
House holiday rentals in Guadalupe
Find and book unique houses on Airbnb
Top-rated house rentals in Guadalupe
Guests agree: These houses are highly rated for location, cleanliness and more.

Beach-themed farmhouse with indoor fireplace
As 23-time Superhosts- we welcome you to the perfect place to relax & unwind after your day. This stylish and spacious home offers a sunny deck, surrounded by trees for sunbathing or watching the sunset. The huge 2nd bdrm is a great place for reading in our hammock chair or for a quiet work space. Downstairs the fully equipped kitchen has everything you need for cooking meals. Outdoor patio is a nice place to bbq & relax as you listen to the hawks, owls, & other birds in this country setting.

Coastal Getaway, Country House, near 101 FWY
Country house surrounded by trees with many windows, wooden floors, lovely kitchen, large sunroom, and huge deck. All located just minutes from Pismo, Grover, Shell and Avila Beach, hot springs, hiking areas, wineries, golf courses, Lake Lopez, ATV riding & outlet shopping, Trader joe's and many other stores. San Luis Obispo is a lovely city just minutes north. and Hearst Castle is less than an hour's drive North. Conveniently situated off the 101 freeway, a nice retreat from the big city.

Hillside view with hot tub too
This house is the 2nd home on the property (main home is also STR). Located at the top of a private driveway with a beautiful view of the hills. Fully stocked kitchen with fridg/freezer, dishwasher, oven, 5 burner stove, microwave, ice maker, osmosis system, fully automatic espresso maker. 65” QLED TVs in living room and bedrooms. Patio furniture wiith covered gazebo, gas BBQ, pellet smoker/BBQ, patio heaters, fire table. Hot tub with gazebo accommodates 6. EV/Tesla charger in garage.

Great outdoor space, King suite, EV Charger, A/C
Come relax and enjoy our peaceful home and outdoor spaces. We are located halfway between Los Angeles and San Francisco. Here you can experience the beautiful Central Coast including wineries, Beaches, Cal Poly and golf courses. We are located in a quiet neighborhood adjacent to an organic blackberry farm. Easy access to the 101 Freeway, where you can easily visit Santa Barbara or Paso Robles wine regions. Our home is FULLY Air Conditioned and features a level 2 Tesla charger for EV cars.

Eagle Creek Ranch 1/2 Block from Bell Street
Eagle Creek Ranch is my special place. I fell in love with it and I knew it was for me. I continue to pour my heart into the property and I love to share with others. The wifi is good. Several times a year it might be out for a few hours or so . There is ample parking. You might see the resident bobcat and fox through every day. You’re a 10 second walk from downtown Bell Street. Freeway, east of property, can be heard on north side of house only. Small gatherings allowed (w/ permission).

Casa Del Mar
Enjoy a little getaway in this cottage by the beach. It’s cozy and simple with all the features of comfort. Walking to the beach is a just a short stroll down a windy little road filled with cool beach vibes. Cross a little wooden bridge and walk down a block or two and you are right in front of the Oceano dunes. Plan a bonfire and make s’mores on the beach. Or better yet, stay at the little cottage, grab a bottle of wine and enjoy a fire pit right outside your bedroom door.

Cozy Plant-Filled Loft in Orcutt
Stylish, plant-filled loft on the Central Coast! Relax under cozy lights surrounded by greenery in this peaceful, thoughtfully designed studio with everything you need. Enjoy a comfy living area with TV, kitchenette, WiFi, and private entrance for easy access. Located just minutes from Old Orcutt’s coffee shops, wine tasting rooms, and restaurants, with quick access to Solvang, SLO, and beaches. Perfect for a quiet getaway, work stay, or exploring the beautiful Central Coast.

Wine cellar House
Welcome to Bodega House, a restored 1920s farmhouse in the center of Los Alamos. The home features a serene queen bedroom and a separate lounge space, along with a sleeper sofa in the living area. Thoughtfully designed for two adults, the house can also comfortably host one to two children on the sleeper sofa. It’s an ideal setting for couples or small families seeking the ease and privacy of a home while being just steps away from the best of Los Alamos.

