Guesthouse holiday rentals in James Island
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Top-rated Guesthouses in James Island
Guests agree: These guesthouses are highly rated for location, cleanliness and more.
Holiday rentals for every style
Get the amount of space that is right for you
Popular amenities for James Island guesthouses
Family-Friendly guesthouses
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 214 reviewsBungalow Under The Oaks
21–28 Sep
Guesthouse in Charleston
4.93 out of 5 average rating, 317 reviewsCozy Island Cottage
1–8 Nov
Guesthouse in North Charleston
4.94 out of 5 average rating, 346 reviewsCozy Park Circle, Charleston Guest House
30 Aug – 6 Sep
Guesthouse in Summerville
4.98 out of 5 average rating, 643 reviews★Delightful guest house near historic plantations★
10–17 Aug
Guesthouse in Johns Island
4.98 out of 5 average rating, 239 reviewsPrivate waterfront apt in the oaks
22–29 Jul
Guesthouse in Mount Pleasant
4.95 out of 5 average rating, 220 reviewsGreen Garden Studio @greengardenstudio2017
23–30 Oct
Guesthouse in North Charleston
5.0 out of 5 average rating, 111 reviewsThe Park Circle Clerestory Studio Guest House
21–28 Jun
Guesthouse in Charleston
4.84 out of 5 average rating, 110 reviewsRomantic Beach Style Cottage close to everything!
10–17 Apr
Guesthouses with a patio
Guesthouse in Charleston
4.98 out of 5 average rating, 123 reviewsPrivate Backyard With Fire Pit, 15 Min to Downtown
15–22 Feb
Guesthouse in Charleston
4.97 out of 5 average rating, 127 reviewsStudio Apartment Minutes to Downtown Charleston
22–29 Apr
Guesthouse in Johns Island
4.91 out of 5 average rating, 105 reviewsCozy Cottage! 5 mins from Kiawah!
19–26 Jul
Guesthouse in Charleston
4.98 out of 5 average rating, 45 reviewsCountry in the City, "The Outback"
25 Feb – 4 Mar
Guesthouse in Charleston
5.0 out of 5 average rating, 23 reviews1/1 sleeps 3 ADU Modern+Amazing!
9–16 Jul
Guesthouse in Charleston
4.95 out of 5 average rating, 40 reviewsGuest suite in Charleston
12–19 Feb
Guesthouse in Charleston
5.0 out of 5 average rating, 13 reviewsGas Light Carriage House James Island
13–20 Aug
Guesthouse in Charleston
4.82 out of 5 average rating, 93 reviewsGuest Suite by the Beach
12–19 Aug
Guest house rentals with a washing machine and dryer
Guesthouse in Charleston
4.96 out of 5 average rating, 237 reviewsUnique Hidden Gem w/ Luxury Shower Near Folly & DT
19–26 Nov
Guesthouse in Charleston
4.98 out of 5 average rating, 107 reviewsCharleston Casita near Folly Beach *Dog Friendly*
15–22 Sep
Guesthouse in Mount Pleasant
4.97 out of 5 average rating, 407 reviewsGuesthouse Convenient to Charleston, Shem Creek, and Beaches
8–15 Mar
Guesthouse in Charleston
4.99 out of 5 average rating, 142 reviewsLarge Guesthouse with Private Dock & Marsh Views
1–8 Jan
Guesthouse in Charleston
4.98 out of 5 average rating, 244 reviewsDetached Guest Suite
20–27 Jan
Guesthouse in Mount Pleasant
4.97 out of 5 average rating, 222 reviewsCozy Apartment in Mount Pleasant
9–16 Dec
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 436 reviewsOld Mt. Pleasant/Shem Creek close to Sullivans/DT
2–9 Nov
Guesthouse in Charleston
4.99 out of 5 average rating, 206 reviewsRedesigned suite! 12min to city, pet-friendly
22–29 Sep
Destinations to explore
- Savannah Holiday rentals
- Hilton Head Island Holiday rentals
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- Folly Beach Holiday rentals
- Surfside Beach Holiday rentals
- Mount Pleasant Holiday rentals
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- Kid-friendly rentals James Island
- Rentals with a patio James Island
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- Waterfront rentals James Island
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