Holiday houses in Osborn Medical Center, Phoenix

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Top-rated holiday rentals in Osborn Medical Center, Phoenix

Guests agree: these stays are highly rated for location, cleanliness and more.

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Top Guest favourite
An inviting pool area features a spacious swimming pool surrounded by lounge chairs and tropical palm trees. A shaded patio with seating overlooks the pool, providing a relaxing outdoor space. The area is enclosed by a wooden fence and has landscaped greenery for added privacy.
Home in Encanto
4.97 out of 5 average rating, 230 reviews

Paradise Found, Conferences, Concerts, GCU, Pool

The historic Willo district of Central Phoenix is the perfect location to relax. Close to many attractions and major freeways, this completely renovated mid-century home offers the ultimate in both luxury and high-end fixtures. Inside, you can pamper yourself in the deep tub (with endless hot water) or multi-faucet shower, snuggle in the luxurious beds, or just laze in front of the 65" 4K TV. Outside, you can relax beside the pool (ask about heating), or just gather under the shaded patio.

Top Guest favourite
A charming historic cottage showcases a white exterior with black trim and a decorative porch railing. Light blue shutters accent the windows, which frame the inviting warm glow inside. Lush greenery borders the front of the house, complemented by a soft, pastel sky at dusk.
Home in Encanto
4.96 out of 5 average rating, 215 reviews

Storybook Perfect Historic Cottage Near Downtown

Reliably operated by a top AZ Superhost with 4,500+ 5 star stays. Best of EVERYTHING - a perfectly preserved historic cottage, with all new mechanicals for reliable comfort, designed and staged by a local legend, on one of the prettiest streets in Del Norte Historic district. The only Phoenix district to be surrounded by greenery on three sides. All just mere minutes to Downtown Phoenix and the airport. The area is terrific - lots of local restaurants and bars, and of course the Arts District.

Top Guest favourite
A charming front porch showcases a light blue door, flanked by two wooden Adirondack chairs. The area is adorned with climbing greenery and decorative stone, while fresh landscaping is visible in the foreground. Soft sunlight creates a welcoming ambiance.
Bungalow in Coronado
4.97 out of 5 average rating, 112 reviews

Rancho Bungalow + Casita with Airstream in Phx

5 minutes to the heart of Downtown! Designed for ultimate entertaining and a relaxing experience while staying in Phoenix! This unique property has a magazine-worthy bungalow with a renovated Airstream and Guest House. Living quarters open up to a private peaceful backyard with jacuzzi, fire pit, fountain, and outdoor seating. A style all its own! You will find yourself right next to stadiums and among the best coffee shops, local eateries, and entertainment the state has to offer. Lucky you!

Superhost
Home in North Encanto
4.79 out of 5 average rating, 199 reviews

Mid-Century Modern Charmer with FREE heated pool!

Newly updated Mid-Century modern residence in the heart of Central Phoenix. VERY private heated swimming pool surrounded by tall greenery. (Pool is heated at no charge) Pets stay for free! Super comfy luxury beds with variety of mattresses! Large open kitchen with full size stainless steel appliances and granite countertops. Located in a quiet historic neighborhood of Central Phoenix and close to fabulous dining, bars and services. Sought after location! 2 car garage! We support equality!

Guest favourite
The exterior of a charming studio guesthouse is visible, showcasing a brown brick facade and a well-kept entrance. A small pathway leads to the door, and palm trees can be seen in the background against a bright blue sky.
Guesthouse in Phoenix College
4.97 out of 5 average rating, 1,304 reviews

Private, Sparkling Clean Historic DTPHX Guesthouse

This charming studio guesthouse in the Campus Vista historic district is a fantastic find! Situated in a friendly neighborhood in the heart of Phoenix, this newly remodeled living space is cozy and practical, surpassing many of the similar properties in quality and character. A short ten-minute drive from the Sky Harbor Airport, and located within walking distance to two major bus lines and the light rail, the guests are sure to enjoy the easy access to all the popular downtown destinations.

Guest favourite
A modern dining area features a large wooden table surrounded by six stylish chairs. The space is adorned with exposed brick walls and large windows, allowing natural light to fill the room. A unique centerpiece sits atop the table, enhancing the contemporary design.
Villa in North Encanto
4.96 out of 5 average rating, 26 reviews

Spanish Modernism 3BR with studio and pool

Modernism meets Spanish revival in this beautifully restored home plus rear studio in the Encanto Historic District. Meticulously restored - everything is brand new but with respect for the homes original character. Our home is located in a quiet, safe neighborhood while also close to hip restaurants, nightlife, and minutes to downtown. This home as been a very special second home for us and we welcome all - we will never decline a guest based on race, color, religion or sexual orientation.

