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Guesthouse holiday rentals in Mesa County

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Top-rated Guesthouses in Mesa County

Guests agree: These guesthouses are highly rated for location, cleanliness and more.

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Guest favourite
A modern kitchen is featured with dark blue cabinetry and stainless steel appliances. The white subway tile backsplash contrasts with the darker tones. Natural light streams in through a window above the sink, illuminating the sleek countertops and the organized shelving.
Guesthouse in Grand Junction

GJ Rafters on Rood - Downtown Location!

Enjoy a stylish experience at this centrally-located spot. Beautiuful apartment just blocks away from downtown Grand Junction. Rafters on Rood welcomes you with a fire pit area equipped with an outdoor eating space as well as a grill. Stepping inside the space you will find two Smart TVs, a comfortable living room area as well as a fashionable kitchen. Top of the line mattresses greet you in each bedroom as well as vaulted ceilings and high end finishes throughout. LOCATION is key! CENTRAL AIR

WalkabilityComfortAir conditioning

4.95 out of 5 average rating, 464 reviews
Top Guest favourite
A covered porch is supported by wooden beams, featuring outdoor seating arranged on a textured rug. Large windows reflect the golden hour light, blending the indoor and outdoor spaces. Scenic views extend beyond the deck, highlighting the natural surroundings.
Guesthouse in Cedaredge

Yonder Mountain Retreat

A beautiful guesthouse on 5 acres a few miles north of the quaint town of Cedaredge. Multiple access points to the Grand Mesa, the ultimate outdoor playground for snowmobiling, hiking, motorcycling, ATVs, UTVs, fishing & hunting! Extra parking for motorcycles, ATVs, UTVs, or snowmobiles! YMR permits guests to bring one furbaby without pre-approval ($100 pet fee still applies). To bring more than one pet, pre-approval & addt’l. fees apply. One external security camera by the kitchen door.

Quiet

4.97 out of 5 average rating, 230 reviews
Top Guest favourite
A rustic bunkhouse exterior is highlighted with various traffic and warning signs, creating an eclectic atmosphere. The walls are painted in a soft hue, while the surrounding landscape features rocky cliffs and blue skies with scattered clouds. Logs are neatly stacked beside the entrance.
Guesthouse in Grand Junction

Unique BUNKHOUSE * Monument Views * Private

There is nothing like it! Decorated with the owners personal vintage collection and quirky style, the bunkhouse is fully furnished with a Queen size bed; luxury bed linens & towels, flat screen TV & Wi-Fi. Enjoy your private bathroom with a Jeep front vanity and a small kitchenette, which includes a real pickup tailgate table with antique implement stools. Come experience a cool atmosphere where you can enjoy some of the best views this property has to offer and a true Colorado experience.

ViewHospitalityAccuracy

5.0 out of 5 average rating, 213 reviews
Top Guest favourite
The converted barn is visible in the background, showcasing an inviting rustic design. A grassy area in the foreground is bordered by a stone wall, adorned with climbing vines. Seasonal decorations are displayed along the barn, enhancing the rural ambiance of the setting.
Guesthouse in Montrose

The Barn in Coal Creek

This delightful space is perfect for your quiet getaway. Set in the country with hundreds of acres of unobstructed views this converted Barn is just what you need to get away and unplug. Bring your dog and take advantage of the gazebo and fire pit. The full kitchen, laundry, jetted tub and comfy reading space you will feel right at home. Stay a night or a week, whatever it takes to recharge your batteries. Traveling nurses and business travelers are welcome. We are happy to have you.

4.83 out of 5 average rating, 277 reviews
Top Guest favourite
A sleeping area features a spacious bed adorned with white linens and a textured gray blanket. Decorative elements include a driftwood piece hanging above the bed and lamps on either side providing soft lighting. A wooden nightstand and a small patterned rug add warmth to the space.
Guesthouse in Grand Junction

Private Guest Suite Over Garage • Near Downtown

Our brand new garage apartment is walking distance from CMU, downtown, and Lincoln Park! Easily bike or walk to morning coffee, the riverfront, or take a short drive to Lunch Loops for mountain biking and hiking (our favorite!) We have a Nespresso machine or french press for morning coffee, washer/dryer, non-toxic shampoo & conditioner, body wash, and lotion, and any kitchen appliances you may need during your stay. Also provided a pack n play, high chair, and baby items for families :)

4.97 out of 5 average rating, 118 reviews
Top Guest favourite
Guesthouse in Palisade

Peach Tiny House / Palisade Vineyard 1 bed 1 bath.

