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Holiday houses in Santa Cruz

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness and more.

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Top Guest favourite
Home in Del Carmen
4.95 out of 5 average rating, 392 reviews

José Clemente Orozco House Coyoacán

Located in Coyoacán, typical Mexican neighborhood surrounded by markets, museums and historical buildings, a few blocks from Museu Frida Khalo, this house was the first studio for the painter and muralist José Clemente Orozco, who designed and build it between 1921 and 1923. All the bedrooms have their own bathroom and the main suite has a king-size bed, Smart TV and a terrace. It has a big and beautiful garden and a work space with its own terrace too. The garden is shared by 2 houses.

Guest favourite
A private terrace features two wicker chairs around a small table, providing a cozy seating area. Glass doors lead into the living space, accentuating the indoor-outdoor flow. Lush greenery is visible nearby, enhancing the tranquil setting.
Apartment in Condesa
4.89 out of 5 average rating, 607 reviews

New luxury apartment with View to Parque España

Enjoy this modern new apartment in the heart of Condesa, conveniently located in front of the beautiful Parque España, where you’ll find plenty of shops, restaurants, coffee shops, bars and more, all within walking distance. The two bedrooms are designed to provide tranquility and privacy. The kitchen is fully equipped, including a stove, oven and refrigerator. Help yourself to complimentary local bathroom products! This is the perfect spot if you enjoy lively, vibrant neighborhoods.

Guest favourite
Apartment in Polanco
4.89 out of 5 average rating, 579 reviews

Kukun Homero Polanco

You’re about to discover your next stay! We’re thrilled to welcome you to our apartments. This building is not only in a prime location, but it also tells a story that celebrates contemporary Mexican art and culture. From handcrafted Talavera pieces made in Puebla to iconic quotes by renowned Mexican creatives like Octavio Paz and Alejandro González Iñárritu, every corner is designed to inspire you. Plus, you’ll get to enjoy one of the best views in the city.

Top Guest favourite
The building presents a modern design with a prominent use of green glass. The façade is enhanced by colorful window coverings, flanked by two parked cars. A clear sky serves as a backdrop, highlighting the structure's height and the surrounding area.
Apartment in Ciudad Nezahualcóyotl
4.98 out of 5 average rating, 256 reviews

Safety and Comfort in Edo.MEX

An apartment with great comfort, space, and security. It has a closed circuit, automatic main entrance door, alarm against theft, carbon monoxide and fire, excellent internet quality, and Smart TV. It has a lighting system with 3 shades: White, semi-warm and warm light, suitable for study and rest. The central stairs have handrails, non-slip, and sensor lighting. Fully-equipped kitchen and bathroom. Practical location with amenities available.

Guest favourite
A cozy bedroom features a spacious bed with a soft grey headboard and decorative cushions. A sleek bedside lamp provides gentle illumination, while modern wooden cabinetry adds warmth to the space. A grey armchair is positioned nearby, complemented by delicate white flowers in the foreground.
Loft in Tlalpan
4.88 out of 5 average rating, 955 reviews

Punto Lofts Periférico Sur (South Peripheral Point Lofts)

Punto Lofts Periférico Sur is a modern concept with 18 fully equipped lofts, ideal for short or long stays. Each loft accommodates up to 3 people and has a queen size bed and sofa bed, offering comfort and rest. Enjoy 24/7 reception, digital key access, and high standards of cleanliness and safety. Located on Periférico Sur, opposite the Azteca Stadium, with easy access to hospitals, restaurants and shopping centers.

Guest favourite
Apartment in Condesa
4.85 out of 5 average rating, 1879 reviews

Chic & Equipped Apt | Rooftop+Gym+B/Center+Lounge

This stylish apartment in the heart Roma Norte and Condesa offers the perfect setup for digital nomads—ultra-fast Wi-Fi, a sleek workspace, and steps from the trendiest cafés, restaurants, and nightlife. Enjoy top-tier amenities: a business center, a full gym, a game room, and a rooftop with stunning views. Stay productive, stay inspired, and experience CDMX like a local.

Guest favourite
A welcoming entrance is displayed with a wooden door featuring decorative glass. Large windows with striped curtains allow natural light to brighten the space. Potted plants line the area, contributing to a serene ambiance. A small decorative item is hung next to the door.
Home in Tláhuac
5.0 out of 5 average rating, 49 reviews

Lovely house in the eastern area

Ideal accommodation for small groups, with a quiet and family-friendly atmosphere. Designed for comfortable stays with all the amenities. Close to the Nopalera Metro station, the ISSSTE General Hospital, the Tláhuac General Hospital, the Marista University, and Plaza Las Antenas.

Top Guest favourite
Guesthouse in Xochimilco
5.0 out of 5 average rating, 52 reviews

Garden and beautiful house for events and stays

Camino Real Event Garden Disconnect from your concerns in this spacious and serene space. Ideal for all kinds of events, children's parties, meetings, weddings, corporate events, workshops, yoga courses or any other outdoor exercise or activity 🍃🌿🌤️

Guest favourite
A spacious sleeping area features a large bed with neutral bedding and a blue throw blanket. Wooden nightstands are placed on either side, while an open shelving unit stands in one corner. Soft lighting enhances the calm atmosphere against the gray walls.
Condo in Iztapalapa
4.93 out of 5 average rating, 553 reviews

HB Flat (2 BR) 15min Airport/10min Estadio GNP

Complete apartment 15 min from the airport, 10 min from the Foro Sol, Palacio de los Deportes and Autodromo Hermanos Rodriguez by car. 2 bedrooms with desk, bathroom, kitchen and living room - dining room.

Top Guest favourite
A spacious living area features a light grey sofa adorned with decorative pillows. An intricate glass coffee table sits on a tiled floor, reflecting light from large windows framed by brick arches. Warm curtains complement the vibrant wall art and ceramic plates displayed nearby.
Home in Coyoacán
4.96 out of 5 average rating, 168 reviews

Colonial house with garden in the center of Coyoacán

Luxury colonial house, 350 meters from the center of Coyoacan. The house has a garden and terrace. We strive to make your stay perfect. If your stay is long, we have cleaning service included.

Guest favourite
A modern living area features a comfortable gray sofa and a round dining table surrounded by white chairs. Large windows provide natural light and views of the surroundings. Indoor plants and shelves with decorative items add a touch of greenery and personalization.
Apartment in Coyoacán
4.95 out of 5 average rating, 275 reviews

Cozy apartment in Joy Coyoacán

Cozy and comfortable apartment with a privileged location: 5 minutes from the Azteca Stadium and next to Club América, the Surgical Specialties Center and the Universidad del Valle de México.

Superhost
A lush field of nopales occupies the foreground, displaying a vibrant green landscape. In the background, rustic red-roofed cabins are visible against a backdrop of rolling hills and a wide sky, offering a glimpse of the tranquil countryside.
Cabin in San Lorenzo Tlacoyucan
4.84 out of 5 average rating, 37 reviews

Resting cabin in Milpa Alta

🤠 Enjoy the countryside in the Milpa Alta ecological reserve, among nopaleras and magueyes, live with the people of the countryside and enjoy beautiful views of the Valley of Mexico.

Popular amenities for Santa Cruz holiday rentals