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Holiday houses in Santa María

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Top-rated holiday rentals in Santa María

Guests agree: these stays are highly rated for location, cleanliness and more.

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Top Guest favourite
Apartment in San Carlos
5 out of 5 average rating, 20 reviews

Casamar | Large terrace and garden overlooking the sea

Apartamento en primera planta, amplia terraza y jardín privado con vista al mar, diseñado con múltiples espacios para relajarse y compartir. Cada recámara cuenta con su propia terraza, además de varios ambientes exteriores en el jardín. Desde la propiedad se accede directamente a una de las piscinas del complejo y se encuentra a pocos pasos del mar y del club de playa, ideal para disfrutar al máximo la experiencia en Casamar. Complejo con waterpark, piscinas y club de playa con acceso al mar.

Guest favourite
A private pool is surrounded by a smooth concrete deck, with gentle steps leading into the water. The adjacent open-air area features large glass doors that highlight the indoor living space, while the softly lit evening sky adds a serene ambiance.
Home in El Higo
4.97 out of 5 average rating, 33 reviews

CasAna

Fantástico lugar con espacios abiertos, luz natural y aire puro, 2 habitaciones con baño interno, terraza para recibir el amanecer y el atardecer, piscina privada que hace sentir que vuelas, mientras puedes compartir con amigos y familiares en un área grupal proporcionada por un espacioso deck, disfrutar de tus asados en la terraza y cocina equipada con todo lo que necesitas Ubicada a 10 mtos de Playa La Ermita y 12 mtos de la entrada del Valle, y a un salto del Restaurante Los Camisones.

Guest favourite
A spacious pool area is featured in the foreground, showcasing a large pool with a shallow entry and a clear blue surface. Multiple sun loungers are positioned around the pool, while palm trees provide a touch of greenery. The villa's exterior and covered terrace are visible in the background.
Villa in Rio Hato
4.91 out of 5 average rating, 86 reviews

Luxury 4BR Villa + Guesthouse & Pool @Buenaventura

Welcome to one of the nicest villas in Buenaventura, Panama's most luxurious beach resort community. This meticulously kept, spacious, 4 bedroom vacation paradise with additional private guest house and pool will make for unforgettable getaways with family and loved ones. Private baths, multiple dining areas, Sonos indoor/outdoor sound system, gorgeous outdoor areas and high end finishes, furnishings, and appliances throughout make every moment spent in Las Portales one to treasure.

Superhost
A scenic view of rolling hills under a colorful sky at sunset. Shades of orange, pink, and purple blend, creating a vibrant horizon. Lush trees are scattered across the landscape, adding a touch of greenery to the terrain.
Cottage in Olá
4.79 out of 5 average rating, 29 reviews

Country House in Olá, rivers, waterfalls, Los Picachos

Finca La Terapia lives up to its name, it is located among the mountains of the picturesque village of Olá de Penonomé, where you can disconnect from the busy day to day of the city. It has 42 private hectares to explore nature. The Olá district is characterized by having the most beautiful natural landscapes, among which we can mention Los Chorros de Olá, Chorros las Mesitas, Cerros los Picachos, Rio San Antonio, Balneario Brujas, among others, just a few minutes from the property.

Guest favourite
A thatched-roof ranch overlooks a swimming pool area, surrounded by vibrant flowering plants. The ranch provides shaded seating, while a hot tub is positioned next to the pool, enhancing the outdoor space's relaxation opportunities.
Villa in Rio Grande
4.94 out of 5 average rating, 84 reviews

Cheerful 3 bedroom countryside Villa with pool.

Forget your worries in this spacious and serene space. This 2 hectares villa includes an 185 square meters house, with 3 air conditioned bedrooms. In addition it includes a swimming pool and 40 square meter ranch. Bedrooms have in total 9 beds, accomodating 12 people. There are 3. 5 bathrooms, internet and hot water. Total perimeter of land is fenced, including an electric gate at the entrance. The price includes the presence of an employee who will support you during your stay.

