
Family-friendly holiday rentals in La Mesa
Find and book unique family-friendly homes on Airbnb
Top-rated family-friendly rentals in La Mesa
Guests agree: These family-friendly homes are highly rated for location, cleanliness and more.
Holiday rentals for every style
Get the amount of space that is right for you
Popular amenities for La Mesa family-friendly rentals
Family-friendly home rentals with a hot tub

Pool Side Safari Cabin (On Backside of our Home)

Large Home Heated Pool Spa | Game Room (Sleeps 30)

Home at the Sanctuary

Guesthouse w/BALCONY!Sunset & Sunrise VIEWS~

Comfy Mountain Top Casita

Da Hui Hut - La Mesa’s best view and spa

Charming Suite in Historic Home

The Outside Inn at The Tipsy Goat Ranch
Family- and pet-friendly home rentals

Clean 1BR/1BA Guest House Peaceful Private Casita

The Queen House

Retro Fun, S'mores & Smiles in Bettie Blue

🤲🏼 Handmade hideaway Mt. Helix - AC/Laundry/Parking

Hacienda de las Campanas (Bell Hacienda)

Private cozy cottage

Dog friendly California Cottage near SDSU

Kensington Classic/Historic Tudor - Fully Licensed
Family-friendly home rentals with a pool

Mountain Retreat Ocean View-Great for Staycation

The BEST NEST Clean, peaceful, private, affordable

Sunny SD l Pool l BBQ l Pool Loungers l Sleeps 10

Private Poolside Cabana

Bright and spacious home with views, pool & spa.

Designer Luxury Rental With Pool

Updated TownHome, Great Location, Fantastic Views

Resort-Style Living, Pool, Close to All San Diego
Quick stats about holiday rentals that are family-friendly in La Mesa
Total rentals
260 properties
Nightly prices starting at
$85 NZD before taxes and fees
Total number of reviews
11K reviews
Pet-friendly rentals
110 properties allow pets
Rentals with a pool
80 properties have a pool
Rentals with dedicated workspaces
180 properties have a dedicated workspace
Destinations to explore
- Southern California Holiday rentals
- Los Angeles Holiday rentals
- Stanton Holiday rentals
- Las Vegas Holiday rentals
- Channel Islands of California Holiday rentals
- San Diego Holiday rentals
- Phoenix Holiday rentals
- Palm Springs Holiday rentals
- San Fernando Valley Holiday rentals
- Scottsdale Holiday rentals
- Henderson Holiday rentals
- Las Vegas Strip Holiday rentals
- Rentals with pools La Mesa
- Private suite rentals La Mesa
- Smoking-friendly rentals La Mesa
- Pet-friendly rentals La Mesa
- Rentals with a fireplace La Mesa
- Rentals with breakfast La Mesa
- Rentals with a hot tub La Mesa
- Rentals with a fire pit La Mesa
- Rentals with outdoor seating La Mesa
- Apartment rentals La Mesa
- Rentals with beach access La Mesa
- Fitness-friendly rentals La Mesa
- Rentals with an EV charger La Mesa
- Guesthouse rentals La Mesa
- Villa rentals La Mesa
- House rentals La Mesa
- Rentals with a patio La Mesa
- Rentals with a beach view La Mesa
- Rentals with a washing machine and dryer La Mesa
- Family-friendly rentals San Diego County
- Family-friendly rentals California
- Family-friendly rentals United States
- Rosarito Beach
- Oceanside City Beach
- Torrey Pines State Beach
- Pacific Beach
- Tijuana Beach
- SeaWorld San Diego
- Coronado Beach
- LEGOLAND California
- University of California San Diego
- San Diego Zoo Safari Park
- Balboa Park
- La Misión Beach
- Oceanside Harbor
- Coronado Shores Beach
- Pechanga Resort Casino
- Black's Beach
- Belmont Park
- Moonlight Beach
- Sesame Place San Diego
- Liberty Station
- Law Street Beach
- Torrey Pines Golf Course
- Mission Beach
- USS Midway Museum