Boutique hotel holiday rentals in Missouri

Find and book unique boutique hotel rentals on Airbnb

Top-Rated Boutique Hotels in Missouri

Guests agree: These boutique hotel rentals are highly rated for location, cleanliness and more.

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Guest favourite

Hotel room in Washington

4.95 out of 5 average rating, 129 reviews

River Sirens Hotel Deluxe Suite

11 Room Boutique Hotel in beautiful Downtown Washington. Each room has: Private Entrance Guest Access - Key Pad, Free Parking, King Size bed, TV, Wifi, Hair Dryer, Individual A/C & Heat. Guests can enjoy a shower room featuring a changing area with separate vanity and water closet spaces. Every room as a very large balcony with river views. Each room is also equipped with a full kitchen featuring large refrigerators w/ ice dispensers, induction stove top, microwave, toaster, and coffee station.

Guest favourite

Hotel room in St. Louis

4.93 out of 5 average rating, 115 reviews

Chic Ultramodern Minimalist Studio Loft + Patio

The Nash Loft is a stunning minimalist studio with 12’ ceilings, a fully-equipped kitchen with black stainless appliances and quartz countertops, stackable washer + dryer, a designer bathroom with black stainless fixtures and frameless glass shower, a comfortable workspace with high-speed internet connection, track lighting, and a lovely patio overlooking the courtyard. Situated along the famous Locust Street in the heart of Midtown, you’ll be steps from SLU, Wells Fargo, BJC, and the Grove.

Top Guest favourite

Hotel room in St. Louis

5 out of 5 average rating, 15 reviews

Luxury Retreat, Hot Tub,En-Suite Bath, Location+

Enjoy timeless elegance in our World's Fair Suite, set within a church-converted-Inn in the heart of St. Louis. This luxurious space features soaring ceilings, original 1900s stained-glass windows, and rich mahogany woodwork. Unwind in the plush four-poster king bed, or pamper yourself in your private en-suite bath with heated floors. Cap off your evening in our rooftop hot tub with stunning city views. One of 4 exclusive suites at our Inn, perfect for romantic getaways or peaceful retreats.

Top Guest favourite

Hotel room in Osceola

4.92 out of 5 average rating, 100 reviews

Historic Commercial Hotel(1868),Sally Rand Suite

The Historic Commercial Hotel (Est.1868) on the Downtown square in beautiful Osceola,Missouri. Old world feel with modernized accommodations. The Historic Commercial Hotel has numerous themed rooms which are designed and named after past historical guests. This specific room is "The Sally Rand Suite". Named after past historical guest Sally Rand ( 1904 – 1979) who was an American burlesque dancer and Silver Screen star, most noted for her ostrich feather fan dance and balloon bubble dance.

Top Guest favourite

Hotel room in Springfield

4.94 out of 5 average rating, 220 reviews

“Camp Rockwood”at Rockwood Motor Court on Route 66

Rockwood Motor Court, on historic Route 66, was built in 1929. Each room is themed and furnished to the era of Route 66. Camp Rockwood pays homage to the important history of motor courts along the road. It is decorated with historic photos of Rockwood and other courts and motels. Newly renovated in 2019, you’ll enjoy clean and comfortable room amenities while experiencing authentic motor court lodging. Need more space? We have larger rooms or can package multiple rooms for your group.

Guest favourite

Hotel room in St. Louis

4.87 out of 5 average rating, 722 reviews

Blue Spruce Room Queen Bed at BnB in CWE!

A Lovely room in a historical St. Louis home! The Blue Spruce Room is on the 2nd floor, and has a recently renovated and beautiful bathroom complete with a walk-in rain shower right next to it. The room has a desk, chair, lamp, table, Amazon Fire TV with basically every major streaming App, newly installed hardwood floors, and a Queen sized-bed. The room has two large windows for plenty of natural light with heavy blinds for sleeping in! Full use of the kitchen upstairs is available!

Guest favourite

Hotel room in Hannibal

4.96 out of 5 average rating, 135 reviews

The Woodsman Suite

A third floor suite, facing the river with the train tracks only a couple blocks away. It took 2 months to do the ceiling. Carefully polished and placed the old lath in a specific design, the ceiling is a work of art. Eighty percent of the material used in this room is from re purposed lumber, either from this building or from a childhood barn built in the late 1800's. It will take you a while to notice every detail down to the toilet paper holder which is from an old barn post.

Guest favourite

Hotel room in Hermann

4.97 out of 5 average rating, 31 reviews

Labby's Homestead Rolling Creek Loft Suite

Our Rolling Creek Loft is located on the second level of our Barndominium featuring a private 2 bedrooms with 2-Queen beds in each & 1 full double vanity bathroom with a tub/shower combination. Your suite will also provide a spacious great room including a 55-in Smart TV already connected to free, secure Wi-Fi, and a full-service kitchen/dining area complete with cookware and utensils; there is also a wine bar to keep your wine at the perfect temperature!

Guest favourite

Hotel room in Eldon

4.93 out of 5 average rating, 46 reviews

#8 A 1930’s Motor Court, Historic Randles Court

Family owned and operated! Built in the early 1930s, our recently restored rooms will take you back to simple times. The days of bus & railway rest stops, road-trips in the family car, and the quintessential motor court. Our town is alive with new and old businesses alike - places to eat, shop, and play for everyone in the family! We’re centrally located in downtown Eldon-just 15 minutes from the Lake of the Ozarks and 30 minutes from Jefferson City.

Superhost

Hotel room in Springfield

4.94 out of 5 average rating, 47 reviews

Culture Boutique Hotel: Casablanca Suite.

Our loft-like suites feature furniture made from reclaimed materials from our building, a converted mattress factory. Each suite is inspired by a city in Eurasia. The rooms boast high ceilings, a 39in tv, a refrigerator, microwave and a V60, Electric Kettle, + complimentary coffee from Eurasia Coffee Co. This room (Casablanca) boasts a jacuzzi and separate shower.

Superhost

Hotel room in Washington

4.87 out of 5 average rating, 170 reviews

430 West Front: Balcony Riverfront View

This room is located on the second floor over our quaint wine bar with a private balcony overlooking the Missouri River. Enjoy a cup of coffee or glass of wine from our wine bar on your private balcony. Just steps from our Historic downtown riverfront community with plenty of bars, restaurants, and charming shops to explore.