Some info has been automatically translated. Show original language

Holiday houses in Isthmus of Panama

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in Isthmus of Panama

Guests agree: these stays are highly rated for location, cleanliness and more.

1 of 1 pages1 / 1
Guest favourite
Two rustic-style cabins are set along the shoreline, surrounded by lush tropical trees. A wide patio is furnished with colorful chairs, offering views of the water. The natural beauty of the landscape is complemented by the tranquil waves gently lapping at the shore.
Home in La Guaira
4.97 out of 5 average rating, 114 reviews

Puntita Manzanillo, fantastic sea and jungle

Come visit one of the most unique and exclusive properties in the Panamanian Caribbean. A magical completely private 5 acre property nestled between the Caribbean Sea (500meters of ocean front) and the jungle. Surrounded by a garden of corals and visited by monkeys and macaws. Our energy is solar and we have our own aqueduct. Temperature oscillates between 72 and 84 degrees F. It is rented in its entirety. It has 3 one bedroom cabins with full baths. Satellite Internet (Starlink) is provided.

Top Guest favourite
Home in San Vito
5 out of 5 average rating, 11 reviews

Private 40-Acre Hacienda Estate

Our Hacienda sits on 40 Acres of land that was once one of the areas original Coffee plantations. Today, it is a private Estate with big jungle trees, about 4km of trails, fruit orchards and beautiful gardens. The house has been fully renovated and is welcoming and comfortable. A large wrap-around terrace looks out toward Volcán Barú and La Amistad Park. Hacienda Viva offers a setting to slow down and reconnect. Our place offers something for everyone..a perfect place to enjoy and make Memories!

Top Guest favourite
Place to stay in Panamá
5 out of 5 average rating, 19 reviews

Casa Condal - Your Luxury Retreat in Cerro Azul

Birdwatching • Romantic Getaway • Remote Work Escape the city. Breathe pure mountain air. Reconnect with nature. Casa Condal - private, modern, sustainable and regenerative hospitality inside Chagres National Park WiFi 65" Smart TV. Sound Bar Self check-in Private parking Fully equipped kitchen 220mts. private trail Deck-Mirador + FirePit, panoramic view of the mountains and valley King bed + Full size sofa bed BBQ Wheelchair accessible 40 min from Tocumen Airport. 1 hr from Panama city.

Top Guest favourite
An open living space features a wooden dining table surrounded by six wicker chairs. Two hanging hammocks are displayed on the covered terrace, offering views of the lush hills. Large glass doors reflect the greenery, blending indoor and outdoor spaces harmoniously.
Cabin in Torio
4.97 out of 5 average rating, 187 reviews

Cozy open space, unique jungle views, river access

An open-style jungle home with mesmerizing treetop and mountain views. Located 10 minute walk to the beach, with a trail that leads to the River. The house is not childproof! It has three individual bedrooms, each with its own key. The price is based on the number of guests. The entire house is always yours. The house offers fiber optic WiFi and two dedicated workspaces. The property is surrounded by large trees, naturally keep the house cool and provide shelter for birds and wildlife.

Top Guest favourite
Villa in Cañas
5 out of 5 average rating, 6 reviews

Luxury villa with ocean view near Playa Venao

A modern tropical villa with stunning ocean views and a private pool and garden. ✔ 2 bedrooms + 1 office space or gym room ✔ Private pool and large outdoor terrace ✔ Views toward Ocean and Isla Cañas ✔ Only 10 minutes from Playa Venao Guests enjoy free access to the signature Blue Beach Club, located in front of the ocean full of amenities. You will also receive 10% discount at selected local restaurants in the area. Perfect for vacations, remote work, or long stays near Playa Venao.

Top Guest favourite
Home in La Barra Número Uno
5 out of 5 average rating, 12 reviews

Private oasis with Ocean Views and Pool

Casa AltaVista is a private, modern hilltop retreat designed for guests who want space, privacy, and elevated comfort . Perched above lush jungle with sweeping ocean vistas. This property is run on solar power. Being that we are solely reliant on the power of the sun, during the evenings we ask that our air conditioning units be switched to 26C to conserve power until the mornings when the sun is back out and AC units can comfortably be switched to any temperature setting you desire.

