
Boutique hotel holiday rentals in St. Louis
Find and book unique boutique hotel rentals on Airbnb
Top-Rated Boutique Hotels in St. Louis
Guests agree: These boutique hotel rentals are highly rated for location, cleanliness and more.
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Guest favourite

Hotel room in Central West End
4.85 out of 5 average rating, 765 reviewsThe Maple Room Queen Bed at BnB in CWE!
CodyRating, 5 stars2 weeks ago
I’ve stayed here twice now. Both stays went perfectly well. Even though this is a shard bathroom/kitchen, you will hardly even notice. The real + is the amount of amenities that the bathroom has and that the kitchen has comparable to a hotel room is unbelievable! You have to see the shower it’s huge! He also responds immediately to any questions or requests that I’ve had. Every time I stay in St. Louis, I will always go back to Brandon’s.
Guest favourite

Hotel room in Central West End
4.9 out of 5 average rating, 900 reviewsKing Redwood Bedroom at BnB in CWE!
Alexandra NoelRating, 5 stars2 weeks ago
Brandon and Sam’s Place was perfect for us it was close to the city. It was easy to take Ubers. we loved walking down the street to Whole Foods. There was also a beautiful Catholic cathedral with mosaics that we went to go explore around the corner Their place was so homey it felt like we were staying with family!! It was very peaceful and quiet. The bed was so comfortable and cozy! I honestly can’t wait to come back. Brandon and Sam are very generous. We enjoyed a bagel one morning!
Guest favourite

Hotel room in Central West End
4.87 out of 5 average rating, 720 reviewsBlue Spruce Room Queen Bed at BnB in CWE!
TannerRating, 5 stars3 weeks ago
Great stay, second time in this location, will be interested in coming back
Guest favourite

Hotel room in Central West End
4.87 out of 5 average rating, 634 reviewsEvergreen Room Queen Bed at BnB in CWE
JocelynRating, 5 stars3 weeks ago
We really enjoyed this Airbnb! They had such clear instructions both in the bathroom and kitchen - I wish more Airbnb’s were that thorough.
Boutique Hotels with a patio

Hotel room in Saint Charles
4.68 out of 5 average rating, 233 reviews1st Capitol Mansion Boutique Hotel - Suite 301
AaronRating, 5 stars1 week ago
We stayed in a small unit - It is just a bedroom and a bathroom - but it was all we needed. I liked it because we couldn't have made use of anything else so the price was excellent AND we there is comfy little coffee shop across the street and I was able to walk into the historic area and around by the river. If I was looking for something super fancy - this wouldn't be it. It was clean, matched expectations, instructions were clear. We would stay again!
Top Guest favourite

Hotel room in St. Louis
5 out of 5 average rating, 12 reviewsLuxury Retreat, Hot Tub,En-Suite Bath, Location+
AkshayRating, 5 stars4 months ago
This is a hidden gem that is maintained exceptionally well. The check in was smooth and the owners are very friendly. Only time we saw them was when we checked in and they gave us a tour of the place. The entire property is squeaky clean and provides every comfort offered in a five star hotel. I've stayed in many five star hotels across the world (Ritz Carlton, Four Seasons, Waldorf Astoria) and this is arguably better than those places given the unique experience it offers and the character of this place. I would definitely recommend this to anyone looking for a unique experience in St. Louis. It is also located in close proximity to a lot of local attractions.
Top Guest favourite

Hotel room in St. Louis
5 out of 5 average rating, 26 reviewsLuxury Retreat, Hot Tub,En-Suite Bath, Location+
StephanieRating, 5 stars1 month ago
Absolutely wonderful stay! Had a kitchen for use! Also was very thoughtful and had random necessities for use if you forgot yours during travel! Very beautiful and would definitely stay again!!!
Top Guest favourite

Hotel room in Saint Charles
5 out of 5 average rating, 14 reviews#3 Betty Bloomer Le Velo Inn
EricRating, 5 stars4 days ago
We really enjoyed our stay at Le Velo in one of their well-appointed suites. The finishes and furnishings were the nicest of any Airbnb we had stayed in before and it was obvious that much care went into creating a really special space for guests (heated seat toilet/bidet was my personal favorite). We love the historical aspect of the entire place (being an original boarding house from the 1800s) as well as the historical theme of the particular room and how much effort was made to reflect that (Parisian chandelier, reuse of vintage doors, etc.) Logistically, it was very easy to get in and out. It was a great location in the Frenchtown part of Old St. Charles, which is a quieter, less developed historical area, but a short 10 minute walk from busier Main St. Area was quiet and safe and still had very close walking options for coffee/breakfast/pizza. And the outdoor lounge area was really nice even though we didn’t make use on this stay. Would love to come back again!
Superhost

Hotel room in Saint Charles
5 out of 5 average rating, 3 reviews#6 The Green Tyke Le Velo Inn
SierraRating, 5 stars1 week ago
The best Airbnb i’ve ever stayed at. The aesthetics are amazing. I took pictures for inspiration -from the glasses to drink out of to the wall decorations - to the couch. I felt right at home & I have such a peaceful experience when I stayed here. I can’t wait to come back.
Top Guest favourite

Hotel room in St. Louis
5 out of 5 average rating, 15 reviewsLuxury Retreat, Hot Tub,En-Suite Bath, Location+
NatalieRating, 5 stars2 weeks ago
This place is even more beautiful in person. It felt safe and clean. We will be back in the future.
Quick stats about boutique hotel rentals in St. Louis
Total rentals
10 properties
Nightly prices starting at
$100 NZD before taxes and fees
Total number of reviews
4.2K reviews
Rentals with dedicated workspaces
10 properties have a dedicated workspace
Wi-Fi availability
10 properties include access to Wi-Fi
Popular amenities
Kitchen, Wi-Fi and Pool
Destinations to explore
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- Busch Stadium
- Six Flags St. Louis
- Saint Louis Zoo
- Central West End
- Enterprise Center
- Gateway Arch National Park
- Missouri Botanical Garden
- City Museum
- St. Louis Aquarium at Union Station
- Cuivre River State Park
- Pere Marquette State Park
- The Winery at Aerie's Resort
- Saint Louis Science Center
- Castlewood State Park
- Cathedral Basilica of Saint Louis
- Missouri History Museum
- Grafton Winery the Vineyards
- St. Louis Country Club
- Norwood Hills Country Club
- Hidden Valley Ski Resort
- Adventure Valley Zipline Tours and Paintball Park
- Boone Valley Golf Club
- Raging Rivers WaterPark
- Bellerive Country Club