Holiday houses in Osborn Medical Center, Phoenix

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in Osborn Medical Center, Phoenix

Guests agree: these stays are highly rated for location, cleanliness and more.

%{current} / %{total}1 / 1
Top Guest favourite
A historic guesthouse is framed by a mix of stone and soft greenery. The outdoor area features a stone pathway, bordered by low shrubs, leading to a covered seating area under a wooden gazebo. Sunlight fills the scene, highlighting the inviting residence.
Guesthouse in Encanto
4.97 out of 5 average rating, 216 reviews

Best Little Guesthouse in Melrose !

Historic guesthouse in the heart of the Melrose District! EV charger! Walking distance to restaurants, bars, coffee shops, the famous Melrose Vintage shops, grocery stores, LA Fitness and more! Want to head downtown to Chase Field, Talking Stick Arena for a game or a show? Campbell Street Light Rail station is only five short blocks away! No need for a car, you can take the Light Rail from Sky Harbor International Airport, save your money for entertainment! Off street parking if you have a car!

Top Guest favourite
An inviting pool area features a spacious swimming pool surrounded by lounge chairs and tropical palm trees. A shaded patio with seating overlooks the pool, providing a relaxing outdoor space. The area is enclosed by a wooden fence and has landscaped greenery for added privacy.
Home in Encanto
4.97 out of 5 average rating, 230 reviews

Paradise Found, Conferences, Concerts, GCU, Pool

The historic Willo district of Central Phoenix is the perfect location to relax. Close to many attractions and major freeways, this completely renovated mid-century home offers the ultimate in both luxury and high-end fixtures. Inside, you can pamper yourself in the deep tub (with endless hot water) or multi-faucet shower, snuggle in the luxurious beds, or just laze in front of the 65" 4K TV. Outside, you can relax beside the pool (ask about heating), or just gather under the shaded patio.

Top Guest favourite
A charming historic cottage showcases a white exterior with black trim and a decorative porch railing. Light blue shutters accent the windows, which frame the inviting warm glow inside. Lush greenery borders the front of the house, complemented by a soft, pastel sky at dusk.
Home in Encanto
4.96 out of 5 average rating, 215 reviews

Storybook Perfect Historic Cottage Near Downtown

Reliably operated by a top AZ Superhost with 4,500+ 5 star stays. Best of EVERYTHING - a perfectly preserved historic cottage, with all new mechanicals for reliable comfort, designed and staged by a local legend, on one of the prettiest streets in Del Norte Historic district. The only Phoenix district to be surrounded by greenery on three sides. All just mere minutes to Downtown Phoenix and the airport. The area is terrific - lots of local restaurants and bars, and of course the Arts District.

Guest favourite
Guesthouse in Encanto
4.97 out of 5 average rating, 227 reviews

PHX's Modern Midtown Carriage House, Free Parking

Experience the perfect blend of historic charm and modern comfort in the heart of Phoenix's Midtown. Our beautifully designed Carriage House offers a unique guest quarters, complete with a full kitchen, luxurious queen bedding, and a private patio. Step outside and explore the vibrant neighborhood, filled with local restaurants, shops, and cultural attractions. Book your stay at the Midtown Carriage House today and discover the best of Phoenix living. check out on insta @midtowncarriagehouse

Top Guest favourite
A swimming pool surrounded by a white wall features a pebble tech finish. Two lounge chairs are positioned on the edge of the pool, with green grass along one side. Bright sunlight reflects off the water, creating a shimmering effect.
Guesthouse in Encanto
4.97 out of 5 average rating, 148 reviews

Poolside Guesthouse with Private Patio in Midtown

Welcome to the Poolside Guesthouse! Everything has been designed with you in mind to help you enjoy your time in Phoenix! Furniture and fixtures have been selected for your comfort and to help maximize the space. The Poolside Guesthouse has fantastic outdoor spaces for you to enjoy our beautiful weather & offers one of the best central locations with easy access to the airport, shopping, arts district, museums, bars and restaurants. TPT License #21525000 City of Phoenix License #2023-4161

Guest favourite
The exterior of a charming studio guesthouse is visible, showcasing a brown brick facade and a well-kept entrance. A small pathway leads to the door, and palm trees can be seen in the background against a bright blue sky.
Guesthouse in Phoenix College
4.97 out of 5 average rating, 1,304 reviews

Private, Sparkling Clean Historic DTPHX Guesthouse

This charming studio guesthouse in the Campus Vista historic district is a fantastic find! Situated in a friendly neighborhood in the heart of Phoenix, this newly remodeled living space is cozy and practical, surpassing many of the similar properties in quality and character. A short ten-minute drive from the Sky Harbor Airport, and located within walking distance to two major bus lines and the light rail, the guests are sure to enjoy the easy access to all the popular downtown destinations.

