
Guesthouse holiday rentals in Upstate South Carolina
Find and book unique guesthouse rentals on Airbnb
Top-rated Guesthouses in Upstate South Carolina
Guests agree: These guesthouses are highly rated for location, cleanliness and more.

Scenic Loft in the Woods
Come relax for a getaway in our elegant guest loft! Located near the end of a quiet road with lots of wide open fields and beautiful tree lines! Our loft features a cute kitchenette, plenty of closet space, TV(YoutubeTV & Roku), an extremely comfortable bed! The loft is kept very clean and neat and will be stocked with all the essentials. Access to a beautiful 33' above ground pool! We are conveniently located about 5 miles from downtown Abbeville, and only a 10 minute drive to Erskine/Due West!
LocationValueBackyard
4.97 out of 5 average rating, 381 reviews
Historic 19th Century Cabin/Guest House
This 19th century cabin is your perfect cozy getaway. This guest house is located on a 3.5 acre property, secluded from the historic neighborhood, though it's just 3 miles from downtown Greenville and the Bon Secours Wellness Arena. Less than a mile to the Swamp Rabbit Trail, this cottage is perfect for jaunts to downtown Greenville, Furman University, Paris Mountain, Travelers Rest and Unity Park! Micro weddings and events are available upon request and approval with applicable fees applied.
ValueLocationComfort
4.93 out of 5 average rating, 754 reviews
Mountain Cabin on Creek at Jocassee Gorge.
Welcome to Laurel Valley. A tiny, sleepy neighborhood at the top of a mountain, hidden from the hustle of civilization. This adorable cabin is nestled in beautiful Jocassee Gorge. Minutes away from multiple attractions including Sassafras Mountain and Twin Falls. Property borders thousands of acres of protected land with 5 star trails . This mountain cabin is in a unique setting that time forgot. The rushing creek outside helps you to peel off the world and get a great night's sleep.
LocationValueWi-Fi
4.91 out of 5 average rating, 453 reviews
The Cottage at Old Oaks Farm
Built in the early 1900's, this serene cottage is located approximately one mile from Furman University at the base of Paris Mt. It has been lovingly improved, but the floors are a bit slanted and no corner is exactly square. Located in a neighborhood on a five acre farm, it consists of three large rooms, comfortably furnished and lots of natural light. The cottage is convenient to downtown Greenville(5 miles),Travelers Rest, Furman, and the Swamp Rabbit Trail. No pet fee or cleaning fee.
FamilyLocationAccess
4.99 out of 5 average rating, 468 reviews
Wolf Lake Escape - lake & mountain retreat
Beautiful secluded setting on Wolf Lake. Private studio apartment with full kitchen and bath. Stunning lake view and full lake access with use of kayaks, canoe and dock in the adjacent cove. Private patio with fire pit and grill. Paradise Falls trailhead 1 mile away. Close to Panthertown Valley Backcountry Area with multiple trails and waterfalls. 45 minutes from Brevard, Sylva and Cashiers, NC. Easy drive to Asheville and Biltmore House. Onsite parking. Well behaved pets welcome
LocationValueQuiet
4.99 out of 5 average rating, 273 reviews
Gorgeous Downtown Studio & Dog Friendly!
This has changed to a minimum of a 3 month rental! Message me if you're trying to book and your dates aren't showing available! This location is unmatched. Steps from Falls Park which includes one of the most majestic waterfalls, green space and Swamp Rabbit Trail for all your running/walking and biking needs. Directly across the street from the Greenville Drive baseball stadium. One block from all the finest restaurants, shopping and best attractions downtown offers.
LocationFamilyLong stay
4.95 out of 5 average rating, 259 reviews
The Lodge at Pythian Park
Situated in a 3+ acre gated compound surrounded on three sides by Fairforest Creek, our guest house feels like a mountain hideaway yet it's only a 3 minute drive to downtown Spartanburg. Enjoy the private patio overlooking the creek to relax or prepare a meal on the gas grill. Dogs are welcome, and we have 2 very social dogs that you will probably encounter during your stay. There's ample parking for vehicles and room to roam and enjoy the park-like setting.
LocationFamilyParking
5.0 out of 5 average rating, 151 reviews
Greenville With A View!
ONLY 10-15 MINUTE DRIVE TO THE HEART OF BEAUTIFUL DOWNTOWN GREENVILLE! We are only 11 miles to GSP Airport; 6 miles to Greenville Downtown Airport; and 10 minutes to the Swamp Rabbit Trail. We are minutes to Furman University, Bob Jones University, North Greenville University and Clemson University is only 45 minutes away. We are tucked away open top of Paris Mountain. If you want to bike, hike, paddle, swim, boat or just soak it all in, start here!
ValueLocationDecor
4.98 out of 5 average rating, 291 reviews
The Dwelling Place: Just a mile from downtown TR
The Dwelling Place was created for guests to enjoy Travelers Rest and the beautiful surrounding areas. It is a studio apartment above a detached garage with a private entrance and driveway. We are a one minute walk from the Swamp Rabbit Trail, a 1.2 mile walk from the idyllic downtown Travelers Rest, 20 min. from Greenville, 8 min. from Furman, 15 min. from North Greenville University, and close to numerous hikes, waterfalls, and outdoor adventures!
LocationValueCleanliness
4.99 out of 5 average rating, 122 reviews
Home on the farm
aprox. 4 miles to Erskine College and aprox. 15 miles to Greenwood sc. You’ll love the farm setting, good for couples, solo adventurers, business travelers, families (with kids), and furry friends (pets).we are aprox. 11 miles from Abbeville SC birth place of the confederacy. aprox. 60 miles to Augusta GA the masters golf tour. aprox. 40 miles to CLEMSON U. The Diamond Hill Mine in Abbeville is about 17 miles from here.
LocationValueView
4.99 out of 5 average rating, 411 reviews
Shou-Sugi-Ban Retreat on the Saluda River
The Shou-Sugi-Ban Guest House is 5 miles from Greenville city center and West Greenville, yet you'll feel like you've escaped it all with the rush of the river and surrounding trees. This cozy, custom space has a king-size bed, and two sets of French doors leading out to a private deck. No matter where you are in the space, you'll have views of the 700 ft of Saluda river frontage.
LocationFamilyPets
4.97 out of 5 average rating, 146 reviews
1 bedroom lake front apartment with gorgeous views
Relax in a cozy apartment on Lake Hartwell. The apartment is located in a secluded peaceful, cove near downtown Hartwell and is in close proximity to hiking and numerous outdoor activities in the hill country of Georgia and South Carolina. The apartment sleeps 2 comfortably and is fully equipped with a kitchen and a private laundry facility.
LocationValueEV charging
4.98 out of 5 average rating, 183 reviewsPopular amenities for Upstate South Carolina guesthouses
Family-Friendly guesthouses

