Guesthouse holiday rentals in Missouri

Find and book unique guesthouse rentals on Airbnb

Top-rated Guesthouses in Missouri

Guests agree: These guesthouses are highly rated for location, cleanliness and more.

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Guest favourite

Guesthouse in Webb City

4.96 out of 5 average rating, 512 reviews

Bright and Modern Private Guesthouse near Route 66

Our guesthouse is ready to host the most discerning traveler. You will appreciate the clean private guesthouse that is located on a quiet neighborhood street in a newer central subdivision that is close to all that SW Missouri has to offer. Please note that we offer a microwave, refrigerator, coffee maker, dishes, and utensils in the kitchen area, there is no stove/ oven. Parties and events are not allowed. Any extra guests need to have prior approval from the host before they arrive on site.

Guest favourite

Guesthouse in Joplin

4.84 out of 5 average rating, 241 reviews

The Courtyard Suite with a POOL, pets stay FREE!!!

The guesthouse is attached via a breezeway to the main house. There is a covered pavilion where you can grill and eat. We have a pool that is open May-September. We have 2.5 acres mostly fenced. There is a concrete walking trail in the back yard about a 1/4 mile loop. The home is pet friendly with NO additional charge, just notify me when you book the house. We allow up to 2 pets. We ask that you keep them on a leash in the pool/courtyard area. They can run in the backyard and potty back there.

Guest favourite

Guesthouse in Joplin

4.99 out of 5 average rating, 136 reviews

Mike & Angie’s Private-Cozy furnished Guest House

Are you needing a private and cozy, furnished Getaway or Work area? Welcome to Red Roof Creekside Getaway. We are Mike and Angie residence of Joplin. Small business owners supporting our community. Our wish is that everyone who stays with us will have a comfortable, relaxing, stress-free time. We're available for any questions or needs. Our guest house sits on a secluded, private, peaceful two-acre lot, surrounded by trees, a creek and lots of wildlife. Close by Route 66 and local amenities.

Guest favourite

Guesthouse in Cape Girardeau

4.93 out of 5 average rating, 490 reviews

Downtown Guesthouse- Romantic Getaway

The guesthouse seamlessly blends modern amenities with historic charm in a cozy, compact space. The antique claw foot tub/shower combo offers a charming, yet snug, spot for a relaxing soak—true to its historic roots, the bathroom could be best described as a quaint water closet. After a day of exploring unwind in the patio. Play a favorite record, and savor your coffee while daydreaming about new experiences. Despite its small size, it provides all the modern comforts you need.

Guest favourite

Guesthouse in Joplin

4.9 out of 5 average rating, 212 reviews

Charming Studio in Roanoke Terrace

New updates January 2023! Improved internet connectivity, new larger shower, plus a new water heater! Adorable studio apartment above our 2-car detached garage. We are located in the scenic Roanoke neighborhood, one of the safest neighborhoods in Joplin. Large trees, character, & beautiful historic houses. We are within 5 miles to both hospitals & walking distance to historic downtown Joplin and Ozark Christian College. Private entry & charming decor in a fresh, new space.

Superhost

Guesthouse in Saint Joseph

4.86 out of 5 average rating, 218 reviews

Vineyard Mansion - Carriage House

The Vineyard Mansion Carriage house is a historic mansion built in 1890. Recently restored, the Carriage House, a 1 bedroom 1 bathroom self sufficient apartment detached from the main house with private access and full home amenities. The mansion is close to the historic city center, art, museums, culture, and parks. You’ll love my place because of the historic neighborhood, the comfy bed, the coziness of the carriage house, and fully functional kitchen.

Superhost

Guesthouse in Salem

4.8 out of 5 average rating, 370 reviews

Courtesy Curve Traveler's Rest

One large room has 1 queen bed, a futon, and we can add a folding twin bed if needed. Full bathroom with shower and sink. Fullsized fridge with freezer, electric cookstove with oven,big screen TV with netflix, Hulu, etc. New Serta mattress, new hardwood floor, Fast WiFi, Close to town but no neighbors, private entrance. Close to the highway, Off road parking space close to the door. Well mannered pets welcome, ill mannered humans not so much.

Guest favourite

Guesthouse in Kansas City

4.98 out of 5 average rating, 943 reviews

Tiny house living in the heart of Kansas City

Our cute little guesthouse above the garage offers comfort and quiet in this urban walk-able neighborhood. We are walking distance to the free Kansas City Street Car, Crown Center, Union Station, and local restaurants. Enjoy all that Kansas City has to offer within a short uber ride or drive; Crossroads, Crown Center, Children's Mercy, Union Station, Liberty Memorial, Westport, River Market, and Power and Light, we are in the heart of it all!

Guest favourite

Guesthouse in Hermann

4.99 out of 5 average rating, 130 reviews

Grapevine Guesthouse

Located in the heart of historic downtown Hermann, Grapevine Guesthouse welcomes guests with a charming mix of vintage and modern furnishings, designed to enhance a memorable getaway experience. Grapevine Guesthouse is located within walking distance to all of the downtown restaurants, bars and shops, as well as Hermannhof Winery and Tin Mill Brewery. The house is just steps away from the trolley stop and 2 blocks from the train station.

Guest favourite

Guesthouse in Union

4.98 out of 5 average rating, 129 reviews

Route 66 Retreat - Pets Welcome - No cleaning fee

Our pet-friendly, peaceful pit stop is perfect for those traveling the Mother Road, heading to Missouri wine country, or exploring St. Louis area attractions like Purina Farms, Meramec Caverns and much more. This newly remodeled, rural retreat has all the amenities you need for a good night’s rest during a road trip or to spend a few days and relax. There is both indoor and outdoor space to enjoy, including a fenced in yard for pets.

Guest favourite

Guesthouse in Lone Jack

4.93 out of 5 average rating, 275 reviews

Adorable cottage on Beautiful property w/ hot tub

Take it easy at this unique and tranquil getaway. Enjoy your own private cottage with all your essentials; You also have access to the property's hot tub and 1 acre pond stocked with catfish, blue gill, and bass! The cottage has a 1 queen size bed and a mattress in the loft . Please note: we do live on this property and the cottage is next to our main house. We have friendly outdoor cats they do freely roam the property.

Guest favourite

Guesthouse in Rocheport

4.98 out of 5 average rating, 166 reviews

Just off the beaten path

Take it easy at this unique and tranquil getaway. 5 minutes from I-70. Enjoy nature in the woods in our cozy, quiet guesthouse. Close to the Katy Trail for cyclists, wineries, and I-70 for the weary traveler needing a quiet rest before hitting the city. We offer an easy, accessible place to store your bikes and gear. Coffee/tea to wake up enjoying breathtaking views from your private deck.