
Guesthouse holiday rentals in Panama City
Find and book unique guesthouse rentals on Airbnb
Quick stats about guesthouse rentals in Panama City

Total holiday rentals
Explore 90 holiday rentals in Panama City

Nightly prices starting at
Panama City holiday rentals start at $17 NZD per night before taxes and fees

Verified guest reviews
Over 2,070 verified reviews to help you choose

Pet-friendly accommodation
Find 20 rentals that welcome pets

Holiday rentals with a pool
20 properties feature pools

Rentals with dedicated workspaces
30 properties have a dedicated workspace

Wi-Fi availability
80 of Panama City holiday rentals include Wi-Fi access

Popular amenities for guests
Guests love Kitchen, Wifi and Pool across Panama City rentals

Nearby attractions
Panama City's top spots, include Miraflores Locks, Museo de Arte Contemporáneo, and Santo Tomas (Panama Metro)
Top-rated Guesthouses in Panama City
Guests agree: These guesthouses are highly rated for location, cleanliness and more.

Unique find: central+urban+ huge green yard+safe
Wake up to the sound of birds in this hidden retreat in the heart of the trendy & safe "El Cangrejo" neighborhood. Housed on the ground-floor of a 2-story building built in the 50's. Features a HUGE private green yard, perfect for relaxing or spotting hummingbirds and local critters with an outdoor dining set. Steps from cafés, galleries, parks, metro, nightlife & restaurants. Free Private parking & Fast WiFi. Thoughtfully decorated for a home feel . The space not suitable for children under 10.
ValueLocationIndoor spaces

Smart Stay by SS • Budget Studio 3+ Airport & Mall
This luxury budget studio is located just 11 minutes from Tocumen Airport and very close to the Panapark Free Zone, making it ideal for both business and transit travelers. The space includes Wi-Fi, a TV with Netflix, and is surrounded by supermarkets and stores. It’s a simple, private, and comfortable place to rest. ✅Perfect for engineers and business travelers looking for a good, nice, and affordable place to stay. ✔ Fast Internet ✔ Self check-in ✔ Modern and secure spaces ✔ A/C
LocationComfortWi-Fi

Efficiency Bungalow - Metropolitan Natural Park
Casita Curundu is located in a quiet and beautiful neighborhood next to the Metropolitan Natural Park. A naturalist delight right in the city, surrounded by an urban jungle forest teeming with birds and wildlife. An amazing place for a couple to stay - you’ll have all the privacy you need but still be close to all the great attractions and the large shopping and transportation hub Albrook Mall, Airport, Bus & Metro Station and yet removed from the hustle and bustle of the city.
LocationValueCleanliness

Cozy private studio near the airport
Welcome to El Rincón de Glenda, a cozy and well-equipped private studio on Vía Tocumen, just steps from the Don Bosco Metro station (Line 2). Ideal for travelers. It has 2 twin beds, a sofa, air conditioning, TV, mini-fridge, kitchenette with kettle and stove, and a private bathroom with a hot water shower. Pets allowed. Check-in from 3:00 p.m. and check-out by 12:00 a.m. No parties or smoking indoors. Your comfortable, quiet, and centrally located space in Panama.
LocationValueAmenities

Garden Cottage in Panama City
Welcome to our charming cottage, an oasis in the heart of the city, ideal for nature lovers and comfort seekers. Located in a central area, this retreat offers the perfect combination of tranquility, comfort, and proximity to Panama's main attractions. Enjoy the balance between urban life and the serenity of the natural surroundings. It features a private entrance, a spacious garden, a barbecue area, and a terrace where you can relax and connect with nature.
LocationFamilyCheckout

The Mexican
La Mexicana in Altos de Cerro Azul 🏔️🌵 Rustic 2-story getaway for 16+ people. 5 bedrooms, 4 bathrooms, equipped kitchen, Wi-Fi and TV. Pet friendly! 🐾 Enjoy the extensive garden, terrace with hammocks, barbecue and dominoes table. Campfire nights in the indoor fireplace and adventure days on nearby rivers and trails. The authentic Mexican "vibe" in the coolness of the mountain. Ideal for large groups looking to disconnect in total comfort. Book your trip!
LocationFamilyCleanliness

Convenient, centrally located suite with parking
This special place is close to everything, making it easy to plan your visit. 5-10 minutes to any attraction in Panama City. Assigned parking and two blocks from major bus stop that can take you anywhere in the city or accross the country. You will have the entire place for yourself with independent entry, air conditioning and kitchen. There are four grocery stores walking distance. You can exercise daily at a park located behind the property.
LocationLong stayIndoor spaces

