
Places to stay near Mission San Luis Obispo de Tolosa
Book unique holiday rentals, homes and more on Airbnb
Top-rated holiday rentals near Mission San Luis Obispo de Tolosa
Guests agree: these stays are highly rated for location, cleanliness and more.

SLO Guesthouse - quiet - near downtown - #115545
Private studio with it's own entrance located in lovely SLO. Includes a queen size Murphy bed (people rave about the comfort of this bed), 3 piece bathroom, table & two chairs, desk, closet, TV, WiFi & kitchenette. Coffee, tea with fixings are provided. 4 blocks from the downtown cultural-hub, hip restaurants, Farmer's Market, the Historic Mission and more. The Edna Valley wine country is 5 minutes away and the Beach is 10 minutes away. The Perfect Location to come experience the "SLO Life"!
4.97 out of 5 average rating, 695 reviews
San Luis Obispo Oasis near DT SLO w/ Hot Tub + EV
Newly renovated SLOasis bungalow 10 mins walk from downtown SLO shops/restaurants/nightlife. New 4-6 person Hot Tub in private yard. Beautiful spacious kitchen, cozy bedrooms and nice porch. Located in the residential High St Neighborhood (SoHi) with easy access to coffee shops, local wineries, wedding venues and local attractions. Enjoy the entire place with relaxing in the hot tub, cooking in the kitchen or taking a short walk to a popular trailhead or downtown shops, bars and restaurants.
4.95 out of 5 average rating, 311 reviews
Eclectic apartment in the heart of downtown SLO.
This charming, newly updated, 1 BR apartment is part of an 1883 Folk Victorian in the heart of SLO's downtown historic district and was recently added to the California Master List of Historic Resources as 'The D.M. & Carrie Proper Meredith House'. This cozy apartment offers convenience, style, safety, and privacy - all while being just a two-minute walk to all your favorite bars, restaurants, cafes, movie theatres, and shops. Your hosts aim to provide you with an amazing 5-star experience!
4.97 out of 5 average rating, 349 reviews
1884 Elegant Home: Fire Pit, Tesla Tech, Near DT
Step into history at this charming 2-bedroom railroad house in downtown SLO. Enjoy its preserved heritage, from the 11-foot tall ceilings to the spacious kitchen. Sleep luxuriously on Purple mattresses in both bedrooms. Unwind next to the fire pit in the backyard. It's a short 7 min. stroll to downtown & next to 5 restaurants including Sally Lou's coffee shop & the train station. Experience SLO's charm like never before with this perfect location home. Send us a message to plan your trip!
5.0 out of 5 average rating, 240 reviews
Cozy Studio Close to Downtown SLO
Cozy Studio is located in a quiet residential neighbor with secure off street parking. Whether you choose to relax in my comfortably furnished studio or enjoy the private outdoor patio, my home will provide a serene retreat. From the house, it is a ten minute walk to downtown. Home features smart tv with Netflix, Hulu, and Sling. It also features high-speed wifi and air conditioning. Please note that the bedroom is upstairs and the bathroom is downstairs . Home Stay Permit # 0235-2020
4.87 out of 5 average rating, 221 reviews
Cottage in SLO / Historic Downtown District
“Cottage in SLO” is located in the historic district of San Luis Obispo with its century old homes and buildings. Enjoy the three block walk to downtown with all its amenities: Restaurants to please every pallet, from BBQ to gourmet. Coffee shops, theaters, galleries, and the world famous Farmers Market event every Thursday night. Bike paths are on the same street that will take you anywhere in SLO and beyond. . (Bikes provided) Perfect for two. Homestay permit # -0606-2019
4.98 out of 5 average rating, 695 reviews
Cozy Historic Craftsman Bungalow
Located in SLO's Old Town Historic District, featuring beautifully restored Victorian and Craftsman homes, this two bedroom Craftsman is less than a 5 minute walk to downtown shops/restaurants/nightlife. Despite its central location, the house is situated on a quiet street without heavy traffic. The property includes a private yard with a large (8 person) hot tub and grill. The kitchen is well stocked with everything you need for gourmet or casual cooking.
4.91 out of 5 average rating, 150 reviews
Serenity On Serrano
Serenity on Serrano is a Frank Lloyd Wright-inspired peaceful haven set in one of SLO's most prestigious neighborhoods right on the edge of a creek. This midcentury modern home is just steps to hiking, the downtown, shopping, and restaurants. Be prepared for nature as it's common to be greeted by wild turkeys, birds, and more. Enjoy the tranquility of minimalist design. Note: There is $25 per night for each extra guest over 4. Permit # H-0408-2023
4.86 out of 5 average rating, 141 reviews
Cozy Retreat Walking Distance to Downtown
This historic home has been recently remodeled. It sits in a quiet, friendly neighborhood which is walking distance to downtown. The second bedroom overlooks a large, beautiful garden and you can hear the gentle song of frogs at night and church bells in the morning. All beds feature luxury linens and the Wifi is fantastic! Forget your worries in this spacious and serene space. Walking distance to High Street Deli and Village Host Pizza.
4.76 out of 5 average rating, 233 reviews
The Downtown House SLO with Private Parking
Charming 1920s bungalow in the heart of downtown San Luis Obispo! Walk to top restaurants, coffee shops, parks, and the famous Farmers Market. Perfect for SLO Marathon runners—just a mile from the starting line. Original details + modern upgrades, A/C, full kitchen, laundry, and parking. Ideal for guests who love vibrant, walkable neighborhoods. We’re locals and happy to share our favorite hikes, wineries, and spots to explore!
4.96 out of 5 average rating, 474 reviews
Mid Century Modern Loft Downtown SLO
This unique place has a style all it's own. Mid century modern loft located just a few blocks from downtown SLO. 10 min walk and 3 min drive to all the great shops and restaurants SLO has to offer. Thick glass walls in the bedroom allow for an open loft like experience. Many fun details throughout the place create a truly unique vibe. This 800sf loft located upstairs above a salon is private and has designed parking.
4.99 out of 5 average rating, 337 reviews
Close to Downtown SLO
Enjoy this clean 420 sqft space in a great SLO location. Close distance to town, restaurants, bike paths & hiking. Private entrance. Open concept style, queen bed and twin sofa option. Large walk-closet with extra bedding and towels. Fully equipped kitchen: refrigerator, oven, microwave, dishwasher, reverse osmosis for drinking water & garbage disposal. Beautifully done bathroom with large shower & vanity
4.99 out of 5 average rating, 184 reviewsPopular amenities for holiday rentals near Mission San Luis Obispo de Tolosa
Condo rentals with Wi-Fi

