
House holiday rentals in Orangeburg County
Find and book unique houses on Airbnb
Top-rated house rentals in Orangeburg County
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Theo's Place
Kick back and relax in this calm, stylish space. I'm happy to offer my 1st home as a host, providing all the amenities I've wanted as a guest in my years of successful stays on the AirBnB platform as a guest (laptop not included). My guest will find various comforts and additions to make their stay as comfortable as can be. I welcome your feedback. My home is available as a 1 Bedroom with a large Den, Living & Dining rooms, 2 Bathrooms, full Kitchen and Laundry room. All new appliances as well.

Ultimate Hideaway in the pines next to Lake Marion
Discover the hidden secrets of the midlands of South Carolina. Minutes away from fishing Lake Marion, and discovering hidden gems of both SC state and national parks. Surrounded by the serenity of nature, near the Palmetto trail and endless hiking and biking trails. Ramble the scenic byways and back roads of the area and discover our hidden small towns, historic sites and natural wonders. Convenient to visitors of Shaw Air force base and within reasonable distance to the charm of Charleston.

The Grand Marshall
Bring the whole family to this renovated 3 BR, 2 bath home +1 BONUS ROOM, which serves as a theatre/game room with 2 queen sleeper sofas. Your family will enjoy: Coffee/beverage/snack bar Central location: Approximately 5 minutes to SC State and Claflin University, OC Tech College, Edisto Gardens, MUSC Health Orangeburg, shopping, dining, and more. Designated office space 1 king bed, 2 queen beds, plus 2 queen sleeper sofas 5 Roku Smart TV’s Smart lock for easy access High speed WiFi

Nanny’s Lake Retreat
Located in a quiet, dead end community. Enjoy the lake sounds from the spacious screened in porch. The porch has a swing, rocking chairs, and table with chairs. The den boasts a beautiful gas log fireplace and has two futons and a loveseat. The house is located in a golf cart community on a cove. Sandy beaches are just minutes away depending on the lake levels. Whether you’re looking for a vacation destination or fishing/hunting trip you will love this home. Pets require pre approval

Luxurious Lakefront Log Home W/Pool & hot tub
Stunning luxury log home on the big waters of Lake Marion, featuring a private fishing pier, boat dock, brand-new saltwater pool, hot tub, and more. This custom-designed retreat offers 3 spacious bedrooms, a loft, and 2 elegant bathrooms—one with a clawfoot soaking tub and separate water closet. Enjoy dining and entertaining on the expansive screened-in porch with a custom 12’ outdoor bar. Just 6 minutes from I-95, this serene lakeside escape blends rustic charm with upscale comfort.

Santee lakefront home, big water right off I-95
Lakefront home on the big water of Lake Marion. This home is on the Santee side of the lake in a quiet neighborhood, 1-2 miles from restaurants, grocery stores, golf courses and I-95. Starbucks is less than 2 miles away. *Home can accommodate 10 guests max. *Indoor hot tub is available October through March. *Only registered guests listed on the booking are authorized at the property unless prior approval has been granted. *STRICT no pet policy. *PARTIES ARE STRICTLY PROHIBITED*

Perfect Family OFF THE GRID retreat at Lake Marion
Great water front family escape! Enjoy our beach, dock and boat ramp as well as our game room and fully stocked kitchen. We purchased our home is 2006 and began a complete interior and exterior renovation. In 2023 we installed solar panels and an electric vehicle charging station, yet we also have access to the grid for cloudy days and when power demand exceeds what our panels generate. We use a deep well for water. Bring your family for an off-the-grid vacation in our lake home!

Ron's Siesta Airbnb
A beautifully renovated Cape Cod, reminiscent of the late 1940's is located near restaurants, groceries, and the universities; some of which are in walking distance. While located on a main thoroughfare, the home exudes a quiet and peaceful atmosphere. There are two bedrooms, bath, kitchen, eating and dinning area. A warn place to feel welcomed and at home. Universities: SCSU walk 18 min 1.0mil; Claflin University walk 15min. 0.8 mil; The Village Center walk: 3min 0.2mil.