Guest favourite
Home in San Carlos
4.94 out of 5 average rating, 16 reviews

Private House + Beach 400m + Jacuzzi + BBQ / 10p

Casa privada en Playa Corona para hasta 10 personas, a solo 400 metros de la playa. Ideal para cumpleaños, escapadas familiares o reuniones con amigos. Disfruta de un jacuzzi grande, espacioso con hidromasaje y burbujas, área de BBQ y bohío amplio para compartir al aire libre. Propiedad cerrada que brinda privacidad y seguridad durante tu estadía. A 5 minutos caminando de la playa y cerca del río. Un espacio cómodo y perfecto para crear momentos inolvidables en grupo.

Guest favourite
A bright bedroom is displayed, featuring a spacious bed covered with a textured white blanket. A television is mounted on the wall opposite the bed. Natural light floods through large windows, accompanied by sheer curtains. A cozy orange chair and potted plant add a touch of warmth.
Tiny home in Playa El Jobo
4.94 out of 5 average rating, 49 reviews

Private Beach Studio · Sunset & Nature Views

Designed for comfort, functionality, and a welcoming atmosphere: • Comfortable bed for a truly restful sleep • Air conditioning • Wi-Fi • Kitchen • 2 Bathrooms • Parking Perfect for short stays or longer breaks. Wake up at your leisure, enjoy a relaxing coffee, stroll to the beach, or simply unwind in this space. This place is ideal for: • Romantic getaways • Personal retreats • “Work from the beach” • Escaping the hustle and bustle of the city

Top Guest favourite
Home in Canto del Llano
4.91 out of 5 average rating, 56 reviews

Santiago city, home w/ spacious living & office

Spacious and peaceful home in a safe area of Santiago. 4 bedrooms (ideal for families and groups), bright living-dining area and large kitchen to share with family or friends, plus a private office for working comfortably. High-speed Wi-Fi, air conditioning and fans in all rooms, fully equipped kitchen, washer/dryer, and safe for valuables. Self check-in with smart lock, parking for several cars, and a coffee station with board games and karaoke.

Top Guest favourite
Home in Cañaveral
5 out of 5 average rating, 16 reviews

Peaceful Garden Home |3BR| Fast WiFi|Near Penonomé

We want you to feel truly comfortable and at home. A home away from home. If you’re looking to spend quality time with family or friends, “Mi casa es su casa” at Villas de Santa María is the perfect place to relax, disconnect, and escape the noise of crowded cities. Enjoy our private garden and unwind on the terrace with stunning views of Guacamayas Hill, where you’ll experience peaceful surroundings and beautiful sunsets every afternoon.

Guest favourite
Home in Chitre
5 out of 5 average rating, 11 reviews

Casa Blu Central Chitre| Sleeps 6| Private Parking

Stay in a newly renovated private home in the center of Chitré with free gated parking, a large backyard, fast Wi-Fi, and space for the whole family. Walk to restaurants, supermarkets and the cathedral while enjoying the comfort of an entire home to yourselves. It combines comfort, spaciousness, and natural light in every corner — perfect for families or groups of friends looking for a place that feels just like home.

Top Guest favourite
A modern beachfront building rises against a bright blue sky, with large windows reflecting the surroundings. Thatched-roof cabanas are visible on the sandy beach, bordered by lush greenery. The structure stands in a tranquil setting, inviting relaxation and enjoying ocean views.
Loft in Rio Hato
4.97 out of 5 average rating, 78 reviews

Beachfront Loft in Farallón

Wake up to the ocean in this beautiful beachfront loft in Farallón, located in the exclusive Miramar Loft next to the Decameron Hotel. Relax on the balcony with sea views, enjoy the pool, and walk to the beach with private cabanas on the sand. The apartment offers 2 bedrooms, a full kitchen, A/C throughout, and fast Wi-Fi. Just 2 hours from Panama City. Book now and live the beach experience you deserve!

Guest favourite
Farm stay in Santa Fe
4.9 out of 5 average rating, 324 reviews

Sun Cabin at Finca Namuiki by the River

Spectacular contemporary style villa surrounded by local flowers and woods. The villas design enhances the relationship with the outside environment with panoramic windows which are found in the dining room and kitchen, this offers an awesome view of the mountains and green flora. The villa is located in a organic quiet farm, with abundant vegetation and great presence of birds.

Popular amenities for Santa María holiday rentals