
Family-friendly holiday rentals in Santee
Find and book unique family-friendly homes on Airbnb
Quick stats about holiday rentals that are family-friendly in Santee

Total holiday rentals
Explore 30 holiday rentals in Santee

Nightly prices starting at
Santee holiday rentals start at $170Â NZD per night before taxes and fees

Verified guest reviews
Over 180 verified reviews to help you choose

Holiday rentals with a pool
30 properties feature pools

Rentals with dedicated workspaces
20 properties have a dedicated workspace

Wi-Fi availability
30 of Santee holiday rentals include Wi-Fi access

Popular amenities for guests
Guests love Kitchen, Wifi and Pool across Santee rentals

4.8 Average rating
Santee stays are highly rated by guests—averaging 4.8 out of 5!
Top-rated family-friendly rentals in Santee
Guests agree: These family-friendly homes are highly rated for location, cleanliness and more.

Lovely Condo w/pool, balcony, and lakeside view!
Relax on the balcony overlooking the pool and lake Marion or go down and relax at the pool, or launch your boat at the boat ramp for the day and go fishing or cruising. There is also a myriad of golf courses near by. For dinner with a great view head over to the other side of the lake to the Lake House bar and grill for adult beverages on the lake with great food. For upscale dining Clark’s restaurant is a good choice. Bike,hike,or cook out over at Santee state park which is only 10 minutes away
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Mulberry Cabin, a rustic tiny house cabin
Mulberry Cabin is conveniently located halfway between Charleston and the capital city of Columbia in Rowesville, SC. Please note the cabin is located in a small town, not in the country. Rowesville is 11 minutes from the beautiful Edisto Memorial Gardens in Orangeburg. Orangeburg has many restaurants, Wal-Mart, and a Starbucks near I-26. Columbia is about an hour away. Charleston is about 75 minutes away. Enjoy a break from Wi-Fi as you watch a DVD and relax in a 130 year old rustic cabin.
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Log home on Lake Marion inlet w/private dock.
Relax with family and friends at this peaceful lake home. Located on an inlet one minute off the largest lake in South Carolina, Lake Marion is known for it's big fish and abundant wildlife. With your own private dock, you can boat/fish all day and leave your boat in the water for your entire stay. If you enjoy golfing, three of the states best golf courses are within minutes. This log home is centrally located between Columbia and Charleston. Restaurants, shopping, and beaches all close by.
Indoor spacesKitchenTV

A relaxing cabin on private pond. Old Bells Secret
Escape to our secluded cabin on 90 acres in St. Matthews, SC! This early 2000s style cabin features 2 cozy bedrooms, 1 bathroom, and a lovely porch. The large pond is perfect for swimming, fishing, or playing. It’s an endless adventure. The house can sleep up to 6 with the pull out couch. Accessible via a private road, it's perfect for weekend getaways with the family or housing for workers. Experience relaxation and adventure in nature at this wonderful cabin. Book now for a memorable stay!
Indoor spacesKitchenOutdoor spaces

The Turtle's Nest
Locally known as the "Turtle's Nest", you will be close to all the action. Located on Goat Island, 2nd row back, right off the big water. Boat ramp, boatslip, and restaurant only .3 miles away. Ramp and beach picnic area included. Remodled to a farmhouse feel, this 3 bedroom, 1 bath has 2 king beds & two singles. Two single beds share the same space as living room. Great retreat after a long day of fishing, or hanging out with family and friends. Be back fast to unwind by the firepit.
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Relaxing Comfortable Waterfront Family Dock Suite
Bring your family or group to this 3 bedroom 1+ bath place in the large trees with lots of room for relaxing and fun (….if you are a jeans and sweatshirt kind of person. It is not the Hilton!) TVs in each room, and 2 covered decks. Fish, or just sit out on the dock, watch the boats run by, and appreciate the lake. We rarely use the dock ourselves. 600’ from our public boat ramp with a park and small beach. Please also note that we do have cameras installed that monitor outside only.
Indoor spacesKitchenAir conditioning

Luxurious Lakefront Log Home W/Pool & hot tub
Stunning luxury log home on the big waters of Lake Marion, featuring a private fishing pier, boat dock, brand-new saltwater pool, hot tub, and more. This custom-designed retreat offers 3 spacious bedrooms, a loft, and 2 elegant bathrooms—one with a clawfoot soaking tub and separate water closet. Enjoy dining and entertaining on the expansive screened-in porch with a custom 12’ outdoor bar. Just 6 minutes from I-95, this serene lakeside escape blends rustic charm with upscale comfort.
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Perfect Family Retreat at Lake Marion
Great water front family escape! Enjoy our beach, dock and boat ramp as well as our game room and fully stocked kitchen. We purchased our home is 2006 and began a complete interior and exterior renovation. In 2023 we installed solar panels and an electric vehicle charging station, yet we also have access to the grid for cloudy days and when power demand exceeds what our panels generate. We use a deep well for water. Bring your family for an off-the-grid vacation in our lake home!
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Pet-Friendly Lake Marion Getaway - Just off I-95!
In the quaint lakefront town of Santee, There exists a special place. Past Main street and down a country road, nestled in a modest lakefront community, with views of the majestic Lake Marion, we've worked tirelessly to create the perfect family retreat. No matter who you call family, this home is perfect for boaters, golfers, and nature enthusiasts. Guests at the Kindred Spirits Retreat experience more than just a beautiful home, they experience the joys of purposeful travel.
Indoor spacesFamilyLayout

