Holiday houses in Byron

Cottage in Lowertown–Perfect for Mayo & Downtown

In Lowertown-this quaint cottage with modern updates is your home away from home! Fully furnished and a well stocked kitchen make it a wonderful place for overnight stays or longer term rentals. Beautiful patio provides an urban sanctuary at the end of a long day. Close proximity to Mayo Clinic-downtown restaurants, grocery stores and shopping are within walking distance. Two blocks in either direction puts you on the trail system. Public transit 1 ½ blocks away and a laundromat is ½ block away.

Restful sanctuary close to Mayo Clinic

This cozy space has private, self-entrance with off-street parking at no cost...a mere 2.5 miles or 10 minute drive to the Mayo Clinic downtown. Located in a quiet neighborhood in NW Rochester. Easy access to highways, grocery store, coffee shop/cafes, Target, and walking trail. Completely furnished with linens, Netflix and Hulu, Wi-fi, and coffee maker. The laundry is shared with the host; who resides in the upper level. Please, no large construction vehicles. Truly a home away from home!

New! MN Comforts The Heart 4Bd/2Bth, 12min to Mayo

Welcome to MN Comforts The Heart! Are you here for work or leisure, or want to feel comforted after a Mayo appts? 12 min to Mayo Clinic, Wifi, work-station, ROKU/Smart TVs, and a fireplace in the family room. We offer a 2nd home feel. Near stores. Split-level, chill, and quiet, thoughtfully designed to cater to your needs, ensuring a comfortable, enjoyable stay. A blend of traditional & modern styling in a tranquil home, with fun opportunities for family & friends. Fully fenced backyard.

Oasis - Comfort & Serenity (Full house near Mayo)

*Discount for extended stays* Seeking a peaceful respite near Mayo Clinic in Rochester, MN? Look no further than "Oasis"–your ultimate home away from home. We offer 5 beds, 2 baths, & can accommodate up to 8 guests. Recharge in the workout & yoga meditation room, stay connected in the office area, & explore Rochester's attractions. Your dedicated host Peggy, a Mayo employee, will ensure a seamless/enjoyable stay. Book now & experience the perfect blend of comfort & serenity at Oasis.

BEST VALUE / Clean& Spacious / 10 minutes Downtown

Nestled in the cul-de-sac of Arcon Lane in the northwest side of Rochester, Minnesota, an Airbnb was established in the summer of 2025. It was given a name called Arcon Hollow B&B. Arcon Hollow B&B can be whatever space you’d like it to be for your stay. It can be your peace and quiet space away from the chaos of life, your rest and restore atmosphere to renew your energy, or your home away from home for different reasons that bring you to our beautiful town Rochester, Minnesota.

The Gwen | 2BR Apt, Fenced Yard, Pets, <3mi Mayo

A fully furnished 2-bed, 1.5-bath upstairs apartment with its own attached fenced yard and patio — a favorite for guests traveling with a dog. Full kitchen, dining area, living room, and a dedicated workspace for remote work. Free parking, quiet neighborhood feel, under 3 mi from Mayo and downtown. • 2 BR / 2 beds / 1.5 baths · sleeps 4 • Fenced yard + patio · workspace • Pet-friendly · free parking • Under 3 mi to Mayo Want the whole building? Book "Century Noll" for both units.

"Walden Pond" Adventure Amidst 44 Private Acres

Embark on your own "Walden Pond" adventure and be at one with nature. Each season brings its own magic: the fiery colors in fall, crunching through snow in the winter, new life in spring, and sports and activities in the summer! The 2000 s.f. log home known as 'The Bungalow" offers romantic fireplace, 2 bedrooms, 2 baths, office/bedroom + huge entertainment room. Easy drive from Rochester and all roads clear in winter. Feel safe from current coronavirus . See more info below.

Downtown Cottages | 5 Blocks From Mayo | No Stairs

Welcome to our Downtown Cottages, Rochester’s First "Tiny Homes" : 3 min drive/10 min walk to the Mayo Clinic Campus. Experience our four charming cottages- Enjoy zero-entry, slab-on-grade living with NO stairs!! Elegantly furnished and fully stocked, each unit also includes off-street parking. Located just 5 blocks from the downtown Mayo Clinic Campus, our cottages offer the perfect blend of comfort and convenience. Book your stay today!

Cedar Loft is a tranquil retreat

If you are looking for a quiet retreat w/private entrance outside the city, you are home. Trees are outside every window with palpable serenity yet is still an easy ten-minute drive to downtown Rochester. This is a family-friendly place with crib and changing table. This is not a party house. It has a kitchenette so we will provide information to restaurants and grocery stores within 5 minutes.

You’re home! St.Augustine MAYO CLINIC garage!

Time to relax! 2 car Garage Parking (a Minnesota must!) Fast WiFi, smart tv! Washer and Dryer and dishwasher! Clean comfortable home in a great SAFE neighborhood convenient to everything. Recliner! Costco, the best grocery’s stores, bars, restaurants, and movie theaters 1 min away. Minutes from the Mayo Clinic! Quick and easy drive! Check out my other listings to see the 5 Star reviews!

1st Premium Luxury Rooftop Stay w/ Elevator

Experience family fun in this stylish new model home featuring four bedrooms and four bathrooms. Enjoy a rooftop patio, an elevator, and a spacious primary suite with stunning views. The elevator provides easy access to all levels, making grocery trips a breeze from the two-car garage. Conveniently located just 12 minutes from the Mayo Clinic, this home showcases luxurious finishes throughout.

Woodhaven West

Unwind in this charming, pet-friendly haven approximately 2 miles west of St. Mary’s Hospital. Perfect for up to 4 guests, this one-level home offers a peaceful stay in a quiet neighborhood. Enjoy a fully stocked kitchen, washer & dryer, and all the comforts of home. Whether you're visiting for work, medical care, or a relaxing getaway, Woodhaven West is your perfect home base!