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Family-friendly holiday rentals in Cape Girardeau

Find and book unique family-friendly homes on Airbnb

Quick stats about holiday rentals that are family-friendly in Cape Girardeau

  • Total holiday rentals

    Explore 70 holiday rentals in Cape Girardeau

  • Nightly prices starting at

    Cape Girardeau holiday rentals start at $101 NZD per night before taxes and fees

  • Verified guest reviews

    Over 4,040 verified reviews to help you choose

  • Pet-friendly accommodation

    Find 20 rentals that welcome pets

  • Rentals with dedicated workspaces

    40 properties have a dedicated workspace

  • Wi-Fi availability

    70 of Cape Girardeau holiday rentals include Wi-Fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi and Pool across Cape Girardeau rentals

  • 4.8 Average rating

    Cape Girardeau stays are highly rated by guests—averaging 4.8 out of 5!

Top-rated family-friendly rentals in Cape Girardeau

Guests agree: These family-friendly homes are highly rated for location, cleanliness and more.

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Top Guest favourite
A vibrant red barn with an American flag motif is featured alongside a well-maintained gravel path. The barn displays a sign quoting a biblical verse, and a historic farmhouse is visible in the background against a clear blue sky.
Farm stay in Frohna

The Weber Farm - Enjoy a beautiful 100 acre farm!

Enjoy a 125+ year old country home with large yard and beautiful shade trees located on a 100-acre farm in the rolling hills of SE Missouri. The house is very clean and spacious with 4 large bedrooms, comfortable beds, beautiful hardwood floors and a large living room. We have hand-made quilts and antique furniture throughout. The kitchen is fully furnished. Relax on our 40’ front porch with swing, by the fire pit or in a hammock. A perfect place for you to recharge from stress & busy schedules!

4.99 out of 5 average rating, 139 reviews
Top Guest favourite
A full-size bed is showcased with a light gray duvet and patterned pillows, positioned against a green headboard. Two bedside lamps are placed on either side of a small nightstand. A wall clock and storage bins add functional touches to the cozy living space.
Guesthouse in Cape Girardeau

Cozy 1-BR guest house w/free parking on premises

Enjoy a cozy experience at this centrally, located place. Literally, a 1-4 minute walk to Mercy Hospital(formerly Southeast Hospital), less than 1 mile to Southeast University Campus, along with downtown(river). A street over is Broadway with many restaurants. Walmart Market and Dollar General are also conveniently located nearby. The kitchen is fully furnished with cooking utensils, clean towels, pots and pans for those who prefer eating in. Please no animals and no smoking in the apartment.

4.94 out of 5 average rating, 174 reviews
Top Guest favourite
A view from the front porch showcases a vibrant autumn scene, with trees covered in golden leaves. A cozy seating area is visible, framed by white railings, and a peaceful street with fallen leaves creates a calm atmosphere.
Apartment in Cape Girardeau

Beautiful Historic Boulevard District Apartment

This beautiful, private upstairs apartment is located on a favorite street in Cape Girardeau’s Historic Boulevard District. It is walking distance to SEMO University, Capaha Park, and the downtown riverfront. Recently remodeled for laundry, spacious rooms offer private bedroom spaces and a cozy den for watching movies or reading. The kitchen is fully equipped with amenities. This quiet neighborhood setting even has a front porch swing and sitting area where you can enjoy your morning coffee.

4.98 out of 5 average rating, 471 reviews
Top Guest favourite
An exterior view of the entrance features a welcoming white door framed by black accents. A small staircase leads up to the door, complemented by a light fixture. A vehicle is parked near the entrance, with a tree and a fenced area visible in the background.
Guest suite in Cape Girardeau

MAINSTAY CAPE [downtown]

Nestled in the heart of the Downtown Historic District, this suite is centrally located as a prime destination for any and all travelers alike. With parking available, this space offers a unique & trendy “midwest boho” vibe. ~WALKABLE~ Our studio is 1 block from the bustling Southeast Missouri State University, 1 block from the gorgeous Capaha Park, and 2 blocks from Mercy Hospital. If you are interested in night life, this space is simply a 5-10 minute walk to all DT bars and restaurants.

4.98 out of 5 average rating, 186 reviews
Top Guest favourite
A spacious living area features large windows allowing natural light to fill the space. A comfortable grey sofa is paired with a unique coffee table, while stylish dining chairs surround a white table. The kitchen area includes modern appliances and cabinetry.
Apartment in Cape Girardeau

Brand new 2 bedroom unit right in downtown Cape.

