
Guesthouse holiday rentals in Panama City
Find and book unique guesthouse rentals on Airbnb
Quick stats about guesthouse rentals in Panama City

Total holiday rentals
Explore 90 holiday rentals in Panama City

Nightly prices starting at
Panama City holiday rentals start at $17 NZD per night before taxes and fees

Verified guest reviews
Over 2,070 verified reviews to help you choose

Pet-friendly accommodation
Find 20 rentals that welcome pets

Holiday rentals with a pool
20 properties feature pools

Rentals with dedicated workspaces
30 properties have a dedicated workspace

Wi-Fi availability
80 of Panama City holiday rentals include Wi-Fi access

Popular amenities for guests
Guests love Kitchen, Wi-Fi and Pool across Panama City rentals

Nearby attractions
Panama City's top spots, include Miraflores Locks, Museo de Arte Contemporáneo, and Santo Tomas (Panama Metro)
Top-rated Guesthouses in Panama City
Guests agree: These guesthouses are highly rated for location, cleanliness and more.

Unique find: central+urban+ huge green yard+safe
Wake up to the sound of birds in this hidden retreat in the heart of the trendy & safe "El Cangrejo" neighborhood. Housed on the ground-floor of a 2-story building built in the 50's. Features a HUGE private green yard, perfect for relaxing or spotting hummingbirds and local critters with an outdoor dining set. Steps from cafés, galleries, parks, metro, nightlife & restaurants. Free Private parking & Fast WiFi. Thoughtfully decorated for a home feel . The space not suitable for children under 10.
4.77 out of 5 average rating, 31 reviews
SMART Stay• Airport 10 Min • Near Mall & Markets
This luxury budget studio its an affordable option just 11min. from Tocumen Airport and very close to the Panapark Free Zone, making it ideal for both business and transit travelers. The space offers Wi-Fi, a TV with Netflix, and is surrounded by supermarkets and stores. It’s a simple, private, and comfortable place to rest. ✔ Fast Internet ✔ Self check-in ✔ Modern and secure spaces ✔ A/C ✅This listing books fast so I suggest confirming your reservation while it’s still available.
4.75 out of 5 average rating, 4 reviews
Efficiency Bungalow - Metropolitan Natural Park
Casita Curundu is located in a quiet and beautiful neighborhood next to the Metropolitan Natural Park. A naturalist delight right in the city, surrounded by an urban jungle forest teeming with birds and wildlife. An amazing place for a couple to stay - you’ll have all the privacy you need but still be close to all the great attractions and the large shopping and transportation hub Albrook Mall, Airport, Bus & Metro Station and yet removed from the hustle and bustle of the city.
4.77 out of 5 average rating, 94 reviews
Cozy private studio near the airport
Welcome to El Rincón de Glenda, a cozy and well-equipped private studio on Vía Tocumen, just steps from the Don Bosco Metro station (Line 2). Ideal for travelers. It has 2 twin beds, a sofa, air conditioning, TV, mini-fridge, kitchenette with kettle and stove, and a private bathroom with a hot water shower. Pets allowed. Check-in from 3:00 p.m. and check-out by 12:00 a.m. No parties or smoking indoors. Your comfortable, quiet, and centrally located space in Panama.
5.0 out of 5 average rating, 17 reviews
Garden Cottage in Panama City
Welcome to our charming cottage, an oasis in the heart of the city, ideal for nature lovers and comfort seekers. Located in a central area, this retreat offers the perfect combination of tranquility, comfort, and proximity to Panama's main attractions. Enjoy the balance between urban life and the serenity of the natural surroundings. It features a private entrance, a spacious garden, a barbecue area, and a terrace where you can relax and connect with nature.
4.78 out of 5 average rating, 264 reviews
The Mexican
La Mexicana in Altos de Cerro Azul 🏔️🌵 Rustic 2-story getaway for 16+ people. 5 bedrooms, 4 bathrooms, equipped kitchen, Wi-Fi and TV. Pet friendly! 🐾 Enjoy the extensive garden, terrace with hammocks, barbecue and dominoes table. Campfire nights in the indoor fireplace and adventure days on nearby rivers and trails. The authentic Mexican "vibe" in the coolness of the mountain. Ideal for large groups looking to disconnect in total comfort. Book your trip!
5.0 out of 5 average rating, 3 reviews
Ancon Garden Studio - Panama City | Fast WiFi
Nestled in the historic former Canal Zone, this cozy studio is ideal for remote work and easy city access. Enjoy fast WiFi, a dedicated workspace, and a peaceful green setting near Cerro Ancón, the Panama Canal Railway Station, City of Knowledge, and Albrook Metro. Just a short walk away is Los Ríos Pool, a popular swimming facility perfect for lap swimming, exercise, or cooling off after a day of exploring. Also, bikes are available upon request.
5.0 out of 5 average rating, 5 reviews
Apartment in a safe residential area
You'll be close to everything when you stay at this centrally located accommodation. About 20 minutes from Tocumen Airport, 15 minutes from Romel Stadium, passing through Colon Free Zone near shops, restaurants, pharmacies, supermarkets, cinemas, easy transportation. Whether the trip is for work, as a tourist, or in transit through Panama, you can be comfortable in this apartment. We are available if you need additional information.
5.0 out of 5 average rating, 31 reviews
For 4 people 2 separate rooms in park
Quiet sleep surrounded by lush greenery 20 minutes from Panama spacious accommodation suitable for 2 couples or family of 4 people 1 queen bed and 2 twins with each en-suite private bathroom, provision of an umbrella bed Rest room hammock , equipped kitchen dining room, a saltwater pool to entertain you facing the ocean whose only users you are surrounded by a large garden Workspace with fast wifi Water sports, hiking nearby
4.88 out of 5 average rating, 34 reviews
Private guest house in Ancón
Enjoy the simplicity of this cozy, quiet, and centrally-located accommodation. Close to places of interest such as the Panama Canal Administration building, Amador Causeway, Albrook Mall, and several restaurants. Personally decorated to provide comfort... large windows in the bedroom provide natural lighting and a view of the garden and green area through the windows; yet it maintains the desired privacy and tranquility.
4.86 out of 5 average rating, 146 reviews
Boho Studio - Private Terrace 9 km from the airport
Perfect for 1–2 guests, Wifi, private terrace, independent studio, has A/C, and its own small bathroom, independent entrance. Located near Tocumen International Airport, 10 to 13 minutes by car. The Studio is close to 2 Shopping Centers, Metromall and Los Pueblos OUTLET. The residential area is safe to walk, organized and clean streets. We have the Cerro Viento Metro station outside in Metromall.
4.88 out of 5 average rating, 272 reviews
Villa Helena Studio 1 Apt. Cerro Azul
One bedroom studio apartment with private kitchen and bathroom in a peaceful compound with shared pool. Internet and free parking available. Laundry facilities available for longer stays. Cook your own meals, or have me cook some authentic Caribbean dishes like curries, or use the restaurant available next door. Surrounded by nature and access to trails, waterfalls, rivers, swimming holes.
5.0 out of 5 average rating, 15 reviewsPopular amenities for Panama City guesthouses
Family-Friendly guesthouses

