Guesthouse holiday rentals in Oconee County

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Top-rated Guesthouses in Oconee County

Guests agree: These guesthouses are highly rated for location, cleanliness and more.

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Top Guest favourite

A porch swing is set on a wooden deck, adorned with plush cushions featuring intricate patterns. Lush greenery and colorful flowers are visible in the background, adding vibrancy to the serene outdoor setting.

Guesthouse in Six Mile

Your Charming Country Cottage

Whether you need a country getaway or a place to lay your head after a football game, our cottage in the foothills of upstate SC is the perfect spot for both. You’ll find us tucked away just outside the quaint little town of Six Mile, 10 miles north of Clemson University and in close proximity to 3 of the upstate's favorite lakes: Lake Keowee, Lake Jocassee and Lake Hartwell. Here you’ll enjoy the serenity of country life without feeling “too far out" or away from all the upstate has to offer.

4.96 out of 5 average rating, 188 reviews

Top Guest favourite

The image captures a stone sign welcoming visitors to historic downtown Toccoa. The sign, adorned with the year 1874, is flanked by lush greenery and shaped hedges, providing a glimpse of the tree-lined street and well-maintained properties that characterize the neighborhood.

Guesthouse in Toccoa

Toccoa Guesthouse.

Our home was built in 1905 with additions in 1996. The Guesthouse was designed as a true ‘in-law’ suite and was constructed in 2010. We're in the historic downtown Toccoa neighborhood where folks still sit on their front porches and greet others as they amble by on the sidewalks. You are welcome to use the rear porch and breezeway during your visit with us. You’ll find the property convenient, safe, quiet & private with the advertised essential amenities available to make your visit pleasurable

5.0 out of 5 average rating, 228 reviews

Top Guest favourite

An inviting entrance features a wooden porch with decorative flowers and a bench. A staircase leads to the upper-level apartment, while an American flag adds a patriotic touch. Natural light illuminates the space, creating a welcoming ambiance.

Guesthouse in Seneca

Hartwell Hideway

Escape to this cozy 1-bedroom, 1-bath apartment perched above a private garage on Lake Hartwell. It's just 15 minutes from Clemson University and quaint downtown Seneca. With a full kitchen, cozy living space, on-site parking, keyless entry, and owners nearby, you’ll have everything you need for a relaxing visit. ✔ New build 2024 ✔ Boat access 5 minutes away ✔ Hiking & waterfalls nearby Whether you're here for a Clemson game, a lake adventure, or a quiet getaway, this is the perfect home base.

4.99 out of 5 average rating, 87 reviews

Guest favourite

A cozy living space features light-colored furnishings, including two comfortable chairs and a spacious sofa. Natural light enters through the partially covered window, complemented by tasteful window treatments. A small wooden desk and a decorative plant add a touch of warmth to the inviting atmosphere.

Guesthouse in Westminster

The Greendoor Guesthouse

Welcome to our peaceful retreat in the heart of the country! Nestled just 20 minutes from Clemson and 5 minutes from Seneca, this charming guesthouse offers the perfect balance of tranquility and convenience. Surrounded by rolling hills and scenic views, it's an ideal spot to unwind. Whether you're visiting for a Clemson game, exploring Oconee County's local waterfalls, or simply seeking a serene getaway, this cozy home offers a peaceful haven with all the comforts you need for a restful stay.

4.92 out of 5 average rating, 24 reviews

Top Guest favourite

Guesthouse in Seneca

The Cottage at Keowee Hollow

Welcome to the Cottage at Keowee Hollow! We are conveniently located minutes from downtown Seneca, 10 miles from Clemson and under an hour from downtown Greenville, Highlands or Cashiers. This cozy 1 bedroom, 1 bath cottage includes a small kitchen, living room and dining area. The back porch offers two chairs where you can start your mornings with a cup of coffee and enjoy a beautiful sunrise over Lake Keowee! Cane Creek and South Cove Park are just around the corner if you want lake access.

4.96 out of 5 average rating, 23 reviews

Top Guest favourite

A view from the porch captures a vibrant sunset, with colorful clouds streaked with pink and orange hues. In the foreground, bright orange flowers add a splash of color against the lush greenery and rolling hills in the background.

Guesthouse in Mountain Rest

Coltsfoot Cottage

Come enjoy the South Carolina mountains of Oconee County. Coltsfoot Cottage, located at Coltsfoot Farm, is tucked away on a small horse farm in the quaint community of Mountain Rest, we are seated at just over 1800 feet of elevation within a mile and a half from the sparkling Chattooga River. Highlands, NC, Clayton, GA and Walhalla, SC are just a short drive of 30 minutes (or less) from this unique property. Relax in beautiful mountain scenery and see astonishing sunsets at Coltsfoot Cottage.

