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Holiday houses in Santa Cruz de la Sierra

Find and book unique accommodation on Airbnb

Quick stats about holiday rentals in Santa Cruz de la Sierra

  • Total holiday rentals

    Explore 4,380 holiday rentals in Santa Cruz de la Sierra

  • Nightly prices starting at

    Santa Cruz de la Sierra holiday rentals start at $17 NZD per night before taxes and fees

  • Verified guest reviews

    Over 59,960 verified reviews to help you choose

  • Family-friendly holiday rentals

    1,170 properties offer extra space and kid-friendly amenities

  • Pet-friendly accommodation

    Find 1,180 rentals that welcome pets

  • Holiday rentals with a pool

    2,980 properties feature pools

  • Rentals with dedicated workspaces

    2,510 properties have a dedicated workspace

  • Wi-Fi availability

    4,040 of Santa Cruz de la Sierra holiday rentals include Wi-Fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi and Pool across Santa Cruz de la Sierra rentals

  • 4.7 Average rating

    Santa Cruz de la Sierra stays receive an average rating of 4.7 out of 5 from guests

Top-rated holiday rentals in Santa Cruz de la Sierra

Guests agree: these stays are highly rated for location, cleanliness and more.

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Top Guest favourite
A modern living area is furnished with a gray sofa and a brown accent chair. A wooden coffee table sits on a textured rug in front of the sofa. Natural light floods in through large windows, illuminating the open layout that connects to an equipped kitchen.
Apartment in Santa Cruz de la Sierra
4.98 out of 5 average rating, 55 reviews

Luxury and comfort in every detail

This apartment combines luxury, style, and comfort in every detail. Designed as a boutique hotel, it offers a unique experience with impeccable finishes, an equipped kitchen, a cozy living room, spacious bedrooms, and a beautiful balcony to relax. Located in the heart of Equipetrol and a short walk from restaurants, shops and attractions. Perfect for business trips or relaxation, this modern and elegant space is ideal for relaxing and enjoying an unforgettable stay. You'll love it! Parking is included!

FamilyValueNearby

Guest favourite
Apartment in Santa Cruz de la Sierra
5 out of 5 average rating, 6 reviews

Skyline Luxury • Rooftop, Piscina, Billar & Lounge

Diseñado para huéspedes de gustos exigentes que buscan una experiencia superior a un hotel 5 estrellas. Ubicado en Equipetrol, la zona más exclusiva y segura de Santa Cruz, este elegante Dpto. en penúltimo piso ofrece doble balcón con vistas únicas! Premium amenities como sky pool, lounge, billar, churrasqueras, gym completo y más! Rodeado de los mejores restaurantes, bares, cafés, teatros, tiendas y centros empresariales. Ideal para viajes ejecutivos, escapadas de lujo o estadías inolvidables.

LocationBathroomIndoor spaces

Top Guest favourite
Apartment in Santa Cruz de la Sierra
4.97 out of 5 average rating, 79 reviews

Depto. Premium 3 dormitorios | Piscina |Macororo.

Disfruta de una estadía cómoda y elegante en este amplio departamento de 3 dormitorios en Macororo 13/14, sobre Av. Los Cusis. Ideal para familias, grupos y viajes de trabajo. • Piscina temperada y áreas sociales • Parqueo privado gratuito • WiFi rápido • Cocina equipada • Lavadora y secadora • Smart TV A pocos pasos encontrarás supermercado 24 horas, Starbucks, restaurantes, centro comercial y gimnasio frente al edificio. Un espacio cómodo, seguro y pensado para una excelente estadía.

FamilyValueHospitality

Top Guest favourite
Apartment in Santa Cruz de la Sierra
5 out of 5 average rating, 19 reviews

POX | Green Tower 17th Floor, Luxury in Equipetrol

✨ Vive la experiencia POX de lujo y confort en el corazón de Equipetrol ✨ Ubicado en el piso 17 de la exclusiva Green Tower, este departamento POX Glam combina diseño moderno, decoración sofisticada y una vista panorámica única de Santa Cruz. Perfecto para viajeros de negocios, parejas o estadías de placer que buscan un espacio premium con todas las comodidades. En POX no solo alquilamos departamentos: te damos un hogar lejos de casa. Nuestro equipo está disponible 24/7 para ayudarte.

