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Holiday houses in Santa Cruz

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness and more.

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Top Guest favourite
Home in Del Carmen
4.95 out of 5 average rating, 391 reviews

José Clemente Orozco House Coyoacán

Located in Coyoacán, typical Mexican neighborhood surrounded by markets, museums and historical buildings, a few blocks from Museu Frida Khalo, this house was the first studio for the painter and muralist José Clemente Orozco, who designed and build it between 1921 and 1923. All the bedrooms have their own bathroom and the main suite has a king-size bed, Smart TV and a terrace. It has a big and beautiful garden and a work space with its own terrace too. The garden is shared by 2 houses.

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Guest favourite
Apartment in Roma Norte
5.0 out of 5 average rating, 11 reviews

Designer's Haven in Roma with Private Rooftop

Experience Mexico City like a local from this beautifully designed three-story home in the heart of Roma Norte. Walk to the city's best restaurants, cafés, boutiques, galleries, and parks. Accommodates up to 6 guests with 3 bedrooms, 3 full bathrooms, a spectacular private rooftop terrace, 4 Smart TVs, private elevator access, parking, and 24/7 security. A rare combination of space, privacy, design, and location in one of the city's most desirable neighborhoods.

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Top Guest favourite
The building presents a modern design with a prominent use of green glass. The façade is enhanced by colorful window coverings, flanked by two parked cars. A clear sky serves as a backdrop, highlighting the structure's height and the surrounding area.
Apartment in Ciudad Nezahualcóyotl
4.98 out of 5 average rating, 254 reviews

Safety and Comfort in Edo.MEX

An apartment with great comfort, space, and security. It has a closed circuit, automatic main entrance door, alarm against theft, carbon monoxide and fire, excellent internet quality, and Smart TV. It has a lighting system with 3 shades: White, semi-warm and warm light, suitable for study and rest. The central stairs have handrails, non-slip, and sensor lighting. Fully-equipped kitchen and bathroom. Practical location with amenities available.

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Top Guest favourite
Loft in Ayapango
5.0 out of 5 average rating, 21 reviews

Beautiful apartment with garden and volcano view

Escape to a dreamy retreat on the volcano route. Perfect for romantic getaways or family gatherings. Enjoy Stunning views of the volcanoes from your private garden, barbecue area and stone oven bring out the chef in you. Spacious and cozy space to relax and enjoy. Located in a picturesque village near Iztapopo National Park, this oasis is the ideal place to disconnect and reconnect with nature and your loved ones.

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Guest favourite
Cabin in Tlalmanalco de Velázquez
5.0 out of 5 average rating, 12 reviews

A little house near the volcanoes.

Village house near the volcanoes Enjoy a unique getaway in our cozy little house, ideal for 2 to 4 people. Perfect for families who want to spend a quiet and cozy weekend. Includes: Bed (King Size) + sofa bed (King Size) Kitchenette Mini fridge Microwave oven TV Wi-Fi Kitchen accessories Experience the local experience with comfort and charm, very close to the volcanoes.

LocationSleep qualityNearby

Guest favourite
Apartment in Condesa
4.84 out of 5 average rating, 1870 reviews

Chic & Equipped Apt | Rooftop+Gym+B/Center+Lounge

This stylish apartment in the heart Roma Norte and Condesa offers the perfect setup for digital nomads—ultra-fast Wi-Fi, a sleek workspace, and steps from the trendiest cafés, restaurants, and nightlife. Enjoy top-tier amenities: a business center, a full gym, a game room, and a rooftop with stunning views. Stay productive, stay inspired, and experience CDMX like a local.

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Top Guest favourite
Apartment in Puebla
4.93 out of 5 average rating, 104 reviews

Logan’s house

Modern and spacious apartment just a 10-minute walk from the Autódromo Hnos. Rodríguez, 15 min from the GNP Forum and Palacio de los Deportes. 2 blocks from Zaragoza Metro and 5 minutes from AICM. It has a premium kitchen, fast Wi-Fi, Cablevision, Netflix, Disney+, Max and Prime Video. Quiet space with 2 bathrooms. Ideal for concerts, F1, business trips or rest.

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Top Guest favourite
A charming outdoor patio is surrounded by vibrant greenery and a blue-walled house. A round glass table is complemented by six white metal chairs, creating an inviting space for dining or gathering. Potted plants and flowers add color to the serene environment.
Home in Coyoacán
4.97 out of 5 average rating, 109 reviews

Casa Omac | Colonial house with two patios

Typical colonial house, located in the most picturesque and emblematic street of Coyoacán. The style is reminiscent of Frida Kahlo's Blue House, which is a few minutes' walk away. Organized around a large internal patio, the house has 5 double rooms and can host up to 10 people, making it ideal for groups and families.

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Guest favourite
A welcoming entrance is displayed with a wooden door featuring decorative glass. Large windows with striped curtains allow natural light to brighten the space. Potted plants line the area, contributing to a serene ambiance. A small decorative item is hung next to the door.
Home in Tláhuac
5.0 out of 5 average rating, 48 reviews

Lovely house in the eastern area

Ideal accommodation for small groups, with a quiet and family-friendly atmosphere. Designed for comfortable stays with all the amenities. Close to the Nopalera Metro station, the ISSSTE General Hospital, the Tláhuac General Hospital, the Marista University, and Plaza Las Antenas.

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Top Guest favourite
Guesthouse in Xochimilco
5.0 out of 5 average rating, 50 reviews

Garden and beautiful house for events and stays

Camino Real Event Garden Disconnect from your concerns in this spacious and serene space. Ideal for all kinds of events, children's parties, meetings, weddings, corporate events, workshops, yoga courses or any other outdoor exercise or activity 🍃🌿🌤️

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Guest favourite
A spacious sleeping area features a large bed with neutral bedding and a blue throw blanket. Wooden nightstands are placed on either side, while an open shelving unit stands in one corner. Soft lighting enhances the calm atmosphere against the gray walls.
Condo in Iztapalapa
4.93 out of 5 average rating, 551 reviews

HB Flat (2 BR) 15min Airport/10min Estadio GNP

Complete apartment 15 min from the airport, 10 min from the Foro Sol, Palacio de los Deportes and Autodromo Hermanos Rodriguez by car. 2 bedrooms with desk, bathroom, kitchen and living room - dining room.

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Top Guest favourite
A spacious living area features a light grey sofa adorned with decorative pillows. An intricate glass coffee table sits on a tiled floor, reflecting light from large windows framed by brick arches. Warm curtains complement the vibrant wall art and ceramic plates displayed nearby.
Home in Coyoacán
4.96 out of 5 average rating, 166 reviews

Colonial house with garden in the center of Coyoacán

Luxury colonial house, 350 meters from the center of Coyoacan. The house has a garden and terrace. We strive to make your stay perfect. If your stay is long, we have cleaning service included.

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Popular amenities for Santa Cruz holiday rentals