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Guesthouse holiday rentals in Mission Bay, San Diego

Find and book unique guesthouse rentals on Airbnb

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Popular amenities for Mission Bay, San Diego guesthouses

Family-Friendly guesthouses

Top Guest favourite
Guesthouse in Talmadge
4.98 out of 5 average rating, 209 reviews

Lovely Guesthouse in garden setting

RamonaRating, 5 stars6 months ago
We are so grateful to have been able to stay at Gwynn's place, it is so peaceful and lovely. Like a secret garden getaway. We loved all the small touches, and beauty of the space. Gwynn made us feel very welcome and comfortable! The pool is amazing and the outdoor spaces are delightful. Can't wait to stay here again.
Guest favourite
Guesthouse in La Jolla
4.79 out of 5 average rating, 193 reviews

San Diego Shangri-La

EricRating, 5 stars3 weeks ago
I really enjoyed staying here. It's on a canyon, which provided a great view and a nice breeze and was very quiet. We had our little dog with us and he loved being able to explore the yard. It's a great location in La Jolla / North PB. It's at the top of my list for my next trip to San Diego.
Top Guest favourite
Guesthouse in La Jolla
4.99 out of 5 average rating, 367 reviews

Charming Seashell Cottage Overlooking Garden

EileenRating, 5 stars3 weeks ago
So eloquently and thoughtfully appointed in terms of design. So quiet and peaceful, and exceptionally clean. All of your potential needs are thought of.
Top Guest favourite
Guesthouse in La Mesa
4.99 out of 5 average rating, 279 reviews

Spacious, private Mt. Helix country style studio

RhondaRating, 5 stars1 month ago
Absolutely worth it. Beautiful place. Cozy with gorgeous gardens. Also a nice welcome touch of bowl of fruits, chocolates and plenty to drink. Loved it.
Top Guest favourite
Guesthouse in Greater North Park
4.97 out of 5 average rating, 186 reviews

New Guest House - North Park

KrystenRating, 5 stars3 weeks ago
Lynae’s place was wonderful, as was Lynae! Balboa park right nearby, with gorgeous trails and scenery. Walkable to North Park area which had a fun variety of bars, shops, and restaurants. Lynae was a wonderful host - responsive, kind, flexible - and the home was bright, airy, with gorgeous views. We couldn’t say enough good things about the wall of jasmine walking in. Thank you Lynae for having us in your home!
Top Guest favourite
Guesthouse in El Cajon
4.98 out of 5 average rating, 222 reviews

Fletcher Hills - modern 1 BR.Easy, no step access.

DesireeRating, 5 stars2 days ago
This air bnb was the best place we could have stayed in San Diego. It had everything we needed and there were so many thoughtful touches. All I wanted was a Southern California beach vacation and Kristen had all of the gear we needed for that. We went to several beaches during our stay and it was about a 30 minute drive to every beach we went after waiting out morning rush hour traffic. Her backyard was my favorite part of our trip as we love watching sunrises and sunsets and it was so peaceful with great views. There is a lot of natural light in the air bnb as I didn’t understand initially there are solar tube lights throughout the unit which I thought were really cool. The air bnb is in a safe and quiet neighborhood and is a convenient location. The bed itself was very comfortable and we enjoyed being able to cook meals with a full kitchen and be able to do laundry. I would definitely will return when back in San Diego.
Guest favourite
Guesthouse in Point Loma Peninsula
4.93 out of 5 average rating, 659 reviews

OB studio, ocean views, hot tub & garage parking!

JesseRating, 5 stars1 month ago
Amazing stay at La casita !! Scott was an amazing host , had a binder of stuff to do locally and super attentive ! Will definitely be staying at La casita soon again
Superhost
Guesthouse in Pacific Beach
4.78 out of 5 average rating, 393 reviews

Law Street Retreat

HilaryRating, 5 stars2 weeks ago
Great, central location with everything we needed for a leaping off spot. Thanks!

Guesthouses with a patio

Top Guest favourite
Guesthouse in Talmadge
4.99 out of 5 average rating, 209 reviews

Adorable cottage in Talmadge

NysaRating, 5 stars2 weeks ago
The place was exactly as described. It was clean, peaceful and private. Their landscape was beautiful with all of the different flowers. Carlos was great with communication and a pleasure to interact with. He made things as simple and straightforward as possible. We would definitely stay at his lovely place again.
Top Guest favourite
Guesthouse in La Jolla
4.97 out of 5 average rating, 118 reviews

Free Bikes. 5 min walk to Windensea Beach La Jolla

ChristinaRating, 5 stars1 week ago
We had a great stay at Carolina's property. The property looks exactly like the pictures (really cute and bright) and any amenity that you might need was provided. Carolina is quick to communicate and very helpful. We will definitely return!
Top Guest favourite
Guesthouse in La Mesa
4.99 out of 5 average rating, 117 reviews

Private 1 BR Paradise retreat

LyndaRating, 5 stars5 days ago
Comfortable, cozy apartment with everything you could possibly need. Lovely setting that was very quiet. We were in town visiting family and did not have time to enjoy the pool and patio much but really appreciated the amenities. John and Jeanne were the best hosts we have ever had a AirBnB! Thank you both for such a great stay!
Guest favourite
Guesthouse in Sherman Heights
4.86 out of 5 average rating, 144 reviews

Downtown Cottage Minutes to Gaslamp & Petco Park

AustinRating, 5 stars1 week ago
Great place to stay if you’re in town by yourself. Walkable to the convention center ~20 mins. Easy to get in and out of and quiet at night.
Top Guest favourite
Guesthouse in San Diego
5 out of 5 average rating, 109 reviews

