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Holiday houses in Santa Cruz

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness and more.

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Top Guest favourite
Home in Del Carmen

José Clemente Orozco House Coyoacán

Located in Coyoacán, typical Mexican neighborhood surrounded by markets, museums and historical buildings, a few blocks from Museu Frida Khalo, this house was the first studio for the painter and muralist José Clemente Orozco, who designed and build it between 1921 and 1923. All the bedrooms have their own bathroom and the main suite has a king-size bed, Smart TV and a terrace. It has a big and beautiful garden and a work space with its own terrace too. The garden is shared by 2 houses.

FamilyValueHeating

4.95 out of 5 average rating, 391 reviews
Guest favourite
A private terrace features two wicker chairs around a small table, providing a cozy seating area. Glass doors lead into the living space, accentuating the indoor-outdoor flow. Lush greenery is visible nearby, enhancing the tranquil setting.
Apartment in Condesa

New luxury apartment with View to Parque España

Enjoy this modern new apartment in the heart of Condesa, conveniently located in front of the beautiful Parque España, where you’ll find plenty of shops, restaurants, coffee shops, bars and more, all within walking distance. The two bedrooms are designed to provide tranquility and privacy. The kitchen is fully equipped, including a stove, oven and refrigerator. Help yourself to complimentary local bathroom products! This is the perfect spot if you enjoy lively, vibrant neighborhoods.

LocationValueAccuracy

4.89 out of 5 average rating, 602 reviews
Guest favourite
The building presents a modern design with a prominent use of green glass. The façade is enhanced by colorful window coverings, flanked by two parked cars. A clear sky serves as a backdrop, highlighting the structure's height and the surrounding area.
Apartment in Ciudad Nezahualcóyotl

Safety and Comfort in Edo.MEX

An apartment with great comfort, space, and security. It has a closed circuit, automatic main entrance door, alarm against theft, carbon monoxide and fire, excellent internet quality, and Smart TV. It has a lighting system with 3 shades: White, semi-warm and warm light, suitable for study and rest. The central stairs have handrails, non-slip, and sensor lighting. Fully-equipped kitchen and bathroom. Practical location with amenities available.

ValueFamilyAccuracy

4.98 out of 5 average rating, 253 reviews
Superhost
An open-plan living area features a dining table with black chairs and a contrasting wooden surface. Natural light floods the space through large windows, illuminating a relaxed seating area and green plants. Decorative wall pieces add character to the minimalist design.
Loft in Coyoacán

Casa Mavi's loft in Coyoacán

Welcome to Coyoacán! Great 120 m2 loft located just a 5-minute walk from downtown Coyoacán. Experience this quiet and bright open space, ideal for resting or working and decorated with objects full of stories. The loft is located on the third floor of Casa Mavi, an old factory that was remodeled to create a place full of charm that makes it unique. It has shared terraces. With option for a third guest. 200 megabyte Wi-Fi.

FamilyValueOutdoor spaces

4.87 out of 5 average rating, 229 reviews
Guest favourite
A cozy bedroom features a spacious bed with a soft grey headboard and decorative cushions. A sleek bedside lamp provides gentle illumination, while modern wooden cabinetry adds warmth to the space. A grey armchair is positioned nearby, complemented by delicate white flowers in the foreground.
Loft in Tlalpan

Punto Lofts Periférico Sur (South Peripheral Point Lofts)

Punto Lofts Periférico Sur is a modern concept with 18 fully equipped lofts, ideal for short or long stays. Each loft accommodates up to 3 people and has a queen size bed and sofa bed, offering comfort and rest. Enjoy 24/7 reception, digital key access, and high standards of cleanliness and safety. Located on Periférico Sur, opposite the Azteca Stadium, with easy access to hospitals, restaurants and shopping centers.

