Holiday houses in Santee River

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Top-rated holiday rentals in Santee River

Guests agree: these stays are highly rated for location, cleanliness and more.

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Top Guest favourite
The living area features a mix of modern and whimsical design, highlighted by a vibrant blue wall and a neon Pegasus light. A plush velvet sofa and coordinating armchairs surround a central wooden coffee table, with a colorful area rug underfoot. Large windows allow natural light to fill the space.
Guesthouse in Summerville
5 out of 5 average rating, 87 reviews

2 King bed 2 Bath*Walkable* Downtown Summerville

Hidden away amidst lush azaleas and towering pines, you will find yourself at the heart of small-town Southern Living. This two-story Guest House provides you with the perfect combination of secluded garden landscapes and downtown accessibility. Modern amenities and a whimsical interior design will make your stay in our charming cottage a time to remember. You'll be within a short walk of local shops and restaurants and an easy drive to downtown Charleston and surrounding beaches and attractions

Top Guest favourite
An airy loft space features a suspended wooden swing, inviting relaxation under the high, timbered ceilings. Natural light streams through large windows, illuminating cozy furnishings including a bed and a dining area with a wooden table. Unique decor elements enhance the overall character.
Guesthouse in Summerville
4.98 out of 5 average rating, 768 reviews

★Delightful guest house near historic plantations★

Nestled in the Historic Plantation District between Summerville & Charleston, our timberframe "bunkhouse" offers privacy, comfort & convenience. This 850+ sq ft retreat includes full kitchen & bath, 2 dbl beds, twin bed & plenty of living space. There's a private entrance, so come & go as you please (we're right next door if you need us). Minutes from Middleton Place, Drayton Hall & Magnolia Gardens, an easy drive to dntn Charleston, historic S'ville, beaches & golf courses. *Now with WiFi*

Top Guest favourite
An elegantly decorated sitting area is presented with a detailed mural ceiling and rich purple drapes. A plush loveseat and two accent chairs surround a circular rug in the center. Windows allow natural light to fill the space, highlighting the ornate moldings.
Apartment in North Charleston
4.96 out of 5 average rating, 161 reviews

Bridgerton inspired fantasy 2 min from park circle

Live out your Bridgerton fantasy in this stunning historic space. The apartment features antique furnishings/art, a private entrance and patio with lounge and a hot tub (The hot tub is available Apr through Nov). Off street parking. A sumptuous bathroom with an oversized soaking tub and a kitchenette. There is also a 55 inch frame tv in the bedroom including WiFi. Available for photo shoots upon request rates may differ please contact host prior. Bridal pics by Olivia Allain Permit#2026-0414

Top Guest favourite
The exterior of a two-story house is nestled among tall trees, showcasing a deck with steps leading to the ground. Screened-in porches on both levels provide ample outdoor space and views of the surrounding greenery.
Home in Georgetown
4.98 out of 5 average rating, 184 reviews

Black River Refuge on the Water

The first guest comment I hear is "Wow - pictures don't do this place justice - the house is incredible and the views are spectacular! The next comment is "I thought we were way out in the country but it's only 20 minutes to the waterfront town of Georgetown, with shops, dining, museums and more. Looking to get away? This place is truly a retreat- a 3 bedroom house on the beautiful Black River in Georgetown. Four kayaks provided, swim or fish off the dock just a few steps from the house.

Superhost
A serene sunset casts warm hues over the water, with a houseboat moored alongside a covered dock. Silhouetted against the sky, fishing rods stand tall, and tall grasses frame the scene, enhancing the tranquility of this riverside setting.
Home in Georgetown
4.86 out of 5 average rating, 165 reviews

Maggie Jo’s paradise on the river !

Reconnect with nature at this unforgettable escape. Maggie jo is a 1970 completely restore houseboat. She has got a full size refrigerator , gas range ,microwave and toaster oven. Out on the back deck she has a gas grill. The aft berth has 2 full beds that are extremely comfortable. Galley dinette make into bed and the couch in the saloon pulls out also. While on the decks you will see eagles, dolphins , gator or fishing jumping out of the water. I also have 2 tandem kayaks for your use.

Guest favourite
A wooden dock extends into calm waters, reflecting the vibrant colors of the sunset. Silhouetted trees frame the scene, which features a serene lake bordered by grassy areas, creating a tranquil lakeside atmosphere.
Home in Cross
4.95 out of 5 average rating, 39 reviews

Lakefront Fishing + Grilling | Home Sweet Home!

