
House holiday rentals in Panama
Find and book unique houses on Airbnb
Top-rated house rentals in Panama
Guests agree: These houses are highly rated for location, cleanliness and more.
Holiday rentals for every style
Get the amount of space that is right for you
Popular amenities for Panama house rentals
House rentals with a pool

BirdHouse@ Gamboa Panamá Canal

Nearly Oceanfront: Blue 3 Bedroom Spacious Villa

Poolside Paradise in Santa Clara

Spacious Vacation Home in a Tourist Area

3 min to Pedasi, 5 min to the Beach, Private Pool!

Modern, Peaceful Torio Treasure

Pedasí, Los Destiladeros Beach / Casa Serena

Marina|Private Pool|Bbq|Garden
Weekly house rentals

Wow House - Central Boquete!

Private Mountain Escape El Valle

La Florecita - Cottage in Valle de Antón

PIPA BEACH | Oceanfront with Beach Access

The Hidden Gem

Casa Blanca- Ocean view, couples & family friendly

Casa Bonita at Hermosa Bay, Chiriqui.

Casa Coco - Beautiful Mountain Villa With AC
Private house rentals

Altos del Maria: Portazul - a Mountain Retreat

Family home in Gamboa next to the Canal

Mountain Retreat: Peaceful & Private Escape

Comfortable, modern house - breathtaking sea view

Casa Verde in Volcán - Peaceful Oasis on the River

The Bird's Nest in the Clouds

NEW! Luxury Home in 5-Star Resort | King | Garden

Beachfront, Kayak, 100 Mbps, PingPong, Jungle, BBQ
Destinations to explore
- Rentals with a fire pit Panama
- Rentals with a home theatre Panama
- Rentals with a fireplace Panama
- Bungalow rentals Panama
- Rentals with a patio Panama
- Townhouse rentals Panama
- Mansion rentals Panama
- Private suite rentals Panama
- Rentals with lake access Panama
- Beachfront rentals Panama
- Rentals with a kayak Panama
- Condo rentals Panama
- Villa rentals Panama
- Hotel rentals Panama
- Waterfront rentals Panama
- Serviced apartment rentals Panama
- Ski-in/ski-out rentals Panama
- Cottage rentals Panama
- Rentals with a hot tub Panama
- Beach house rentals Panama
- Nature eco lodge rentals Panama
- Pet-friendly rentals Panama
- Rentals with an accessible height bed Panama
- Fitness-friendly rentals Panama
- Rentals with a sauna Panama
- Tiny house rentals Panama
- Smoking-friendly rentals Panama
- Lakehouse rentals Panama
- Rentals with an EV charger Panama
- Hostel rentals Panama
- Guesthouse rentals Panama
- Rentals with a washing machine and dryer Panama
- Boutique hotel rentals Panama
- Apartment rentals Panama
- Rentals with beach access Panama
- Boat rentals Panama
- Tree house rentals Panama
- Cabin rentals Panama
- Rentals with outdoor seating Panama
- Island rentals Panama
- Family-friendly rentals Panama
- Bed and breakfasts Panama
- Loft rentals Panama
- Rentals with breakfast Panama
- Farmstay rentals Panama
- Chalet rentals Panama
- Rentals with pools Panama
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