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Holiday houses in Santa Clara, Panama City

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Top-rated holiday rentals in Santa Clara, Panama City

Guests agree: these stays are highly rated for location, cleanliness and more.

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Guest favourite
Apartment in Panamá
4.93 out of 5 average rating, 138 reviews

Apto 4 min from Tocumen Airport | 24-hr check-in

Layover in Panama? Stay where everything is easy and comfortable Just 4 minutes from Tocumen International Airport – perfect for early flights or quick stopovers A modern, comfortable, and secure apartment with: • Fast WiFi and air conditioning • Smart lock and flexible check-in • 24/7 security • Pool, gym, and fully equipped kitchen • Steps from the ITSE Metro station Ideal for layover travelers, curious tourists, or business trips. 🌴 Just arrive — everything’s ready for you. We’ll be waiting!

Top Guest favourite
A modern living area features a light-colored sofa adorned with colorful cushions. A round coffee table sits on a textured rug, while a dining table for six is visible in the background. Large windows present striking views of the city skyline.
Apartment in San Francisco
5 out of 5 average rating, 71 reviews

Luxury apt in Panama City 2 Rooms 3 Baths

El edificio Wanders by yoo esta ubicado en el corazón de la ciudad, es un proyecto fuera de serie donde cada rincón tiene una historia que contar. Recepción 24/7, muchas areas de esparcimiento, estación de hidratación. En las afueras del lobby tenemos la Cafetería cafe con teclas y un restaurante de Carnes Popino. En el area social servicio de barra en la piscinas, parque de niños, sala de juegos con pantallas en e l techo baños, salon de eventos, cocina para eventos, gym full equipado y más

Superhost
Apartment in Panamá
4.95 out of 5 average rating, 44 reviews

5MINUTOSCOSTADELESTEwifi6-tvstreaming

BIENVENID@! disfruta de la sencillez de este alojamiento tranquilo y céntrico. El apartaestudio es ideal para esas personas que quieren conocer la ciudad y también para el que viene por trabajo,ya que tiene su escritorio y su comodidad,esta cerca de plaza de comidas,supermercados,gym,etc. queda cerca a algunos lugares turísticos,como costa del este centro de negocios,malecón,Panamá Viejo.. te puedo horientar para sitios turísticos si necesitas carro en alquiler también tenemos esa opción 😇

Guest favourite
Loft in Panamá
4.95 out of 5 average rating, 20 reviews

Entire Apartment #7, 20 minutes from the airport

Comfortable and cozy loft on Avenida la Pulida! Equipped for executives and couples, this loft apartment features a bedroom with a queen bed, a full bathroom, a fully equipped kitchen, a living/dining room, a Smart TV, air conditioning, a water heater, a laundry area, and a walk-in closet. Just an 8-minute walk from the Cincuentenario Metro Station and with easy access to any point in the city. Located in a quiet and discreet central building. Enjoy a perfect stay! Parking available.

Top Guest favourite
Apartment in San Felipe
5 out of 5 average rating, 22 reviews

Luxury Balcony Stays + Pool Casco Viejo

Wake up overlooking one of the last historic bastions of Casco Viejo, sip your morning cofee on a private balcony, and step directly into Panama City most vibrant and wakable neighboorhood. Surrounded by colonial architecture, charming plazas, and a vibrant culinary scene, this space invites you to experience Panama with style and tranquility. Ideal for those seeking an exclusive, walkable, and characterful environment in one of the city's most iconic areas.

Guest favourite
A woven basket holds neatly rolled towels in soft neutral tones, positioned on a glass shelf. The background displays a clean and bright bathroom environment, with a hint of greenery from a small plant, enhancing the overall space.
Guest suite in Panamá
4.93 out of 5 average rating, 76 reviews

Aeropuerto | Check-in fácil y flexible

✈️ Perfect for layovers, late or early flights and short stays Stay just 10 minutes from Tocumen Airport and recharge comfortably before your next flight. • Easy Check-in 🛏️ Private studio for up to 2 guests ❄️ Air conditioning 📶 Fast WiFi 🚿 Hot shower 🍳 Equipped kitchen 🔒 Safe residential community 🚗 Airport shuttle available (pre-book) 🕒 Flexible self check-in after 3pm Ideal for travelers in transit, couples, or short stays without hassle.

