
Family-friendly holiday rentals in Santee
Find and book unique family-friendly homes on Airbnb
Quick stats about holiday rentals that are family-friendly in Santee

Total holiday rentals
Explore 30 holiday rentals in Santee

Nightly prices starting at
Santee holiday rentals start at $172Â NZD per night before taxes and fees

Verified guest reviews
Over 180 verified reviews to help you choose

Holiday rentals with a pool
30 properties feature pools

Rentals with dedicated workspaces
20 properties have a dedicated workspace

Wi-Fi availability
30 of Santee holiday rentals include Wi-Fi access

Popular amenities for guests
Guests love Kitchen, Wifi and Pool across Santee rentals

4.8 Average rating
Santee stays are highly rated by guests—averaging 4.8 out of 5!
Top-rated family-friendly rentals in Santee
Guests agree: These family-friendly homes are highly rated for location, cleanliness and more.

Lovely Condo w/pool, balcony, and lakeside view!
Relax on the balcony overlooking the pool and lake Marion or go down and relax at the pool, or launch your boat at the boat ramp for the day and go fishing or cruising. There is also a myriad of golf courses near by. For dinner with a great view head over to the other side of the lake to the Lake House bar and grill for adult beverages on the lake with great food. For upscale dining Clark’s restaurant is a good choice. Bike,hike,or cook out over at Santee state park which is only 10 minutes away

Mulberry Cabin, a rustic tiny house cabin
Mulberry Cabin is conveniently located halfway between Charleston and the capital city of Columbia in Rowesville, SC. Please note the cabin is located in a small town, not in the country. Rowesville is 11 minutes from the beautiful Edisto Memorial Gardens in Orangeburg. Orangeburg has many restaurants, Wal-Mart, and a Starbucks near I-26. Columbia is about an hour away. Charleston is about 75 minutes away. Enjoy a break from Wi-Fi as you watch a DVD and relax in a 130 year old rustic cabin.

Log home on Lake Marion inlet w/private dock.
Relax with family and friends at this peaceful lake home. Located on an inlet one minute off the largest lake in South Carolina, Lake Marion is known for it's big fish and abundant wildlife. With your own private dock, you can boat/fish all day and leave your boat in the water for your entire stay. If you enjoy golfing, three of the states best golf courses are within minutes. This log home is centrally located between Columbia and Charleston. Restaurants, shopping, and beaches all close by.

Heated Indoor Pool on Lake Marion with Dock
Lake Marion Lakefront on a private 2.5 acres. Two houses - 4500 sq. ft. of space, plenty of room for 14! Dock to fish off of or bring your fishing boat. Heated indoor pool and Margaritaville-themed bar. Firepit, pool table, games, and dining table for 14 people. Great spot for Family Gatherings or Friends' Getaway. Golf, fishing, fruit picking, and amazing country food restaurants - 25 min drive. 5% Discount Gov. Employees :) Parties over 14 ppl ++ fees apply, details discussed prior.

The Turtle's Nest
Locally known as the "Turtle's Nest", you will be close to all the action. Located on Goat Island, 2nd row back, right off the big water. Boat ramp, boatslip, and restaurant only .3 miles away. Ramp and beach picnic area included. Remodled to a farmhouse feel, this 3 bedroom, 1 bath has 2 king beds & two singles. Two single beds share the same space as living room. Great retreat after a long day of fishing, or hanging out with family and friends. Be back fast to unwind by the firepit.

Relaxing Comfortable Waterfront Family Dock Suite
Bring your family or group to this 3 bedroom 1+ bath place in the large trees with lots of room for relaxing and fun (….if you are a jeans and sweatshirt kind of person. It is not the Hilton!) TVs in each room, and 2 covered decks. Fish, or just sit out on the dock, watch the boats run by, and appreciate the lake. We rarely use the dock ourselves. 600’ from our public boat ramp with a park and small beach. Please also note that we do have cameras installed that monitor outside only.

Luxurious Lakefront Log Home W/Pool & hot tub
Stunning luxury log home on the big waters of Lake Marion, featuring a private fishing pier, boat dock, brand-new saltwater pool, hot tub, and more. This custom-designed retreat offers 3 spacious bedrooms, a loft, and 2 elegant bathrooms—one with a clawfoot soaking tub and separate water closet. Enjoy dining and entertaining on the expansive screened-in porch with a custom 12’ outdoor bar. Just 6 minutes from I-95, this serene lakeside escape blends rustic charm with upscale comfort.

Perfect Family Retreat at Lake Marion
Great water front family escape! Enjoy our beach, dock and boat ramp as well as our game room and fully stocked kitchen. We purchased our home is 2006 and began a complete interior and exterior renovation. In 2023 we installed solar panels and an electric vehicle charging station, yet we also have access to the grid for cloudy days and when power demand exceeds what our panels generate. We use a deep well for water. Bring your family for an off-the-grid vacation in our lake home!

