
House holiday rentals in La Mesa
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Top-rated house rentals in La Mesa
Guests agree: These houses are highly rated for location, cleanliness and more.

SDSU Beach Cottage
Welcome to our stunning SDSU Beach Cottage. Our home is 10 minutes away from everything amazing in San Diego! Our home is Centrally located in San Diego and in a desirable neighborhood. We are steps away from a Local favorite Eatery, Wine Bar, Beer Pub, Natural-Holistic Market, Pizza shop, Liquor Store, Nail shop, and Einstein's Bagels. Play in San Diego or stay and relax in our tropical yard that is set up to entertain you and your family with outside games and Ping Pong. 25 Yr's of age req'd

Snazzy Spot with yard near beaches and downtown
Welcome to this modern get-away that is as bright and cheerful as a sunny day! You'll be sure to be rejuvenated here after your trips to the nearest beach (only a 15 minute drive) and outings on the town (only 10 minutes by car to downtown). This spot includes a private parking spot and a private yard. Yours to enjoy are a very comfortable queen bed, TV in bedroom, Fast WiFi, and a well stocked kitchenette. There are also two canyon hikes within a 2 minute walk with views of downtown for sunset.

Golden Hill Tree House
The Golden Hill Tree House is an urban oasis hiding in the branches of two mature trees in the heart of San Diego. While you enjoy elevated privacy you can also treat yourself to a soaker tub with double shower heads or settle down in a cozy reading nook to enjoy a good book! You'll also be walking distance to some amazing restaurants and super close to the best of San Diego, including downtown, the beach and the zoo! It's a perfect place to recharge after a long day of business or pleasure!

Private Canyon Sanctuary
Enjoy fantastic forever views of Mission Valley in this adorable 1 bed/bath newly remodeled home located just 2 blocks from excellent dining and nite life. *Full size kitchen, W/D. * Strong Wi-Fi, TV’s and SonoS sound system. * New bed and always white linens. * Easy in/out with garage parking included. * Safe and private (no surveillance on property). *Fast EV charger (no fee) This property also comes with radiant healing energy. Check out our reviews for confidence, book and enjoy.

Cottage in the Garden! New! Modern!
COTTAGE IN THE GARDEN - New! Modern! Find beauty and serenity in this special guest house in one of San Diego's most desirable areas! Flowering bushes, plants, olive tree and fruit trees seen from all windows. All amenities: WiFi, Cable, serving dishes and tableware, full coffee bar, Ninja Blender, Flat screen TVs, 100% Egyptian Cotton Sheets or Boll and Branch Sheets (used by 3 Presidents), Japanese Toilette and more. 15 minutes to Downtown San Diego and 20 minutes to the beach!

Zen Retreat: 3-Bedroom Oasis near La Mesa Village
Relax in this charming 3-bedroom, 1-bathroom home located just 1 mile from the heart of Historic Downtown La Mesa Village. Nestled in a quiet, central neighborhood, this cozy retreat offers easy access to major freeways, top-rated restaurants, and the local trolley line making it a breeze to explore the best of San Diego. Within 10 to 15 miles, you’ll find yourself in iconic destinations like Downtown San Diego, Balboa Park, Coronado Island, scenic beaches, and beautiful mountain trails.

SDCannaBnB #2 *420 *parking *dog-friendly *hot tub
Welcome to SDCannaBnB - San Diego's premier cannabis-friendly rental! Our studio is newly remodeled with luxury ammenities. We proudly cater to the cannabis community and non-users alike. Our studio has HEPA air purifiers, is fully ventilated and receives deep cleanings between each guest. This ensures that every guest checks into a clean, fresh-smelling place that feels like home. Our studio is located in our quiet, fully fenced in backyard, close to San Diego's attractions

Mid-Century Style Family House with Spa
Beautiful Mt. Helix mid-century modern family home with incredible views, designed by architect of original Las Vegas, Desert Inn 3/4 acre.Less than 20 minute drive to beaches/Zoo/Sea World/Downtown, . With a swimming pool/hot tub, whole House have AC to. surrounded by California Oak/orange/lemonpomegranate trees and herb garden this home is the epitome of 1950’s luxury. A perfect family oasis, you won’t even want to leave the property. No loud parties please, this is a quite community.