This special place is close to everything, making it easy to plan your visit. Walking distance to restaurants, the river and nightlife. Property includes wifi, full kitchen, laundry, deck and private parking for one. One king bed room and a twin bed room in addition to a roll out twin bed along with a 60 inch smart television. Dog bed and bowls included along with board games! Property is conveniently located across the street from "The Bar" the famous spot from the movie "Gone Girl" .

4.95 out of 5 average rating, 320 reviews
Top Guest favourite
The building features classic brick architecture with ornate ironwork detailing on the balcony. A large clock is positioned on the exterior wall. Nearby streets and parked vehicles are visible, along with a clear blue sky providing a bright backdrop.
Apartment in Cape Girardeau

Historical Kage House

The Building is reminiscent of eighteenth-century New Orleans architecture, and was built sometime before 1883. The Kage House is located at 120 Broadway in the historical district and is less than a minutes walk to Main Street and less than a 10 minutes walk to the Isle of Capri Casino. On Main Street you will find many fine shops and restaurants, or just enjoy the scenic area as you walkabout. This is by far one of the best places in Cape. Additional reviews can be read on the VRBO website.

4.98 out of 5 average rating, 114 reviews
Guest favourite
The custom-built treehouse is elevated on stilts, surrounded by greenery. A spacious deck features a railing, offering access to the entrance. Steps lead to the ground below, while large glass doors enhance the connection to nature.
Treehouse in Cape Girardeau

Twisted Sassafras Treehouse

A custom-built treehouse located on 10 acres with a water view that you can take in from the hot tub on the deck! It is nestled high in the trees and is the perfect romantic getaway for two! Feel like you are away from it all without being away from it all! This treehouse is located on a county road just minutes from Cape Girardeau. Enjoy catch and release fishing on site, local wineries, shopping in historic downtown Cape Girardeau, local restaurants, gambling, historical sites & more!

5.0 out of 5 average rating, 214 reviews
Superhost
A spacious living room is furnished with a large sectional couch, complemented by decorative pillows. A wooden coffee table sits center stage on an area rug. A ceiling fan is visible, and light enters through window treatments, creating a comfortable atmosphere.
Home in Cape Girardeau

5 Bed Home in Great Neighborhood - Sleeps 10

Looking for a comfortable and spacious Airbnb in Cape Girardeau? 🏡✨ This 3 bedroom, 2 bathroom home in a great neighborhood is the perfect spot for your next group stay. This home features great living areas to relax and unwind including a living room with a large sectional and 70 inch TV. The game room features an air hockey table, dart board, and other board games. It will sleep 10 comfortably. Make this your destination for your next girls trip, sports tournament, or SEMO event.

4.82 out of 5 average rating, 152 reviews
Top Guest favourite
A modern farmhouse is depicted at sunset, featuring a welcoming entrance with a covered porch. A stone pathway leads to the front door, bordered by a grassy lawn that extends to fields and trees in the background.
Barn in Cape Girardeau

Under the Stars - Farmhouse

Enjoy the tranquility of this modern farmhouse charmer! Custom built minutes from downtown Cape. Relax outside around the fire pit, roast marshmallows and watch the sunset. Finish the night with a long soak in the hot tub. Start the morning on the front porch rocking chairs and take in a sunrise. Open concept, fully equipped kitchen, 3 Bd. including King master/full bath, 2 Queens with full guest bath. Near Trail of Tears and walking distance to classic dive bar/burger joint

4.94 out of 5 average rating, 281 reviews
Top Guest favourite
A spacious bedroom features a queen-size bed with a patchwork quilt, complemented by bedside tables and lamps. Natural light floods through large windows adorned with sheer curtains. A ceiling fan is mounted on the wooden-paneled ceiling, adding to the comfortable ambiance.
Guesthouse in Cape Girardeau

Private two room suite in downtown Cape Girardeau

Spacious two room suite with a queen size bed in one room along with a single bed and a futon sofa in the other room. Private full bathroom. Kid friendly. Refrigerator with drinks available. Separate heating and cooling control. Cathedral ceiling. Located in a good neighborhood. Walking distance to downtown, riverfront, restaurants, and musical venues such as the university River Campus. A wide porch and large goldfish pond are in front. The suite is on the second level of the home.

