
Guesthouse holiday rentals in Panama City
Find and book unique guesthouse rentals on Airbnb
Quick stats about guesthouse rentals in Panama City

Total holiday rentals
Explore 90 holiday rentals in Panama City

Nightly prices starting at
Panama City holiday rentals start at $17 NZD per night before taxes and fees

Verified guest reviews
Over 2,070 verified reviews to help you choose

Pet-friendly accommodation
Find 20 rentals that welcome pets

Holiday rentals with a pool
20 properties feature pools

Rentals with dedicated workspaces
30 properties have a dedicated workspace

Wi-Fi availability
80 of Panama City holiday rentals include Wi-Fi access

Popular amenities for guests
Guests love Kitchen, Wifi and Pool across Panama City rentals

Nearby attractions
Panama City's top spots, include Miraflores Locks, Museo de Arte Contemporáneo, and Santo Tomas (Panama Metro)
Top-rated Guesthouses in Panama City
Guests agree: These guesthouses are highly rated for location, cleanliness and more.

The Alci-Los Altos de Cerro Azul "Niebla" cabin
🏡 El Refugio de Alci – “Niebla” Central ground floor of a cozy family chalet, located in Chagres National Park, surrounded by rivers, waterfalls and forest. “Niebla” accommodates 7 people + 5 on the left and 4 on the right. The main house has 2 bedrooms, 2 bathrooms, an equipped kitchen, a ranch and a gazebo. Balconies overlooking the forest and the stream, relaxing sounds. 🌿 Right side 1 guest house: (bungalow, Rio) 2 rooms for 4 people. The Guesthouse Izq Bosque for 5 people Goal: pay for what is used
4.81 out of 5 average rating, 27 reviews
Unique find: central+urban+ huge green yard+safe
Wake up to the sound of birds in this hidden retreat in the heart of the trendy & safe "El Cangrejo" neighborhood. Housed on the ground-floor of a 2-story building built in the 50's. Features a HUGE private green yard, perfect for relaxing or spotting hummingbirds and local critters with an outdoor dining set. Steps from cafés, galleries, parks, metro, nightlife & restaurants. Free Private parking & Fast WiFi. Thoughtfully decorated for a home feel . The space not suitable for children under 10.
4.77 out of 5 average rating, 31 reviews
Efficiency Bungalow - Metropolitan Natural Park
Casita Curundu is located in a quiet and beautiful neighborhood next to the Metropolitan Natural Park. A naturalist delight right in the city, surrounded by an urban jungle forest teeming with birds and wildlife. An amazing place for a couple to stay - you’ll have all the privacy you need but still be close to all the great attractions and the large shopping and transportation hub Albrook Mall, Airport, Bus & Metro Station and yet removed from the hustle and bustle of the city.
4.76 out of 5 average rating, 93 reviews
Cozy private studio near the airport
Welcome to El Rincón de Glenda, a cozy and well-equipped private studio on Vía Tocumen, just steps from the Don Bosco Metro station (Line 2). Ideal for travelers. It has 2 twin beds, a sofa, air conditioning, TV, mini-fridge, kitchenette with kettle and stove, and a private bathroom with a hot water shower. Pets allowed. Check-in from 3:00 p.m. and check-out by 12:00 a.m. No parties or smoking indoors. Your comfortable, quiet, and centrally located space in Panama.
5.0 out of 5 average rating, 17 reviews
Garden Cottage in Panama City
Welcome to our charming cottage, an oasis in the heart of the city, ideal for nature lovers and comfort seekers. Located in a central area, this retreat offers the perfect combination of tranquility, comfort, and proximity to Panama's main attractions. Enjoy the balance between urban life and the serenity of the natural surroundings. It features a private entrance, a spacious garden, a barbecue area, and a terrace where you can relax and connect with nature.
4.78 out of 5 average rating, 264 reviews
Convenient, centrally located suite with parking
This special place is close to everything, making it easy to plan your visit. 5-10 minutes to any attraction in Panama City. Assigned parking and two blocks from major bus stop that can take you anywhere in the city or accross the country. You will have the entire place for yourself with independent entry, air conditioning and kitchen. There are four grocery stores walking distance. You can exercise daily at a park located behind the property.
4.53 out of 5 average rating, 17 reviews
Ancon Garden Studio - Panama City | Fast WiFi
Nestled in the historic former Canal Zone, this cozy studio is ideal for remote work and easy city access. Enjoy fast WiFi, a dedicated workspace, and a peaceful green setting near Cerro Ancón, the Panama Canal Railway Station, City of Knowledge, and Albrook Metro. Just a short walk away is Los Ríos Pool, a popular swimming facility perfect for lap swimming, exercise, or cooling off after a day of exploring. Also, bikes are available upon request.
5.0 out of 5 average rating, 4 reviews
Apartment in a safe residential area
You'll be close to everything when you stay at this centrally located accommodation. About 20 minutes from Tocumen Airport, 15 minutes from Romel Stadium, passing through Colon Free Zone near shops, restaurants, pharmacies, supermarkets, cinemas, easy transportation. Whether the trip is for work, as a tourist, or in transit through Panama, you can be comfortable in this apartment. We are available if you need additional information.
5.0 out of 5 average rating, 31 reviews
Private guest house in Ancón
Enjoy the simplicity of this cozy, quiet, and centrally-located accommodation. Close to places of interest such as the Panama Canal Administration building, Amador Causeway, Albrook Mall, and several restaurants. Personally decorated to provide comfort... large windows in the bedroom provide natural lighting and a view of the garden and green area through the windows; yet it maintains the desired privacy and tranquility.
4.86 out of 5 average rating, 143 reviews
Boho Studio - Private Terrace 9 km from the airport
Perfect for 1–2 guests, Wifi, private terrace, independent studio, has A/C, and its own small bathroom, independent entrance. Located near Tocumen International Airport, 10 to 13 minutes by car. The Studio is close to 2 Shopping Centers, Metromall and Los Pueblos OUTLET. The residential area is safe to walk, organized and clean streets. We have the Cerro Viento Metro station outside in Metromall.
4.88 out of 5 average rating, 269 reviews
Charming accommodation, tropical vegetation, ocean-facing
Relaxation facing the ocean in tropical vegetation, 20 minutes from Panama, close to shops and transport, spacious room with private bathroom, equipped kitchen, outdoor lounge, saltwater pool. You will enjoy having your breakfast while observing dozens of birds. For nature lovers, calm and relaxation but also hiking, beaches and water sports. No pets allowed
4.91 out of 5 average rating, 64 reviews
Cozy apartment with a hot tub
In this accommodation you can breathe tranquility: relax with the whole family! It is located 20 minutes from the Miraflores Locks of the Panama Canal, In the residential complex we have the Riba Smith supermarket, restaurants such as Nacion Sushi, Farmacias Arrocha and activities such as a pleasant ecological walk. This is the second floor
4.61 out of 5 average rating, 33 reviewsPopular amenities for Panama City guesthouses
Family-Friendly guesthouses

