
House holiday rentals in Panama City
Find and book unique houses on Airbnb
Quick stats about house rentals in Panama City

Total holiday rentals
Explore 480 holiday rentals in Panama City

Verified guest reviews
Over 8,400 verified reviews to help you choose

Family-friendly holiday rentals
200 properties offer extra space and kid-friendly amenities

Pet-friendly accommodation
Find 160 rentals that welcome pets

Holiday rentals with a pool
90 properties feature pools

Rentals with dedicated workspaces
240 properties have a dedicated workspace

Wi-Fi availability
440 of Panama City holiday rentals include Wi-Fi access

Popular amenities for guests
Guests love Kitchen, Wifi and Pool across Panama City rentals

4.7 Average rating
Panama City stays receive an average rating of 4.7 out of 5 from guests

Nearby attractions
Panama City's top spots, include Miraflores Locks, Museo de Arte Contemporáneo, and Santo Tomas (Panama Metro)
Top-rated house rentals in Panama City
Guests agree: These houses are highly rated for location, cleanliness and more.

Welcome to Zola Sierra! Your Escape Into Nature.
Welcome to Zola Sierra. Your Private Escape Into the Heart of Nature. Step into the serenity of Zola Sierra, a one-of-a-kind 3-bedroom, 3-bath sanctuary nestled deep within the protected highlands of Cerro Azul, Panama. Designed for dreamers, seekers, and soul-restorers, this home is more than a stay — it’s a nature-immersive experience that effortlessly blends modern luxury with untamed wilderness. Come for the views. Stay for the stillness. Fall in love with the wild magic of Zola Sierra!

Central|Confort|surrounded by nature|Wifi|parking
Conectar con la ciudad y la maravillosa naturaleza al mismo tiempo. Descansar en una hamaca en el balcón lo hace único. Te quedará genial si deseas visitarnos de placer, trabajo (WiFi de alta velocidad); en familia o en grupos de amigos. Casa de la Antigua Zona del Canal, Primer Alto; desde aquí para explorar lugares turísticos y restaurantes. (Cerca Terminal de Buses, Metro Tren, Albrook Mall, parque Metropolitano, Aeropuerto Marcos Gelabert, Casco Antiguo, Coast Way de Amador, Canal de 🇵🇦)

3BR Home in Ancon Hill - Urban Oasis
Discover our home at Ancon Hill in Panama City, steps from Supreme Court. The hill offers scenic hiking trails to the top with city views, lush greenery, and wildlife. 5 min to Albrook Mall. 10 min to Casco Viejo (UNESCO site, restaurants, museums, nightlife), Amador Causeway, Cinta Costera, Metropolitan Park, Panama Convention Center, and Albrook Airport. 20 min to Panama Canal Miraflores Locks and Veracruz beach (across Bridge of Americas, gateway to countryside). 35 min to Tocumen Airport.

Mountain Retreat
Relax and unwind at this peaceful property nestled on two hectares of lush tropical vegetation surrounded by the sights & sounds of nature. Located at Panama's Blue Mountain(Cerro Azul), 30 kilometres from Panama City. This cozy & comfortable home is equipped with modern amenities & chic decorative touches. It consists of a main house with 2 bedrooms & a 2 bedroom cottage. It has a spacious terrace, pool & jacuzzi overlooking Panama City. The property also boasts its own spring water well

Cozy and Safe Environment Near the Airport
Casa ideal para disfrutar una estancia cómoda y tranquila con acceso independiente. Cuenta con 2 recámaras amplias (1 con cama queen y aire acondicionado, la otra con 2 camas individuales y abanico), 1 baño higiénico, sala con muebles cómodos, comedor, cocina equipada, lavandería, estacionamiento gratuito, terraza, Wiffi y Tv de 50". Ubicada en una calle sin tráfico con fácil acceso a avenidas principales, centros comerciales, transportes y a pocos minutos del Aeropuerto Internacional.