The Hideaway in SLO
4.86 out of 5 average rating, 487 reviews
Beautiful Walk to Downtown from European Flat.
4.94 out of 5 average rating, 249 reviews
Downtown Loft with Panoramic Rooftop
4.87 out of 5 average rating, 108 reviews
Avila Good Life - A luxury 2 Bdrm condo 3 houses f
4.96 out of 5 average rating, 122 reviews
Coastal Home w/ EV Charger & BBQ near The Village
4.99 out of 5 average rating, 291 reviews
Spacious Luxury Condo! Recently Built 324 Stimson
4.99 out of 5 average rating, 150 reviews
Spacious Pismo Beach condo -block to sand and fun!
4.97 out of 5 average rating, 278 reviews
Grand Getaway: Ocean Views and Open Living Space!
4.98 out of 5 average rating, 266 reviewsFamily-friendly house rentals

OMG Playground, close to Beach, Family Fun
4.97 out of 5 average rating, 106 reviews
Cozy, Clean and Close to downtown SLO!
4.9 out of 5 average rating, 567 reviews
Boutique Bungalow, San Luis Obispo
4.88 out of 5 average rating, 307 reviews
Downtown Craftsman with Courtyard
4.99 out of 5 average rating, 161 reviews
Family Home Close to Downtown
4.91 out of 5 average rating, 411 reviews
The Cottage on Palm
4.95 out of 5 average rating, 102 reviews
Upscale. Pet friendly. Great location! 6-10 guests
4.95 out of 5 average rating, 256 reviews
Spacious SLO Retreat | Walk to DT/Parks
4.9 out of 5 average rating, 120 reviewsApartment rentals with air conditioning

Pet Friendly Bright & Airy SLO Apartment
4.99 out of 5 average rating, 301 reviews
Mountain View Studio - No Cleaning Fee!
4.97 out of 5 average rating, 397 reviews
Very Spacious Edna Valley Luxury Apartment
5.0 out of 5 average rating, 173 reviews
Downtown View Suite at Pismo Beach Club
4.87 out of 5 average rating, 430 reviews
Boho Bungalow with Ocean View in Grover Beach
4.89 out of 5 average rating, 426 reviews
Spacious 2BD w/rural views
4.98 out of 5 average rating, 291 reviews
Village Oasis
4.87 out of 5 average rating, 296 reviews
URGH Casita (Small House in a barn)
4.88 out of 5 average rating, 543 reviewsOther great holiday rentals near Mission San Luis Obispo de Tolosa

Amazing Airstream in private garden
4.86 out of 5 average rating, 343 reviews
Downtown Historic District Sunset Studio
4.97 out of 5 average rating, 631 reviews
Cozy Casita: Private Guest Unit in SLO
4.94 out of 5 average rating, 142 reviews
The "Chicken House" - Cozy, downtown SLO
4.99 out of 5 average rating, 251 reviews
Stylish and Comfortable Lofted Townhouse, Downtown SLO
4.99 out of 5 average rating, 578 reviews
Guesthouse Studio
4.97 out of 5 average rating, 117 reviews
Downtown SLO Abode- Walk downtown & close to Poly
5.0 out of 5 average rating, 156 reviews
Harris House
4.92 out of 5 average rating, 507 reviewsDestinations to explore
- Cayucos Beach
- Moonstone Beach
- Pismo State Beach
- Hearst Castle
- Morro Strand State Beach
- Montaña de Oro State Park
- Los Padres National Forest
- Cayucos State Beach
- Morro Rock Beach
- California Polytechnic State University
- Dinosaur Caves Park
- Sensorio
- Pismo Preserve
- Charles Paddock Zoo
- Monarch Butterfly Grove
- Vina Robles Amphitheatre
- JUSTIN Vineyards & Winery
- Tablas Creek Vineyard
- Downtown City Park
- Niner Wine Estates
- Talley Vineyards
- Harmony Headlands State Park
- Fess Parker Winery & Vineyard
- Adelaida Vineyards & Winery





