
Holiday houses in Panama City
Find and book unique accommodation on Airbnb
Quick stats about holiday rentals in Panama City

Total holiday rentals
Explore 5,590 holiday rentals in Panama City

Verified guest reviews
Over 149,670 verified reviews to help you choose

Family-friendly holiday rentals
1,780 properties offer extra space and kid-friendly amenities

Pet-friendly accommodation
Find 1,940 rentals that welcome pets

Holiday rentals with a pool
2,960 properties feature pools

Rentals with dedicated workspaces
3,570 properties have a dedicated workspace

Wi-Fi availability
5,430 of Panama City holiday rentals include Wi-Fi access

Popular amenities for guests
Guests love Self check-in, Gym and BBQ grill across Panama City rentals

4.7 Average rating
Panama City stays receive an average rating of 4.7 out of 5 from guests

Nearby attractions
Panama City's top spots, include Miraflores Locks, Museo de Arte Contemporáneo, and Santo Tomas (Panama Metro)
Top-rated holiday rentals in Panama City
Guests agree: these stays are highly rated for location, cleanliness and more.

CASA SAEMA -PRESTIGIOUS DUPLEX PENTHOUSE WITH TERRACES
Spectacular duplex penthouse in Panama's Casco Antiguo, 265 m2 with balconies, private outdoor terraces, an indoor garden lounge, a dining room, 3 bedrooms (+ sofa bed in the studio), recently renovated with a loft concept, exclusive, unique and comfortable design, in the best area of the Casco Viejo, perfect for relaxing and unwinding, kitchen, dishwasher, living room with washing machine, shared pool, elevator, 24/7 doorman, children who cannot swim are not allowed, wide variety of leisure activities in the area.

The View of Casco: Designer Loft with best Balcony
Sip your morning coffee or evening wine on the balcony, taking in a stunning, panoramic view of the city skyline! Experience the absolute best of Casco Viejo from this elegant, fully remodeled 1-bedroom loft. Nestled inside a beautifully restored 1850 colonial building—featuring historic, original calicanto walls—this stylish space puts the entire city at your doorstep. You are just steps away from world-class dining, vibrant cafes, museums, and Casco's legendary nightlife

Unique Luxury 3-story Loft at the Yoo
Experience the luxury of a world renowned Philippe Starck designed building. Our 3-bedroom sanctuary is a unique 3-story loft that boasts breathtaking city views, an open-plan kitchen, sleek marble floors, and premium amenities. Steps away from Panama City’s premier attractions, shopping, and dining. Dive into top-tier amenities: a pristine pool, state-of-the-art gym, relaxing spa, and three of the best restaurants in the city! Embrace Panama in unmatched style.

Ocean View Apt in Panama, Yoo&Arts
Iconic luxury at Yoo&Arts Panama. This spectacular 130m² (1,400 sq ft) apartment offers sophisticated design and a breathtaking panoramic view of the Pacific Ocean. Enjoy breakfast on the balcony with an exceptional breeze, watch the sunrise from your bedroom, or work in an inspiring environment. Located on Avenida Balboa, the city's most exclusive area, you’ll have direct access to fine dining inside the building, premium supermarkets, and shopping malls nearby.

Luxury apt in Panama City 2 Rooms 3 Baths
The Wanders by yoo building is located in the heart of the city. It is an extraordinary project where every corner has a story to tell. 24/7 reception, many recreation areas, hydration station. Outside the lobby, there is the Cafetería cafe con teclas and a Popino Carnes restaurant. In the social area, bar service in the pools, children's park, games room with screens on the ceiling bathrooms, function room, kitchen for events, fully equipped gym and more

Beautiful House in Panama w/ King Beds + Pool
Beautiful home in Punta Paitilla featuring 6 bedrooms, 5.5 bathrooms, and 8 beds, comfortably accommodating up to 16 guests. Enjoy a private pool, in-home gym, and spacious, modern living areas designed for families, groups, or business travelers. The layout offers both privacy and comfort across two levels. Located in one of Panama City’s most exclusive neighborhoods, just minutes from restaurants, shopping centers, supermarkets, and the Cinta Costera.

Modern apt ocean view in heart of Panamá yoo tower
This special place is close to everything, making it easy to plan your visit. Ph Yoo and Arts, located on Av. Balboa, very central This beautiful and modern property has a unique style and an incredible ocean view, high floor, 2 bedrooms, 2.5 full bathrooms, laundry, large terrace, dimmable lights throughout the space, dining room, movie room, workspace, 3 smart TVs, 3 central air conditioners, fully equipped kitchen, modern glassware.

