
Holiday houses in Santa Cruz
Find and book unique accommodation on Airbnb
Top-rated holiday rentals in Santa Cruz
Guests agree: these stays are highly rated for location, cleanliness and more.

José Clemente Orozco House Coyoacán
Located in Coyoacán, typical Mexican neighborhood surrounded by markets, museums and historical buildings, a few blocks from Museu Frida Khalo, this house was the first studio for the painter and muralist José Clemente Orozco, who designed and build it between 1921 and 1923. All the bedrooms have their own bathroom and the main suite has a king-size bed, Smart TV and a terrace. It has a big and beautiful garden and a work space with its own terrace too. The garden is shared by 2 houses.
FamilyValueHeating
4.95 out of 5 average rating, 391 reviews
New luxury apartment with View to Parque España
Enjoy this modern new apartment in the heart of Condesa, conveniently located in front of the beautiful Parque España, where you’ll find plenty of shops, restaurants, coffee shops, bars and more, all within walking distance. The two bedrooms are designed to provide tranquility and privacy. The kitchen is fully equipped, including a stove, oven and refrigerator. Help yourself to complimentary local bathroom products! This is the perfect spot if you enjoy lively, vibrant neighborhoods.
LocationValueAccuracy
4.89 out of 5 average rating, 602 reviews
Safety and Comfort in Edo.MEX
An apartment with great comfort, space, and security. It has a closed circuit, automatic main entrance door, alarm against theft, carbon monoxide and fire, excellent internet quality, and Smart TV. It has a lighting system with 3 shades: White, semi-warm and warm light, suitable for study and rest. The central stairs have handrails, non-slip, and sensor lighting. Fully-equipped kitchen and bathroom. Practical location with amenities available.
ValueFamilyAccuracy
4.98 out of 5 average rating, 253 reviews
Casa Mavi's loft in Coyoacán
Welcome to Coyoacán! Great 120 m2 loft located just a 5-minute walk from downtown Coyoacán. Experience this quiet and bright open space, ideal for resting or working and decorated with objects full of stories. The loft is located on the third floor of Casa Mavi, an old factory that was remodeled to create a place full of charm that makes it unique. It has shared terraces. With option for a third guest. 200 megabyte Wi-Fi.
FamilyValueOutdoor spaces
4.87 out of 5 average rating, 229 reviews
Punto Lofts Periférico Sur (South Peripheral Point Lofts)
Punto Lofts Periférico Sur is a modern concept with 18 fully equipped lofts, ideal for short or long stays. Each loft accommodates up to 3 people and has a queen size bed and sofa bed, offering comfort and rest. Enjoy 24/7 reception, digital key access, and high standards of cleanliness and safety. Located on Periférico Sur, opposite the Azteca Stadium, with easy access to hospitals, restaurants and shopping centers.
LocationFamilyNearby
4.88 out of 5 average rating, 945 reviews
Beautiful apartment with garden and volcano view
Escape to a dreamy retreat on the volcano route. Perfect for romantic getaways or family gatherings. Enjoy Stunning views of the volcanoes from your private garden, barbecue area and stone oven bring out the chef in you. Spacious and cozy space to relax and enjoy. Located in a picturesque village near Iztapopo National Park, this oasis is the ideal place to disconnect and reconnect with nature and your loved ones.
QuietDecorIndoor spaces
5.0 out of 5 average rating, 21 reviews
Chic & Equipped Apt | Rooftop+Gym+B/Center+Lounge
This stylish apartment in the heart Roma Norte and Condesa offers the perfect setup for digital nomads—ultra-fast Wi-Fi, a sleek workspace, and steps from the trendiest cafés, restaurants, and nightlife. Enjoy top-tier amenities: a business center, a full gym, a game room, and a rooftop with stunning views. Stay productive, stay inspired, and experience CDMX like a local.
ValueLocationCheck-in
4.84 out of 5 average rating, 1867 reviews
Lovely house in the eastern area
Ideal accommodation for small groups, with a quiet and family-friendly atmosphere. Designed for comfortable stays with all the amenities. Close to the Nopalera Metro station, the ISSSTE General Hospital, the Tláhuac General Hospital, the Marista University, and Plaza Las Antenas.
FamilyLocationQuiet
5.0 out of 5 average rating, 47 reviews
Garden and beautiful house for events and stays
Camino Real Event Garden Disconnect from your concerns in this spacious and serene space. Ideal for all kinds of events, children's parties, meetings, weddings, corporate events, workshops, yoga courses or any other outdoor exercise or activity 🍃🌿🌤️
FamilyValueOutdoor spaces
5.0 out of 5 average rating, 50 reviews
Fresh and cozy rest.
Relax with the whole family in this accommodation where tranquility is breathed 35 minutes away, Hacienda Panoaya, Christmas tree forest, country restaurants, shopping plazas, games, courts within the unit.
LocationSleep qualityAccuracy
4.82 out of 5 average rating, 17 reviews
HB Flat (2 BR) 15min Airport/10min Estadio GNP
Complete apartment 15 min from the airport, 10 min from the Foro Sol, Palacio de los Deportes and Autodromo Hermanos Rodriguez by car. 2 bedrooms with desk, bathroom, kitchen and living room - dining room.
FamilyValueAccuracy
4.93 out of 5 average rating, 550 reviews
Colonial house with garden in the center of Coyoacán
Luxury colonial house, 350 meters from the center of Coyoacan. The house has a garden and terrace. We strive to make your stay perfect. If your stay is long, we have cleaning service included.
FamilyLocationBathroom
4.96 out of 5 average rating, 166 reviewsPopular amenities for Santa Cruz holiday rentals
Other great holiday rentals in Santa Cruz

A little house near the volcanoes.
LocationCleanlinessIndoor spaces
5.0 out of 5 average rating, 12 reviews
Comfortable family home
FamilyLocationCleanliness
4.98 out of 5 average rating, 62 reviews
Stay in a beautiful country estate.
LocationFamilyWalkability
5.0 out of 5 average rating, 22 reviews
My San Angel Refuge
FamilyLocationGetting around
4.94 out of 5 average rating, 33 reviews
Designer's Haven in Roma with Private Rooftop
LocationCheckoutAccuracy
5.0 out of 5 average rating, 11 reviews
Come & Dream in Quetzalcoatl`s Nest
FamilyLocationQuiet
4.94 out of 5 average rating, 627 reviews
A new home, comfortable and quiet.
NearbyComfortHospitality
5.0 out of 5 average rating, 3 reviews
Modern house for 6 people with garden and 2 parking spaces
FamilyLocationBathroom
4.94 out of 5 average rating, 17 reviewsDestinations to explore
- The Angel of Independence
- Foro Sol
- Val'Quirico
- Reforma 222
- Aztec Stadium
- Palacio de los Deportes
- Autódromo Hermanos Rodríguez
- Basilica of Our Lady of Guadalupe
- World Trade Center Mexico City
- Auditorio Nacional
- Six Flags Mexico
- Monument To the Revolution
- Pyramids Of Teotihuacán
- Las Estacas Parque Natural
- Alameda Central
- Pepsi Center Wtc
- Palacio de Bellas Artes
- Los Dinamos
- Izta-Popo Zoquiapan National Park
- El Rollo Parque Acuático
- Jardines de México
- Constitution Square
- Bosque Geométrico
- Citibanamex Center