Ancon Garden Studio - Panama City | Fast WiFi
Nestled in the historic former Canal Zone, this cozy studio is ideal for remote work and easy city access. Enjoy fast WiFi, a dedicated workspace, and a peaceful green setting near Cerro Ancón, the Panama Canal Railway Station, City of Knowledge, and Albrook Metro. Just a short walk away is Los Ríos Pool, a popular swimming facility perfect for lap swimming, exercise, or cooling off after a day of exploring. Also, bikes are available upon request.
LocationHospitalityWi-Fi

Apartment in a safe residential area
You'll be close to everything when you stay at this centrally located accommodation. About 20 minutes from Tocumen Airport, 15 minutes from Romel Stadium, passing through Colon Free Zone near shops, restaurants, pharmacies, supermarkets, cinemas, easy transportation. Whether the trip is for work, as a tourist, or in transit through Panama, you can be comfortable in this apartment. We are available if you need additional information.
ValueLocationCleanliness

Private guest house in Ancón
Enjoy the simplicity of this cozy, quiet, and centrally-located accommodation. Close to places of interest such as the Panama Canal Administration building, Amador Causeway, Albrook Mall, and several restaurants. Personally decorated to provide comfort... large windows in the bedroom provide natural lighting and a view of the garden and green area through the windows; yet it maintains the desired privacy and tranquility.
LocationValueAmenities

Boho Studio - Private Terrace 9 km from the airport
Perfect for 1–2 guests, Wifi, quiet terrace, separate room, has A/C, and its small bathroom. Located near Tocumen International Airport, 10 to 13 minutes by car. The Studio is close to 2 Shopping Centers, Metromall and Los Pueblos OUTLET. The residential area is safe to walk, organized and clean streets. We have the Cerro Viento Metro station outside in Metromall.
ValueFamilyKitchen

Charming accommodation, tropical vegetation, ocean-facing
Relaxation facing the ocean in tropical vegetation, 20 minutes from Panama, close to shops and transport, spacious room with private bathroom, equipped kitchen, outdoor lounge, saltwater pool. You will enjoy having your breakfast while observing dozens of birds. For nature lovers, calm and relaxation but also hiking, beaches and water sports. No pets allowed
LocationFamilyKitchen
Popular amenities for Panama City guesthouses
Family-Friendly guesthouses

Where Rosie goes every year. 500 without furniture and 575 with furniture

Guest house with air conditioning, Wi-Fi,

Mochila & Art Family House

Lodging in North Panama

Casa Real
LocationValueGetting around

Gabriel House 3
ValueLocationQuiet

Tocumen Sweet Home
ValueLocationComfort

Bamboo a place to relax
LocationValueTV
Guesthouses with a patio

La Casita Garden Guest House in Panama City

Bedroom#6+kitchen+WiFi+A/C+Close to the subway
LocationIndoor spacesAir conditioning

CY4 l Private room in Marbella
LocationCheck-inBathroom

Quiet bedroom 15 minutes from the airport
KitchenComfortGetting around

Comfortable room #4 with air conditioning
QuietHospitalityComfort

great guest house rec 12
LocationComfortHospitality

Room+Parking+TV+Kitchen+Work Area+WiFi@PanamáCity
LocationValueComfort

Smart Hostel Perfectly located.
Guest house rentals with a washing machine and dryer

THIS CONDITION
Hospitality

Romantic cabin with jacuzzi + pet friendly
LocationFamilyTV

Room, nature, sauna and eveything, near the sea.
ValueLocationIndoor spaces

Sofa Bed Stay Rooftop Pool & Gym, Avenida Balboa N

Rest near the airport without paying so much

Ocean front Apartment by San Francisco, PTY

Villa Helena 3 Bedrooms Los Altos de Cerro Azul
LocationFamilyView

Smart Stay by SS • Budget Studio 4+ Airport & Mall
ValueLocationComfort
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- Things to do Panama
- Landmarks Panama
- Water sports Panama
- Nature and outdoors Panama
- Food tours Panama
- Sports activities Panama
- Tastings Panama
- Sightseeing Panama
- Wildlife Panama
- Outdoors Panama
- Cultural tours Panama
- Tours Panama
- Food and drink Panama
- Art and culture Panama
- Cooking Panama