Guest favourite
The kitchen area features modern cabinetry with a beige countertop. A refrigerator, microwave, and coffee maker are visible, alongside a sink. The walls are adorned with textured tiles in shades of brown, and a pendant light hangs above, providing illumination.
Home in Panamá
4.94 out of 5 average rating, 410 reviews

Private Studio 10 Min from the Airport!

Apartamento Entero a 10 MINUTOS del Aeropuerto! El apartamento está completamente amueblado incluyendo electrodomésticos y artículos de cocina , productos de aseo , sala comedor ,mesa de trabajo y demás. A sólo minutos caminando de la Estacion de METRO SAN ANTONIO y METROMALL. Ofrecemos Tours a San Blas -Tours a Monkey Island y el Canal de Panamá para que aproveches al maximo tu viaje. Nuestra casa es Tu casa en Panamá 🇵🇦

Superhost
Guesthouse in Panama City
4.88 out of 5 average rating, 254 reviews

Boho Studio - Private Terrace 9 km from the airport

Perfecto para 1–2 huéspedes, Wifi, Terraza tranquila, cuarto independiente, cuenta con A/C , y su baño pequeño. Ubicado cerca del Aeropuerto Internacional de Tocumen, de 10 a 13 minutos en auto. El Studio está Cerca de 2 Centros Comerciales, Metromall y Los Pueblos OUTLET. La zona residencial es segura al caminar, calles organizadas y limpias. Tenemos la estación del Metro de Cerro Viento afuera en Metromall.

Guest favourite
Apartment in San Francisco
4.99 out of 5 average rating, 149 reviews

Full apartment in Panama

This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.

Superhost
A spacious lounge chair with an umbrella provides a relaxing spot beside the infinity pool, which stretches towards the horizon. The pool features clear blue water, and the cityscape, along with the coastline, is visible in the background.
Apartment in Panamá
4.81 out of 5 average rating, 42 reviews

Luxury Suite 18th View Coco del Mar Panama

Immerse yourself in the elegance and comfort of this beautiful apartment located in the heart of Panama. With stunning views of the ocean and the city, it is designed to provide you with a unique experience. Equipped with top-notch amenities such as a pool, gym and social areas, this space guarantees a stay full of tranquility, luxury in this haven of tranquility and exclusivity. Your home away from home!

Top Guest favourite
A dining table is set with elegant glassware and plates, positioned by a balcony that overlooks lush green foliage. The scene captures the natural light filtering through nearby plants, providing a nice view of the tranquil outdoor setting.
Condo in San Felipe
4.99 out of 5 average rating, 284 reviews

Patty’s Charming Serene Studio in Casco Viejo

Best location by the “El Rey" Supermarket...Casco's only grocery store! Prime location steps away from restaurants, bars, cafes, plazas and great little breakfast places with the lovely water front promenade around the corner making it the perfect “pied-à-terre!” The studio has a fully stocked kitchen aside from the main living space. It is spacious, comfortable and tastefully decorated!

Top Guest favourite
A modern rooftop pool area features a spacious infinity pool surrounded by comfortable loungers. The city skyline is visible in the background, complemented by clear blue skies and a touch of greenery. Adjacent, a smaller jacuzzi enhances the relaxing atmosphere.
Apartment in Costa del Este
5 out of 5 average rating, 32 reviews

Elegant Apt in Costa del Este. Premium Amenities

Enjoy a luxurious stay in our modern design apartment located in the exclusive Costa del Este area. It has a room with a private bathroom, a cozy living room, and a fully-equipped kitchen. Building facilities include a state-of-the-art gym, swimming pool, and co-working space ideal for remote work. Perfect for extended stays, combining comfort and convenience in the heart of Panama.

Popular amenities for Santa Clara, Panama City holiday rentals

  1. Airbnb
  2. Panama
  3. San Miguelito
  4. Santa Clara