
Villa holiday rentals in La Mesa
Find and book unique villas on Airbnb
Top-rated villa rentals in La Mesa
Guests agree: These villas are highly rated for location, cleanliness and more.

LUX/6BR/21 Bed•Pool/SPA/Golf/Grill/Game/Sleep 46
Make dreams come true w/ this luxurious resort-style home, packed w/amenities. From mini golf, pool, spa, playground, game room & arcades, relaxation & entertainment comes easy. 4,000 sq ft of living space on quarter acre, plenty of room for the whole family. Over 100 amenities Book Now 😊 19 min - San Diego Airport🛬/Downtown San Diego🏟️ 18 min - Balboa Park/Zoo🦁 23 min - Mission Beach/Pacific Beach 🏖️ 28 min - Mexico 🇲🇽 border 10 min - Barona Casino 🎰 5 min - Lake Jennings🎣 22 min - Sea World 🐳

Amazing WaterView Penthouse w/AC
AMAZING WATER VIEW PENTHOUSE!! Over 300 5 star reviews from our listings! Perfect for Executives, Quiet mature couples, Healthcare Professionals, Physicians/Traveling Nurses. Immaculate Luxury/Centrally-located. Peaceful, family friendly, every amenity. Private hot tub/private deck/patio furniture/private bbq grill/private fire pit/5 Star Resort Experience/robes/slippers, hot tub towels, fully stocked kitchen/pots/pans/spices/cookware/stemware/dishes/flatware/WiFi/Smart TVs/cable/Netflix/YouTube

Fun Get Away, Vaulted Ceiling, Pool, Hot Tub, New.
Enjoy a stylish experience at this centrally-located place. Great place to stay for those seeking an experience close to the beach and mountains and anywhere in San Diego you'd like to visit. 5 min from trails and Cowles Mountain. 15 min to Sea World, Animal Park, beaches, parks, downtown, Balboa park, the Midway museum, Coronado, Torrey Pines, La Jolla Cove, and much more! 2 min to a kid playground. Nice Villa in a really nice and Quiet Neighborhood, but will also accommodate your best party!

Vintage Home on the Canyon’s Edge
We’re excited to offer our beautiful home in University Heights- just 5 mins from downtown SD. Perched on the edge of a peaceful canyon, the house is surrounded by nature, offering a serene escape while keeping you close to the city’s best attractions. Home features: • 2 comfortable bedrooms • A dedicated study that can double as a third bedroom • 2 full bathrooms • Fully equipped kitchen • Smart TV, WiFi, washer & dryer • A private balcony overlooking the canyon and our inviting hot tub

6-bed Paradise Villa Pool, hot-tub massage chair
*EV charging available Welcome to Casa Cerro-my incredible chic high-tech modern villa in San Diego! This stylish place to stay is perfect for families and group trips. Its open and airy layout can accommodate up to 11 people. This completely remodeled home is furnished with all the luxuries of home and more that is powered by an iPad for you to use. I love technology. But don't worry you don't have to use it to power up the house, everything has traditional switches/remotes if you choose.

@Fantastic villa, giant pool, guest house, golf !
This unique fantastic villa with a separate pool house sitting on 1 acre with a spacious living space with large windows. Main house has 4 bedrooms with 2 baths, and a guest house has 1 bedroom with 1 bath. +8 car parking, nice privacy and a fantastic view! Brand new giant size SALT pool with huge size jacuzzi, pool toys, golf zone, a huge grass event field, game field, pool table, foosball, ping pong, Nitendo,2 fire pits and more! Truly one-of-a-kind property don’t miss out! ToT:COSD-00749

Zen Resort w Infinity Pool/Spa +360° Socal views
Relax, rejuvenate, & revive at your own hilltop paradise with no nearby neighbors and a private gated driveway. This hacienda offers a year round temp controlled Infinity edge pool & Spa complete with 360° views, outdoor fire-pit, custom tiki hut and a seamless indoor outdoor flow. Accommodation includes the main house, a charming casita, and an optional Airstream-sleeping 20+ guests in comfort. A perfect blend of seclusion, and resort-level amenities & just 15 min. from Downtown San Diego.

Enchanted Paradise! ♨ Pool+Spa+Outdoor Kitchen ☀
Brand New Property! Massive garden of Eden style resort home with sprawling outdoor entertainment area and spacious open concept inside, perfect for large families with kids and responsible adults. Updated top to bottom with all new outdoor and indoor furniture, modern upgrades in all bedrooms and common areas. Centrally located and 20 minutes from the beach and all of SD's top attractions! 8 person hot tub, sparkling gas heated saltwater pool and new outdoor kitchen. Don't miss out!

