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Guesthouse holiday rentals in Panama City

Find and book unique guesthouse rentals on Airbnb

Top-rated Guesthouses in Panama City

Guests agree: These guesthouses are highly rated for location, cleanliness and more.

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Guesthouse in Panamá
5 out of 5 average rating, 3 reviews

Smart Stay by SS • Budget Studio 3+ Airport & Mall

This luxury budget studio is located just 11 minutes from Tocumen Airport and very close to the Panapark Free Zone, making it ideal for both business and transit travelers. The space includes Wi-Fi, a TV with Netflix, and is surrounded by supermarkets and stores. It’s a simple, private, and comfortable place to rest. ✅Perfect for engineers and business travelers looking for a good, nice, and affordable place to stay. ✔ Fast Internet ✔ Self check-in ✔ Modern and secure spaces ✔ A/C

The bungalow is nestled among lush greenery, with tall trees and vibrant plants surrounding its entrance. A private parking space is visible in front, and the structure features a light-colored exterior with a welcoming porch. The clear blue sky adds to the serene atmosphere.
Guesthouse in Panama City
4.75 out of 5 average rating, 89 reviews

Efficiency Bungalow - Metropolitan Natural Park

Casita Curundu is located in a quiet and beautiful neighborhood next to the Metropolitan Natural Park.  A naturalist delight right in the city, surrounded by an urban jungle forest teeming with birds and wildlife. An amazing place for a couple to stay - you’ll have all the  privacy you need but still be close to all the great attractions and the large shopping and transportation hub Albrook Mall, Airport, Bus & Metro Station and yet removed from the hustle and bustle of the city.

A modern living space is outlined with light colors and simple furnishings. A wall-mounted TV is positioned above a low cabinet, while a cozy sofa bed is accompanied by a decorative pillow. Large sliding glass doors invite natural light and provide views of the outdoor patio area.
Guesthouse in Panamá

Trendy Tiny Apartment in Ancon

Nestled in the former Canal Zone, this cozy apartment offers comfort, nature, and city access. Near the City of Knowledge, The Panama Canal and Albrook, it’s perfect for exploring history and culture. We proudly welcome LGBTQ+ travelers and allies to a safe, inclusive space where you can relax and feel at home. Whether you're a solo traveler, a couple, or a digital nomad, you’ll find a warm, affirming environment here. Enjoy tropical hikes, city views, and local events. 🌈

Guest favourite
Guesthouse in El Cangrejo
4.79 out of 5 average rating, 24 reviews

Rare find: central+urban+ private green yard

Wake up to the sound of birds in this peaceful retreat in the heart of trendy and safe "El Cangrejo" neighborhood. Housed on the ground-floor apartment of a 2-story building built in the 50's. Features a private green yard — perfect for relaxing or spotting hummingbirds with an outdoor dining set. Steps from cafés, galleries, parks, metro, nightlife and many restaurants. Only one other neighbor on site. Private parking. Thoughtfully decorated to help you feel at home.

Guesthouse in Panamá
New place to stay

villa serena

Comfortable two-level home, ideal for families or groups. It has 3 bedrooms: the main one with a private bathroom and air conditioning, the other two have portable fans. TV room, dining room and equipped kitchen. It has parking and the entrance is shared with another accommodation. Perfect for quiet and well-located stays. Outside the city, west of Panama, Arraijan Vista Alegre, an hour from Panama City, you can visit the beaches of the interior of the country.

Top Guest favourite
Guesthouse in Panamá
4.77 out of 5 average rating, 251 reviews

Garden Cottage in Panama City

Welcome to our charming cottage, an oasis in the heart of the city, ideal for nature lovers and comfort seekers. Located in a central area, this retreat offers the perfect combination of tranquility, comfort, and proximity to Panama's main attractions. Enjoy the balance between urban life and the serenity of the natural surroundings. It features a private entrance, a spacious garden, a barbecue area, and a terrace where you can relax and connect with nature.

Superhost
The kitchen features modern appliances, including a stainless steel gas stove and a white refrigerator. A compact sink is positioned beneath a small window, while kitchen essentials are arranged along a shelf above. Counter space is available for meal preparation, complemented by subtle wall tiles.
Guesthouse in Panamá
4.5 out of 5 average rating, 16 reviews

Convenient, centrally located suite with parking

This special place is close to everything, making it easy to plan your visit. 5-10 minutes to any attraction in Panama City. Assigned parking and two blocks from major bus stop that can take you anywhere in the city or accross the country. You will have the entire place for yourself with independent entry, air conditioning and kitchen. There are four grocery stores walking distance. You can exercise daily at a park located behind the property.