Family-Friendly Panama Canal Home with Fenced Yard
Welcome to our 3-bedroom vacation rental in Cardenas, Panama Canal area! Perfect for families, this home boasts a kitchen with quality appliances, including a 6-burner gas stove and a large fridge. Relax in stylish bedrooms, featuring a king suite with a private bath, and enjoy the lush surroundings filled with wildlife. Located next to a park with sports courts, this kid-friendly neighborhood offers outdoor fun. Experience the unique blend of comfort and nature right at your doorstep!

Large Private Residence in an Excellent Area
House in the best area of the country. Very quiet street, central, close to restaurants, pharmacies, mall among others. Large comfortable residence for groups or families. Private parking for up to 2 cars 4 spacious bedrooms, 2 comfortable studios, living room, breakfast room, large terrace. *Kosher Option Available* House in one of the best areas of the country. Very quiet street, central, close to restaurants, pharmacies, mall, and more. Large, comfortable residence for groups.

Spacious Panama House in the 'heart of the city'
You couldn't ask for a better place to stay while you visit Panama. This location is perfect, while other properties might advertise similar amenities; not one of them can boast a combination of space and amazing location quite like this one. This is very private & secure property in a fantastic, & very safe area right in the heart of the city & close to everything! An oasis in the middle of the city with AC IN EVERY ROOM AND DININING ROOM.

Private Studio 10 Min from the Airport!
Apartamento Entero a 10 MINUTOS del Aeropuerto! El apartamento está completamente amueblado incluyendo electrodomésticos y artículos de cocina , productos de aseo , sala comedor ,mesa de trabajo y demás. A sólo minutos caminando de la Estacion de METRO SAN ANTONIO y METROMALL. Ofrecemos Tours a San Blas -Tours a Monkey Island y el Canal de Panamá para que aproveches al maximo tu viaje. Nuestra casa es Tu casa en Panamá 🇵🇦

Cozy house in Casco Viejo with private pool
Historic accommodation in the heart of the Old Town Enjoy a unique experience in this accommodation located in the center of the Old Town. The property has been carefully restored several times by renowned Panamanian architects, including Sebastián Paniza. Among its most outstanding features is a historic well within the property, as well as original walls and floors that preserve the spirit and authenticity of the place.

3BR Mountain Retreat | Starlink WiFi | Cerro Azul
Escape to the cool mountain weather of Cerro Azul and enjoy a modern home surrounded by nature. Perfect for families, groups of friends, and remote work, with high-speed Starlink internet for seamless video calls and streaming. Relax on the spacious balcony, enjoy the BBQ gazebo, and unwind from city life while surrounded by fresh air, peaceful surroundings, and natural views. Have questions? Send us a message today!

Casa Blanca · Private pool, minutes from the city
White House · by Monova Modern house among pine trees, designed to disconnect and breathe. Clean design, large windows and private pool surrounded by nature. Bright spaces, visual balance and real calm. Ideal for couples or families seeking rest, comfort and aesthetics in a safe and exclusive environment. Only 45 minutes from the city, with the peace that is not found in it.
Popular amenities for Panama City house rentals
House rentals with a pool

Capira Lidice 3 bedroom house bbq area

Villa la Vista - majestic mountain hideaway

Beautiful house in Brisas del Golf

La Fontana Scape

House with Private Pool and two parking spaces

Oceanfront views/access w/ Pool, Privacy & Space

House of the waterfalls

Great Studio
Weekly house rentals

house-ac-wifi6-parking-family-rentacar

House near the airport

Cozy 1 bdr Apartment with A/C near Santa Maria

A little House in Panama City

Comfortable and luxurious apartment

Entire Home · Close to Irving Saladino Complex

Wonderful nature

Designer Canal Home - Med or Longterm
Private house rentals

Designer loft with private terrace

Casco Viejo 02, Luxury Condo, Panama Bay.

Forest View Cabin | Wi-Fi | BBQ | Cerro Azul

Tiny House in the Nature by HYTTE HOMES

Swiss-Designed Cozy Home w/ Stunning Rooftop

Entire Apartment | 3 Bedrooms in San Francisco

6A Golden Space | Design By Paradox

La Cabaña de Lu, a mountain retreat.
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- Things to do Panama
- Nature and outdoors Panama
- Sightseeing Panama
- Tours Panama
- Food and drink Panama
- Art and culture Panama