Escape to our serene Lakehouse Hideaway on Lake Moultrie, the perfect retreat for family vacations, fishing trips, or peaceful getaways. This charming 3-bedroom, 2-bath home features a spacious family room, fully equipped kitchen, kids’ room, queen bedrooms, and a lakefront porch on nearly an acre of private property. Enjoy fishing, relaxing, and exploring Lowcountry dining nearby. Just over an hour from Charleston, this tranquil oasis offers the ideal blend of relaxation and adventure.

Top Guest favourite
The entrance of the cabin features a modern black exterior with a circular welcome mat and a stylish door showcasing large glass panes. Potted white flowers add a touch of nature, while an outdoor chair invites relaxation amidst the greenery of surrounding trees.
Farm stay in Georgetown
4.99 out of 5 average rating, 73 reviews

Lo & Billy’s Place a Historic 1940s Newlywed Cabin

This romantic cabin located on our small farm just outside of town in the country offers a history all its own. Lo was Billy’s nickname for Lorene Ella. Lo & Billy got married in the 1950s and lived here. Renovated after meeting Lo and hearing her stories. We pay homage to the rich history of Georgetown and the Southerners that have called Lo & Billy’s Place home. Heavy on coziness & design. Full kitchen; good coffee; & comfy queen bed w/high end linens. The perfect escape.

Guest favourite
Tiny home in Saint Stephen
4.94 out of 5 average rating, 17 reviews

"The Nest" At Maple Hollow

Welcome to our space-age glamping oasis, where you can immerse yourself in nature without sacrificing comfort. Our 400 SF ecological home, designed with advanced technology and sustainable features, offers a unique living experience. Nestled in a tranquil, rural setting, you'll enjoy stunning views of a duck and goose pond, providing a serene escape from the bustling city life. Despite its peaceful surroundings, our intelligent home ensures you stay connected to the world.

Superhost
Aerial view of a lakefront property shows a private dock extending into calm waters, surrounded by lush greenery. The house, nestled among trees, features a spacious yard with a fenced area and a screened porch visible. The tranquil setting emphasizes the natural beauty of the location.
Cottage in Manning
4.75 out of 5 average rating, 171 reviews

A Great Lake house. Near Manning, SC and I-95.

Secluded and serene, our private lakefront property in South Carolina's Lake Marion region offers a community feel with minimal traffic and noise. The fenced-in property has 2 cozy bedrooms, a large open floor plan, and a screen porch with a beautiful lake view. Enjoy the private dock, kayaks, and floats, and relax with a bonfire and grill. Conveniently located just 20 minutes from Manning and I-95, our retreat is perfect for travelers looking to unwind and recharge.

Top Guest favourite
Guest suite in McClellanville
4.96 out of 5 average rating, 153 reviews

Resort @ Kit Hall Pool & Gardens, near Charleston

Centrally located between Myrtle Beach, Mount Pleasant and Charleston SC ( closest beach 36 miles by car. A sanctuary with an amazing freshwater (not chlorine or salt but Ionized)swimming pool, between two national parks, The Francis Marion National Forest & Cape Romain Wildlife Refuge. Near waterways, hiking, cycling trails, fishing, low country dining, historical plantations and more. 2 bedrooms & a screened sleeping porch. 4 beds + library, kitchenette & 2 ba

Top Guest favourite
Large triangular windows provide panoramic views of the river and surrounding greenery. A small wooden table and two black chairs sit in the corner, complementing the spacious interior. Natural light fills the room, enhancing the sense of openness and connection to nature.
Dome in Moncks Corner
5 out of 5 average rating, 64 reviews

River Dome Retreat

Escape to a unique geodesic dome nestled along the serene riverbanks, offering a one-of-a-kind retreat for nature lovers. This architectural gem features panoramic views allowing guests to unwind. The interior boasts a cozy living space with modern amenities. Step outside to the spacious deck and immerse yourself in the sights and sounds of nature. Enjoy your own private boat ramp and dock! This geodesic dome on the river promises a memorable stay.

Top Guest favourite
A field of blooming yellow flowers is displayed in the foreground, with delicate petals and green stems. In the background, a white farmhouse is visible, providing a serene country setting. The scene captures the tranquility of the flower field adjacent to the cottage.
Tiny home in Moncks Corner
4.95 out of 5 average rating, 165 reviews

The Goose Cottage at Wild Goose Flower Farm

Located next to the family farmhouse at Wild Goose Flower Farm, The Goose Cottage was designed to immerse guests in our calm and peaceful country life. We are located 15 minutes from the hearts of Cane Bay, Nexton and Exit 194 on I-26, and 45 minutes from Downtown Charleston. Two can sleep in the queen size bed and one can sleep on the couch. Please reach out with further questions or if you would like to inquire about an extended stay.

Popular amenities for Santee River holiday rentals