The Peach House is a Tiny Home! Private parking, entrance and the entire tiny house is yours with a studio apartment vibe. Kitchenette (sink, coffee maker, toaster, fridge and microwave). Full bathroom with shower, double bed, TV and a comfy couch. Private outdoor patio, firepit and unobstructed view of Palisade vineyards, Mt. Garfield and Colorado sunsets. Tiny and set among the vines and peach orchards. Close to wineries, hiking, river activities and downtown Palisade.

4.99 out of 5 average rating, 172 reviews
Superhost
A modern guest house with large windows showcases a stone patio area featuring various seating options. A flag flutters in the breeze, and a fire pit is centrally located, providing an inviting space for relaxation. The surrounding landscape includes distant mountains and greenery.
Guesthouse in Clifton

Colorado river guest house

Welcome to Happy Tails animal sanctuary we are a nonprofit animal rescue in palisade wine country. 10 acre animal sanctuary w alpaca, goats, pigs, dogs, chickens peacocks even a emu that all free range. Fish, kayak, paddleboard, canoe on our 2 acre fully stocked fishing lake. Float the Colorado river from Riverbend park in Palisade to our private beach. The views of the Colorado river, Grand Mesa & mount Garfield are breathtaking the animals are all friendly and love people

4.83 out of 5 average rating, 465 reviews
Top Guest favourite
A modern kitchen features navy blue cabinetry and a central island with seating for four. Stainless steel appliances include a refrigerator and microwave. Natural light illuminates the space, highlighting the stone backsplash and wooden flooring.
Guesthouse in Palisade

Enjoy Grand Mesa View & Peach Orchard Yoga

Welcome to our guest house at Peach Orchard Yoga. This newly built one bedroom guest home has stunning views of the Grand Mesa and is surrounded by Palisade’s Peach Orchards. While staying here you’ll have the opportunity to meet our Alpine goats Peter and Harry, enjoy fresh eggs and have easy access multiple winery’s that are in walking and biking distance. If you enjoy yoga, Peach Orchard Yoga is located on the property offering weekly group classes or private classes.

5.0 out of 5 average rating, 105 reviews
Top Guest favourite
A modern living area features a spacious dark gray sectional sofa adorned with colorful accent pillows. A light wood coffee table is centered on a patterned area rug, with vibrant landscape artwork hanging on the wall above, adding a touch of color to the neutral decor.
Guesthouse in Fruita

Fruita Retreat + View ⛰🌵

Peacefully situated beyond city limits yet just minutes away from downtown Fruita, our cozy haven offers open space for relaxation on your private patio, where you can soak in mountain views & beautiful sunsets while gathered around the cozy gas firepit. Outdoorsy types will appreciate our property's easy access to trails, providing ample opportunities for hiking, biking, and exploration. But all will love the tranquility and convenience of our countryside escape!

Hospitality

4.98 out of 5 average rating, 298 reviews
Top Guest favourite
Guesthouse in Grand Junction

412 Chipeta Best Guesthouse Walk to Downtown

Brand new listing! You'll have a great time in this quiet comfortable neighborhood Victorian duplex. New construction and Best High Quality Guesthouse in town! Long term stays welcome. Only 4 blocks to main street shops, restaurants, bars, and brew pubs, 1/2 block to city park. Security gates front and rear. Well appointed King bedroom and a Queen bedroom both with their own private bathrooms, workspace/ office, central cooling, private patio and BBQ.

5.0 out of 5 average rating, 112 reviews
Top Guest favourite
The exterior of the modern carriage house displays a distinctive metal facade under the evening sky. Large windows illuminate the interior, highlighting the unique architecture. Surrounding landscape includes gravel pathways and greenery, enhancing the rural charm of the property.
Guesthouse in Palisade

Modern Carriage House in Colorado's wine country

Modern carriage house situated on a small farm property walking distance to downtown Palisade and numerous wineries. One bedroom, luxurious bathroom, and fully appointed kitchen with amazing views of the Grand Mesa, Bookcliffs, and surrounding orchards. Enjoy the bright, modern indoor space with vaulted ceilings, wood floors, and custom metal-work or head out to the balcony overlooking peach orchards and the unique geography of the Grand Valley.