Loft 3b Old Town Best! It's 150 m2 (492 feet)
Immerse yourself in the historic charm and modern elegance of our 3-bedroom, 150 m2 loft in the heart of the Old Town. With wooden floors that radiate warmth and a modern open-plan kitchen ideal for sharing, this space guarantees a memorable vacation. Located on Avenida A, you'll find yourself just a few steps away from exquisite restaurants, museums, colonial churches, and the Casco's coveted rooftops, making every day an adventure.

Beautiful Apt, Best Location 2BR
Beautiful apartment, high floor up, with 2 bedrooms, 2 bathrooms, walking closet, and essential closet for the second bedroom. Extra twin bed available in the apartment. High speed internet, 300Mbps by Wifi aprox. , 600Mbps by cable. Social area on the roof with swimming pool, gym, sauna and bbq area. The building location is excellent, We are walking distance for grocery stores, restaurants, bank, Hilton Hotel&Casino.

Full apartment in Panama
This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.

Hotel-Style Room at The Hub, San Francisco
Elegant hotel-style room at PH The Hub, located on 74th Street and 50th Street in San Francisco, a short walk from Omar Park. Ideal for a maximum of 2 people, it has a full private bathroom, balcony, mini refrigerator, microwave, coffee maker and electric kettle. Enjoy the building's amenities, such as a swimming pool, gym, and 24/7 security, in one of the most vibrant neighborhoods in Panama City.

Luxury Centric 2BR Apartment in Casco Viejo
Welcome to our charming and spacious apartment in the heart of Casco Viejo. We are located directly across the street from the landmark Hotel La Compañia. From the balcony you can look at the remaining structure of the centuries-old La Compañia de Jesus, a former Jesuit temple and convent. In the apartment, you can relax in the spacious and comfortable space.
Popular amenities for Panama City holiday rentals
Other great holiday rentals in Panama City

