
Apartment holiday rentals in Panama City
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Top-rated apartment rentals in Panama City
Guests agree: These apartments are highly rated for location, cleanliness and more.

In the heart of Casco, refurbished and with parking
Escape and discover the old town in this remodeled, comfortable and central accommodation in the heart of Casco Viejo. Our location is the best, it will make you come back. Close to restaurants, bars, impressive churches, and museums. The property dates back to the 17th century (1756) history and good atmosphere. You can explore the area on foot, fully equipped kitchen, European king bed, you will feel right at home, surrounded by the famous calicanto walls. -A large living room -Fully-equiped kitchen

Apto 4 min from Tocumen Airport | 24-hr check-in
Layover in Panama? Stay where everything is easy and comfortable Just 4 minutes from Tocumen International Airport – perfect for early flights or quick stopovers A modern, comfortable, and secure apartment with: • Fast WiFi and air conditioning • Smart lock and flexible check-in • 24/7 security • Pool, gym, and fully equipped kitchen • Steps from the ITSE Metro station Ideal for layover travelers, curious tourists, or business trips. 🌴 Just arrive — everything’s ready for you. We’ll be waiting!

Casco Viejo 360° View Old Tower Penthouse
Located in one of the oldest buildings in Panama and set over 3 stories with unrivaled panoramic views over the historical Casco Viejo, the skyline of Panama City and views of the causeway, our gorgeous penthouse is the ideal space to take in the local sights, sounds, art, culture, socialize with your friends and family, or simply relax in a cozy love nest! Top speed wifi, excellent location, and fully equipped with all the home comforts, the penthouse is the perfect spot to explore Panama.

Elegant Apt - View to Main Plaza of Casco Viejo
Experience the charm of Casco Viejo with this beautiful apartment, located in the heart of the historic neighborhood - close to many dining options, cafes, supermarkets and attractions. Enjoy the stunning views of the Main Plaza from the comfort of your balcony or rest easy inside with the soundproof doors and strong WIFI connection. We provide a water biden throughout your stay for hydration and Panamanian coffee renowned as one of the best in the world, at the moment of check in.

Cozy 2 Bedroom w/ Splash Pool
Our place is a 3-story apartment located on the quiet side of Casco Viejo. It has a very private feel to it, which allows for an incredible afternoon of sunbathing or bbqing on our private rooftop. The splash pool allows for a refresh and fits 2 people at a time. This place has so much character from with original exposed stone walls, to the sweeping view of the Arto Chato ruins. It also has a great work space, all the necessities to stay in and cook, watch a movie, etc.

Modern Cozy Apartment · Pool, Gym & Coworking
Welcome to our charming apartment in the heart of Panama City! Perfect for digital nomads who take their office with them. At LIVING 73 you will enjoy a wide range of amenities, such as swimming pool, a coworking space and gym. Located in the San Francisco area, it's the perfect starting point for exploring the city. You will find within a 5 minute walk a wide range of restaurants, supermarkets and the Multiplaza Mall, the largest and most varied in the city.

Beauty Balcony •Remote Working • Near Multiplaza
➤ Stylish and beautiful apartment, tailored for remote workers with balcony, minutes away from Multiplaza Mall . ★ Perfect for Remote Workers, desktop and 150 MB speed internet. ★ Walk 5-10 mins to Restaurants, Supermarkets, Multiplaza Mall, Cafes & Shopping ➤ Urban Escape - Building Highlights: ★ Gym ★ 2 Co-Working Space with 500 MB speed internet ★ Pool on the Rooftop Terrace ➤ Located in San Francisco: Explore the City Easily | Uber-Friendly

Amazing loft with an iconic view of Casco Viejo
Enjoy a unique experience, in this elegant and centrally-located loft. Fully remodeled 1 bedroom apartment, in a central location in Casco Viejo (the old city). You will be just steps away from many restaurants, cafes, museums, and the existing night life casco has to offer. Located in “Jeronimo,” this restored- colonial building was built in the year 1850, and features unique crafted wall décor, as well as some of the original "calicanto" walls.

k*| Delightful 1 BR w/King Bed in Calle 50
Calle 50 es el Times Square de la Ciudad de Panamá. Esta emblemática calle resguarda a la concurrida Area Bancaria. La ubicación del apartamento es excepcional y céntrica, cercana a: ->Estación Iglesia del Carmen [Línea 1 del Metro de Panamá] ->Cinta Costera ->Parque Urracá ->Supermercado Rey ->F&F Tower (Edificio del "Tornillo") ->Nightlife en Calle Uruguay Desde el piso 19 se ofrecen vistas a la ciudad y a la selva.

Beautiful apartment in Casco Viejo ST. George D
Welcome to our spacious and charming apartment in Casco Viejo. Located in a vibrant and historic neighborhood. You will love the warm atmosphere created by the lime and pebble walls, in perfect harmony with our modern and elegant decor. The space is large and comfortable, ideal for relaxing after a day exploring the city. As a host, I'm available 24/7 to answer questions and make sure you make the most of your stay.

Full apartment in Panama
This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.

Jacuzzi in colonial ruins in beautiful apartment
Welcome to Casa Marquez Portazgo! This cozy apartment in the heart of Panama City offers comfort and convenience, ideal for your stay. With one bedroom and capacity for two people, you'll enjoy a relaxing atmosphere in 70 m². Located in the San Felipe neighborhood, just steps from the entrance to the Casco Antiguo, it offers a unique experience. You can also unwind in the jacuzzi.
Popular amenities for Panama City apartment rentals
Weekly apartment rentals

Oceanview 1BR in Yoo Panama

Cozy Casco Viejo Apartment

Centrally located, elegant and minimalist

Poin apartment ocean view + pool + gym

Unique Luxury 3-story Loft at the Yoo

Avenida Balboa Ocean View

The Captain's Canal View Penthouse

New Apartment in Panama City
Private apartment rentals

Cozy apartment in Panama

Panoramic View Penthouse with Luxury Amenities

Área Bancaria · Rooftop Pool - Gym - Top Location

1bd/2Bthrm East Coast-Panama

Cozy apartment with amazing views

Serena House Obarrio by God Housing

VIP Suite/ Sea View + Pool & Sky Lounge + Gym

Cozy Ocean-view Retreat Panama
Apartment rentals with a hot tub

Suite Luxury 30th View Yoo Panamá & Arts Tower

Luxury 2BR Suite with Pool & Views

Apartment between ocean and jungle

PH Yoo 44i – Ocean View Apartment

New Flat with Ocean + City Views

Coastal View Executive Studio in Panama City

Tropical Paradise at Playa Bonita

Panama Dream View Escape
Quick stats about apartment rentals in Panama City

Total holiday rentals
Explore 2,890 holiday rentals in Panama City

Nightly prices starting at
Panama City holiday rentals start at $17 NZD per night before taxes and fees

Verified guest reviews
Over 79,200 verified reviews to help you choose

Family-friendly holiday rentals
900 properties offer extra space and kid-friendly amenities

Pet-friendly accommodation
Find 1,090 rentals that welcome pets

Holiday rentals with a pool
1,840 properties feature pools

Rentals with dedicated workspaces
1,770 properties have a dedicated workspace

Wi-Fi availability
2,760 of Panama City holiday rentals include Wi-Fi access

Popular amenities for guests
Guests love Kitchen, Wifi and Pool across Panama City rentals

4.7 Average rating
Panama City stays receive an average rating of 4.7 out of 5 from guests

Nearby attractions
Panama City's top spots, include Miraflores Locks, Museo de Arte Contemporáneo, and Santo Tomas (Panama Metro)
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