5.0 out of 5 average rating, 167 reviews
Top Guest favourite
A circular seating area made up of four wooden chairs surrounds a stone fire pit, set on a gravel base. Lush green grass and various trees provide a natural backdrop, while sandstone formations rise in the distance under a clear blue sky.
Guesthouse in Grand Junction

Chic 2 Bedroom Cottage with Monument Views

Mountain biking, hiking, motorcycling? It's all right here! Our newly built 2 bedroom private cottage sits at the base of Colorado National Monument and is thoughtfully designed to help you relax and unwind. Ride out the back door or take a short drive to the legendary trails of Grand Junction and Fruita. When the fun is done, rest your legs on your secluded patio and watch the sunset over the sand stone towers looming in the backyard.

4.99 out of 5 average rating, 386 reviews

Popular amenities for Mesa County guesthouses

KitchenWifiFree parking on premisesAir conditioning

Family-Friendly guesthouses

Top Guest favourite
A charming guest house is presented in a vibrant blue hue, surrounded by lush greenery. A flagstone patio extends from the house, featuring outdoor seating and a fire pit. Flowering plants in pots add a touch of color along the patio's edge.
Guesthouse in Paonia

The Garden Cottage in Paonia

4.9 out of 5 average rating, 268 reviews
Top Guest favourite
A white horse grazes peacefully in a lush green pasture, framed by a rustic wooden fence. The vibrant sunset casts warm oranges and yellows across the sky, with silhouettes of trees and distant structures enhancing the serene countryside setting.
Guesthouse in Montrose

Tilted Rooster Ranch Guest House

4.97 out of 5 average rating, 112 reviews
Top Guest favourite
An outdoor view of the guest house features a gravel pathway leading to the door. Air conditioning units are positioned beside the entrance. A calm canal is visible nearby, with fields and distant hills framing the background.
Guesthouse in Clifton

Guest Cottage

4.99 out of 5 average rating, 67 reviews
Top Guest favourite
The modern guest house features a dark wooden exterior and large windows, with a view of Mt. Garfield in the background. A shaded tree stands beside the house, and an old tractor is visible in the foreground, set amidst open agricultural fields.
Guesthouse in Palisade

Studio 36.3

4.93 out of 5 average rating, 46 reviews
Top Guest favourite
A comfortable sleeping space features a spacious bed with neutral linens and decorative pillows. Two bedside lamps provide soft lighting on either side, while a wooden bench at the foot of the bed adds functionality. A window with curtains allows natural light to illuminate the room.
Guesthouse in Crawford

Foreman's Quarters @ Wrich Ranch

5.0 out of 5 average rating, 41 reviews
Guest favourite
Guesthouse in Loma

Private Tiny Home Getaway

5.0 out of 5 average rating, 6 reviews
Top Guest favourite
Aerial view captures the expansive green grounds surrounding the cottage, with neatly arranged trees and shrubs. The rolling vineyards and orchards extend in the background, framed by the mountains, which provide a natural backdrop to the serene landscape.
Guesthouse in Palisade

Vineyard Cottage - Palisade, CO

LocationBikingCleanliness

5.0 out of 5 average rating, 92 reviews
Top Guest favourite
The exterior of the guest house is shown, featuring a simple façade with beige walls and a pitched roof. A white door with a round window is centered beneath an overhang. Two large windows flank the entrance, allowing for natural light, while a small flower pot is placed to one side.
Guesthouse in Loma

The Little House…in Loma.

5.0 out of 5 average rating, 25 reviews

Guesthouses with a patio

Guest favourite
A bright studio space is showcased, featuring a spacious bed with textured bedding and a minimalist artwork above. A comfortable couch sits nearby, complemented by a small side table with a lamp. Light wood flooring enhances the airy atmosphere.
Guesthouse in Grand Junction

Welcome to The Peaceful Place (Dog Friendly)

4.98 out of 5 average rating, 205 reviews
Superhost
The cabin features a rustic exterior with rich wooden tones and large windows. A spacious deck offers multiple seating options, including rocking chairs and a dining area. Surrounding greenery and trees enhance the serene setting, creating a peaceful retreat.
Guesthouse in Grand Junction