Cheerful 3 bedroom home on the lake
Great 3 bedroom home on the water. Perfect for family vacations, a weekend getaway or a stay for local fishing tournaments. This home is on a quiet cove that opens up to the larger lake. Get the best of both worlds. The cove is perfect for paddle boating, kayaking, fishing off the dock, grilling on the deck, or just relaxing on the screened porch enjoying the view. But, with the private dock you can bring your boats and jet skis to enjoy the entire lake.
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Beautiful Lake Marion Townhome
Forget your worries in this spacious and serene space. Enjoy the beautiful lake view from our patio. 3 large bedrooms and 3 spacious bathrooms, along with a fully equipped kitchen and comfortable family room make this townhome an outstanding family retreat. 3 golf courses and beautiful Lake Marion make this a fine place to visit on a yearly basis.
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Lake Marion | Chill, Cruise, or Cast a Line for 8!
Wake up to quiet mornings, sip coffee by the water, cast a line, and let the day slow down. This Lake Marion home is all about relaxing, fishing, and unplugging with your favorite people. This is the perfect place to reset, recharge, and enjoy the simple things. No rush. No noise. Just lake life, done right.
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Popular amenities for Santee family-friendly rentals
Family-friendly home rentals with a hot tub

Luxury Farm Stay | Hot Tub, Pool & Animals
FamilyKitchenHot tub

KING, 4 beds, 5 minutes to I-26
KitchenIndoor spacesDecor

Lake Moultrie retreat
FamilyKitchenValue

Lakeview Leisure-Face to the Sun
Indoor spacesKitchenCleanliness

Pickleball/Basketball Court - Movie Room - Hot Tub
Indoor spacesKitchenOutdoor spaces

The Canopy | Glamping Tent
Indoor spacesSleep qualityHot tub

Ultimate Lake Marion Dream Home W/Pool & Swim Spa
Indoor spacesKitchenBackyard

The Santee House - Georgeous Lake Front Home
Indoor spacesKitchenOutdoor spaces
Family- and pet-friendly home rentals

Reelaxation-At Lake Marion
FamilyAmenitiesQuiet

Lakefront home with boat ramp and game room
Indoor spacesFamilyCheckout

Congaree Vines - Barn Bungalow by a Vineyard!
FamilyKitchenLaundry

Lakefront Fishing + Grilling | Home Sweet Home!
FamilyKitchenValue

LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks
Indoor spacesKitchenAccuracy

Lake Life Living-W/Boat waterfront condo
Indoor spacesFamilyAccess

Lakefront Lookout
FamilyIndoor spacesQuiet

Lakefront Retreat | Dock, Firepit & Pet Friendly
KitchenFamilyPets
Family-friendly home rentals with a pool

Spacious Retreat Near Charleston, Pet Friendly
Indoor spacesFamilyCleanliness

Lakeside Bliss: 2BR Suite at Wyndham Lake Marion
CleanlinessAmenitiesAccuracy

Hearts & Dreams Peaceful Family Retreat w/ pool
KitchenIndoor spacesPool

Lakeside Bliss: 3BR Suite at Wyndham Lake Marion
FamilyAccuracyCleanliness

Lakefront Farmhouse Retreat+Pool at Lake Marion
KitchenIndoor spacesBackyard

Wyboo Retreat at Lake Marion W/Pool
KitchenFamilyQuiet

Lake Marion "Penthouse" at Club Wyndham Resort
FamilyIndoor spacesLocation

Lakeside Bliss: 2BR Suite at Wyndham Lake Marion
HospitalityBathroomCleanliness
Destinations to explore
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- Congaree National Park
- University of South Carolina
- Riverbanks Zoo and Garden
- North Charleston Coliseum & Performing Arts Center
- Magnolia Plantation & Gardens
- Middleton Place
- Williams Brice Stadium
- South Carolina State House
- Cypress Gardens
- South Carolina State Museum
- Charleston Southern University
- Colonial Life Arena
- Columbia Museum of Art
- West Columbia Riverwalk Park and Amphitheater
- Sesquicentennial State Park
- Columbia Metropolitan Convention Center
- Wannamaker County Park
- Edventure
- Riverfront Park
- Soda City Market
- Whirlin' Waters Adventure Waterpark
- Koger Center for the Arts
- Segra Park
- Azalea Park





