Guesthouse holiday rentals in Greenville County

Find and book unique guesthouse rentals on Airbnb

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Popular amenities for Greenville County guesthouses

Family-Friendly guesthouses

Top Guest favourite
Guesthouse in Travelers Rest
5 out of 5 average rating, 48 reviews

Travelers Rest Country Retreat Two miles to NGU

PeggyRating, 5 stars9 months ago
I can't say anything negative about Cliff and Mary's place. It is a gem. You watch horses graze on one side of the house and overlook a pond on the other side. Cliff and Mary are very responsive and go out of their way anticipating their guests needs, stocking the kitchen and fridge with snacks, coffee, cream, and other goodies. Any questions we had about the area were answered immediately. They are pleasant people that I would be glad to call new friends!
Top Guest favourite
Guesthouse in Tryon
4.98 out of 5 average rating, 111 reviews

Historic Jockey Cottage, TIEC 20 mins, Tryon 5

CourtenayRating, 5 stars3 weeks ago
I’m selfishly not wanting to write this great review because I will be sad if the place is booked when I go back to Tryon! The place was perfect for my pup and I while showing at TIEC. The hosts are lovely, and the place stocked with a coffee bar and water, and the community itself is beautiful. Quiet, peaceful, yet super convenient for restaurants and shopping. I will be back! Also, apologies. I stole your box of tissue under the bathroom sink because my allergies were killing me at the horse show: I meant to replace it with one I night but I forgot this morning. I apologize again and thank you!
Guest favourite
Guesthouse in Pendleton
4.89 out of 5 average rating, 264 reviews

La Bella Farm

BrandonRating, 5 stars2 weeks ago
Had an amazing time at this gorgeous space. It was exactly as advertised, and Jessica was extremely responsive and proactive as a host. Thank you so much! Will definitely book there again!
Top Guest favourite
Guesthouse in Liberty
4.93 out of 5 average rating, 197 reviews

Holly Hideaway! 10 Highway miles to Clemson U!

RittaRating, 5 stars1 month ago
Jen’s Hideaway is the perfect private spot to come back to after visiting Central and Clemson. It is extremely clean and well appointed. The bed is very comfortable. Jen is a friendly host. She even baked us delicious blueberry muffins.
Guest favourite
Guesthouse in Simpsonville
4.94 out of 5 average rating, 244 reviews

Private Suite in Downtown Simpsonville

DarlaRating, 5 stars3 weeks ago
I had a great stay in Simpsonville, SC. Everyone was very helpful and polite. Thank you!
Guesthouse in Greenville
4.78 out of 5 average rating, 46 reviews

Quiet Guest Apartment in the Woods

JenniferRating, 5 stars32 months ago
Miranda's guest apartment was perfect for a long term stay. It was well equipped, neat, and ideally located with easy proximity to Paris Mountain State Park as well as downtown Greenville. Miranda was a wonderful host and prompt to respond the few times I needed something.
Guest favourite
Private room in Pelzer
4.98 out of 5 average rating, 129 reviews

South Oaks Guesthouse

MelissaRating, 5 stars4 days ago
Diane’s home is lovely! T It was relaxing, comfortable and welcoming! We will stay again!

Guesthouses with a patio

Guest favourite
Guesthouse in Lyman
4.94 out of 5 average rating, 32 reviews

Budget Bliss: Cozy Elegance

Jonathan Rating, 5 stars1 month ago
Was very nice and cozy. the water pressure was perfect. host was super friendly and responded quicker than I expected. had great air conditioning so I never got hot. overall pleasent stay! the only downside I discovered was for some reason Domino's wouldn't deliver to that area, but that's Domino's fault, not the host. would definitely stay again!~
Top Guest favourite
Guesthouse in Travelers Rest
4.86 out of 5 average rating, 7 reviews

Guest Cottage with Private Drive

RobertRating, 5 stars2 weeks ago
Dustin was easily accessible and quickly responsive when I had questions. his accommodations at the cottage far exceeded my expectations. I would definitely recommend for other guests to try it out. and if in the area again I would definitely try to stay there. highly recommended.
Guest favourite
Guesthouse in Greenville
4.9 out of 5 average rating, 70 reviews

Chic Studio with Private Deck

TemperanceRating, 5 stars1 month ago
This is hands down the BEST air bnb in the Greenville area for couples to enjoy a romantic getaway. Very nice secluded location, within a few minutes of tons of restaurants and retail stores and the cleanliness is top tier. Will definitely be booking any time we come to visit Greenville!
Guest favourite
Guesthouse in Brevard
4.95 out of 5 average rating, 94 reviews

Country-Clubhouse Tiny Home. Close to downtown!

