Boutique hotels in Middlesex County

Find and book unique boutique hotels on Airbnb

Top-rated boutique hotels in Middlesex County

Guests agree: These boutique hotels are highly rated for location, cleanliness and more.

1 of 1 pages1 / 1
Hotel room in Sherborn

Orchard Room: The Inn at Fireside Tavern Sherborn

The perfect blend of New England charm and modern boutique luxury, The Inn at Fireside Tavern Sherborn offers 4 private suites, thoughtfully designed around unique local characteristics. Located in the heart of Sherborn, our guest rooms sit directly above our vibrant community tavern, providing a sophisticated and convenient haven for your stay. Whether here for a wedding, local getaway, or peaceful one-night stay, you’ll find a seamless connection between upscale comfort and exceptional dining.

Guest favourite
Hotel room in Brookline
5 out of 5 average rating, 12 reviews

Boutique Hotel/Brokline | Boston | Longwood area

Stay in the center of the action in this one-of-a-kind place. More than just a place to stay, this 1886 Victorian home is an experience in itself. Imagine waking up every day in a Queen Anne mansion filled with character - wooden details and elegant parlors. Here, history and comfort blend seamlessly. Whether you’re here for weeks or months, you’ll feel at home in an inspiring space designed for slow mornings, quiet reading by the window, and evenings that carry the elegance of another time.

Guest favourite
Hotel room in Brookline
4.94 out of 5 average rating, 33 reviews

Medical | Longwood Area | Perfect for Long Stays

Stay in a charming 1886 Victorian home in the heart of Brookline, Boston. Perfect for long stays, with cozy parlors and timeless charm. 🏡 Location & Accessibility Public Transport Nearby: Just a block from Saint Mary's Street Station, offering easy access to downtown Boston and surrounding areas. Restaurants & Local Shops: The vibrant Coolidge Corner neighborhood is only about 1 mile. Museums & Cultural Attractions: Fenway Park, Boston’s iconic baseball stadium, is about 1.2 miles away.

A cozy room features a queen-sized bed adorned with a patterned blue and gold coverlet, complemented by an array of framed artwork on the walls. A dark leather sofa sits adjacent to the bed, while a small round table rests on a warm wood floor, creating a welcoming atmosphere.
Hotel room in Worcester
5 out of 5 average rating, 48 reviews

JD Hotel “Blue Lagoon”

Welcome to the new opening of the JD hotel! Full service fine art boutique hotel! Queen size temperpedic, massage chair,cedar closet ,new tv with Roku, Netflix’s starz’s and Wi-Fi!!Front hall kitchen area when you first walk in is equipped with everything! There’s also a mini fridge in the room and a private shower room attached to the room! Right near the Worcester airport! Free laundry and dish service.The bus stop is right outside! 🏳️‍🌈 very clean loft! All the art is for sale.

Hotel room in Woburn
4.16 out of 5 average rating, 69 reviews

Prime Location! Unit w/ Parking, Pet-friendly!

Just minutes from the hustle and bustle of downtown Boston, this property offers a convenient, budget-friendly stay in the Boston area. Head to the nearby Stone Zoo or the Liberty Ride Trolley Tour for a fun day with the family. If you’re visiting the area for a campus visit, MIT, Harvard, Tufts, Boston University, and several other schools are just minutes away. Close to all the action, but away from the crowds, this property is a great choice for your Boston area getaway!

Superhost
Hotel room in Cambridge
4.57 out of 5 average rating, 7 reviews

(31) Bright large room with skylight on top floor

This sun-filled large room is situated on the top floor of our large Victorian-style house. It has three windows and a skylight with ample natural light and a view of our lovely ginkgo trees in the front. The room has one queen bed, and two twin beds for a perfect family stay up to four people, two adults and two children. This centrally situated house is only 7 minute walk from the red line subway station, 10 minute walk to Harvard, and a WholeFoods within 5 minute walk.

