
House holiday rentals in Santee
Find and book unique houses on Airbnb
Top-rated house rentals in Santee
Guests agree: These houses are highly rated for location, cleanliness and more.

Bungalow on Bobs
This charming 3 bedroom, 2 bathroom brick home features an updated kitchen with granite countertops and stainless steel appliances. The great backyard space is fully-fenced, with a large deck, charcoal grill, and fire pit. The spacious master bedroom has a private bathroom and a large walk-in closet. The master bedroom and living room both have Smart TVs. Log in to your own streaming accounts, or enjoy the complimentary Hulu account. The split floor plan allows for easy separation of guests.

The Grand Marshall
Bring the whole family to this renovated 3 BR, 2 bath home +1 BONUS ROOM, which serves as a theatre/game room with 2 queen sleeper sofas. Your family will enjoy: Coffee/beverage/snack bar Central location: Approximately 5 minutes to SC State and Claflin University, OC Tech College, Edisto Gardens, MUSC Health Orangeburg, shopping, dining, and more. Designated office space 1 king bed, 2 queen beds, plus 2 queen sleeper sofas 5 Roku Smart TV’s Smart lock for easy access High speed WiFi

Charming 3 bedroom bungalow
You’ll be close to everything when you stay at this centrally-located bungalow. You’re a 1 minute walk from beautiful Swan Lake Iris Gardens. Drive to downtown Sumter in 4 mins & Shaw AFB in 15 mins. Enjoy the cozy porch or outdoor fire pit with seating & basketball goal. There's a fenced yard for kids/pets. 3 bedrooms/1 bath; extra room with loveseat, TV, games/books/toys. Spacious kitchen & laundry room for your convenience. Enjoy free Wifi & Smart TVs. I am a licensed real estate agent.

Your home away from home in Pinopolis
Nestled at the end of a quiet cul-de-sac, this house is close to Lake Moultrie & the Cooper River. It’s also very close to popular wedding venues: Somerset Point, Pineland Village, & Old Santee Canal Park. Moncks Corner Recreational Complex, where many tournaments are hosted, is also about 3 miles away. Pinopolis is less than 20 miles from Summerville & the Volvo area, 40 miles from coastal beaches, and just 45 minutes away from Downtown Charleston. It’s a great location for work or play!

Gorgeous 2 bed Farmhouse 15 mins from downtown
Forget your worries in this spacious and serene space. Our home welcomes you with 2 beds, 2 baths, a gorgeous fenced in yard, a screened in porch, and a beautiful fountain to calm your mind. All of your day to day conveniences are available in our home allowing you to settle in like it’s yours. Located 15 mins to downtown Summerville, 25 mins to downtown Charleston, and 30 mins to multiple beautiful beaches. For more space check out my other listing: https://www.airbnb.com/h/chucktowneapt

The Parkside Retreat
Welcome to our beautiful Airbnb! Located next to a serene and picturesque park, our home is perfect for families or groups looking for a comfortable stay. With two king master suites and a cozy kids room, we can accommodate up to 6 guests, making it an ideal choice for a family or a group getaway. Each master suite features a comfortable king-sized bed, plush linens, and ample storage space providing a tranquil retreat after a day of exploring the local attractions. Book your stay today!

Private home | 7 Acres Near Lake | Tucked away
The little house on Lincreek is tucked away down a hidden drive on 7 acres of beautiful wooded land with a creek, historic covered bridge and plenty of wildlife. Private one bedroom, one bath home with a full kitchen, breakfast nook, family room and spacious bedroom. Relax on the large front porch and enjoy being immersed in nature. The home is located less than 2 minutes from Lake Murray Dam. There is parking on site for a boat/trailer. 15 min to Columbia. *No smoking / No parties.

