Hotel holiday rentals in St. Charles County

Find and book unique hotels on Airbnb

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Popular amenities for St. Charles County hotels

Family-Friendly hotels

Private room in Wentzville
4.63 out of 5 average rating, 64 reviews

Midwest Guest Room "E"

ElijahRating, 5 stars15 months ago
The room was perfect for what I needed. Very simple but definitely worth the price. It was nice to come back to a quiet place after working doubles and being able to relax and sleep.
Guest favourite
Hotel room in St. Louis
4.9 out of 5 average rating, 899 reviews

King Redwood Bedroom at BnB in CWE!

TremainRating, 5 stars2 weeks ago
Everything Was wonderful and clean as it look on the picture. Cozy big bed , 2 big tvs , quite neighborhood. Definitely worth it
Private room in Wentzville
4.73 out of 5 average rating, 91 reviews

Midwest Guest Room "B"

JimRating, 5 stars3 months ago
We have stayed at this location several times and always have enjoyed ourselves. It is a great value for the money.
Guest favourite
Hotel room in St. Louis
4.87 out of 5 average rating, 720 reviews

Blue Spruce Room Queen Bed at BnB in CWE!

TannerRating, 5 stars3 weeks ago
Great stay, second time in this location, will be interested in coming back
Private room in Wentzville
4.61 out of 5 average rating, 71 reviews

Midwest Guest Room "A"

Mary PatRating, 5 stars5 months ago
This placed worked perfectly for us. It was close to where we needed to be, and also close to restaurants and other businesses. The room we stayed in was clean, had comfortable beds and good water pressure in the shower. We'll definitely be coming back to visit and this will be our first choice in lodging. Thank you!
Private room in Wentzville
4.76 out of 5 average rating, 63 reviews

Midwest Guest Room "C"

JimRating, 5 stars25 months ago
This place is perfect for us every time we come to Wentzville. The campus setting is peaceful, and the location is handy to the places we love to visit.
Private room in Wentzville
4.73 out of 5 average rating, 22 reviews

Midwest Guest Room "H"

EmilyRating, 5 stars10 months ago
This place was exactly what I needed for a quiet work location. The room was spacious, and the stay was quiet, without interruption, allowing me to get much-needed work done. The bed was comfortable, and the two large desks allowed me plenty of room to spread out. The wifi worked well for my needs. I would definitely stay here again for a quiet work time or a much-needed retreat from hectic daily life.
Guest favourite
Hotel room in St. Louis
4.87 out of 5 average rating, 634 reviews

Evergreen Room Queen Bed at BnB in CWE

JocelynRating, 5 stars3 weeks ago
We really enjoyed this Airbnb! They had such clear instructions both in the bathroom and kitchen - I wish more Airbnb’s were that thorough.

Hotels with a patio

Private room in St. Louis
5 out of 5 average rating, 10 reviews

Lovely spacious 2 room King suite, super quiet

KathyRating, 5 stars21 months ago
I'm a repeat visitor at Tim's. I have occasional work in the area and appreciate that his place is so close to my destination. The place is clean and comfortable. Appliances are all new. Wifi was solid for me to stream a show and maintain fast remote connection to my client's site for after hours work. There's Aldi's grocery a few blocks away so I shop and eat in for time and cost savings. Tim is super responsive, always helpful.
Top Guest favourite
Hotel room in Saint Charles
5 out of 5 average rating, 14 reviews

#3 Betty Bloomer Le Velo Inn

EricRating, 5 stars3 days ago
We really enjoyed our stay at Le Velo in one of their well-appointed suites. The finishes and furnishings were the nicest of any Airbnb we had stayed in before and it was obvious that much care went into creating a really special space for guests (heated seat toilet/bidet was my personal favorite). We love the historical aspect of the entire place (being an original boarding house from the 1800s) as well as the historical theme of the particular room and how much effort was made to reflect that (Parisian chandelier, reuse of vintage doors, etc.) Logistically, it was very easy to get in and out. It was a great location in the Frenchtown part of Old St. Charles, which is a quieter, less developed historical area, but a short 10 minute walk from busier Main St. Area was quiet and safe and still had very close walking options for coffee/breakfast/pizza. And the outdoor lounge area was really nice even though we didn’t make use on this stay. Would love to come back again!
Top Guest favourite
Hotel room in St. Louis
5 out of 5 average rating, 26 reviews

Napoleon's Retreat Burgundy Room

JimRating, 5 stars3 days ago
Really enjoyed the place. We had a couple of questions that were quickly and clearly answered. Strongly recommend!
Hotel room in Saint Charles
4.53 out of 5 average rating, 15 reviews

1st Capitol Mansion - Suite 302

MarthaRating, 5 stars3 weeks ago
We had a wonderful stay at Jon’s charming vintage home! It has all the nostalgic charm of a classic college apartment—think character, cozy vibes, and personality—but with the added bonus of thoughtful renovations, true cleanliness, and modern comforts. One of our favorite features was the beautiful wooden staircase accented by a lovely stained glass window—it made every trip upstairs special. The price was very reasonable, especially for the quality of the space, and Jon was a friendly, attentive host who made sure everything was just right. Highly recommend if you're looking for something unique, welcoming, and budget-friendly!
Top Guest favourite
Hotel room in St. Louis
5 out of 5 average rating, 14 reviews

Luxury Retreat, Hot Tub,En-Suite Bath, Location+

DerrekRating, 5 stars1 month ago
Such attention to detail! Loved every minute of our stay!
Hotel room in St. Louis
4.57 out of 5 average rating, 28 reviews

The West End by Cortex, Forest Park, BJC & Zoo

JasimineRating, 5 stars2 days ago
Heather was a great and responsive host. I reached out to her at the last minute due to another host cancelling my reservations the day of my trip as I was already on my way. I reached out to heather, explaining my situation and with all the questions I had. Heather was very attentive and made booking her place a success. She answered all the questions I had and made sure to check in with me throughout my ride making sure I was ok and giving me all the information I needed to check in. This will definitely be my go to spot when I come back to St. Louis!!! Rooms were clean and they had a great set up in the lobby and kitchen area.
Top Guest favourite
Hotel room in St. Louis
5 out of 5 average rating, 12 reviews

Luxury Retreat, Hot Tub,En-Suite Bath, Location+

AkshayRating, 5 stars4 months ago
This is a hidden gem that is maintained exceptionally well. The check in was smooth and the owners are very friendly. Only time we saw them was when we checked in and they gave us a tour of the place. The entire property is squeaky clean and provides every comfort offered in a five star hotel. I've stayed in many five star hotels across the world (Ritz Carlton, Four Seasons, Waldorf Astoria) and this is arguably better than those places given the unique experience it offers and the character of this place. I would definitely recommend this to anyone looking for a unique experience in St. Louis. It is also located in close proximity to a lot of local attractions.
Top Guest favourite
Hotel room in St. Louis
5 out of 5 average rating, 26 reviews

Luxury Retreat, Hot Tub,En-Suite Bath, Location+

StephanieRating, 5 stars4 weeks ago
Absolutely wonderful stay! Had a kitchen for use! Also was very thoughtful and had random necessities for use if you forgot yours during travel! Very beautiful and would definitely stay again!!!

Destinations to explore