Top Guest favourite
A charming green guesthouse is framed by lush landscaping under a vibrant sunset sky. Outdoor string lights provide a warm glow, enhancing the welcoming ambiance. A manicured grassy area and stone pathway lead to the inviting entrance of the standalone property.
Guesthouse in Phoenix
4.97 out of 5 average rating, 327 reviews

Cute Casita Guesthouse (No Cleaning Fee)

Cute guesthouse w/kitchen, comfy queen bed, twin sofa bed couch, walk-in shower, nicely landscaped yard w/grill, fire pit & outdoor seating. Located in the heart of Central Phoenix. 15 min from PHX w/ easy access to major attractions (i.e., Camelback, Piestewa Peak, Desert Botanical Garden, Heard Museum). Centrally located near to the 10 Cactus League Spring Training MLB stadiums for 15 teams. Minutes from great restaurants and shopping. Non-smoking/no-vaping property/no pets.

Top Guest favourite
The kitchen features a large central island with seating for four, complemented by modern stainless steel appliances and sleek cabinetry. A cozy dining area is positioned next to large windows, allowing natural light to fill the space and providing views of the outdoor surroundings.
Home in Encanto
5 out of 5 average rating, 103 reviews

2 Bedroom 2 Bath Home in Historic Neighborhood

This beautiful historic home is perfectly located for your stay in the Valley of the Sun. PHX Retreat is just minutes from Phoenix Sky Harbor Airport, downtown Phoenix, and Arcadia neighborhoods. PHX Retreat is also located in close proximity to multiple highways, so you will have a quick drive to Scottsdale, Tempe, Spring Training Venues, GCU, and any other destinations you are looking to explore. The quiet residential neighborhood is the perfect escape after a day of exploring.

Guest favourite
An open living area features a wooden dining table surrounded by four chairs, adjacent to a cozy seating area with a red couch. A decorative area rug enhances the floor, while artwork adorns the walls, contributing to a welcoming ambiance.
Home in Encanto
4.83 out of 5 average rating, 301 reviews

Central PHX, Pet-friendly, 3 Bedroom, 2 Bath House

Pet friendly, Central Phoenix house. Remodeled, 3 comfy bedrooms, spa-like baths & a family room large enough to accommodate everyone. The private backyard provides a great space for BBQ's, family celebrations (on approval only) or just relaxing around the fire pit (while your pets run & stretch their legs). CENTRALLY LOCATED TO DOWNTOWN, GCU, LIGHT RAIL, HIKING, RESTAURANTS, THEATRES, SHOPPING & STADIUMS! Small gatherings ON APPROVAL ONLY! NO PARTIES! STR-2025-002573

Guest favourite
Guesthouse in Phoenix
4.95 out of 5 average rating, 589 reviews

Spacious Studio in Uptown Historic Neighborhood

Discover Uptown Phoenix and its vibrant charm! Nestled in the historic district, our property offers a serene escape in the heart of the Valley. This spacious, private studio features a resort-style outdoor retreat, a shared courtyard, a gourmet grill, two outdoor dining areas, and a cozy fire pit to unwind. Inside, relax in a comfortable living room, enjoy meals or card games at the dining table, and retreat to a glamorous bedroom for the perfect end to your day.

Guest favourite
The inviting bedroom features a queen size bed with a quilted cover, complemented by soft blue curtains. Natural light enters through double doors that lead to the outside. A cozy seating area is situated nearby, enhancing the room's comfort and warmth.
Guesthouse in Encanto
4.95 out of 5 average rating, 757 reviews

Guesthouse in city's most walkable neighborhood

Central location, easy access to I-10, I-17, 202, 51, and 9 minutes from Phoenix Sky Harbor Airport. Amenities abound in this updated private studio guesthouse in the upscale Encanto-Palmcroft Historic District of downtown Phoenix. Homes here have stunning architectural diversity. Recently ranked the wealthiest neighborhood in Phoenix, Phoenix Magazine named Encanto-Palmcroft 2009's "Best Places to Live" and the "Best Neighborhood to Walk Through" in 2015.

Top Guest favourite
A spacious living area contains a light grey loveseat and a small wooden desk paired with a chair. A decorative lamp provides soft lighting beside the couch. Artwork is displayed on the wall above the desk, and large windows allow natural light to fill the room.
Guesthouse in Encanto
5 out of 5 average rating, 238 reviews

Adorable Willo Cottage in Historic Central Phoenix

Peaceful one bedroom cottage in unbeatable location within Central Phoenix. Walking/ biking distance from light rail, restaurants, Heard Museum and Phoenix Art Museum. Enclosed backyard with a shared washer/dryer on property. The cottage has a queen bed, mini kitchen and private patio. Property is cleaned and sanitized according to the Airbnb cleaning procedures. 15 minutes from Sky Harbor Airport. 5 minutes from Encanto Park (Golf Course)

Popular amenities for Osborn Medical Center, Phoenix holiday rentals