Serenity On Serrano
Serenity on Serrano is a Frank Lloyd Wright-inspired peaceful haven set in one of SLO's most prestigious neighborhoods right on the edge of a creek. This midcentury modern home is just steps to hiking, the downtown, shopping, and restaurants. Be prepared for nature as it's common to be greeted by wild turkeys, birds, and more. Enjoy the tranquility of minimalist design. Note: There is $25 per night for each extra guest over 4. Permit # H-0408-2023

Wine Country Hilltop Retreat
Kick back and relax in this calm, stylish space with spectacular Edna Valley views. Read a book on your hillside patio and see buffalo and longhorns grazing in neighboring fields. After an incredible sunset, unwind by your firepit at night under a sky full of stars. This private country escape is also at the center of it all - 15 minutes to beaches & Cal Poly, 5 minutes to airport & 20+ wineries/tasting rooms, 10 minutes to beautiful downtown SLO.

Luxurious Santa Ynez Valley wine country cottage
This cozy cottage is located in scenic Ballard Canyon amid lush vineyards and breathtaking views of the surrounding mountains. The house is situated on a 5 acre ranch and features high end modern appliances, entertainment system and hot tub. The two-bedroom one-bath cottage is located halfway between Solvang and the quaint town of Los Olivos. Stroll remote country lanes and enjoy views of rolling hills and the nearby goats, llamas and horses!

Mid-century home in the heart of Arroyo Grande.
Welcome to the Eman House! I can't wait to host you at the 1950's mid century in Arroyo Grande, CA. Enjoy the beautiful remodeled kitchen, private backyard and patio, and two cozy bedrooms while soaking up the best of the central coast. Just a 10 minute walk to the historic Arroyo Grande village, a 5 minute drive to the beaches of Grover, and tucked away in one of Arroyo Grande's most peaceful cul-de-sacs.
Popular amenities for Guadalupe house rentals
House rentals with a pool

Hidden Views

Pool & view in Sta Rita Hills Wine Country, Lompoc

Spacious SLO CAL Home w/ Pool, Spa. Pet Friendly!

San Luis Obispo House With Pool And Hot Tub

Getaway at the Highlands+Heated Pool+Hot Tub

Heated pool (82 degrees), hot tub, gas firepit

FairView Lavender Estate

Ranch Style Home w/ Bikes! Heart of Wine Country
Weekly house rentals

20 private acres, 180 degree views

Central Coast Getaway

Los Olivos Vineyard Home on Winery Estate

RELAX ❤️SEASIDE RETREAT ~ 2 min to PISMO BEACH

Beautiful Country Home

1 Block from Beach with long driveway for parking

Pacific Coast Highway Milkhouse

In the Heart of Los Olivos
Private house rentals

Steps to the Beach! Rooftop Deck! Firepit & BBQ!

Beach Bungalow w/ Outdoor Shower & Fenced Yard

Entire Home - Luxurious California Coastal Retreat

Home, comfortable to rest and relax. Welcome

Luxe Hideaway: Prvt Patio BBQ Winery, 20 min-Beach

Nipomo Getaway

Updated 3 Bd Home, Pet Friendly, Backyard Oasis

La Ranchita Wine Country Equine retreat and Spa
Destinations to explore
- Southern California Holiday rentals
- Los Angeles Holiday rentals
- Stanton Holiday rentals
- Northern California Holiday rentals
- Channel Islands of California Holiday rentals
- San Francisco Bay Area Holiday rentals
- San Diego Holiday rentals
- San Francisco Holiday rentals
- Gold Country Holiday rentals
- Central California Holiday rentals
- Palm Springs Holiday rentals
- San Francisco Peninsula Holiday rentals
- Cayucos Beach
- Montaña de Oro State Park
- Morro Strand State Beach
- El Capitán State Beach
- Cayucos State Beach
- Pismo State Beach
- Morro Rock Beach
- Morro Bay Golf Course
- Solvang Windmill
- Mission San Luis Obispo de Tolosa
- Los Padres National Forest
- Oceano Dunes State Vehicular Recreation Area
- Dinosaur Caves Park
- Charles Paddock Zoo
- Pismo Preserve
- Sensorio
- Monarch Butterfly Grove
- Vina Robles Amphitheatre
- Nojoqui Falls Park
- Talley Vineyards
- Harmony Headlands State Park
- Austin Hope Winery
- Atascadero Lake Park
- Tablas Creek Vineyard





