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Holiday houses in Santa Isabel District

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in Santa Isabel District

Guests agree: these stays are highly rated for location, cleanliness and more.

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An aerial view showcases a rustic cottage surrounded by lush palm trees, located near a sandy beach. The gentle waves of the ocean are visible, along with several red-roofed structures nestled within the greenery, creating a serene coastal atmosphere.
Cottage in Palenque
4.87 out of 5 average rating, 95 reviews

Beachfront House in Caribbean sandy beach

Enjoy this rustic and cozy cottage with its almost private beach surrounded by beautiful palm trees along the whole area. With 2 oceanview bedrooms, 2 full bathrooms and a third bedroom in a mezzanine. Has a patio with a built in uruguayan parrilla, ideal for BBQs. Step in beautiful white sand and bath in crystal clear water. Coconut breakfasts watching the sunrise become a routine in this paradise. - This is a rural setting. Not a 5 star hotel. Insects and small animals can be around.

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Home in Playa Chiquita
5.0 out of 5 average rating, 7 reviews

Caribbean Jungle Beach House

Secluded loft beach house on 7 hectares of jungle with pristine beach. Enjoy the peaceful tranquility of coconut palm tree covered golden sand beach with shallow warm water great for swimming and body surfing. Lounge chairs, barbecue, kayaks, snorkel masks, boogie boards, hammocks and a fire pit for beach bonfires under the starry night sky all available. Great for families, couples or groups of friends. Delicious Panamanian food made to order on site. Tent camping (glamping) also available.

A two-story house is illuminated at night, accentuating its spacious design. Light fixtures highlight the outdoor area, featuring a lawn with soft green grass. The large balcony is adorned with seating, while tall palm trees add to the natural surroundings.
Home in Garrote, Colón
5.0 out of 5 average rating, 11 reviews

Ocean Front Villa

This is a unique oportunity to live in a house on a sea shore yet having wild nature in the backyard. There is soft, green grass area, hamaks, garden chairs and cosy light arrangements so the river shore and the mangroove system looks magical in the night. They attracts variety of wildlife so sometimes, making your morning coffee, you can spot monkeys, sloths, sea birds and lizards, right though the window of the kitchen, or maybe later, resting in the shade of the trees in the hammock

Top Guest favourite
A spacious terrace features four hammocks suspended between columns, inviting relaxation with a view of the serene ocean. A dining table with surrounding chairs is positioned nearby, overlooking calm waters and lush greenery, enhancing the outdoor living experience.
Apartment in Juan Gallego
4.88 out of 5 average rating, 220 reviews

Pebos Reef Apt 1 · Beachfront · Sea View Terrace

This spectacular beachfront property is ideally situated with an incredible view of neighboring islands, fishing friendly waters, and mesmerizing snorkeling spots for children and adults to enjoy. Monkey greetings from the jungle adjacent, octopus and colorful native fish inhabited waters, and lazy bear sloth sightings are all part of your daily experiences here at Pebos Reef! If you are lucky you will even see dolphins from the terrace ! A terrace on the sea is all you need.

A spacious terrace features various hammocks in vibrant colors, providing a comfortable resting area. The area is shaded by an overhead roof and surrounded by green grass and tropical plants, creating an inviting outdoor space for relaxation and leisure.
Home in La Guaira
4.5 out of 5 average rating, 8 reviews

Oceanfront Villa on Isla Grande

Enjoy a Villa in front of the sea. No need to drive or walk miles to the beach. Villa Espe is just a few steps from a spectacular and peaceful Caribbean beach of white sand and crystal clear waters. The house is surrounded by a large patio where children can play and run with their pets and the expansive oceanfront terrace has hammocks to relax and rest. The entire property has perimeter fence, surveillance cameras and private parking for added security.