Luxurious Lakefront Log Home W/Pool & hot tub
Stunning luxury log home on the big waters of Lake Marion, featuring a private fishing pier, boat dock, brand-new saltwater pool, hot tub, and more. This custom-designed retreat offers 3 spacious bedrooms, a loft, and 2 elegant bathrooms—one with a clawfoot soaking tub and separate water closet. Enjoy dining and entertaining on the expansive screened-in porch with a custom 12’ outdoor bar. Just 6 minutes from I-95, this serene lakeside escape blends rustic charm with upscale comfort.

Santee lakefront home, big water right off I-95
Lakefront home on the big water of Lake Marion. This home is on the Santee side of the lake in a quiet neighborhood, 1-2 miles from restaurants, grocery stores, golf courses and I-95. Starbucks is less than 2 miles away. *Home can accommodate 10 guests max. *Indoor hot tub is available October through March. *Only registered guests listed on the booking are authorized at the property unless prior approval has been granted. *STRICT no pet policy. *PARTIES ARE STRICTLY PROHIBITED*

Guest House/Villa
Enjoy your stay at this immaculately designed new build Villa. Located on a family property surrounded by 2 acres of trees, in a quiet rural neighborhood. Lots of privacy, peace and quiet, yet only 5 minutes from restaurants and stores. 15 minutes from Downtown Summerville, 40 minutes from Charleston and various coastal attractions. The villa is separate from main house and has no shared space other than the driveway. NO smoking, No pets. Laundry service available for long stays.

Pet-Friendly Lake Marion Getaway - Just off I-95!
In the quaint lakefront town of Santee, There exists a special place. Past Main street and down a country road, nestled in a modest lakefront community, with views of the majestic Lake Marion, we've worked tirelessly to create the perfect family retreat. No matter who you call family, this home is perfect for boaters, golfers, and nature enthusiasts. Guests at the Kindred Spirits Retreat experience more than just a beautiful home, they experience the joys of purposeful travel.

Exceptional Heathwood Gem Near USC & Fort Jackson!
Perfectly situated in an upscale, quiet, tree-lined neighborhood, this hip 1940 classic renovated home is super-close to many of Columbia's classiest cafes, boutiques, USC campus, Fort Jackson, USC Law Center and other major attractions. It strikes just the right balance of location, peacefulness, style and comfort. Here, you can hang on the front porch to serenading birds and nearby church chimes or relax indoors with the 65" HDTV Surroundsound system and super-fast WiFi!
Popular amenities for Santee house rentals
House rentals with a pool

Share-in Dipity Refined 4 bedrooms pool not heated

Lavish Home 4BR/3BA, King, Games, Grill, Pool!

Gorgeous Executive Home on Pond *5 beds*

Family Friendly House in Charleston’s Park Circle

4 Bedrooms + 4 En-Suite Baths | North Charleston

Park Circle Tropical Oasis 3BR/2BA with Pool

Happy Stays, Mins to Park Circle, Dtwn, CHS Beach

Lakefront w pool, dock and pool table, sleeps12
Weekly house rentals

Old Man’s Fishing Hole (Lake Front-Lake Marion)

Jewel on the Lake

Lakefront home with boat ramp and game room

Anchor Out Lake Marion

The Heron Lake House

Lakefront w/ dock at Mill Creek

Lake Marion Cottage

The Merry Inn @ Lake Marion
Private house rentals

The Fishnet

Lake House at Lake Marion

Rest and Relaxation

The Sunset Chaser

Comfy Suite Sleeps 3 Near I20&95

SANTEE LAKE MARION GOAT ISLAND AREA NEWLY UPDATED

Relaxing Lake Marion Home, near 3 boat landings

Country Resting Spot
Quick stats about house rentals in Santee

Nightly prices starting at
Santee holiday rentals start at $165 NZD per night before taxes and fees

Verified guest reviews
Over 30 verified reviews to help you choose

Popular amenities for guests
Guests love Kitchen, Wi-Fi and Pool across Santee rentals

4.9 Average rating
Santee stays are highly rated by guests—averaging 4.9 out of 5!
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