Top Guest favourite
The exterior of the cabin is showcased amidst lush greenery, featuring a sloped roof and large glass windows. A wooden staircase leads up to the entrance, while a stone pathway meanders through the garden, enhancing the natural surroundings.
Cabin in Penonome
4.98 out of 5 average rating, 135 reviews

Aqeel cabin in the nature

Relax at this unique and tranquil getaway surrounded by nature. If you're lucky, you may wake up to see white-faced capuchins from your bedroom window and spot an abundance of birds, such as the crested oropendola or a toucan. The property offers river access with a sandy, beach-like area, and there is a 1 km walking trail alongside the river. With satellite high-speed internet access, you'll stay connected, though the river and sandy area may not be accessible during rainy days.

Superhost
A tranquil dipping pool is framed by lush greenery, featuring white loungers and a large umbrella for shade. The pool area exudes a serene vibe with vibrant bougainvillea in the background, enhancing the inviting outdoor space.
Home in Taboga Island
4.94 out of 5 average rating, 221 reviews

Casa Rosie - Dream Home on Tabogá Island

Casa Rosie is a gorgeous villa on Taboga island with an intimate vibe and spectacular views of the ocean. The perfect place for couples, small groups, and families to unwind and make magical memories! . With great wifi, fully equipped kitchen, 3 inviting bedrooms, and a spacious yet personal feel… Casa Rosie is your home away from home. Included in every stay is free pick up and drop off to the ferry terminal - please let us know the details of your arrival.

Superhost
Home in Altos del Maria
4.76 out of 5 average rating, 156 reviews

Villa Acuario

Relaxation is guaranteed in this one-of-a-kind glass house nestled in the lush mountains of Altos del María. Surrounded by nature and designed with floor-to-ceiling glass walls on all sides— as if you’re living inside a crystal ball. With no direct neighbors, panoramic forest views, it is perfect for a family getaway, a quiet reset, or an extended stay. The home offers light-filled interiors during the day and unforgettable stargazing nights from the rooftop.

Top Guest favourite
Apartment in Panamá
4.94 out of 5 average rating, 48 reviews

Casco Antiguo Apartment with Balcony & Stone Wall

Elegante apartamento en el corazón de Casco Antiguo. Disfruta de un espacio colonial con paredes de piedra expuesta, iluminación cálida y un encantador balcón con vista a calles vibrantes. Ubicado en Avenida B, a pasos de restaurantes, cafeterías, rooftop bars y lugares históricos. Capacidad para hasta 5 huéspedes. Perfecto para vivir la cultura y energía de Casco Viejo. Debido al ambiente animado del área, puede escucharse ruido nocturno los fines de semana.

Top Guest favourite
A private deck features two modern chairs with a small table between them, positioned on a textured area rug. A custom-built jacuzzi is visible in the background, surrounded by a wooden railing. Natural light floods the indoor living area through expansive glass doors.
Cabin in Boquete
5 out of 5 average rating, 10 reviews

New World Casita @ Finca Panda

Mundo Novo is one of our new, one-room casitas and has one of the most incredible views on the property. Perfect for couples, singles or family with a small child, Geisha sleeps 2 people comfortably in one king bed (maximum 3 guests when using sofa). Geisha was designed with every amenity needed to have a perfect and relaxing stay. Custom-built jacuzzi, fire-pit, kitchen, incredible shower, high-speed WiFi and more

Top Guest favourite
A wooden cabin is nestled among lush greenery, surrounded by vibrant tropical plants. The structure features large windows that allow natural light to illuminate the interior. Tall trees create a natural frame, enhancing the secluded and tranquil setting.
Cabin in Bocas del Toro
5 out of 5 average rating, 75 reviews

Carenero Hills 3 - Beach & Surf Bungalows.

Wake up, watch the sunrise, and check the surf from our garden, the bungalows have beautiful view of the Carenero Surf Break. No waves? then you can explore the vibrant marine life by snorkeling just steps away or relax in the peaceful embrace of the jungle. Unwind with stunning sunsets from our private dock and let the beauty of Carenero rejuvenate you.

Popular amenities for Isthmus of Panama holiday rentals