LocationLayoutWalkability

Guest favourite
Apartment in Santa Cruz de la Sierra
4.85 out of 5 average rating, 33 reviews

Penthouse on Avenida Beni

This is the one! Located minutes from restaurants, shopping, and downtown, it doesn't get much more convenient than this! With a fully equipped kitchen, comfortable bedrooms and a cozy environment Step into this apartment and let the cozy surroundings instantly appeal to you! Here you will find everything you need to make this your home away from home. From the thoughtful decor and thoughtful furnishings, this place has been designed to make everyday life beautiful.

ValueFamilyAir conditioning

Guest favourite
Apartment in Santa Cruz de la Sierra
5 out of 5 average rating, 7 reviews

Mare Residence · Piso 15 · Monoambiente

Disfruta una estadía moderna en Mare, uno de los edificios más exclusivos de Santa Cruz. Este elegante monoambiente en piso 15 ofrece vista a la ciudad, balcón privado, cama de 2 plazas y sofá cama para hasta 3 huéspedes. Cuenta con Smart TV, Netflix, WiFi, aire acondicionado, cocina equipada, horno y microondas. Disfruta áreas sociales tipo resort con piscina de 30m, cowork, bar, billar, áreas verdes y excelente ubicación cerca de restaurantes y centros comerciales.

LocationValueGetting around

Superhost
A balcony is visible, featuring a small round table with a potted plant and two woven chairs. In the background, a serene pool area is framed by palm trees and the picturesque landscape of the property. A dog is seated on the chair, enjoying the view.
Apartment in Santa Cruz de la Sierra
4.88 out of 5 average rating, 80 reviews

Mar Adentro 1st row SANTA CRUZ

Front row ground floor apartment with ocean views. Walk just a few steps and you'll be enjoying one of the largest pools in Latin America. Live a Caribbean dream in the heart of Santa Cruz. This one-bedroom apartment invites you to enjoy its spacious living room, large patio and private barbecue with all the luxury you deserve. Let yourself be captivated by the majestic beach with crystal clear water in the most beautiful and best located space of the condominium.

LocationFamilyGetting around

Guest favourite
Apartment in Santa Cruz de la Sierra
5 out of 5 average rating, 5 reviews

Beautiful, spacious and unique apartment in the best area.

Create unforgettable memories in this unique and family home. Exceptional apartment of 122 m2 in the heart of Equipetrol. Very quiet place to rest or work, but at the same time close to fun. You will have an amazing stay! Spacious, modern, furnished and decorated, A/C, Wifi, Smartv 4k 65' and 55', kitchen, 2 bedrooms, 3 bathrooms, own washing and drying area, large free parking at the entrance 24 hours. Beautiful pool and sauna. Large balcony with a nice city view.

FamilyComfortHospitality

Guest favourite
A contemporary entryway featuring sleek, metallic walls and smooth marble flooring. A minimalist reception desk with soft ambient lighting displays the name 'NUU.' A large potted plant adds a touch of greenery, while well-placed lighting creates a bright atmosphere.
Apartment in Santa Cruz de la Sierra
4.92 out of 5 average rating, 76 reviews

apartment with an excellent view

Apartment located in the Equipetrol area. Located on the 13th floor, you'll enjoy stunning views in a comfortable and elegant atmosphere. This apartment has two bedrooms and two bathrooms, ideal for families or groups. It's fully equipped to make you feel at home. Among the building's amenities, you will find a cinema, a swimming pool, a barbecue area, an equipped gym, a playground, and parking for visitors. Easy access to restaurants, shops, and attractions.

LocationValueCleanliness

Top Guest favourite
A comfortable sleeping area features a spacious bed adorned with soft pillows and a decorative throw. Warm bedside lamps illuminate the space, while large windows offer views of the surrounding cityscape and allow natural light to brighten the room.
Apartment in Santa Cruz de la Sierra
4.98 out of 5 average rating, 135 reviews

13° SmartLife - Luxury Equipetrol

Welcome to your sanctuary of sophistication and elegance at the top. This exceptionally cozy and stylish studio on the 13th floor invites you to experience luxury and comfort at their finest. Ready to experience the perfect combination of sophistication, comfort, and technology? Don't miss out on this unique opportunity. Book your stay at "13° SmartLife" and be seduced by the charm of this incomparable space! Your urban retreat awaits.

