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Hotels in South San Francisco

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Top-rated hotels in South San Francisco

Guests agree: these hotels are highly rated for location, cleanliness and more.

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Superhost
Hotel room in Downtown / Union Square
4.88 out of 5 average rating, 17 reviews

Convenient location in Union Square- Free wifi

Private HOTEL room w/private bathroom, timeshare hotel property at THE DONATELLO in UNION SQUARE (sleeps 4) in the heart of San Francisco You are not obligated to attend a timeshare presentation. The front desk will require the following in order to get the room key: 1. Refundable security deposit $250 - credit card preferred Bank issued debit cards may be accepted. Sorry Chime, Netspend, Visa Gift etc are not accepted at this time for the deposit 2. Valid photo Government ID - must be 18+

Guest favourite
Hotel room in Yerba Buena
4.97 out of 5 average rating, 59 reviews

Sophisticated Stay | Cable Cars Tours. Gym

Located on Market Street, Hyatt Regency San Francisco Downtown SOMA is a sophisticated destination hotel close to the city’s most innovatively stimulating sights. Attractions are just nearby: ✔Picturesque picnics at Golden Gate Park ✔Contemporary and modern paintings, photographs, sculptures and designs from the 20th century, all housed at SF MOMA ✔Postcard-worthy shots, at Golden Gate Bridge ✔Beaux-Arts wonder, the Palace of Fine Arts ✔Best views of San Francisco at Twin Peaks

Guest favourite
The exterior view of The Marker showcases its Beaux-Arts architecture with elegant detailing. Multiple stories feature large windows, illuminated at dusk, creating a welcoming ambiance. The building is framed by trees and streetlights, set against a softly lit sky.
Hotel room in Tenderloin
4.91 out of 5 average rating, 238 reviews

Union Square Steps Away | On-Site Dining + Gym

Steps from San Francisco’s vibrant Union Square, The Marker blends over a century of hospitality with modern elegance. This boutique Beaux-Arts hotel offers curated amenities like PATH water bottles, FloWater stations, and a 24-hour state-of-the-art fitness center. Dine at Tratto, serving rustic Italian dishes and craft cocktails. With concierge service, curbside valet parking, and California Green Lodging certification, The Marker pairs timeless charm with contemporary comfort.

Superhost
Hotel room in Downtown / Union Square
4.81 out of 5 average rating, 134 reviews

Book-filled Writer’s Alcove in the lobby

Channeling the spirit of the Beat Generation, every room at Hotel Emblem is a creative retreat featuring a writing desk with an inspiration board. Enjoy plush pillowtop beds with Italian linens, a 55" HD TV, and unique touches like a meditation bowl, typewriter, and coloring books. Thoughtful amenities include in-room coffee and tea, ROIL bath products, and high-speed internet. With pet-friendly options and hotel bikes, your San Francisco stay is both inspiring and comfortable.

Superhost
A room with two double beds is framed by wooden headboards, featuring crisp white linens. A nightstand with a lamp and a phone is positioned between the beds, enhancing the functionality of the space.
Hotel room in Millbrae
4.87 out of 5 average rating, 106 reviews

Bay Area Escape | Hotel Room. Free Breakfast

If you plan to explore the Bay Area, The Millwood Inn & Suites is a great jumping-off point. This quaint hotel is located in Millbrae, California, only minutes from Bay Area attractions such as the Golden Gate Bridge. It is also only a six-minute drive from San Francisco International Airport, perfect for those flying in! Be welcomed into a world of comfort and convenience after a long day of exploring California's best. ✔ Free breakfast ✔ Free parking ✔ Fitness center

Superhost
Hotel room in North Los Altos
4.68 out of 5 average rating, 85 reviews

Near Stanford Univ + Breakfast. Kitchen. Pool.

Stay minutes from Stanford University, Google, and downtown Palo Alto at Residence Inn Palo Alto Los Altos. Enjoy spacious suites with full kitchens, separate living areas, and free Wi-Fi. Start your day with a complimentary hot breakfast, unwind by the outdoor pool, or keep up with workouts in the fitness center. Steps from shopping, dining, and tech hubs, this pet-friendly hotel offers the perfect blend of convenience, comfort, and Northern California charm.

Guest favourite
A cozy room is presented with a spacious bed topped with smooth white linens. Soft natural light enters through a large window covered by a beige roller shade. A small table next to the bed is complemented by a decorative flower arrangement.
Hotel room in Downtown / Union Square
5 out of 5 average rating, 25 reviews

Fun Escape | Happy Hour. Game Room. Location.