Suite Luxury 30th View Yoo Panamá & Arts Tower

Mountain Retreat

PH The Gray | Balcony Views · Pool · Gym

Ocean View | Rooftop Pool | Luxury Stay

Old Town & Ocean View

Studio for the Coffee-Obsessed | near Casco Viejo

Panoramic Casco Viejo Lookout in The Sands

YC 3403 l 1 BDR Apartment Av. Balboa with balcony
Frequently Asked Questions
What are the best places to stay in Panama City?
Panama City has stays in vibrant neighborhoods like Casco Viejo, known for historic charm, and Punta Pacifica, often suggested for modern towers and city views. Many visitors also enjoy options around El Cangrejo for its mix of cafes and local culture.
What are the best things to do in Panama City with kids?
Explore the Biomuseo’s interactive exhibits, walk the Amador Causeway for city and canal views, or visit parks like Parque Natural Metropolitano to spot wildlife. Many families enjoy boat tours or learning about the canal’s history.
What are some of the best things to do in Panama City?
Wander historic streets in Casco Viejo, explore exhibits at the Panama Canal Museum, and stroll the Cinta Costera waterfront. Food and markets, canal tours, and cultural centers are frequently suggested for first-time visitors.
How is the weather in Panama City?
Panama City has a tropical climate with warm temperatures year-round, often around 75–88°F (24–31°C). Visitors can expect higher humidity, with occasional rain, especially during the wet season.
What are the best places to visit in Panama City?
Casco Viejo’s historic architecture, the Panama Canal, and the Biomuseo are often highlighted for visitors. The Amador Causeway is also suggested for scenic walks and views over the bay.
What are some hiking trails in Panama City?
Parque Natural Metropolitano has trails through tropical forest with city vistas and wildlife. The Sendero El Gaital path and walking routes around Cerro Ancón are also frequently suggested for those who want a nature escape near urban sights.
What are some family activities we can do in Panama City?
Families often enjoy the interactive displays at Biomuseo, relaxing on the Amador Causeway, and wildlife spotting in Parque Natural Metropolitano. Parks with playgrounds and canal boat tours are also popular with kids.
What are some of the best day trip ideas from Panama City?
Day trips from Panama City often include hiking in nearby rainforest reserves, visiting Gamboa for canal views and nature tours, or relaxing on beaches around the Pearl Islands. Guided excursions introduce travelers to indigenous cultural sites as well.
Are there any pet friendly accommodations available in Panama City?
Panama City has pet-friendly stays, especially in neighborhoods like El Cangrejo and San Francisco, where parks and walkable streets make it easy to enjoy the city with your pet. Many hosts welcome dogs and cats with advance notice.
What are some local tips for visiting Panama City?
When exploring Panama City, lightweight clothing helps with humidity, and a reusable water bottle is useful. Street murals around Casco Viejo show local talent, while trying fresh seafood in city markets gives a taste of regional flavors.
What is Panama City known for?
Panama City is known for the Panama Canal, mix of colonial and modern architecture, and vibrant culinary scene. Its waterfront walks and lively festivals celebrate a crossroads of cultures.
What are the best hidden gems to explore in Panama City?
Panama City has tucked-away art galleries in Casco Viejo, quiet gardens at Mi Pueblito, and street food stands in Santa Ana that attract locals. Seek out small museums and indie coffee shops for a neighborhood experience.
What are the best foods to try in Panama City?
Local favorites include sancocho chicken stew, patacones (fried plantains), and ceviche from city markets. Panamanian seafood, fresh tropical fruits, and pastries filled with local flavors are frequently suggested.
What should I bring for a trip to Panama City?
Bring lightweight, breathable clothing for the tropical climate, comfortable walking shoes, and sun protection like hats and sunscreen. A rain jacket and an adapter for electronics are also practical for your stay.
What is the nightlife in Panama City like?
Panama City has a vibrant nightlife scene, with lively rooftop bars, salsa venues, and music lounges in Casco Viejo. Neighborhoods like Calle Uruguay and El Cangrejo are known for dance clubs, craft cocktail spots, and casual pubs. Visitors often explore a mix of local rhythms and international influences after dark.
What are the most popular events or festivals in Panama City?
Carnival is one of the most popular celebrations, filling Panama City with music, parades, and color before Lent. Jazz festivals, local art fairs, and folklore events also draw crowds throughout the year.
Are there family friendly vacation rentals in Panama City?
Panama City has family-friendly vacation rentals, especially in areas near parks and cultural attractions like El Cangrejo, San Francisco, and Casco Viejo. Many hosts provide amenities for children and groups traveling together.
When is the best time to visit Panama City?
The drier season is often recommended for clearer skies and outdoor activities. Many travelers prefer visiting when major cultural events and festivals enliven the city’s atmosphere.
Destinations to explore
- Cartagena Holiday rentals
- Cahuita Holiday rentals
- Bahía Ballena Holiday rentals
- Coveñas Holiday rentals
- Puerto Viejo de Talamanca Holiday rentals
- Bocas del Toro Province Holiday rentals
- Uvita Holiday rentals
- San Andrés Holiday rentals
- Boquete Holiday rentals
- Rio Hato Holiday rentals
- El Valle Holiday rentals
- Valle de Antón Holiday rentals
- Family-friendly rentals Panama City
- Serviced apartment rentals Panama City
- Rentals with lake access Panama City
- Rentals with a sauna Panama City
- Pet-friendly rentals Panama City
- Boutique hotels Panama City
- Bed and breakfasts Panama City
- Apartment rentals Panama City
- Beachfront rentals Panama City
- Rentals with a hot tub Panama City
- Hotel rooms Panama City
- Guesthouse rentals Panama City
- Cabin rentals Panama City
- Townhouse rentals Panama City
- Hostel rentals Panama City
- Condo rentals Panama City
- Private suite rentals Panama City
- Rentals with an accessible height bed Panama City
- Loft rentals Panama City
- Rentals with breakfast Panama City
- Rentals with beach access Panama City
- Rentals with pools Panama City
- Villa rentals Panama City
- Waterfront rentals Panama City
- House rentals Panama City
- Things to do Panama City
- Landmarks Panama City
- Food tours Panama City
- Cooking Panama City
- Wildlife Panama City
- Tastings Panama City
- Outdoors Panama City
- Cultural tours Panama City
- Things to do Panamá Province
- Cultural tours Panamá Province
- Water sports Panamá Province
- Cooking Panamá Province
- Outdoors Panamá Province
- Food tours Panamá Province
- Wildlife Panamá Province
- Landmarks Panamá Province
- Tastings Panamá Province
- Things to do Panama
- Landmarks Panama
- Water sports Panama
- Food tours Panama
- Tastings Panama
- Wildlife Panama
- Outdoors Panama
- Cultural tours Panama
- Cooking Panama