LocationFamilyNearby

4.88 out of 5 average rating, 945 reviews
Top Guest favourite
Loft in Ayapango

Beautiful apartment with garden and volcano view

Escape to a dreamy retreat on the volcano route. Perfect for romantic getaways or family gatherings. Enjoy Stunning views of the volcanoes from your private garden, barbecue area and stone oven bring out the chef in you. Spacious and cozy space to relax and enjoy. Located in a picturesque village near Iztapopo National Park, this oasis is the ideal place to disconnect and reconnect with nature and your loved ones.

QuietDecorIndoor spaces

5.0 out of 5 average rating, 21 reviews
Guest favourite
Apartment in Condesa

Chic & Equipped Apt | Rooftop+Gym+B/Center+Lounge

This stylish apartment in the heart Roma Norte and Condesa offers the perfect setup for digital nomads—ultra-fast Wi-Fi, a sleek workspace, and steps from the trendiest cafés, restaurants, and nightlife. Enjoy top-tier amenities: a business center, a full gym, a game room, and a rooftop with stunning views. Stay productive, stay inspired, and experience CDMX like a local.

ValueLocationCheck-in

4.84 out of 5 average rating, 1867 reviews
Guest favourite
A welcoming entrance is displayed with a wooden door featuring decorative glass. Large windows with striped curtains allow natural light to brighten the space. Potted plants line the area, contributing to a serene ambiance. A small decorative item is hung next to the door.
Home in Tláhuac

Lovely house in the eastern area

Ideal accommodation for small groups, with a quiet and family-friendly atmosphere. Designed for comfortable stays with all the amenities. Close to the Nopalera Metro station, the ISSSTE General Hospital, the Tláhuac General Hospital, the Marista University, and Plaza Las Antenas.

FamilyLocationQuiet

5.0 out of 5 average rating, 47 reviews
Top Guest favourite
Guesthouse in Xochimilco

Garden and beautiful house for events and stays

Camino Real Event Garden Disconnect from your concerns in this spacious and serene space. Ideal for all kinds of events, children's parties, meetings, weddings, corporate events, workshops, yoga courses or any other outdoor exercise or activity 🍃🌿🌤️

FamilyValueOutdoor spaces

5.0 out of 5 average rating, 50 reviews
Superhost
A well-maintained entryway is framed by neatly trimmed grass and flower beds. The white front door is flanked by large windows, allowing natural light to enter. A soft path of concrete slabs leads to the entrance, accented by vibrant greenery and colorful flowers.
Home in San Martín Cuautlalpan

Fresh and cozy rest.

Relax with the whole family in this accommodation where tranquility is breathed 35 minutes away, Hacienda Panoaya, Christmas tree forest, country restaurants, shopping plazas, games, courts within the unit.

LocationSleep qualityAccuracy

4.82 out of 5 average rating, 17 reviews
Superhost
A spacious sleeping area features a large bed with neutral bedding and a blue throw blanket. Wooden nightstands are placed on either side, while an open shelving unit stands in one corner. Soft lighting enhances the calm atmosphere against the gray walls.
Condo in Iztapalapa

HB Flat (2 BR) 15min Airport/10min Estadio GNP

Complete apartment 15 min from the airport, 10 min from the Foro Sol, Palacio de los Deportes and Autodromo Hermanos Rodriguez by car. 2 bedrooms with desk, bathroom, kitchen and living room - dining room.

FamilyValueAccuracy

4.93 out of 5 average rating, 550 reviews
Top Guest favourite
A spacious living area features a light grey sofa adorned with decorative pillows. An intricate glass coffee table sits on a tiled floor, reflecting light from large windows framed by brick arches. Warm curtains complement the vibrant wall art and ceramic plates displayed nearby.
Home in Coyoacán

Colonial house with garden in the center of Coyoacán

Luxury colonial house, 350 meters from the center of Coyoacan. The house has a garden and terrace. We strive to make your stay perfect. If your stay is long, we have cleaning service included.

FamilyLocationBathroom

4.96 out of 5 average rating, 166 reviews

Popular amenities for Santa Cruz holiday rentals