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House holiday rentals in Panama City

Find and book unique houses on Airbnb

Top-rated house rentals in Panama City

Guests agree: These houses are highly rated for location, cleanliness and more.

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Superhost
Home in Veracruz
4.67 out of 5 average rating, 6 reviews

On the beach, entire apartment, panoramic terrace and more

For those who love: Sea, Sun, Tropical, Tranquility, Freedom, Comfort. This exclusive apartment, directly on the beach, offers a unique view of the Gulf. Enjoy sunsets, sunrises, and walks. - On the large panoramic terrace, a sea-view bathtub. Sofa. Unique emotions. - 360° panoramic view with palm-leaf roof. - Queen bed, sofa, bathroom with shower, kitchen. * In the beachfront social area: - Hammock, barbecue, sofas, gazebo, kitchen, pool. Dcent of Paradise Pure Life Suitable for long stays.

Guest favourite
The exterior of a two-story residence is shown, featuring a classic design with a stone façade and wooden accents. Lush greenery surrounds the entrance, where steps lead to the upper level. Two friendly dogs can be seen in the foreground, adding a welcoming touch to the scene.
Home in Panama City
4.88 out of 5 average rating, 89 reviews

Central|Confort|surrounded by nature|Wifi|parking

Conectar con la ciudad y la maravillosa naturaleza al mismo tiempo. Descansar en una hamaca en el balcón lo hace único. Te quedará genial si deseas visitarnos de placer, trabajo (WiFi de alta velocidad); en familia o en grupos de amigos. Casa de la Antigua Zona del Canal, Primer Alto; desde aquí para explorar lugares turísticos y restaurantes. (Cerca Terminal de Buses, Metro Tren, Albrook Mall, parque Metropolitano, Aeropuerto Marcos Gelabert, Casco Antiguo, Coast Way de Amador, Canal de 🇵🇦)

Top Guest favourite
An inviting living area features a grey reclining chair and a light wooden coffee table with decorative plants. In the background, a dining table set for four is visible, along with a stone accent wall that adds texture. Natural light fills the room through a nearby window.
Home in Panamá
4.95 out of 5 average rating, 41 reviews

Cantabria House - 10 minutes from the Airport

Spacious and comfortable home just 10 minutes from Tocumen Airport and only 200 meters from the Metro. Perfect for families, groups, or business trips. Fast 500 Mbps Wi-Fi, 3 bedrooms, 2 full bathrooms, fully equipped kitchen, air conditioning throughout the house, cable TV, patio with outdoor furniture, private parking, and self check-in. Long layover, family trip, or work in the city? This home has it all: comfort, location, and privacy. Book now and feel at home from the very first moment!

Guest favourite
A stone pathway leads through lush tropical foliage toward a welcoming entrance. Tall trees and vibrant greenery frame the path, creating a serene approach to the property, which is partially visible in the background, surrounded by nature's tranquility.
Home in Panama City
4.98 out of 5 average rating, 62 reviews

Mountain Retreat

Relax and unwind at this peaceful property nestled on two hectares of lush tropical vegetation surrounded by the sights & sounds of nature. Located at Panama's Blue Mountain(Cerro Azul), 30 kilometres from Panama City. This cozy & comfortable home is equipped with modern amenities & chic decorative touches. It consists of a main house with 2 bedrooms & a 2 bedroom cottage. It has a spacious terrace, pool & jacuzzi overlooking Panama City. The property also boasts its own spring water well

Top Guest favourite
Home in Panamá
4.93 out of 5 average rating, 40 reviews

Apartamento Lilia Airport 1

"Experimenta una estancia cómoda y conveniente en nuestro acogedor apartamento, ubicado a solo 10 minutos del aeropuerto Tocumen. Equipado con todas las comodidades necesarias para tu descanso, desde conexión WiFi hasta una cocina equipada, este espacio te ofrece la oportunidad de relajarte y recargar energías. Disfruta del confort del aire acondicionado, agua caliente/fria en el baño, una cama y sofá cama para tu comodidad, televisión con cable , y toallas y sobrecama para tu conveniencia.

Guest favourite
Home in Panamá
4.86 out of 5 average rating, 21 reviews

Charming House in Casco Viejo

This recently renovated house is an absolute treasure. It blends history, charm, and modern comfort. Archeologists uncovered artifacts dating to the seventeenth century. Tastefully furnished with modern comforts and antiques, it's steps away from the Panama Canal Museum and in the heart of Casco Viejo, perfect for guests looking to immerse themselves in the cultural and culinary delights before retreating to the comfort and tranquility of their temporary home.