Top Guest favourite
Two wooden lounge chairs are positioned on a well-maintained grassy area facing the water, allowing for peaceful views of the surrounding landscape. Palm trees are visible in the background, contributing to a serene outdoor setting.
Home in La Guaira
5.0 out of 5 average rating, 12 reviews

Apt near sea+Parking+TV+AC+Kitchen+WiFi@IslaGrande

✔️ Superhost Verified Your stay will be in the best hands! 🚨Send us a message with the word DISCOUNT and ask about special promotions 📍 Apartment in Colón Province, Panama 🇵🇦 🏡 Clean, comfortable and safe space, great location 🧼 Equipped with supplies and cleaning supplies During your booking, your Airbnb has: 🌐 Wi-Fi. 📺 TV 🍳 Kitchen ❄️ A/C 🌊 Close to the beach 🚗 Parking 👉Send us a message with the word DISCOUNT and ask for promotions

Home in La Guaira
4.73 out of 5 average rating, 37 reviews

Bella Casa, Caribbean Sea, Juan Gallego (waterfront)

Beautiful Beach House, facing the Caribbean sea, to rest and relax 100%. The house has a privileged location, it has 4 bedrooms (one of them has a partition to divide the living room and expand that area if desired), living room, dining room, private terrace, facing Isla Grande. 4 bedrooms. 3 have cable TV and an extra TV in the living room. All with air conditioning. It has 2 full bathrooms. Equipped kitchen and ready to enjoy and WiFi

An aerial view shows a property situated by the water, featuring red-roofed cottages and a grassy yard. Kayaks are visible in the water, along with seating areas under palm trees. A smooth pathway leads down to the water's edge, offering direct access for guests.
Home in Viento Frio
5.0 out of 5 average rating, 8 reviews

Casa Canalú

Enjoy the sounds of the sea when you stay at this unique place. The sea in front of the property is like a natural pool. The property is located six meters from the sea so you can always enjoy the sea breeze from a hammock. Those who like to cook will have a fully equipped kitchen. The 3 comfortable rooms, which are separated from each other, have air conditioning, fans and WiFi. Parking for several cars. Pedal boat, Kayak, Canoe

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Home in Palenque
4.5 out of 5 average rating, 4 reviews

Palenque Beach House · Pool & BBQ

Escape to this stunning beachfront home in Palenque! With 5 spacious bedrooms and 16 beds, it’s perfect for families, retreats, or group getaways. Enjoy a private pool, BBQ area, and direct beach access. The two-story layout offers ocean views, a full kitchen, and open living spaces for comfort and connection. Relax, recharge, and make unforgettable memories by the sea in this tropical gem!

Guest favourite
An aerial view showcases the property nestled between two natural beaches, surrounded by lush greenery. Calm waters and rocky formations are visible nearby, alongside beachside features that highlight the area's tropical environment.
Villa in Palenque
5.0 out of 5 average rating, 10 reviews

Beach Front House Surrounded by 2 Private Beaches

The property is surrounded by two natural beaches. It preserves a primary forest with multiple kinds of trees endemic to the area that serve as food for howler monkeys, titis, sloths and many birds, especially toucans that come to eat tropical grapes. We have an internal path to observe the jungle. Between March-May and August-October, the migration of birds is observed.

Chalet in Viento Frio
5.0 out of 5 average rating, 4 reviews

Spacious seaside villa

Duplex home. Great for events or groups for short stays. Equipped for families on long stays. Beach without sea urchins or stones. Waves and sea breeze on one side; and on the other side, the town center, the park and a century-old church. Village with annual celebrations such as "Race Day". I can give you an offer for 4 people, for a single night or for less.

A view of the house, set against a backdrop of palm trees, showcases its two-story structure with large windows and a red-tiled roof. The property overlooks a calm lagoon, with a stone pathway leading down to the water's edge.
Home in Palenque
5.0 out of 5 average rating, 9 reviews

Beach Front Caribbean Paradise at Palenque

Amazing beach front view will make you feel in touch with the ocean and its creation. A perfect place to relax and meditate . Located 2 hours and a half from Panama City is a place to enjoy the beach while listening to the sound of the waves and swim in shallow waters with sand button. You wilo feel the beauty and power of its creator!

Popular amenities for Santa Isabel District holiday rentals