Pet-Friendly Lake Marion Getaway - Just off I-95!
In the quaint lakefront town of Santee, There exists a special place. Past Main street and down a country road, nestled in a modest lakefront community, with views of the majestic Lake Marion, we've worked tirelessly to create the perfect family retreat. No matter who you call family, this home is perfect for boaters, golfers, and nature enthusiasts. Guests at the Kindred Spirits Retreat experience more than just a beautiful home, they experience the joys of purposeful travel.

A Great Lake house. Near Manning, SC and I-95.
Secluded and serene, our private lakefront property in South Carolina's Lake Marion region offers a community feel with minimal traffic and noise. The fenced-in property has 2 cozy bedrooms, a large open floor plan, and a screen porch with a beautiful lake view. Enjoy the private dock, kayaks, and floats, and relax with a bonfire and grill. Conveniently located just 20 minutes from Manning and I-95, our retreat is perfect for travelers looking to unwind and recharge.

Cheerful 3 bedroom home on the lake
Great 3 bedroom home on the water. Perfect for family vacations, a weekend getaway or a stay for local fishing tournaments. This home is on a quiet cove that opens up to the larger lake. Get the best of both worlds. The cove is perfect for paddle boating, kayaking, fishing off the dock, grilling on the deck, or just relaxing on the screened porch enjoying the view. But, with the private dock you can bring your boats and jet skis to enjoy the entire lake.

Sunset Serenity Pool/Swim Spa
Experience next-level lakefront luxury in this brand-new 5BR/3BA custom home featuring a massive open-concept layout, chef’s kitchen, two master suites, and resort-style amenities like 20x40 infinity pool, swim spa, and fire pit. Enjoy a private dock, multiple lounge spaces, dual laundry sets, paddleboard/kayaks, and designer finishes throughout. Every detail of Sunset Serenity was designed for comfort, beauty, and unforgettable moments on Lake Marion.
Popular amenities for Santee family-friendly rentals
Family-friendly home rentals with a hot tub

KING, 4 beds, 5 minutes to I-26

Luxury Farm Stay | Hot Tub, Pool & Animals

Lakeview Leisure-Face to the Sun

Sandy Shores Pool & Spa Retreat w/Hot Tub/Beach

The Canopy | Glamping Tent

Lakeside Dreams W/Pool & Spa

Luxe Lake Marion Oasis with Pool/Hot Tub/Dock

Lake Moultrie retreat
Family- and pet-friendly home rentals

Congaree Vines - Woodland Cottage by a Vineyard!

The Goose Cottage at Wild Goose Flower Farm

Viridian Retreat

Reelaxation-At Lake Marion

Lakefront Retreat | Dock, Firepit & Pet Friendly

LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks

Lake Life Living-W/Boat waterfront condo

Lakefront home with boat ramp and game room
Family-friendly home rentals with a pool

Private Pool and Game Room Retreat

Waterfront Lake Marion Retreat • Pool • Gazebo

Lake Marion "Penthouse" at Club Wyndham Resort

Wyboo Retreat at Lake Marion W/Pool

Lakefront Farmhouse Retreat+Pool at Lake Marion

Lake and pool side vacationing

Quiet Retreat:Secluded & Idyllic

Lakeside Bliss: 2BR Suite at Wyndham Lake Marion
Destinations to explore
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- Rentals with pools Santee
- Rentals with lake access Santee
- Lakehouse rentals Santee
- Pet-friendly rentals Santee
- Rentals with a patio Santee
- Apartment rentals Santee
- Rentals with a washing machine and dryer Santee
- Fitness-friendly rentals Santee
- House rentals Santee
- Family-friendly rentals Orangeburg County
- Family-friendly rentals South Carolina
- Family-friendly rentals United States
- Congaree National Park
- Riverbanks Zoo and Garden
- North Charleston Coliseum & Performing Arts Center
- University of South Carolina
- Magnolia Plantation & Gardens
- Williams Brice Stadium
- South Carolina State House
- South Carolina State Museum
- Cypress Gardens
- Columbia Museum of Art
- Colonial Life Arena
- West Columbia Riverwalk Park and Amphitheater
- Sesquicentennial State Park
- Columbia Metropolitan Convention Center
- Wannamaker County Park
- Edventure
- Riverfront Park
- Soda City Market
- Whirlin' Waters Adventure Waterpark
- Koger Center for the Arts
- Azalea Park
- Bee City Zoo & Honey Bee Farm
- Frankie's Fun Park





