftop jogging track. Bright, modern space with smart TVs, designer office, and telescope. Steps from Coyoacán, near Subway Line 12 and the Olympic Gym, a 20-minute walk to the Frida Kahlo Museum. Quiet, well-connected area. A short drive to Estadio Azteca—perfect for families, professionals, and World Cup fans. Sleeps up to 8.
ValueLocationView

Family Home in a Private, Quiet, and Safe Area.
Your home away from home in the State of Mexico! 🏡✨ Enjoy a peaceful, comfortable, and safe stay in this spacious house that accommodates 5 people. It features: 🛏️ 3 bedrooms, each with a double bed. 🛋️ 2 hallways, each with a sofa bed. 🚽 2.5 bathrooms (2 full bathrooms and one half-bath). 🍳 Fully equipped kitchen, Smart TV, and Wi-Fi. 🚗 Private, secure parking. Pets welcome (please check the rules regarding the 500 MXN surcharge). Total privacy for your trip! Pura vida! 🇨🇷🇲🇽
FamilyLocationBathroom

José Clemente Orozco House Coyoacán
Located in Coyoacán, typical Mexican neighborhood surrounded by markets, museums and historical buildings, a few blocks from Museu Frida Khalo, this house was the first studio for the painter and muralist José Clemente Orozco, who designed and build it between 1921 and 1923. All the bedrooms have their own bathroom and the main suite has a king-size bed, Smart TV and a terrace. It has a big and beautiful garden and a work space with its own terrace too. The garden is shared by 2 houses.
ValueFamilyShared spaces

Stay in a beautiful country estate.
Beautiful Hacienda Campestre in Milpa Alta, Mexico City, ideal for disconnecting from the hustle and bustle and being in contact with nature in a quiet and safe place. The property is located 25 minutes from the Xochimilco sports complex in the mountains. We are only 10 minutes from the magical neighborhood of San Pedro Atocpan. It has parking for several cars, a barbecue area, a beautiful campfire area, mini goals and an inflatable for young children. We are pet friendly.
FamilyLocationBathroom

Designer's Haven in Roma with Private Rooftop
Experience Mexico City like a local from this beautifully designed three-story home in the heart of Roma Norte. Walk to the city's best restaurants, cafés, boutiques, galleries, and parks. Accommodates up to 6 guests with 3 bedrooms, 3 full bathrooms, a spectacular private rooftop terrace, 4 Smart TVs, private elevator access, parking, and 24/7 security. A rare combination of space, privacy, design, and location in one of the city's most desirable neighborhoods.
LocationDecorLayout

Safety and Comfort in Edo.MEX
An apartment with great comfort, space, and security. It has a closed circuit, automatic main entrance door, alarm against theft, carbon monoxide and fire, excellent internet quality, and Smart TV. It has a lighting system with 3 shades: White, semi-warm and warm light, suitable for study and rest. The central stairs have handrails, non-slip, and sensor lighting. Fully-equipped kitchen and bathroom. Practical location with amenities available.
ValueFamilyCondition

Punto Lofts Periférico Sur (South Peripheral Point Lofts)
Punto Lofts Periférico Sur is a modern concept with 18 fully equipped lofts, ideal for short or long stays. Each loft accommodates up to 3 people and has a queen size bed and sofa bed, offering comfort and rest. Enjoy 24/7 reception, digital key access, and high standards of cleanliness and safety. Located on Periférico Sur, opposite the Azteca Stadium, with easy access to hospitals, restaurants and shopping centers.
LocationValueWi-Fi

Beautiful apartment with garden and volcano view
Escape to a dreamy retreat on the volcano route. Perfect for romantic getaways or family gatherings. Enjoy Stunning views of the volcanoes from your private garden, barbecue area and stone oven bring out the chef in you. Spacious and cozy space to relax and enjoy. Located in a picturesque village near Iztapopo National Park, this oasis is the ideal place to disconnect and reconnect with nature and your loved ones.
Outdoor spacesCleanlinessSleep quality

A little house near the volcanoes.
Village house near the volcanoes Enjoy a unique getaway in our cozy little house, ideal for 2 to 4 people. Perfect for families who want to spend a quiet and cozy weekend. Includes: Bed (King Size) + sofa bed (King Size) Kitchenette Mini fridge Microwave oven TV Wi-Fi Kitchen accessories Experience the local experience with comfort and charm, very close to the volcanoes.
LocationHeatingComfort

Chic & Equipped Apt | Rooftop+Gym+B/Center+Lounge
This stylish apartment in the heart Roma Norte and Condesa offers the perfect setup for digital nomads—ultra-fast Wi-Fi, a sleek workspace, and steps from the trendiest cafés, restaurants, and nightlife. Enjoy top-tier amenities: a business center, a full gym, a game room, and a rooftop with stunning views. Stay productive, stay inspired, and experience CDMX like a local.
ValueLocationOutdoor spaces

Lovely house in the eastern area
Ideal accommodation for small groups, with a quiet and family-friendly atmosphere. Designed for comfortable stays with all the amenities. Close to the Nopalera Metro station, the ISSSTE General Hospital, the Tláhuac General Hospital, the Marista University, and Plaza Las Antenas.
ValueLocationNearby

Garden and beautiful house for events and stays
Camino Real Event Garden Disconnect from your concerns in this spacious and serene space. Ideal for all kinds of events, children's parties, meetings, weddings, corporate events, workshops, yoga courses or any other outdoor exercise or activity 🍃🌿🌤️
LocationValueGetting around
Popular amenities for Santa Cruz holiday rentals
Other great holiday rentals in Santa Cruz

My San Angel Refuge
LocationFamilyCondition

Come & Dream in Quetzalcoatl`s Nest
FamilyValueAccuracy

A new home, comfortable and quiet.
ComfortAmenitiesCleanliness

Modern house for 6 people with garden and 2 parking spaces
LocationFamilyNearby

Beautiful, large and spacious house
HospitalityCleanlinessComfort

Cozy cabin with fireplace, Quinta Josefina
LocationValueBreakfast

Ground floor apartment with large garden in Coyoacán
FamilyLocationIndoor spaces

Rest house - Xochimilco kayak tours
FamilyLocationOutdoor spaces
Destinations to explore
- The Angel of Independence
- Foro Sol
- Val'Quirico
- Reforma 222
- Aztec Stadium
- Palacio de los Deportes
- Autódromo Hermanos Rodríguez
- Basilica of Our Lady of Guadalupe
- World Trade Center Mexico City
- Auditorio Nacional
- Six Flags Mexico
- Monument To the Revolution
- Pyramids Of Teotihuacán
- Las Estacas Parque Natural
- Alameda Central
- Pepsi Center Wtc
- Palacio de Bellas Artes
- Los Dinamos
- Izta-Popo Zoquiapan National Park
- El Rollo Parque Acuático
- Jardines de México
- Constitution Square
- Bosque Geométrico
- Citibanamex Center