ValueLocationAccuracy

Guest favourite
A bright and airy bedroom features a spacious bed adorned with white bedding. Soft, sheer curtains filter natural light from the large window. A bedside lamp provides additional illumination, while a delicate arrangement of orchids adds a touch of elegance to the serene ambiance.
Apartment in Santa Cruz de la Sierra
4.86 out of 5 average rating, 22 reviews

Luxury apartment with swimming pool in Equipetrol

Enjoy a luxury experience in this exclusive apartment in the heart of Equipetrol, the best financial and leisure area of ​​Santa Cruz. Close to hospitals, restaurants and cafes, but on a quiet street. Swimming pool, 2 barbecues, gym and chill out area. All social areas with stunning views. You can find more photos, videos and recommendations of places to eat or visit on the Insta account: deluxe santacruz bolivia

LocationValueAccuracy

Guest favourite
Apartment in Santa Cruz de la Sierra
4.94 out of 5 average rating, 16 reviews

The best view of Santa Cruz

From this apartment in the best area of Santa Cruz (Equipetrol Norte, in the business center) you will have the best apartment with a pleasant climate. It is located on the 16th floor, unsurpassed views and sunsets. The whole group will enjoy easy access to supermarkets, restaurants, pharmacies, banks, transportation, paddle courts, etc. The Ventura mall is steps away from the apartment.

LocationAccuracyAmenities

Popular amenities for Santa Cruz de la Sierra holiday rentals

Other great holiday rentals in Santa Cruz de la Sierra

Top Guest favourite
Apartment in Santa Cruz de la Sierra
4.97 out of 5 average rating, 30 reviews

Comfortable apartment with balcony in Sky Luxia

ValueLocationIndoor spaces

Superhost
Apartment in Santa Cruz de la Sierra
5 out of 5 average rating, 4 reviews

Exclusive 2-bedroom apartment on the 21st floor, Mare - Equipetrol

FamilyLocationCondition

Top Guest favourite
Condo in Santa Cruz de la Sierra
4.96 out of 5 average rating, 24 reviews

Beautiful Apartment In Equipetrol

LocationComfortBarbecue

Top Guest favourite
Apartment in Santa Cruz de la Sierra
5 out of 5 average rating, 8 reviews

Beautiful view, vacation-friendly & worker-friendly, lounge area, Wi-Fi (350 MB)

LocationValueKitchen

Top Guest favourite
A modern studio apartment is shown with a spacious bed featuring a striped grey and white duvet. A partition defines the sleeping area, while a kitchenette is visible in the background, equipped with dark cabinetry. Two stylish stools and small tables complement the layout.
Apartment in Santa Cruz de la Sierra
4.99 out of 5 average rating, 69 reviews

Cozy luxury apartment in Equipetrol

LocationValueCheckout

Top Guest favourite
Condo in Santa Cruz de la Sierra
4.92 out of 5 average rating, 13 reviews

Equipetrol Premium Suite

FamilyLocationNearby

Guest favourite
Apartment in Santa Cruz de la Sierra
5 out of 5 average rating, 9 reviews

Equipetrol Norte, 2 Bedrooms + Pool + Balcony

LocationHospitalityCheck-in

Top Guest favourite
A modern interior is presented, featuring a cozy seating area with a dark sofa, complemented by a circular coffee table. A wooden divider offers separation from the sleeping area, where a spacious bed with neutral bedding is visible. Natural light fills the space from the nearby window.
Apartment in Santa Cruz de la Sierra
4.98 out of 5 average rating, 45 reviews

SkyLuxia New Equipetrol Apartment - Safe & Luxurious

LocationValueComfort

Frequently Asked Questions

  • What are the best places to stay in Santa Cruz de la Sierra?

    Santa Cruz de la Sierra has stays in lively neighborhoods like Equipetrol, known for dining and nightlife, and around the city center near plazas and shops. Guests often appreciate areas with leafy streets, local cafes, and easy access to cultural sites.

  • What are the best things to do in Santa Cruz de la Sierra with kids?

    Families can explore city parks, interactive museums, and local zoos featuring native wildlife. Playgrounds and green spaces in residential neighborhoods add opportunities for outdoor fun.