Columbia Road Retreat
Renovated recently, convenient in town location. Nicely appointed with comfortably furnishings. The downstairs: Living & Dining Rooms, Kitchen, 1 bedroom (King) 1 bedroom (Queen) and 1 bath, The Upstairs: Additional 1 or 2 bedrooms and bath are available for additional charges. Message me Pet Notes: Pets must be approved in advance of stay and pet fees are charged based on number of dogs and breed. Some breed are restricted by insurance company. Contact me before booking

Pet-Friendly Lake Marion Getaway - Just off I-95!
In the quaint lakefront town of Santee, There exists a special place. Past Main street and down a country road, nestled in a modest lakefront community, with views of the majestic Lake Marion, we've worked tirelessly to create the perfect family retreat. No matter who you call family, this home is perfect for boaters, golfers, and nature enthusiasts. Guests at the Kindred Spirits Retreat experience more than just a beautiful home, they experience the joys of purposeful travel.

Cheerful 3 bedroom home on the lake
Great 3 bedroom home on the water. Perfect for family vacations, a weekend getaway or a stay for local fishing tournaments. This home is on a quiet cove that opens up to the larger lake. Get the best of both worlds. The cove is perfect for paddle boating, kayaking, fishing off the dock, grilling on the deck, or just relaxing on the screened porch enjoying the view. But, with the private dock you can bring your boats and jet skis to enjoy the entire lake.

Oak View
Enjoy having a cup of coffee relaxing in the swing on the front deck or sitting on the back deck facing the woods and watching the chickens pecking for food. Or take a stroll down the lane and inspect the muscadine/scuppernong vines and enjoy luscious grapes and figs in season. Enjoy a slice of country life on 2 1/2 acres.
Popular amenities for Orangeburg County house rentals
House rentals with a pool

Colonial Farmhouse - 6 bedroom with a pool

The Sunset Chaser

Lake House Retreat

Sunset Serenity Pool/Swim Spa

Out Aways House with a POOL on a POND

The Merry Inn @ Lake Marion

Heated Indoor Pool on Lake Marion with Dock

Lakefront Lookout
Weekly house rentals

Beautiful 3-Bedroom House

Lakefront Cabin Off i95, Bells Marina & Resort

Santee/Lizzie's Creek Lakefront

A Lake Slice of Heaven

Almost Heaven on Lake Marion, SC

Lakeview Leisure-Face to the Sun

SANTEE LAKE MARION GOAT ISLAND AREA NEWLY UPDATED

Lake life paradise!! Lake Marion waterfront.
Private house rentals

In town cottage

Cozy, comfy, convenient, cottage!

Cypress shores cottage. Lake Marion Sc

The Pond House at Salkehatchie Farms

Lowcountry river life

No Cleaning Fee 3BR | Sleep 10 | Near Santee Lakes

The Pointe at Goat Island W/Pool, boat ramp & Pier

Lake Marion Beauty w/ 5br/3ba
Destinations to explore
- Rentals with pools Orangeburg County
- Condo rentals Orangeburg County
- Rentals with a washing machine and dryer Orangeburg County
- Hotel rooms Orangeburg County
- Apartment rentals Orangeburg County
- Family-friendly rentals Orangeburg County
- Rentals with a kayak Orangeburg County
- Fitness-friendly rentals Orangeburg County
- Pet-friendly rentals Orangeburg County
- Rentals with a fireplace Orangeburg County
- Rentals with a fire pit Orangeburg County
- Rentals with outdoor seating Orangeburg County
- Rentals with a patio Orangeburg County
- Rentals with a hot tub Orangeburg County
- Rentals with lake access Orangeburg County
- House rentals South Carolina
- House rentals United States
- Riverbanks Zoo and Garden
- South Carolina State House
- Congaree National Park
- Frankie's Fun Park
- Columbia Museum of Art
- South Carolina State Museum
- University of South Carolina
- Colonial Life Arena
- Williams Brice Stadium
- Columbia Metropolitan Convention Center
- Saluda Shoals Park
- West Columbia Riverwalk Park and Amphitheater
- Edventure
- Soda City Market
- Riverfront Park
- Dreher Island State Park




