Hotels in Orangeburg County

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Top-rated hotels in Orangeburg County

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The building showcases a three-story structure set against lush greenery and autumn foliage. Balconies extend from the second and third floors, overlooking a calm waterway. A dock with a kayak sits to the right, adding a recreational touch to the serene lakeside setting.
Hotel room in Santee
5 out of 5 average rating, 4 reviews

Wyndham Lake Marion * 2 Bedroom Deluxe

Lakeside Charm Just off the Beaten Path. Between Columbia and Charleston, on the banks of a quaint branch of South Carolina's largest lake, lies a charming and comfortable home base for your forays into the heart of the state. The resort is on the shore of Lake Marion's Chapel Branch, a calm, tree-lined waterway that creates the perfect escape for you and your family. Outdoor activities and convenient to more heavily populated pursuits, you won't need to go far to find your own brand of fun.

Guest favourite
A bright guest room features a queen-sized bed with dark bedding, complemented by a work desk and chair. Large sliding glass doors provide access to a balcony that offers views of the surrounding greenery, including trees and a flag. A flat-screen TV is mounted on the wall.
Private room in Eutawville
4.91 out of 5 average rating, 34 reviews

Lakefront Room w/Kitchenette Bells Marina & Resort

Our newly remodeled rooms feature a 180-degree view of our private cove. At Bells Marina, we redefine lakeside living in our Queen Room with a Kitchenette. Enjoy the serenity of the lake coupled with modern comforts. Our well-equipped kitchenette adds a layer of convenience, and for your entertainment, a 50" flat-screen TV awaits you after a great day at the lake. Whether it's a weekend retreat or an extended escape, book your stay now for the perfect blend of comfort and lakeside allure!

Hotel room in Manning

Best Inn with 2 full size bed, WiFi, bathroom

Whether you’re here for a quick stop or a longer stay, our cozy, reliable inn offers comfort, great value, and easy access off I-95 an ideal halfway point between the Northeast and Florida for road trippers, business travelers, and vacationers. • Guest rooms with comfortable bedding, free Wi-Fi, cable TV, mini-fridges, and microwaves • Daily housekeeping to keep things fresh • Free parking right at your door • 24/7 front desk support—we’re always here for you

Guest favourite
A spacious guest room features two queen beds with crisp white linens, positioned on a wood-look floor. Light-colored walls complement the minimalistic decor, while two floral art pieces are displayed above the beds. The entry door is visible at the far side of the room.
Hotel room in Barnwell
4.82 out of 5 average rating, 11 reviews

Lofts on Burr- Second Floor - 2 Queen

Welcome to our boutique hotel, offering 5 unique rooms, each with its own character. This room has 2 queen beds and one bathroom, located on the second floor with no elevator access. An ADA suite is available on the first floor upon request. Situated on the Circle in downtown Barnwell, SC, our hotel blends timeless charm with modern convenience. Enjoy a seamless stay with our contactless key code entry.

A large outdoor swimming pool is surrounded by lush landscaping and shaded seating areas. Nearby, several resort buildings maintain a cohesive design with balconies visible on the upper levels, offering a peaceful setting for relaxation.
Resort in Santee

Lakeside Bliss: 3BR Suite at Wyndham Lake Marion

Escape to lakeside bliss at our spacious 3-bedroom, 3-bathroom resort suite located in the serene Wyndham Lake Marion. Embrace the tranquility of the picturesque surroundings as you unwind in this comfortable retreat. Book your stay at our lakeside 3BR suite and experience the perfect blend of relaxation and adventure at Wyndham Lake Marion. Create unforgettable memories in this scenic oasis.

An expansive outdoor swimming pool is surrounded by well-maintained grounds, featuring lounge chairs along the water's edge. Residential buildings are visible in the background, framed by trees and landscaping, under a clear blue sky.
Resort in Santee

Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

Escape to lakeside bliss at our spacious 2-bedroom, 2-bathroom resort suite located in the serene Wyndham Lake Marion. Embrace the tranquility of the picturesque surroundings as you unwind in this comfortable retreat. Book your stay at our lakeside 2BR suite and experience the perfect blend of relaxation and adventure at Wyndham Lake Marion. Create unforgettable memories in this scenic oasis.