  • What are some of the best things to do in Santa Cruz de la Sierra?

    Discover central plazas, explore Museo de Historia Natural Noel Kempff Mercado, and wander bustling traditional markets. The city also has botanical gardens, art spaces, and vibrant street life.

  • How is the weather in Santa Cruz de la Sierra?

    Santa Cruz de la Sierra generally has warm, humid conditions year-round, with wetter spells in certain months and a tropical atmosphere. Lightweight clothing and sun protection are often suggested, especially for daytime outings.

  • What are the best places to visit in Santa Cruz de la Sierra?

    Explore Plaza 24 de Septiembre, admire local art at Museo de Arte Contemporáneo, and stroll the city’s botanical gardens. Markets and lively pedestrian zones add extra color to the experience.

  • What are some hiking trails in Santa Cruz de la Sierra?

    Santa Cruz de la Sierra has nature reserves and eco-parks where visitors can follow shaded trails amidst tropical plants and birds. Urban green spaces and parks also provide pathways for relaxed walks.

  • What are some family activities we can do in Santa Cruz de la Sierra?

    Families frequently explore city zoos, botanical gardens, interactive museums, and open-air playgrounds. Participating in local craft workshops or tasting fresh fruit at traditional markets brings a sense of discovery.

  • What are some of the best day trip ideas from Santa Cruz de la Sierra?

    Day trips often include exploring nature reserves, visiting Jesuit mission towns, or discovering small communities with locally rooted traditions. Eco-parks around the city provide hiking, birdwatching, and opportunities to connect with regional culture.

  • Are there any pet friendly accommodations available in Santa Cruz de la Sierra?

    Santa Cruz de la Sierra has pet-friendly vacation rentals in neighborhoods like Equipetrol, Urbarí, and around the city center. Many stays include access to green spaces and parks for walks with your pet.

  • What are some local tips for visiting Santa Cruz de la Sierra?

    Locals appreciate lightweight clothes for the heat, insect repellent, and comfortable shoes for exploring urban sights. Trying locally grown fruits at traditional markets is frequently suggested, and learning some Spanish phrases adds ease to your experience.

  • What is Santa Cruz de la Sierra known for?

    Santa Cruz de la Sierra is known for its lively main plaza, tropical botanical gardens, and dynamic blend of Indigenous and European traditions. The city’s vibrant markets, local cuisine, and arts scene are frequently highlighted.

  • What are the best hidden gems to explore in Santa Cruz de la Sierra?

    Around Santa Cruz de la Sierra, visitors often discover small artisan shops, tranquil eco-parks, and street murals tucked in residential neighborhoods. Community-run cafés and weekend craft markets add unique flavor.

  • What are the best foods to try in Santa Cruz de la Sierra?

    Local favorites include salteñas, sonso de yuca, and traditional dishes made from corn, plantain, and tropical fruits. Refreshing drinks such as mocochinchi and locally roasted coffee are often recommended.

  • What should I bring for a trip to Santa Cruz de la Sierra?

    Pack lightweight clothing, sun protection, insect repellent, and comfortable shoes for walking. Bringing a reusable water bottle and rain jacket can add convenience, especially if you plan outdoor excursions.

  • What is the nightlife in Santa Cruz de la Sierra like?

    Santa Cruz de la Sierra has lively nightlife, with bars and clubs frequently suggested around the Equipetrol neighborhood. In the city center, you can explore relaxed venues featuring live music, local cocktails, and outdoor patios.

  • What are the most popular events or festivals in Santa Cruz de la Sierra?

    Santa Cruz de la Sierra has celebrated cultural festivals, Carnaval, and regional fairs throughout the year. Music, dance, and food events are frequently suggested, especially around holidays and community celebrations.

  • Are there family friendly vacation rentals in Santa Cruz de la Sierra?

    Family-friendly vacation rentals can be found in Equipetrol, Urbarí, and the city center, many with spacious layouts and access to parks or play areas. Hosts often provide amenities for children to make visits comfortable.

  • When is the best time to visit Santa Cruz de la Sierra?

    Visitors often prefer the drier months for outdoor activities and exploring city sights, while some enjoy the lush greenery during wet seasons. Popular festivals and pleasant evenings draw many travelers throughout the year.