(Relist!) Relax at a Stunning 1931 Historic Tudor!
Come & enjoy our 1931 historic tudor home! Beautifully rebuilt within the last 2 years. This house has a huge front lawn and space to roam. Enjoy the serenity this large property has to offer. Three peaceful patios to enjoy your morning coffee. The kitchen has an 48-inch 1950’s oven for the chef in the family. Bay windows, arched entryways and original light fixtures make this such a charming place to stay. Centrally located to enjoy everything San Diego & La Mesa has to offer.

Peaceful Casita | Firepit • Near SDSU
Welcome to our cozy home, perfect for couples visiting the area. It's also a great spot for SDSU parents visiting their kids. Conveniently close to the campus but far enough to enjoy some peace and quiet. If you enjoy this listing, click the heart icon ❤ in the top-right corner to bookmark it for easy access! Minutes from key attractions: ★ 6 min to SDSU/Viejas Arena ★ 14 min to Balboa Park ★ 17 min to Downtown SD (Gaslamp) ★ 19 min to San Diego Zoo ★ 21 min to the Airport

Bright Contemporary 5-Bedroom Oasis, Pool and Yard
Welcome to our 5-bedroom, 3-bathroom home, offering ample space for your entire group. With a myriad of amenities, games, and relaxation areas, you may find yourself wanting to spend your entire stay simply enjoying the comforts of this exceptional home. Whether that be opting for a pool day relaxing in San Diego's mediterranean climate, or cozying up next to the fireplace with your fav movie on. This spacious rental will ensure a memorable San Diego experience! 🌄

Urban Oasis: Modern Comfort 3.6 miles from Downtwn
Important: STREET PARKING is available. For closer parking options, it's best to arrive around check-in time. The neighborhood is dense, so depending on how late you return, you may need to walk 1-2 blocks Our Airbnb features a plush queen-sized bed, inviting you to unwind and rest in absolute comfort. Additionally, a full-size sofa bed -65-inch Smart TV -Washer/Dryer(detergent not included) -Full-size fridge, gas stove, dishwasher, and coffee maker
Popular amenities for La Mesa house rentals
House rentals with a pool

The Board

Lionhead - Private Boutique Home

Bright and spacious home with views, pool & spa.

University Heights Oasis Getaway

Mid-Century Modern and Contemporary House

Flamingo Sunset House: Sleeps 10: Pool + Hot Tub

Updated TownHome, Great Location, Fantastic Views

Custom Guesthouse, Balboa Park/Zoo/Hillcrest& pool
Weekly house rentals

Tiny Home with a View

Shadow House Mt. Helix

Airbnb Luxe: Designer Pool, Fitness and Office

Discover La Mesa: Your Perfect Cozy Base

Helix Haven

The Pool House

Cozy quiet getaway, great mattress (1-br)

25% off, Pool, Hot Tub, BBQ, EV, Central-SD, SDSU
Private house rentals

Surreal Serenity Escape wIth Game Room, Pool & Spa

Serenity in San Diego

San Diego's Finest Retreat

Modern, Private, & Stylish Home

Private House in the Hills, Pool, Pickleball court

Serene retreat with valley view!

Golden Hour Bliss: Pool, Hot Tub & Firepit

La Mesa's Jewel Cottage
When is the best time to visit La Mesa?
| Month | Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sep | Oct | Nov | Dec |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Avg. price | $307 NZD | $307 NZD | $325 NZD | $308 NZD | $315 NZD | $366 NZD | $428 NZD | $361 NZD | $317 NZD | $315 NZD | $307 NZD | $330 NZD |
| Avg. temp | 15°C | 15°C | 16°C | 17°C | 18°C | 20°C | 21°C | 22°C | 22°C | 20°C | 17°C | 14°C |
Quick stats about house rentals in La Mesa

Total holiday rentals
Explore 300 holiday rentals in La Mesa

Nightly prices starting at
La Mesa holiday rentals start at $34 NZD per night before taxes and fees

Verified guest reviews
Over 13,300 verified reviews to help you choose

Family-friendly holiday rentals
190 properties offer extra space and kid-friendly amenities

Pet-friendly accommodation
Find 100 rentals that welcome pets

Holiday rentals with a pool
80 properties feature pools

Rentals with dedicated workspaces
180 properties have a dedicated workspace

Wi-Fi availability
300 of La Mesa holiday rentals include Wi-Fi access

Popular amenities for guests
Guests love Kitchen, Wi-Fi and Pool across La Mesa rentals

4.9 Average rating
La Mesa stays are highly rated by guests—averaging 4.9 out of 5!
Destinations to explore
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- Rentals with an EV charger La Mesa
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- SeaWorld San Diego
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