Where Rosie per year. 500 without furniture and 600 with furniture

Mochila & Art Family House
4.4 out of 5 average rating, 5 reviews
Lodging in North Panama

Guest house with air conditioning, Wi-Fi,

Casa Real
4.96 out of 5 average rating, 133 reviews
Gabriel House 3
4.95 out of 5 average rating, 39 reviews
Tocumen Sweet Home
4.82 out of 5 average rating, 179 reviews
Bamboo a place to relax
4.75 out of 5 average rating, 32 reviewsGuesthouses with a patio

La Casita Garden Guest House in Panama City
New place to stay
Spacious, bright room surrounded by nature
5.0 out of 5 average rating, 7 reviews
great guest house rec 12
4.67 out of 5 average rating, 3 reviews
Bedroom#6+kitchen+WiFi+A/C+Close to the subway
5.0 out of 5 average rating, 3 reviews
Comfortable room #4 with air conditioning
5.0 out of 5 average rating, 4 reviews
Room+Parking+TV+Kitchen+Work Area+WiFi@PanamáCity
4.57 out of 5 average rating, 7 reviews
Smart Hostel Perfectly located.

Casa Relic - Room #7 Mixed Dormitory
Guest house rentals with a washing machine and dryer

Convenient, centrally located suite with parking
4.53 out of 5 average rating, 17 reviews
THIS CONDITION

SMALL FURNISHED APARTMENT, SERVICES INCLUDED.

Romantic cabin + pet friendly
4.97 out of 5 average rating, 34 reviews
Room, nature, sauna and eveything, near the sea.
4.64 out of 5 average rating, 11 reviews
Luxury Oceanview Room • Rooftop • Pool

Ocean front Apartment by San Francisco, PTY

Rest near the airport without paying so much
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