Top Guest favourite
Home in Panama City
4.94 out of 5 average rating, 16 reviews

A Charming Colonial House in Casco Antiguo

Welcome to Casa Arango, a beautifully restored 19th-century gem in the heart of Casco Antiguo. Located on a quiet, picturesque street, this colonial house blends historic charm with modern comforts. Casa Arango offers three elegant rooms with private bathrooms, a front balcony, and a spacious patio with a barbecue and private bar. Perfect for families or groups of up to 8, the property also includes two private parking spaces—an exclusive luxury in the area.

Superhost
A bright bedroom features a spacious bed with a neutral gray quilt and two matching pillows. Natural light enters through multiple windows, which are flanked by light curtains. An air conditioning unit is mounted on the wall, adding comfort to the space.
Home in Panamá
4.64 out of 5 average rating, 33 reviews

Beautiful spacious full apartment near Albrook

Spacious and cozy apartment in a very quiet area surrounded by nature. The apartment is complete, everything is ready to welcome you. All services are included. Close to the Miraflores locks, Ciudad del Saber, the Metropolitan National Park, Cerro Ancón, and Albrook Terminal. Close to the Los Ríos pool. Accessibility for buses and taxis. For security reasons, cameras in the main entrance, terrace and patio. There are no cameras in indoor spaces.

Guest favourite
A lush green lawn showcases well-maintained grass, framed by tropical plants with vibrant yellow leaves. In the background, a spacious outdoor area is visible, featuring a covered seating area. Hammocks are gently swaying, inviting relaxation amidst the natural surroundings.
Home in Panamá
4.82 out of 5 average rating, 45 reviews

Wonderful nature

Enjoy a family retreat in the heart of nature, where tranquility envelops you. This cozy accommodation, surrounded by a beautiful garden in the Metropolitan Natural Park, offers you a unique escape just 3 minutes from Albrook Mall and 5 minutes from downtown. Wake up to birdsong and a visit from the ñeques (agoutis), while relaxing in an exclusive and lively atmosphere. The perfect getaway to disconnect and enjoy nature with all the amenities!

Top Guest favourite
A spacious living and dining area is depicted, featuring a blue sectional sofa with yellow accent pillows. A glass dining table with yellow placemats and black chairs is shown. Natural light enters through windows, revealing a glimpse of greenery outside.
Home in Panama City
4.82 out of 5 average rating, 114 reviews

Spacious Panama House in the 'heart of the city'

You couldn't ask for a better place to stay while you visit Panama. This location is perfect, while other properties might advertise similar amenities; not one of them can boast a combination of space and amazing location quite like this one. This is very private & secure property in a fantastic, & very safe area right in the heart of the city & close to everything! An oasis in the middle of the city with AC IN EVERY ROOM AND DININING ROOM.

Superhost
A serene courtyard features a small pool surrounded by terracotta tiles and smooth wooden planks. Lush green plants are displayed throughout the space, enhancing the tranquil environment. The walls are adorned with original stonework, blending history with nature.
Home in Panama City
4.78 out of 5 average rating, 99 reviews

Cozy house in Casco Viejo with private pool

Historic accommodation in the heart of the Old Town Enjoy a unique experience in this accommodation located in the center of the Old Town. The property has been carefully restored several times by renowned Panamanian architects, including Sebastián Paniza. Among its most outstanding features is a historic well within the property, as well as original walls and floors that preserve the spirit and authenticity of the place.

Top Guest favourite
The kitchen area features a black dining table with four chairs, complementing a modern microwave and refrigerator. Warm decorative elements, including wall art and a candle, add character to the space, which is equipped with essential appliances and a clean countertop.
Home in Panamá
4.94 out of 5 average rating, 394 reviews

Private Studio 10 Min from the Airport!

Entire apartment 10 minutes from the airport! The apartment is fully furnished including appliances and kitchen items, toiletries, dining room, work table and more. Just a few minutes walk from the SAN ANTONIO METRO Station, restaurants, shopping malls, laundries, supermarkets and pharmacies. We offer tours to San Blas to make the most of your trip. Our house is your house in Panama 🇵🇦

Popular amenities for Panama City house rentals

Quick stats about house rentals in Panama City

  • Total holiday rentals

    Explore 470 holiday rentals in Panama City

  • Verified guest reviews

    Over 7,710 verified reviews to help you choose

  • Family-friendly holiday rentals

    180 properties offer extra space and kid-friendly amenities

  • Pet-friendly accommodation

    Find 160 rentals that welcome pets

  • Holiday rentals with a pool

    90 properties feature pools

  • Rentals with dedicated workspaces

    230 properties have a dedicated workspace

  • Wi-Fi availability

    430 of Panama City holiday rentals include Wi-Fi access

  • Popular amenities for guests

    Guests love Kitchen, Wi-Fi and Pool across Panama City rentals

  • 4.7 Average rating

    Panama City stays receive an average rating of 4.7 out of 5 from guests

  • Nearby attractions

    Panama City's top spots, include Miraflores Locks, Museo de Arte Contemporáneo, and Santo Tomas (Panama Metro)

Destinations to explore

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