IritRating, 5 stars1 week ago
We had such a great stay at Adam’s tiny house. The space was cozy, clean private, and had everything we needed. It was our first time exploring Brevard and the location was perfect. We will be back for there are more waterfalls to explore.
Top Guest favourite
Guesthouse in Pelzer
4.98 out of 5 average rating, 45 reviews

Serene country escape on 11 acres

CourtneyRating, 5 stars2 weeks ago
Quiet, peaceful, stay. Amy was very responsive and helpful with local recommendations. We enjoyed our stay with our two dogs, felt right at home!
Top Guest favourite
Guesthouse in Easley
5 out of 5 average rating, 49 reviews

Fun, cozy cottage for two w/games, deck in Easley

BaxterRating, 5 stars1 month ago
We enjoyed our stay on a trip to Clemson for a graduation. It was easy to find and so peaceful and quiet. Shannon and David have done a wonderful job of decorating and we enjoyed looking at everything. They pay attention to detail which makes for a pleasant stay. The kitchen had everything and the bathroom was clean and every need was provided for. We would definitely stay here again.
Top Guest favourite
Guesthouse in Greer
4.96 out of 5 average rating, 50 reviews

Sugar Creek Retreat

WendellRating, 5 stars1 month ago
We really enjoyed our stay at Sugar Creek Retreat. The downstairs apartment is very clean and easy to access with its separate entrance. The kitchen was well appointed and allowed us to make a few meals - primarily breakfast - during our stay. The Sugar Creek neighborhood is very nice and quiet while being well located for quick access to both Greer and Greenville. Kristen shares in her listing that their family lives above so you will hear some foot traffic typically when their children are headed out or arriving home but it was not an issue during our stay. The queen bed is very good and on the firm side. Again, we really enjoyed our stay!!
Top Guest favourite
Guesthouse in Greenville
4.95 out of 5 average rating, 40 reviews

Tranquil 2BR Guest House on Pond by Furman

GinnyRating, 5 stars2 weeks ago
Our stay at Gabriella's was wonderful. It is close enough to major roads to get anywhere quickly yet in a quiet neighborhood and very private. The living room was comfortable, the kitchen was well equipped, the bedrooms were large and everything was beautifully decorated. With family new to the area, I've already asked to stay there again!

Guest house rentals with a washing machine and dryer

Superhost
Guesthouse in Travelers Rest
4.8 out of 5 average rating, 20 reviews

Quiet King Two Bedrm House

LESLIERating, 5 stars1 month ago
This was a quiet spot with friendly neighbors. Be careful if you walk to Travelers Rest as some dogs are off leash. One chased me onto a porch. This was a cross street to the rental location. The rest of the stay was nice and the hosts were very accommodating!
Guest favourite
Guesthouse in Taylors
4.96 out of 5 average rating, 72 reviews

The oaks cottage

EdnaRating, 5 stars1 month ago
Just amazing. Close to everything. It was perfect.
Guest favourite
Guesthouse in Taylors
4.97 out of 5 average rating, 140 reviews

Just off Main near Taylors Mill - Clean & Comfy

CathyRating, 5 stars1 month ago
We were in town for family events. Natalie’s place was exactly as described, clean and spacious for my Mom, husband and I. Fully equipped kitchen , comfy living area and plenty of linens. Check in instructions were clear and Natalie was easy to communicate with. Would stay again if the opportunity arises.
Guest favourite
Guesthouse in Duncan
4.98 out of 5 average rating, 63 reviews

Adorable renovated private house w/ parking.

LisaRating, 5 stars3 months ago
Great place to stay!
Top Guest favourite
Guesthouse in Greenville
5 out of 5 average rating, 20 reviews

Upscale 1BR pet+ monthly near everything GVL

RyanRating, 5 stars3 months ago
Charming guest house with easy access to downtown and plenty of local food options
Top Guest favourite
Guesthouse in Mauldin
5 out of 5 average rating, 8 reviews

Beautiful guest house

PeggyRating, 5 stars1 month ago
Peaceful place to stay in a quiet neighborhood. Convenient to interstate and everything we needed. James was proactive in communicating and clear in his instructions. Would stay again! Two thumbs up 👍🏼
Guest favourite
Guesthouse in Greenville
4.96 out of 5 average rating, 96 reviews

Nishleigh's Nook - West End Downtown Greenville

TeriRating, 5 stars1 week ago
Clean, modern, with thoughtful and quality finishes. The bed was SUPER with top-notch memory foam pillows. This was a great find, close to downtown and Unity Park, a nice place to get outside. You do have to walk up 21 stairs to the unit but it was worth it. If we had to describe this listing with one word, we'd use the word "comfortable". We plan to return in the future. Thank you, Nicholas, for providing just what we needed while in Greenville.
Top Guest favourite
Guesthouse in Greenville
4.99 out of 5 average rating, 298 reviews

Prime Downtown Home—Walk to Main St, Trails&Dining

ArleneRating, 5 stars18 months ago
The loveliest space imaginable. It is so well built, a custom home, the floors, the cabinets, the tile, everything was so classic and comfortable and well appointed. Walked to and from the Peace Center for a show and walked all over town, very safe, very clean neighborhood. Fabulous stay! Ready to plan the next trip back.

Destinations to explore