5.0 out of 5 average rating, 72 reviews

Superhost

A cozy sleeping area features a white metal bed adorned with a textured blanket and a decorative pillow. Natural light filters through a nearby window, illuminating the wood-beamed ceiling and soft white curtains. A lantern and a small side table complete the inviting ambiance.

Guesthouse in Westminster

Country Guest House

Experience a peaceful stay in a cabin /guest house surrounded by old oaks and pines. Off the beatin path but only 3 miles from restaurants and shopping. Lovely deck for sitting and watching the deer. Fire pit for evening fires and roasting marshmallows. A gravel road leads up to the main house and the guest house is behind the main house with convenient parking and easy access. 1/8th mile from the paved road, so drive slowly to the dead end of the road where it enters the access driveway.

4.76 out of 5 average rating, 45 reviews

Guest favourite

A serene scene of a wooden dock extending into clear water, framed by trees with vibrant autumn leaves. The calm lake reflects the blue sky, inviting relaxation by the water's edge.

Guesthouse in West Union

Lake Keowee hillside delight

Relax with your family or friends at this unique brand-new water-front home on a hillside. Relish lake Keowee and nature while you can reach Clemson within a 25-mintute drive. You are heading for an easy and comfortable stay with plenty of choices for your activities. Whether you plan to kayak or bring your boat, finish your favorite book or grill your best recipe, you only regret not to come to Lake Keowee sooner. It is beautiful all year round and so is our home from sunrise to sunset.

4.8 out of 5 average rating, 75 reviews

Guest favourite

Guesthouse in Westminster

Our Nest, a well loved retreat by Lake Hartwell

Our Nest is a beloved private, upstairs carriage house retreat (above our detached garage) that was built & designed for getaways! It is an airy, beautiful apartment which has a French country farmhouse design & feel. Clemson, Seneca, GA & NC are close by. We are located in Foxwood Hills Resort with a seasonal, Olympic outdoor salt water pool, playground, pickleball/basketball, restaurant/bar, and boat ramp on Lake Hartwell. 5 star, very clean, safe, quiet and relaxing vacation spot.

4.98 out of 5 average rating, 87 reviews

Top Guest favourite

The entrance to the guest house is framed by rich wooden siding and features a charming porch. A small seating area with decorative cushions invites relaxation, while foliage and seasonal plants add natural beauty. The double doors provide a welcoming entry point.

Guesthouse in Mountain Rest

The Guest House By The River

Our Guest House is a quaint little place perfect for couples getaway. It is located on Chauga River, with a great swimming hole and beach. Perfect location if you are interested in River rafting (Chattooga River rafting is near by). If you enjoy hiking, fishing or just enjoying outdoors this is the place for you. Guest House is located to the right of the main house, but it is private. We would love to have you!! Close to Clemson, Cashiers, Highlands, Chattooga Belle Farms.

5.0 out of 5 average rating, 113 reviews

Top Guest favourite

A hand is shown holding a ceramic cup with the phrase 'Rise and shine' printed on it. The background features a serene lake reflecting a colorful sunset, with warm hues spreading across the sky and the water. A dock can be seen in the distance.

Guesthouse in Six Mile

Lakeside Haven on Lake Keowee

Relax at this cozy lakefront studio on Lake Keowee with access to kayaks, paddleboards, a dock, fire pit, and pool. Perfect for unwinding or exploring, it's close to state parks with hiking trails and just a short drive to Clemson University-great for football weekends. The studio includes a full kitchen, private bath and in-unit washer/dryer providing all the comforts of home. Whether you're here for adventure or relaxation, this lakeside retreat has everything you need.

5.0 out of 5 average rating, 39 reviews

Top Guest favourite

The exterior of the cabin is framed by lush greenery and a well-maintained lawn. A wooden porch, equipped with swings and rocking chairs, welcomes guests. Twinkling lights hang above, adding to the rustic charm. A stone pathway leads to the entrance, enhancing accessibility.

Guesthouse in Toccoa

Cozy Rustic Lakefront Cabin

“on the edge” is a small, cozy, rustic, lakefront cabin with easy walk to a private dock on Lake Hartwell. Great for fishing and swimming. Public boat ramp 2 miles. Living/dining area, two bedrooms. Relax on the large porch with swing and rocking chairs or enjoy fire pit area. No kitchen but includes microwave, full fridge, toaster, Keurig, coffee maker and gas grill. Perfect getaway but also near charming downtown Toccoa, Toccoa Falls, Currahee Mountain, hiking…..

4.98 out of 5 average rating, 184 reviews