Peaceful Cabin Near National Monument and Downtown

4.87 out of 5 average rating, 332 reviews
Top Guest favourite
The entrance of the property is framed by vibrant flower beds, leading to a welcoming doorway adorned with a sign. The exterior features a mix of light gray siding and natural wood accents under clear blue skies, surrounded by greenery and trees.
Guesthouse in Fruita

Desert's Edge Fruita. Pet/Bike Friendly-4 acres

HospitalityComfort

4.98 out of 5 average rating, 141 reviews
Top Guest favourite
A cozy outdoor space is illuminated by string lights, featuring a circular arrangement of four white chairs surrounding a central fire pit. A rug sits beneath the furniture, and a large tree provides shade nearby. The atmosphere is tranquil and inviting.
Guesthouse in Fruita

Charming, private guest suite in downtown Fruita!

LocationAir conditioningNearby

4.89 out of 5 average rating, 254 reviews
Top Guest favourite
Guesthouse in Mesa County

The Cozy Cottage on Purdy Mesa

4.96 out of 5 average rating, 57 reviews
Top Guest favourite
Guesthouse in Grand Junction

Canyon View Casita - A relaxing nature retreat

5.0 out of 5 average rating, 18 reviews
Top Guest favourite
A cozy seating area is shown with a brown sectional couch adorned with decorative pillows. Natural light enters through a large window, offering views of the surrounding mountains and greenery outside.
Guesthouse in Palisade

Palisade Cowgirl Cabin

4.98 out of 5 average rating, 54 reviews
Top Guest favourite
A comfortable living area features a brown leather sectional sofa positioned across from a wooden coffee table. A large flat-screen TV is mounted on the wall, and a small workspace with a desk chair is visible. The space has tasteful wood cabinetry and an inviting kitchen area in the background.
Guesthouse in Grand Junction

Scenic mornings. Spacious living

4.97 out of 5 average rating, 38 reviews

Guest house rentals with a washing machine and dryer

Guest favourite
Guesthouse in Grand Junction

Quiet neighborhood getaway

4.94 out of 5 average rating, 71 reviews
Top Guest favourite
Guesthouse in Grand Junction

Hillside Holiday Home

5.0 out of 5 average rating, 20 reviews
Top Guest favourite
The exterior of a contemporary studio apartment is shown, featuring a distinctive angled facade. A gravel area is visible in front, with a private entrance and a garage. Two blue chairs are positioned near the entrance, surrounded by landscaping that includes shrubs and trees.
Guesthouse in Grand Junction

The Bungalow at Casa Del Sol in Mantey Heights

4.97 out of 5 average rating, 96 reviews
Top Guest favourite
A modern kitchen and dining area are highlighted, showcasing dark cabinetry and stainless steel appliances. A dining table with four chairs sits centrally, while a comfortable yellow armchair and dark sofa add warmth to the space. Natural light enters through the window above the sink.
Guesthouse in Fruita

Fruita Hideaway!

4.91 out of 5 average rating, 76 reviews
Superhost
An aerial view captures a spacious home set against a natural landscape, with rolling hills and sparse vegetation. A patio area is visible, surrounded by rocks, while a tree offers shade near the entrance. The blue sky is dotted with clouds, adding to the serene environment.
Guesthouse in Mesa

Beehive house

4.78 out of 5 average rating, 18 reviews
Top Guest favourite
A bright living area features a spacious gray sectional sofa with decorative pillows and an orange accent ottoman. A large wall-mounted TV is present, alongside a potted plant in the corner. Two high windows allow natural light to illuminate the room, enhancing the neutral color palette.
Guesthouse in Fruita

Pabor Ave Guesthouse

5.0 out of 5 average rating, 67 reviews
Top Guest favourite
A modern two-story condo is shown, featuring green siding and a garage. A vehicle with kayaks secured on the roof is parked in the driveway. A spacious upper deck is visible, providing an outdoor area for relaxation. The surrounding landscape is complemented by blue sky.
Guesthouse in Grand Junction

Private downtown condo & your walkable basecamp

5.0 out of 5 average rating, 39 reviews
Guest favourite
A charming cottage exterior is displayed, featuring a metal roof and a covered porch. Two chairs sit on the porch, while the front door is framed by stone accents. A gravel pathway leads to the entrance, surrounded by open land and distant horse pastures.
Guesthouse in Fruita

Tumbleweed: 2 Cozy Suites, BBQ Grill & More

4.95 out of 5 average rating, 39 reviews

Destinations to explore