An outdoor swimming pool is centrally situated within the resort, featuring a clear blue surface reflecting the sky. Surrounding the pool, shaded lounge chairs are positioned for relaxation, while manicured landscaping adds a touch of greenery, enhancing the tranquil ambiance.
Resort in Santee

Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

Escape to lakeside bliss at our spacious 2-bedroom, 2-bathroom resort suite located in the serene Wyndham Lake Marion. Embrace the tranquility of the picturesque surroundings as you unwind in this comfortable retreat. Book your stay at our lakeside 2BR suite and experience the perfect blend of relaxation and adventure at Wyndham Lake Marion. Create unforgettable memories in this scenic oasis.

A large outdoor swimming pool is surrounded by lush landscaping and residential buildings. Sun loungers and umbrellas are arranged along the poolside, inviting relaxation under the clear blue sky.
Resort in Santee

Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

Escape to lakeside bliss at our spacious 2-bedroom, 2-bathroom resort suite located in the serene Wyndham Lake Marion. Embrace the tranquility of the picturesque surroundings as you unwind in this comfortable retreat. Book your stay at our lakeside 2BR suite and experience the perfect blend of relaxation and adventure at Wyndham Lake Marion. Create unforgettable memories in this scenic oasis.

An outdoor swimming pool is surrounded by landscaped areas and sun loungers. Adjacent buildings house resort suites, with a mix of balconies and patios visible. The calm water reflects the clear sky, creating a serene atmosphere for relaxation.
Resort in Santee

Lakeside Bliss: 3BR Suite at Wyndham Lake Marion

Escape to lakeside bliss at our spacious 3-bedroom, 3-bathroom resort suite located in the serene Wyndham Lake Marion. Embrace the tranquility of the picturesque surroundings as you unwind in this comfortable retreat. Book your stay at our lakeside 3BR suite and experience the perfect blend of relaxation and adventure at Wyndham Lake Marion. Create unforgettable memories in this scenic oasis.

An outdoor swimming pool is depicted with clear blue water, surrounded by lounge chairs and landscaped gardens. The resort buildings are visible in the background, featuring balconies and a variety of exterior colors under a bright sky.
Resort in Santee

Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

Escape to lakeside bliss at our spacious 2-bedroom, 2-bathroom resort suite located in the serene Wyndham Lake Marion. Embrace the tranquility of the picturesque surroundings as you unwind in this comfortable retreat. Book your stay at our lakeside 2BR suite and experience the perfect blend of relaxation and adventure at Wyndham Lake Marion. Create unforgettable memories in this scenic oasis.

An outdoor swimming pool is featured at the resort, with clear blue water reflecting the sky. Surrounding palm trees and manicured landscaping enhance the environment, while the view includes several two-story buildings in the background, providing a picturesque setting for relaxation.
Resort in Santee
4.8 out of 5 average rating, 5 reviews

Lakeside Bliss: 3BR Suite at Wyndham Lake Marion

Escape to lakeside bliss at our spacious 3-bedroom, 3-bathroom resort suite located in the serene Wyndham Lake Marion. Embrace the tranquility of the picturesque surroundings as you unwind in this comfortable retreat. Book your stay at our lakeside 3BR suite and experience the perfect blend of relaxation and adventure at Wyndham Lake Marion. Create unforgettable memories in this scenic oasis.

A spacious outdoor swimming pool is surrounded by lounging chairs, with gentle waves reflecting the clear sky. The resort buildings are visible in the background, framed by greenery and palm trees, enhancing the serene atmosphere of the area.
Resort in Santee

Lakeside Bliss: 3BR Suite at Wyndham Lake Marion

Escape to lakeside bliss at our spacious 3-bedroom, 3-bathroom resort suite located in the serene Wyndham Lake Marion. Embrace the tranquility of the picturesque surroundings as you unwind in this comfortable retreat. Book your stay at our lakeside 3BR suite and experience the perfect blend of relaxation and adventure at Wyndham Lake Marion. Create unforgettable memories in this scenic oasis.

Popular amenities for Orangeburg County hotels