Hidden Villa with Beautiful Furnished Garden Patio
Close to everything, quiet and private. This beautiful 2 Bd Villa seems to be loved by all who stay here. The outdoor private patio feels like your in the forest. Gorgeous custom bath with large marble shower. Full size laundry. Great entertainment system,DVD's, Roku, Amazon Prime. The home has open beam ceilings, lots of light and a fabulous patio fully furnished for guests, outdoor dining and barbecuing. The home is private, fenced, furry friends are welcome.

TooHotTooSettle•Free HotTub•Pool•GameRoom•Spacious
Comfort Getaway in Mount Helix | Pool • Hot Tub • Games Welcome to your private oasis in beautiful Mount Helix! This stylish 4-bedroom home is designed for relaxation and entertainment, featuring a sparkling pool, a soothing hot tub, and a game area for endless fun. With spacious living areas, modern decor, and a fully equipped kitchen, this home is perfect for families, friends, or a weekend getaway. Book now and experience the best of San Diego in style!

The Crown Jewel Villa with AC!Bikes,Kayak and SUP!
Escape to the peaceful and coveted beach community of Crown Point in San Diego! This highly sought after neighborhood boasts mostly permanent residents, creating a serene and tranquil environment for our guests. Right across the street from the home, you can find Ski Beach and Park, a favorite spot for families and kids. Explore the variety of local eateries and coffee shops, or take a short walk to popular Sail Bay and the ocean.

Modern 3-Bedroom Villa, Luxurious Outdoor Oasis
Welcome to Your Perfect Spring Valley Villa! Nestled in the heart of Spring Valley, our charming spacious 3-bedroom, 2-bath home offers the perfect blend of comfort, style, and modern amenities. Whatever your planning, our home provides an ideal setting for a memorable stay. Need a rental car? We have a 2019 Blue Jeep Wrangler Unlimited Sport available via Turo right outside ready for use. Link to book available inside.
Popular amenities for La Mesa villa rentals
Private villa rentals

The Bonita Bungalow

Lux Villa: Heated Pool, Sauna, & Gym

Casa Charles, Tropical backyard, Pool & Pizza oven

The Crown Jewel Villa with AC!Bikes,Kayak and SUP!

Cheerful 4-bedroom villa with free parking.

Historic 4 bedroom villa, fast wifi, free parking

8BR 21 Bed Sprawling Villa! Great For Large Groups

Zen Resort w Infinity Pool/Spa +360° Socal views
Luxury villa rentals

Sanctuary 4BR Church & Deck Near Downtown (18 ppl)

Elegant Hillside Estate | Heated Pool+Sunset Views

Beautiful house in mira mesa

Cali Paradise w/ Pool & Views! 5 Bedroom Sleeps 15

8BR 21 Bed Sprawling Villa! Great For Large Groups

NEW! Mediterranean-Style Villa in Point Loma

10 ACRE Rolling Hills Villa

Gorgeous Beach Villa | Ocean Views + Sleeps 12!
Villa rentals with a pool

Leyla| Pool/Spa|Downtown|Freeways|Beaches

Grand 5-Bedroom San Diego Home w/ Pool & Views!

Solar Heated Pool•Complimentary HotTub •GameRoom

1 PRIVATE OCEAN VIEW ROOM IN LUXURY COASTAL HOUSE

Villa L'Auberge - 5 star hotel

Private oasis

CASA GRANDE|Pool/Spa|Downtown|Attractions

Apartment in hilltop villa: Torrey Pines Suite
Quick stats about villa rentals in La Mesa

Total holiday rentals
Explore 10 holiday rentals in La Mesa

Nightly prices starting at
La Mesa holiday rentals start at $106 NZD per night before taxes and fees

Verified guest reviews
Over 410 verified reviews to help you choose

Family-friendly holiday rentals
10 properties offer extra space and kid-friendly amenities

Holiday rentals with a pool
10 properties feature pools

Rentals with dedicated workspaces
10 properties have a dedicated workspace

Wi-Fi availability
10 of La Mesa holiday rentals include Wi-Fi access

Popular amenities for guests
Guests love Kitchen, Wi-Fi and Pool across La Mesa rentals

4.7 Average rating
La Mesa stays receive an average rating of 4.7 out of 5 from guests
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- Rosarito Beach
- Oceanside City Beach
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- SeaWorld San Diego
- LEGOLAND California
- Coronado Beach
- San Diego Zoo Safari Park
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- Pechanga Resort Casino
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