A cozy studio area features a spacious bed with a striped blanket. A small round table with two chairs is situated near a window adorned with dark curtains. A television stands on a dresser, and a door leads to a closet space. An air conditioning unit is mounted on the wall.
Guesthouse in Panamá
4.79 out of 5 average rating, 19 reviews

Private studio annex near Costa del Este

Small, very nice and cozy studio type annex (all in one area) very cozy, super nice, clean. Annex adjacent to our house, private and independent with all the amenities inside it for your stay, with split air conditioning, smart TV, wifi, large bathroom shower with hot water, kitchen with all its appliances, area to park a car. Located in a very quiet residential area, a very good area. Great location. Just minutes away from Costa del Este.

A small private pool is surrounded by lush greenery, creating a serene atmosphere. Large glass doors lead into the interior space, framed by decorative vases on either side. The pool area features a textured concrete deck, enhancing the connection with the tropical environment.
Guesthouse in Panamá
4.76 out of 5 average rating, 86 reviews

Cool Guesthouse+WiFi+Pool+Tv+AC @ Panama Canal

✔️Verified Superhost! Your stay will be in the best hands Guest house, Near the City of Knowledge 🇵🇦 📍 In the tropical forest of the old Clayton base, with amenities, parks, sports and gastronomy. Close to the city, shopping malls, the Miraflores Locks and the transoceanic railway🇵🇦 We offer: 💧 Hot Water 📶 Wifi ❄️ AC 🏊‍♂️ Pool 📺 Smart TV and Cable 🚗Parking This strategic location, with a high level of security in the area.

Guest favourite
A well-lit bedroom features a spacious bed dressed in a light quilt. Two bedside tables with lamps sit on either side. Blue decorative pillows add a pop of color against the neutral walls, while an air conditioning unit and a vibrant artwork piece enhance the atmosphere.
Guesthouse in Distrito San Miguelito, Brisas del Golf, Panama City
5 out of 5 average rating, 28 reviews

Apartment in a safe residential area

You'll be close to everything when you stay at this centrally located accommodation. About 20 minutes from Tocumen Airport, 15 minutes from Romel Stadium, passing through Colon Free Zone near shops, restaurants, pharmacies, supermarkets, cinemas, easy transportation. Whether the trip is for work, as a tourist, or in transit through Panama, you can be comfortable in this apartment. We are available if you need additional information.

Guest favourite
A small seating area is visible outside the entrance, featuring two black metal chairs positioned on tiled flooring. Nearby, a plant is displayed on a low table, while decorative plants add a green touch to the surrounding space. A large window lets in natural light.
Guesthouse in Panamá
4.93 out of 5 average rating, 42 reviews

CASA PINO, a forest in the city

Excellent independent studio apartment with everything you need, private bathroom, kitchenette, fridge, and WiFi. Very safe. You can use machines in the park to exercise. We are located in a privileged area on the banks of the Canal, with lots of vegetation and forests, but very close to all the recreational amenities of the City of Knowledge. Very central, 10 minutes by metro-bus to Albrook Mall, 10 minutes from the Panama Canal.

Top Guest favourite
A cozy sleeping area features a wooden bed dressed in a floral-patterned quilt and decorative pillows. Soft lighting is provided by bedside lamps, while light filters through a window adorned with sheer curtains, enhancing the calming atmosphere of the room.
Guesthouse in Balboa
4.88 out of 5 average rating, 86 reviews

Private guest house in Ancón

Enjoy the simplicity of this cozy, quiet, and centrally-located accommodation. Close to places of interest such as the Panama Canal Administration building, Amador Causeway, Albrook Mall, and several restaurants. Personally decorated to provide comfort... large windows in the bedroom provide natural lighting and a view of the garden and green area through the windows; yet it maintains the desired privacy and tranquility.

Popular amenities for Panama City guesthouses

Quick stats about guesthouse rentals in Panama City

  • Total holiday rentals

    Explore 80 holiday rentals in Panama City

  • Nightly prices starting at

    Panama City holiday rentals start at $17 NZD per night before taxes and fees

  • Verified guest reviews

    Over 1,640 verified reviews to help you choose

  • Pet-friendly accommodation

    Find 20 rentals that welcome pets

  • Holiday rentals with a pool

    10 properties feature pools

  • Rentals with dedicated workspaces

    30 properties have a dedicated workspace

  • Wi-Fi availability

    80 of Panama City holiday rentals include Wi-Fi access

  • Popular amenities for guests

    Guests love Kitchen, Wi-Fi and Pool across Panama City rentals

  • Nearby attractions

    Panama City's top spots, include Miraflores Locks, Museo de Arte Contemporáneo, and Santo Tomas (Panama Metro)

Destinations to explore