Guest favourite
A spacious bedroom is furnished with a queen bed dressed in white linens. A plush area rug with a subtle design covers the wooden floor. Two armchairs are positioned near a small table, with natural light streaming through the large windows.
Hotel room in Cambridge
5 out of 5 average rating, 45 reviews

Deluxe Queen at Ginkgo House

This sun-filled large bedroom is situated on the second floor our large Victorian-style house. It has four large windows with ample natural light and a view of our lovely ginkgo trees in the front. The room has one queen bed, and two twin beds for a perfect family stay up to four people, two adults and two children. This centrally situated house is only 7 minute walk from the red line subway station, 10 minute walk to Harvard, and a WholeFoods within 5 minute walk.

Guest favourite
A spacious room features a patterned accent wall in warm tones, paired with a plush, comfortable bed with crisp white linens. Soft lighting is provided by stylish wall lamps on either side, and a wooden dresser is visible in the background, contributing to a calm ambiance.
Hotel room in Cambridge
4.83 out of 5 average rating, 60 reviews

Prentiss House by Thatch | King Suite #12

Prentiss House by Thatch is a 20-room boutique hotel nestled between Harvard and Porter Square in an iconic Cambridge neighborhood setting. Built in 1843 and renovated in 2022, the building's rich architecture is complimented by modern amenities and fresh design, providing an upscale yet laid-back atmosphere. Using state of the art technology, roaming staff and a virtual front desk, most guests enjoy their stay without ever needing assistance from our staff.

A cozy room features a full-size bed with a light gray patterned blanket. Two side tables with lamps are positioned beside the bed. A piece of decorative wall art is displayed above the headboard. An open door reveals a bathroom area with modern fixtures.
Hotel room in Boston
4.76 out of 5 average rating, 85 reviews

Charlesmark, boutique hotel room in Copley Square

Originally built in 1886 as a private residence in the heart of Boston's Back Bay neighborhood, the hotel has been completely renovated. Our European style boutique hotel features a hip cocktail lounge with an outdoor patio. (Lounge currently unavailable) Premier location. Exceptional value. European ambiance. The Charlesmark combines it all to create a memorable lodging experience. Ambiance - Genuine, Intimate Service

A cozy sleeping area is featured with a spacious bed and a decorative pillow. A wooden wall unit serves as a backdrop, housing artwork depicting a train platform. Natural light enters through large windows adorned with dark curtains, adding a serene ambiance to the room.
Hotel room in Boston
4.44 out of 5 average rating, 615 reviews

Hotel IVY Boston Common- Queen Room, Boston Common

Stay in a restored 1877 landmark in downtown Boston, perfectly positioned for both leisure and medical stays. You’re just steps from Boston Common and within walking distance of Tufts Medical Center, the Theater District, shopping, dining, and public transit. Ideal for guests who need fast, reliable access to the city’s core whether for appointments, patient support, work, or exploring Boston car-free.

A spacious room features two large beds dressed in crisp white linens, complemented by a decorative throw pillow. Natural light filters through sheer curtains, illuminating a cozy seating area with a modern couch and accent lamp. A flat-screen TV is mounted above a dark wooden dresser.
Hotel room in Boston

The Whitney Boston, Classic Double Queen

The newly-opened Whitney rocks a classic brick townhouse vibe in lovely Beacon Hill, with thoughtful perks like house bikes and a Mediterranean-inspired restaurant, starring creative, seasonally-driven menus. Your room charge will be paid prior to your arrival. The remaining balance of taxes (14.95%) will be charged upon arrival. A refundable security deposit of $XX will also be collected.

Guest favourite
A well-lit guest room features a full-size bed with crisp white linens. Two windows provide natural light, framed by light gray curtains. A small desk and chair are situated by one window, while a patterned chair adds an element of comfort to the space.
Hotel room in Cambridge
4.93 out of 5 average rating, 82 reviews

(SG) Sunny single, yard-facing with shared bath

Blending modern conveniences with historic charm in this 1867 Victorian-style house, this guest room has one full-size bed and can be booked together with Room 27 for a family or large group trip up to 4 people. This affordable single room has a shared bathroom with one other guest room. Located just 7 minutes from the Red Line T, we are at the heart of Cambridge between Harvard and MIT.

Popular amenities for Middlesex County boutique hotels

Destinations to explore