
House holiday rentals in Isla Grande
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Top-rated house rentals in Isla Grande
Guests agree: These houses are highly rated for location, cleanliness and more.

Puntita Manzanillo, fantastic sea and jungle
Come visit one of the most unique and exclusive properties in the Panamanian Caribbean. A magical completely private 5 acre property nestled between the Caribbean Sea (500meters of ocean front) and the jungle. Surrounded by a garden of corals and visited by monkeys and macaws. Our energy is solar and we have our own aqueduct. Temperature oscillates between 72 and 84 degrees F. It is rented in its entirety. It has 3 one bedroom cabins with full baths. Satellite Internet (Starlink) is provided.
LocationFamilyWalkability

The Bird's Nest in the Clouds
Escape to the Clouds: A Nature Lover’s Retreat. Welcome to The Bird's Nest, a serene loft in Santa Rita Arriba, Colón, 50 minutes from the city. Perched in the mountains, this open-concept space offers breathtaking views, fresh breezes, and the sounds of nature - rain and birds. Sleep with doors open, no AC. Perfect for nature lovers, not for those needing silence or climate control. Pool with breathtaking view, wifi and modern comforts included. PLEASE READ ENTIRE DESCRIPTION BEFORE BOOKING.
LocationFamilyGetting around

AeolusGuestHouse Home in Portobelo National Park
Welcome to AeolusGuestHouse, a hidden retreat in Jose del Mar, inside the Portobelo National Park. Surrounded by protected jungle, mangroves, and calm lagoon. Ideal for disconnecting in nature. Kayaks are available, and boats pick you up at the dock in front of the house for local tours, including Venas Azules just 15 minutes away. The home offers 2 bedrooms, 4 beds, an equipped kitchen, AC, parking, and helpful hosts always ready to assist. Pure nature, zero crowds, unforgettable stays.
LocationFamilySleep quality

Beachfront Home | En-Suites + Chef & Tours Available
Wake up to the sound of the waves… More than a beachfront home, Zola Sol is a curated wellness and lifestyle experience, thoughtfully designed around you. Whether you’re looking to relax, reconnect, or celebrate, we can personalize your stay with experiences such as private chef, wellness services, juice offerings, boat tours, and more—all seamlessly arranged before or during your visit. Your Airbnb reservation is simply the first step in creating an unforgettable Zola Sol experience.
LocationFamilyBeach

Beachfront · Large Sea View · Family Friendly
Welcome to Kasa Leilani, a charming beach house nestled between the jungle and the reef in the heart of a natural park. With stunning views of the nearby Caribbean islands, this peaceful retreat offers the perfect blend of nature and comfort. Surrounded by abundant wildlife, you can relax, explore the reef, or discover the island and crystal-clear waters. Kasa Leilani provides a serene escape for nature lovers and beach enthusiasts alike, offering an unforgettable tropical getaway.
ValueLocationCleanliness

Family Style Living, in Colon #3
Relax with the whole family at this peaceful place. This house is located on reverted Areas transferred back to Panamá, called Arco Iris, there’s plenty of space outside, the inside consist of a modern combination living room+kitchen, bathroom and a large bedroom with acomodación for 4 guest, the place is Airconditioned with Celling fans in the living room and bedroom. This is a third house constructed next to our first rental called, Family Style Living and close to the Panamá Canal
LocationValueHospitality

Beachfront House + Kitchen + Balcony + A/C + Wi-Fi @ Isla Grande
✔️Verified Superhost Your stay will be in the best hands! 🚨Send us a message with the word DISCOUNT and ask about special promotions 📍 Apartment in Isla Grande, Colón Province, Panama 🇵🇦 🏡 Clean, comfortable and safe space, great location 🧼 Equipped with supplies and cleaning supplies During your booking, your Airbnb has: 🌐Wi-Fi. 📺TV 🍳Kitchen Ocean 🌊front ❄️A/C 🚗Parking 👉Send us a message with the word DISCOUNT and ask for promotions
FamilyLocationCleanliness

Villa with Private Terrace in Playa Escondida
**The apartment** Ground floor with private terrace and the beach is just steps away! Our villa is one of the most accessible options for families with children and older adults!! >>>>you can get to the beach and pools without worrying about climbing stairs or using elevators <<<< *Resort Amenities* -Gym -Kayak, rowing boats, Bohío with BBQ (prior reservation) -Restaurants -Soccer field, paddle tennis and volleyball -Water park -Shop
FamilyLocationNearby

Palenque Beach House · Pool & BBQ
Escape to this stunning beachfront home in Palenque! With 5 spacious bedrooms and 16 beds, it’s perfect for families, retreats, or group getaways. Enjoy a private pool, BBQ area, and direct beach access. The two-story layout offers ocean views, a full kitchen, and open living spaces for comfort and connection. Relax, recharge, and make unforgettable memories by the sea in this tropical gem!
LocationOutdoor spacesKitchen

“Beautiful and Comfortable Villa at Playa Escondida Resort”
Luxury resorts and villa, front lagoon view, and just 2 minutes from the beach. Enjoy a comfortable and peaceful stay in this fully equipped accommodation, ideal for couples, families, small groups, or business travelers. It can accommodate up to 6 guests, offering a cozy, clean and functional atmosphere, a spacious terrace, definitely for a pleasant stay,
FamilyLocationAmenities

Casa "El Terrenito" - Ocean Front
Spacious waterfront house with 2 bedrooms, one room with 3 queen beds and 2nd with a king and a twin. Kitchen, living room, dining room. It has all the utensils for kitchen, sheets, stove,refrigerator, A/C. Special to relax!! For fishing fans we can provide a fishing panga! Additional price per day and captain. You can bring a pet.
LocationFamilyBeach

Casa Palenque Panama
Enjoy a spectacular oceanfront house, ideal for groups and families of up to 14 people. Relax with direct beach views, spacious indoor and outdoor spaces, and all the comforts for an unforgettable stay. Perfect for resting, living and creating unique memories with the sound of the sea in the background. We are pet friendly.
LocationFamilyPool
Popular amenities for Isla Grande house rentals
House rentals with a pool

El Paraiso
ValueLocationNearby

Tomorrow will be nice 15 people
ConditionKitchenBathroom

Brother Sun
Family

Oceanfront Villa | Pool | Near Isla Grande

Your oceanfront paradise
FamilyGetting aroundCleanliness

Villa in Juan Gallego, facing Isla Grande Colón
ValueLocationBathroom

Natural Pool in Colón

Palenque Beach House
LocationFamilyPool
Weekly house rentals

Entire house on 4th floor Colón
LocationParkingAccess

Seaside Caribbean Beach House
ValueLocationPool

Bella Casa, Caribbean Sea, Juan Gallego (waterfront)
LocationFamilyOutdoor spaces

OCEAN FRONT HOUSE AT THE CARIBBEAN - Pets allowed
LocationFamilyAccess

Casa la Perfecta, Big Island, Oceanfront
LocationValueComfort

Isla Grande’s Coastal Getaway
LocationFamilyBathroom

Casa de Playa, Colón Panama

Paco's Place in La Guaira
Private house rentals

hidden beach! Beach Villa
LocationValueLaundry

Beach house on Isla Grande

Caribbean Beach House
FamilyRiverAir conditioning

Casa de Pharmes, Escobal, Gatún Lake

Iguanita Point connects Playas del Caribe-Panama
FamilyLocationIndoor spaces

Tropical Paradise on Lago Gatun pure Nature

House facing the sea - Portobelo - Panama
FamilyLocationCheck-in

Blissful oceanfront villa on the Caribbean
FamilyValueBeach
Destinations to explore
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