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Boutique hotels in Missouri

Find and book unique boutique hotels on Airbnb

Top-rated boutique hotels in Missouri

Guests agree: These boutique hotels are highly rated for location, cleanliness and more.

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Superhost
A spacious bedroom is highlighted by a king-sized metal four-poster bed dressed in crisp white linens. A cozy seating area features a dark blue couch beside a traditional fireplace with a mantel. Natural light filters through the windows adorned with light blinds.
Hotel room in Kansas City
5 out of 5 average rating, 5 reviews

William Rockhill Nelson at Southmoreland

Southmoreland is a historic 1913 Mansion whose goal is to provide hospitality and comfort. It is conveniently located in the heart of Kansas City’s Country Club Plaza. If your goal is to find a unique alternative to the classic downtown hotel, then look no further! The main floor boasts a living room with a gas fireplace and wet bar, a dining room with a lengthy wood table and a sunroom with a porch swing. The veranda is lined with floor to ceiling windows overlooking the garden in summer.

Top Guest favourite
The room features a queen size bed adorned with a decorative red and gold coverlet. Two windows are dressed with plush maroon curtains. A dresser with a mirror and a TV are positioned against one wall, while a faux fireplace adds warmth to the inviting space.
Hotel room in Osceola
4.93 out of 5 average rating, 111 reviews

Historic Commercial Hotel(1868),Sally Rand Suite

The Historic Commercial Hotel (Est.1868) on the Downtown square in beautiful Osceola,Missouri. Old world feel with modernized accommodations. The Historic Commercial Hotel has numerous themed rooms which are designed and named after past historical guests. This specific room is "The Sally Rand Suite". Named after past historical guest Sally Rand ( 1904 – 1979) who was an American burlesque dancer and Silver Screen star, most noted for her ostrich feather fan dance and balloon bubble dance.

Guest favourite
The spacious common area features an open kitchen with a dark granite countertop, blending modern functionality with historic charm. Two large stained glass windows cast colorful light throughout the room, while a grand staircase leads to an upper level, showcasing the building's architectural elegance.
Hotel room in St. Louis
4.98 out of 5 average rating, 53 reviews

Luxury Retreat, Hot Tub,En-Suite Bath, Location+

Discover refined elegance in The Riverfront Suite, where Gothic grandeur meets contemporary comfort. This distinctive retreat showcases original stained glass windows and exotic wood finishes . A plush queen bed and ambient electric fireplace create an intimate atmosphere, while the luxurious en-suite bathroom features heated floors, designer tile work, and a 2-person soaking tub. Take in panoramic city views from the shared rooftop hot tub. Perfect for couples seeking a romantic escape.

Top Guest favourite
A charming motor court unit is showcased, featuring rustic stone walls and vibrant green front doors. Two red chairs and a small table are positioned on the porch, complemented by a plant nearby. The structure is outlined against a clear sky.
Hotel room in Springfield
4.94 out of 5 average rating, 250 reviews

“Camp Rockwood”at Rockwood Motor Court on Route 66

Rockwood Motor Court, on historic Route 66, was built in 1929. Each room is themed and furnished to the era of Route 66. Camp Rockwood pays homage to the important history of motor courts along the road. It is decorated with historic photos of Rockwood and other courts and motels. Newly renovated in 2019, you’ll enjoy clean and comfortable room amenities while experiencing authentic motor court lodging. Need more space? We have larger rooms or can package multiple rooms for your group.

Top Guest favourite
A spacious interior features a four-poster bed with ornate detailing, complemented by elegant bedding. A seating area is visible with a light-colored sofa. Dark wood furniture, including a large armoire, enhances the room's historic charm. Crystal light fixtures add a touch of sophistication.
Hotel room in Excelsior Springs
4.96 out of 5 average rating, 49 reviews

Beautiful Historic Suite

The Hope Loft Suite, located on the second floor of Casa Di Vite International Wine Café," in Excelsior Springs, Missouri, offers a delightful place to stay. This exquisitely furnished loft is crafted to reflect the style of the early 1900s, featuring a generous king-size bed and an additional room with a twin-size bed. Its location in historic downtown Excelsior Springs ensures easy access to diverse dining choices and shopping experiences. A private staircase in the back offers access.

Superhost
A bright bedroom is adorned with a light blue wall, creating a serene atmosphere. The spacious bed is covered with a decorative blanket, flanked by crisp white linens. A bedside table and a dresser provide practical storage, while a large window allows natural light to fill the room.
Hotel room in St. Louis
4.86 out of 5 average rating, 759 reviews

Blue Spruce Room Queen Bed at BnB in CWE!