SDSU Central Cozy Casita | Fast Wi-Fi | Walkable

AllisonRating, 5 stars6 days ago
This little house was so cute! it was no problem to find, street parking was easy, it's close to SDSU, check in instructions were very clear. One thing to know is that the bedroom of the casita is directly next to the main house's patio, and sound travels.
Top Guest favourite
Guesthouse in Point Loma Peninsula
4.93 out of 5 average rating, 116 reviews

Charming Casita with City and Bay Views

LenoreRating, 5 stars1 week ago
Our hosts were extremely gracious, helpful and available. The casita was as advertised (clean and charming). The yard full of plants was very serene and charming. We would definitely stay here again!
Guest favourite
Guesthouse in Serra Mesa
4.95 out of 5 average rating, 106 reviews

Cozy, Quiet and Private Backyard Studio Escape

JoeeRating, 5 stars2 weeks ago
I had an absolutely wonderful stay at Stephanie's place! The space was spotless and made me feel right at home. The location was fantastic and the check-in process was incredibly easy. Stephanie was an outstanding host, always quick to respond to any questions. I especially loved the rain shower! I highly recommend this Airbnb to anyone visiting San Diego and would definitely love to stay here again!
Top Guest favourite
Guesthouse in Greater North Park
4.98 out of 5 average rating, 125 reviews

New (2022) North Park Abode w/ Roof Deck

KimRating, 5 stars1 month ago
A fantastic location in North Park near Balboa Park with gorgeous views from the 2nd floor deck. It made for a gorgeous backdrop for graduation family photos! There are ample nearby restaurant choices for this safe and quiet neighborhood. Comes with a very comfortable bed, and a variety of pillows with an efficient kitchenette.. only wish the shower head streamed more water. Hosts were very gracious and responsive to our requests. I definitly plan to stay here again and have already recommended this awesome place to friends.

Guest house rentals with a washing machine and dryer

Guest favourite
Guesthouse in Ocean Beach
4.96 out of 5 average rating, 288 reviews

Private beach guesthouse w/ private parking

KcRating, 5 stars1 week ago
This was my second time staying here and it was—once again—perfect! The location is amazing, the size is wonderful, and I loved all of the amenities.
Guest favourite
Guesthouse in La Jolla
4.98 out of 5 average rating, 418 reviews

Beautiful Private Villa walk to beach

ChristineRating, 5 stars3 weeks ago
We loved staying at Kim’s villa, we were comfortable and very much at home. We slept well and loved the surroundings. Thank you Kim, will definitely be back!
Top Guest favourite
Guesthouse in Greater North Park
4.99 out of 5 average rating, 163 reviews

Carrie’s North Park Casita, in Heart of San Diego

JaneRating, 5 stars1 month ago
Carrie's Casita was perfect for the two of us. A private little courtyard with lemon and orange trees and the scent of jasmine was very welcoming! The studio-style space was very comfortable and well-appointed. We took advantage of the outdoor seating for downtime after busy mornings of sightseeing. The walkable neighborhood has many architecturally interesting, historic homes with amazing front gardens filled with succulents and cacti of all shapes and sizes. The location is great for accessing great restaurants and boutiques. We would love to visit again!
Superhost
Guesthouse in Bay Ho
4.88 out of 5 average rating, 102 reviews

Bay Ho Cottage w/ Ocean & Bay Views and Roof-Deck

MimiRating, 5 stars2 months ago
Shane is a very helpful and responsive host! The condo is wonderfully clean and nicely furnished. The rooftop and back patio areas are private and great for eating outdoors. The condo and neighborhood are super quiet - the location is easy to get to. Parking is on the street next to the condo and we could always find a spot. We would definitely stay here again!
Guest favourite
Guesthouse in Pacific Beach
4.85 out of 5 average rating, 246 reviews

Sea Star Cottage

AmyRating, 5 stars3 days ago
This place was super cute and a good location. Unfortunately, we had hot water issues. However, Jeff was quick to respond and check it out. He also, offered us a refund since the water couldn't be fixed during our stay and we chose to leave early. We highly recommend Jeff as a host and this cute cottage
Guest favourite
Guesthouse in Point Loma Peninsula
4.94 out of 5 average rating, 175 reviews

Point Loma Private Apartment

MakitaRating, 5 stars1 week ago
The stay was amazing! Very safe and quiet neighborhood, parking was easy, unit was perfectly clean and roomy enough for the 2 of us. We stayed for a week so it was nice to have laundry and a full kitchen available. Check in was easy and all necessary information was provided before check-in so we never even had to contact the hosts!
Guest favourite
Guesthouse in San Diego
4.93 out of 5 average rating, 150 reviews

Clean Cozy Private Guesthouse - Central San Diego

MoniqueRating, 5 stars2 weeks ago
This airbnb was very nice for two people. It was a perfect space with a spot on the driveway for one car. Walking in, the airbnb was clean and smelled really good. There was plenty of amenities and our host Frank was friendly and responsive. We would book again!
Guest favourite
Guesthouse in Point Loma Peninsula
4.87 out of 5 average rating, 100 reviews

Point Loma Oasis - Blocks From Sunset Cliffs

StephenRating, 5 stars6 days ago
Great location, moments away from Sunset Cliffs and Ocean Beach. The unit was exceptional and easy to find . We were only there for one evening but it was peaceful and quiet and the entire area is beautiful. The communication from the host was on point . Highly recommend

Quick stats about guesthouse rentals in Mission Bay, San Diego

  • Total rentals

    20 properties

  • Nightly prices starting at

    $201 NZD before taxes and fees

  • Total number of reviews

    2.8K reviews

  • Rentals with dedicated workspaces

    10 properties have a dedicated workspace

  • Wi-Fi availability

    20 properties include access to Wi-Fi

  • Popular amenities

    Kitchen, Wi-Fi and Pool

Destinations to explore