Where Rosie per year. 500 without furniture and 600 with furniture

Guest house with air conditioning, Wi-Fi,

Mochila & Art Family House
4.4 out of 5 average rating, 5 reviews
Lodging in North Panama

Casa Real
4.96 out of 5 average rating, 126 reviews
Gabriel House 3
4.97 out of 5 average rating, 34 reviews
Tocumen Sweet Home
4.82 out of 5 average rating, 177 reviews
Bamboo a place to relax
4.75 out of 5 average rating, 32 reviewsGuesthouses with a patio

The Mexican
5.0 out of 5 average rating, 3 reviews
La Casita Garden Guest House in Panama City
New place to stay
great guest house rec 12
4.67 out of 5 average rating, 3 reviews
Bedroom#6+kitchen+WiFi+A/C+Close to the subway
5.0 out of 5 average rating, 3 reviews
Comfortable room #4 with air conditioning
5.0 out of 5 average rating, 3 reviews
Room+Parking+TV+Kitchen+Work Area+WiFi@PanamáCity
4.57 out of 5 average rating, 7 reviews
Triple Room in Smart Hostel

Casa Relic - Room #7 Mixed Dormitory
Guest house rentals with a washing machine and dryer

THIS CONDITION

Romantic cabin + pet friendly
4.97 out of 5 average rating, 33 reviews
Room, nature, sauna and eveything, near the sea.
4.64 out of 5 average rating, 11 reviews
Luxury Oceanview Room • Rooftop • Pool

Ocean front Apartment by San Francisco, PTY

Rest near the airport without paying so much
New place to stay
Villa Helena 3 Bedrooms Los Altos de Cerro Azul
4.78 out of 5 average rating, 9 reviews
Romantic Getaway IFogata Private
4.63 out of 5 average rating, 24 reviewsDestinations to explore
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