Axiom Hotel, a 4-star establishment in San Francisco's city center, is an ideal accommodation for those looking for a fun hotel to stay in during their trip to SF. It features a fitness center and a game room. Guests can also venture out to see prime attractions nearby, like Moscone Center and the Ferry Building. ✔ Fitness center ✔ Robot-delivered room service ✔ Pet-friendly ✔ Arcade games ✔ Cafe on-site ✔ Breakfast, lunch, dinner, boba and a full bar

Guest favourite
A well-lit bedroom features a spacious bed with white linens, complemented by a cozy towel arranged at the foot. A large television is positioned against a light-colored wall, while teal cabinetry adds a touch of color, creating a serene atmosphere.
Hotel room in Pacific Heights
4.8 out of 5 average rating, 51 reviews

Anchor Studio 225

The Monroe Residence Club is a residential hotel located centrally in the heart of San Francisco with public transportation at our doorstep and local shops and businesses nearby. It is conveniently located just a block from Whole Foods, blocks from a the iconic Lafayette Park, within walking distance of several hospitals and more! The Monroe offers 24-hour front desk security, breakfast and dinner on-site, as well as common areas for congregating.

Top guest favourite
A comfortable living area features a light-colored sofa with green accent pillows, accompanied by a modern armchair. A round coffee table sits in the center, complemented by a decorative piece. Natural light enters through two windows, framed by soft curtains, highlighting the warm tones of the walls.
Hotel room in Nob Hill
5 out of 5 average rating, 36 reviews

Nob Hill Inn 1 Bedroom Apartment

This 1-bedroom apartment with a living room in the heart of Nob Hill offers the perfect blend of comfort and convenience. What makes this space special is the combination of privacy and space, featuring a separate living area for relaxation and a well-appointed bedroom for restful nights. Located in the prestigious Nob Hill neighborhood, you’ll be steps away from top San Francisco attractions, iconic landmarks, and local dining gems.

Superhost
A spacious room is highlighted by bold blue accent walls and a light wood tone ceiling. A large bed with white linens sits in the center, complemented by a modern TV and a dresser. Glass sliding doors lead to an attached bathroom area.
Hotel room in Belmont
4.57 out of 5 average rating, 612 reviews

Silicon Valley Inn, 1 Full Bed

Fuss-free motel-style setup right off Route 82, a 5-minute stroll from Belmont train station and 3 miles from Hiller Aviation Museum. San Mateo, San Carlos and Redwood City are easily accessible via CalTrain. Your room charge will be paid prior to your arrival. The remaining balance of taxes (12% City Transient Tax) will be charged upon arrival. A refundable security deposit of $XX will also be collected.

The Clift Royal Sonesta San Francisco
4.93 out of 5 average rating, 14 reviews

The Clift Royal Sonesta San Francisco

Experience the perfect blend of historic charm and modern style in our newly renovated deluxe king room. Relax in a plush king bed, enjoy a spa-inspired rainfall shower, and stay productive at the sleek work desk. With premium amenities like a mini-bar, Keurig coffee maker, streaming TV, and complimentary WiFi, your stay is both luxurious and convenient.

Superhost
A spacious room features a queen bed with crisp white bedding, a flat-screen TV, and custom-designed furniture. A blue accent chair and small side table enhance the sitting area. The bathroom entrance is visible, indicating convenient access from the room.
Hotel room in Nob Hill
4.82 out of 5 average rating, 105 reviews

Restless City | Cable Cars Tours. Historic Sites

While our views are amazing, it’s the city’s energy and restless spirit of transformation that quickens your heartbeat and gets your mind spinning. At Stanford Court Hotel, we’ve crafted an experience that plays off this buzzing atmosphere.

Popular amenities for South San Francisco hotels

Quick stats about hotels in South San Francisco

  • Total holiday rentals

    Explore 50 holiday rentals in South San Francisco

  • Nightly prices starting at

    South San Francisco holiday rentals start at $238 NZD per night before taxes and fees

  • Verified guest reviews

    Over 310 verified reviews to help you choose

  • Family-friendly holiday rentals

    20 properties offer extra space and kid-friendly amenities

  • Pet-friendly accommodation

    Find 40 rentals that welcome pets

  • Holiday rentals with a pool

    20 properties feature pools

  • Rentals with dedicated workspaces

    50 properties have a dedicated workspace

  • Wi-Fi availability

    50 of South San Francisco holiday rentals include Wi-Fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi and Pool across South San Francisco rentals

Destinations to explore