A Lovely room in a historical St. Louis home! The Blue Spruce Room is on the 2nd floor, and has a recently renovated and beautiful bathroom complete with a walk-in rain shower right next to it. The room has a desk, chair, lamp, table, Amazon Fire TV with basically every major streaming App, newly installed hardwood floors, and a Queen sized-bed. The room has two large windows for plenty of natural light with heavy blinds for sleeping in! Full use of the kitchen upstairs is available!

Guest favourite
The spacious studio features high ceilings and large industrial steel-frame windows, allowing natural light to fill the room. A modern sofa and armchairs are arranged around a wooden coffee table. A dining area with seating is visible, complementing the minimalist design.
Hotel room in St. Louis
4.91 out of 5 average rating, 158 reviews

Chic Ultramodern Studio Loft w/ Designer Features

The Nash Loft is a stunning minimalist studio with 12’ ceilings + bright 7’ industrial steel-frame windows, a spacious open layout, stackable washer + dryer, a designer bathroom with black stainless fixtures and frameless glass shower, an Edison-illuminated community courtyard, and a fully-equipped kitchen with black stainless appliances and quartz countertops. Situated along the famous Locust Street in the heart of Midtown, you’ll be steps from SLU, Wells Fargo, BJC, and the Grove.

Top Guest favourite
The room features exposed brick walls and a wooden ceiling, enhancing the rustic charm. A spacious bed sits beside a cozy seating area with an orange armchair and a guitar. Natural light floods in through multiple large windows, with decorative elements like a cowhide rug and artwork adding character.
Hotel room in Hannibal
4.97 out of 5 average rating, 150 reviews

The Woodsman Suite

A third floor suite, facing the river with the train tracks only a couple blocks away. It took 2 months to do the ceiling. Carefully polished and placed the old lath in a specific design, the ceiling is a work of art. Eighty percent of the material used in this room is from re purposed lumber, either from this building or from a childhood barn built in the late 1800's. It will take you a while to notice every detail down to the toilet paper holder which is from an old barn post.

Top Guest favourite
A well-lit room features a spacious bed topped with white bedding and pillows. A flat-screen TV is mounted on the wall opposite a large mirror, enhancing the sense of space. A sleek bathroom area is visible, showcasing modern fixtures and marble flooring.
Hotel room in Washington
4.94 out of 5 average rating, 115 reviews

River Sirens Hotel Junior Suite

11 Room Boutique Hotel in beautiful Downtown Washington. Each room has: Private Entrance Guest Access - Key Pad, Free Parking, King Size bed, TV, Wifi, Hair Dryer, Individual A/C & Heat. Guests can enjoy a shower room featuring a changing area with separate vanity and water closet spaces. Each room is also equipped with a full kitchen featuring large refrigerators with ice dispensers, induction stove top, microwave, toaster, and coffee station.

Guest favourite
A cozy bedroom features a spacious bed adorned with a textured blanket. A decorative area rug lies on the floor, contrasting with the dark green walls. Natural light filters in through curtains, and a bedside lamp and artwork add to the inviting decor.
Hotel room in Fairfax
5 out of 5 average rating, 6 reviews

TheInn on Main Fairfax-private room/bath, no steps

You booked the Maine room on the main floor. This room has a queen bed and a private bathroom. This room has no stairs - you can take a ramp to the front door and there’s a minimal step to get in the shower. This room also has a pull bar by the toilet and shower for your safety. The shower is a stall type shower. There's also a fan in the room for your comfort. Air mattresses are available for $10/ night.

Superhost
Hotel room in Springfield
4.93 out of 5 average rating, 55 reviews

Culture Boutique Hotel: Casablanca Suite.

Our loft-like suites feature furniture made from reclaimed materials from our building, a converted mattress factory. Each suite is inspired by a city in Eurasia. The rooms boast high ceilings, a 39in tv, a refrigerator, microwave and a V60, Electric Kettle, + complimentary coffee from Eurasia Coffee Co. This room (Casablanca) boasts a jacuzzi and separate shower.

Guest favourite
A porcelain clawfoot soaker tub is situated against a textured, gold-hued wall. The tub features elegantly designed legs and a handheld shower attachment, providing a classic touch to the relaxing space.
Hotel room in Washington
4.88 out of 5 average rating, 188 reviews

430 West Front: Balcony Riverfront View

This room is located on the second floor over our quaint wine bar with a private balcony overlooking the Missouri River. Enjoy a cup of coffee or glass of wine from our wine bar on your private balcony. Just steps from our Historic downtown riverfront community with plenty of bars, restaurants, and charming shops to explore.

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