5.0 out of 5 average rating, 129 reviews
Top Guest favourite
A cozy living space features exposed brick walls complemented by a patterned area rug. Two armchairs provide comfortable seating, one in a checked pattern and the other a textured fabric. A window is adorned with sheer and geometric-patterned curtains, allowing natural light to illuminate the room.
Guesthouse in Cape Girardeau

Downtown Guesthouse- Romantic Getaway

The guesthouse seamlessly blends modern amenities with historic charm in a cozy, compact space. The antique claw foot tub/shower combo offers a charming, yet snug, spot for a relaxing soak—true to its historic roots, the bathroom could be best described as a quaint water closet. After a day of exploring unwind in the patio. Play a favorite record, and savor your coffee while daydreaming about new experiences. Despite its small size, it provides all the modern comforts you need.

4.94 out of 5 average rating, 608 reviews
Top Guest favourite
A modern kitchen is presented, featuring stainless steel appliances and a combination of open shelves and cabinets. Cookware and dishes are arranged thoughtfully, while natural light highlights the sleek countertop and wooden accents. A dark chair adds a touch of contrast.
Home in Cape Girardeau

Tiny Cozy Apt. (Suite A) in Cape Girardeau MO

Welcome to our cozy & tiny apt. attached to our house ! You are going to have an entire space for yourself with private entry ! You can almost drive to everywhere within 5mins-10mins in Cape Girardeau/Jackson , and very peaceful and quiet neighborhood. Very close distance to some restaurants, gas station, and Cape trail to take a walk or bike ride. You might see some deer in our front / back yard in the evening

4.99 out of 5 average rating, 129 reviews

Popular amenities for Cape Girardeau family-friendly rentals

KitchenWifiPoolFree parking on premisesAir conditioning

Family-friendly home rentals with a hot tub

Top Guest favourite
Home in Alto Pass

Fall in Shawnee | 20 Acres | Wine & Bourbon

4.96 out of 5 average rating, 108 reviews
Top Guest favourite
A modern dome structure features large glass panels creating a bright and inviting environment. Surrounded by lush greenery, the architecture harmonizes with nature. A wooden deck with seating is visible in front, offering a space for relaxation and outdoor enjoyment.
Dome in Cobden

The Dome At Blueberry Hill

5.0 out of 5 average rating, 224 reviews
Top Guest favourite
The treehouse structure is elevated, supported by stilts, with large windows that reflect the surrounding greenery. The exterior features a combination of wood finishes, and warm lighting casts a welcoming glow in the evening. The pathway leads through the natural landscape to the entrance.
Treehouse in Perryville

Private Treehouse Retreat | Hot tub

5.0 out of 5 average rating, 716 reviews
Top Guest favourite
An inviting modern cabin exterior is illuminated at dusk. The deck features outdoor seating with a table and chairs, complemented by a hot tub nearby. Soft lighting outlines the steps, providing a warm glow against the backdrop of a deep blue sky.
Cabin in Pomona

Modern Cabin at Trillium Ridge

5.0 out of 5 average rating, 160 reviews
Top Guest favourite
A cozy living area is presented, featuring a stone fireplace with a mounted television above. Comfortable seating options include a leather armchair and a soft couch, arranged around a wooden coffee table. Natural light filters in through the window, enhancing the tranquil environment.
Cabin in Makanda

Sanctuary Cabin- Hot Tub & Woods

4.98 out of 5 average rating, 173 reviews
Top Guest favourite
The bedroom features a spacious bed with a textured tan coverlet, flanked by two bedside lamps. A large window offers views of the outdoors, while an armchair adds a cozy seating option. A decorative area rug enhances the room's comfort and style.
Cabin in Carbondale

Wooded Cabin · Hot Tub, Firepit & Giant City

4.99 out of 5 average rating, 113 reviews
Top Guest favourite
Treehouse in Perryville

Rustic reTREEt Treehouse Getaway

4.95 out of 5 average rating, 210 reviews
Guest favourite
A charming exterior view of a blue house is presented, featuring white trim and multiple windows. A covered porch area includes two red chairs and a black barbecue grill. Flower beds with plants are positioned along the front, set against a gravel area and surrounding greenery.
Home in Cobden

Wine trail cozy cabin! Hot Tub!

4.95 out of 5 average rating, 103 reviews

Family- and pet-friendly home rentals

Guest favourite
Home in Cape Girardeau

College town Charm: Minutes from Downtown Cape

4.92 out of 5 average rating, 183 reviews
Top Guest favourite
The geodesic dome is illuminated warmly from within, creating a welcoming glow against the night sky. The structure's unique shape and large window reveal a glimpse of the cozy interior, showcasing a serene space ideal for relaxation and connection with nature.
Dome in Perryville

The Snow Globe*OffGrid DomeGLAMP*Adventurers Only

4.94 out of 5 average rating, 177 reviews
Guest favourite
A cozy living area is furnished with a large sectional sofa and a matching armchair, complemented by decorative cushions. Light filters through window blinds, and a soft area rug covers the hardwood floor. A small table is positioned nearby.
Home in Carbondale