Top Guest favourite
A modern sleeping area features a spacious bed adorned with textured pillows. Natural light illuminates the room, enhancing the minimalist decor of framed artwork on the walls. A cozy bench and nightstand complement the design, while a private entrance is visible in the background.
Guesthouse in Story
5 out of 5 average rating, 116 reviews

Downtown Phoenix Private Casita - Story & Sol

Story & Sol is a new, fully equipped casita in the heart of FQ Story neighborhood in Downtown Phoenix. Stroll palm-lined streets and admire historic Arizona homes with charming landscapes as you discover all that Phoenix has to offer. Truly a cozy oasis in the heart of the City... minutes from restaurants, coffee shops, bars, farmers markets, & museums. Located off the I-10, Story & Sol is the perfect launch pad for adventures across the Valley of the Sun in our beautiful Grand Canyon state.

Top Guest favourite
A dining area features a white pedestal table surrounded by soft pink chairs. A light fixture hangs above, and the adjacent kitchen displays pastel pink cabinetry with floral detailing. Natural light enters through nearby windows, enhancing the bright and welcoming ambiance.
Home in Encanto
4.92 out of 5 average rating, 107 reviews

Historic Cottage! Walk to Restaurants & Nightlife

Welcome to Melrose Cottage, a 1937 historic gem with timeless charm and a playful pink accents . Nestled in Phoenix’s vibrant Melrose District, you’ll be steps from top-rated restaurants and bars like Across the Pond and Clever Koi. Inside, enjoy original oak floors, arched walkways, and a spacious backyard perfect for relaxing. Lovingly cared for over the decades, Melrose Cottage combines vintage character with an unbeatable location in one of Phoenix’s most culturally rich neighborhoods.

Guest favourite
The facade of the red brick home is framed by two tall pine trees, with a well-maintained front lawn featuring green grass. A concrete driveway leads towards the entrance, while landscaping with shrubs and a gravel border adds to the exterior appeal.
Home in Encanto
4.92 out of 5 average rating, 366 reviews

Beautifully Charming Redbrick Home

Two-bedroom home with an office located within a few miles of Downtown and Uptown Phoenix.  Location is perfect for easy access to all that Phoenix provides. This charming 1943 red brick home features a classic design with a warm, inviting facade. Spanning 1,380 square feet, it includes two cozy bedrooms and office with two full bathrooms, making it ideal for couples or families seeking extra space. We also have a guest house in the rear of the property that is leased on Airbnb.

Guest favourite
Home in Phoenix
4.93 out of 5 average rating, 505 reviews

Uptown Historic Home | Resort Style Outdoor Space

Experience Monarch House in a Phoenix Historic District—your spa-like retreat with unique artistic touches. The well-designed interior features a dining room and a fully equipped kitchen, perfect for memorable meals. Located in Uptown Phoenix, enjoy trendy restaurants, local boutiques, and vibrant nightlife just minutes away. Seamlessly switch between two private outdoor spaces and a shared courtyard, featuring an outdoor dining room and cozy fire pit.

Top Guest favourite
A spacious living area contains a light grey loveseat and a small wooden desk paired with a chair. A decorative lamp provides soft lighting beside the couch. Artwork is displayed on the wall above the desk, and large windows allow natural light to fill the room.
Guesthouse in Encanto
5 out of 5 average rating, 238 reviews

Adorable Willo Cottage in Historic Central Phoenix

Peaceful one bedroom cottage in unbeatable location within Central Phoenix. Walking/ biking distance from light rail, restaurants, Heard Museum and Phoenix Art Museum. Enclosed backyard with a shared washer/dryer on property. The cottage has a queen bed, mini kitchen and private patio. Property is cleaned and sanitized according to the Airbnb cleaning procedures. 15 minutes from Sky Harbor Airport. 5 minutes from Encanto Park (Golf Course)

Top Guest favourite
An outdoor patio area features a dining table and comfortable seating, overlooking a private unheated pool. A barbecue grill is positioned nearby, with a television mounted on the wall for entertainment. Lush landscaping and a palm tree are visible in the background.
Home in Phoenix
4.95 out of 5 average rating, 236 reviews

Home in Camelback East

Newly renovated home with an amazing backyard in the prime location of Uptown Phoenix! A great place to stay for families and friends. There are 3 bedrooms, two with full bathrooms. Stocked with all the essentials. Enjoy the backyard retreat with pool, bbq, as well as a TV to enjoy watching sports or anything you choose. Close to many restaurants and shopping. Only 15 minute drive from Phoenix Sky Harbor International airport. Peloton bike!

Popular amenities for Osborn Medical Center, Phoenix holiday rentals