Relaxing 3 Bedroom Cottage in Quiet Neighborhood

4.87 out of 5 average rating, 331 reviews
Top Guest favourite
A serene cabin sits amidst lush greenery, surrounded by trees that reflect in a tranquil pond. A well-kept lawn leads up to the entrance, enhancing the peaceful setting. Blossoming branches frame the scene, adding a touch of nature’s elegance.
Cabin in Cobden

Unique luxury cabin with fireplace and pond view

4.97 out of 5 average rating, 146 reviews
Top Guest favourite
A rustic cottage is nestled among tall trees, showcasing a natural setting during autumn. Colorful fall foliage blends with the greenery, while fallen leaves cover the ground. The warm tones of the cottage complement the serene landscape.
Place to stay in Cobden

Cobden Retreat in the Woods

4.95 out of 5 average rating, 341 reviews
Guest favourite
A charming duplex exterior is shown, featuring a red wooden facade with a light brown roof. Flower pots line the front, and multiple windows allow natural light. A gravel driveway leads to the entrance, with a satellite dish mounted on the roof.
Home in Makanda

Cedar Lake Retreat A

4.85 out of 5 average rating, 143 reviews
Superhost
A living area features a brown leather sofa complemented by decorative cushions. A wooden coffee table sits atop a patterned area rug, while wall decor adds visual interest. Soft natural light enters through nearby windows, illuminating the space with a warm ambiance.
Home in Murphysboro

Country Club Road Getaway

4.9 out of 5 average rating, 105 reviews
Top Guest favourite
A spacious living area features exposed brick walls and original wood floors. Large windows provide natural light, while a comfortable sofa and dining table accommodate relaxation and meals. An area rug adds color, and modern lighting enhances the inviting atmosphere.
Loft in Perryville

Downtown Urban Loft #9 – Above Mary Jane Burgers

4.97 out of 5 average rating, 335 reviews

Family-friendly home rentals with a pool

Top Guest favourite
A charming log cabin is framed by vibrant autumn foliage, with trees and shrubs displaying various shades of orange and green. A circular driveway leads to the entrance, where a welcoming porch provides a space to enjoy the surrounding nature and seasonal changes.
Home in Murphysboro

Embers of Murphysboro

4.98 out of 5 average rating, 168 reviews
Guest favourite
A wooden Japanese Ofuro soaking tub is illuminated by soft ambient lighting. Two individuals relax with their feet visible, surrounded by lush greenery and colorful garden lights. A glass of wine rests within reach, enhancing the serene ambiance.
Guesthouse in Carbondale

Carbondale Pool House - Sauna, Hot Tub, Dogs OK

4.99 out of 5 average rating, 282 reviews
Guest favourite
A rustic cabin entrance is framed by wooden logs, featuring a simple porch with a swing. A single door is adorned with a number, while a window allows natural light to enter the space. Lush greenery surrounds the cabin for a tranquil setting.
Cabin in Perryville

Rustic Bass Cabin KK3

4.92 out of 5 average rating, 12 reviews
Top Guest favourite
The cabin features a welcoming entrance with a ramp and wooden deck, surrounded by a natural landscape. The exterior is constructed from warm-toned logs, complemented by a green roof and large windows providing plenty of natural light.
Cabin in Sedgewickville

Cozy Country Cabin

5.0 out of 5 average rating, 55 reviews
Top Guest favourite
The master suite features a spacious bed adorned with colorful bedding, complemented by a cozy seating area. Large windows provide natural light and views of the surrounding landscape. Tile flooring and warm-colored walls enhance the inviting atmosphere of the room.
Home in Cobden

House 36

5.0 out of 5 average rating, 37 reviews
Guest favourite
Home in Cape Girardeau

3+ acre:King Bed, Hot Tub, Mini Golf, Pool Table

4.74 out of 5 average rating, 263 reviewsA calming saltwater pool is surrounded by a black metal fence, with a vibrant tree providing shade nearby. The pool area features an inviting blue hue, contrasting with the warm tones of the adjacent landscaping and architecture.
Apartment in Cape Girardeau

Location, Location, Location!

Superhost
A cozy cabin is set amongst trees, featuring a wooden porch with steps leading up to a welcoming entrance. Large windows with shutters allow natural light to brighten the interior. The earthy tones of the wooden exterior blend harmoniously with the surrounding nature.
Cabin in Perryville

Black Bear Cabin K03A

5.0 out of 5 average rating, 7 reviews