Private-Lake getaway-7 mile view from dock
FamilyValueBeach
4.94 out of 5 average rating, 219 reviews
Campus Cottage
ValueLocationLaundry
4.98 out of 5 average rating, 123 reviews
Windcrest Loft- charming retreat near the river.
ValueLocationBreakfast
4.97 out of 5 average rating, 368 reviews
Elfwing Carriage House
FamilyValueView
4.98 out of 5 average rating, 228 reviews
Warrior Hall Cottage 1
FamilyLocationPool
4.97 out of 5 average rating, 169 reviews
Cozy Rustic Lakefront Cabin
FamilyValueWalkability
4.97 out of 5 average rating, 186 reviews
1-bedroom guesthouse in Abbeville, SC
ValueLocationAir conditioning
4.96 out of 5 average rating, 185 reviews
Lit'l Bit O' Heaven- Rocky Top Lodge
LocationFamilyKitchen
4.99 out of 5 average rating, 196 reviewsGuesthouses with a patio

Blessed Haven - king bed guest house
ValueLocationAir conditioning
4.94 out of 5 average rating, 132 reviews
Modern guesthouse in downtown TR
FamilyLocationCondition
4.95 out of 5 average rating, 151 reviews
Sally's Cottage
FamilyValueDecor
5.0 out of 5 average rating, 197 reviews
Cozy guest cottage at The Black Walnut Chateau
LocationFamilyBarbecue
4.98 out of 5 average rating, 317 reviews
Starswept Studio–Near GSMNP, BRP, walk to Joey’s.
LocationFamilyAmenities
5.0 out of 5 average rating, 495 reviews
Fletcher NC Getaway
FamilyLocationGetting around
4.96 out of 5 average rating, 101 reviews
Carriage House in the Woods
ValueLocationTV
5.0 out of 5 average rating, 110 reviews
Country-Clubhouse Tiny Home. Close to downtown!
LocationFamilyCondition
4.93 out of 5 average rating, 124 reviewsGuest house rentals with a washing machine and dryer

MeadowHill Guesthouse - Mountain view-3 mi to town
FamilyLocationPets
5.0 out of 5 average rating, 123 reviews
Modern Carriage House
ValueLocationCondition
4.97 out of 5 average rating, 207 reviews
Upscale cottage in Downtown Fountain Inn
ValueLocationSleep quality
4.98 out of 5 average rating, 134 reviews
Carolina Cottage Guest House
LocationFamilyParks
4.98 out of 5 average rating, 327 reviews
Farmhouse by the lake - Private guest house
ValueLocationCondition
4.87 out of 5 average rating, 218 reviews
Love Shack
ValueLocationBackyard
5.0 out of 5 average rating, 205 reviews
The Guest House By The River
LocationBikingBackyard
5.0 out of 5 average rating, 113 reviews
Lake front Lake Murray in the Heart of Lexington
FamilyLocationBathroom
4.97 out of 5 average rating, 176 reviewsDestinations to explore
- Nashville Holiday rentals
- Atlanta Holiday rentals
- Myrtle Beach Holiday rentals
- Charlotte Holiday rentals
- Gatlinburg Holiday rentals
- Savannah Holiday rentals
- Pigeon Forge Holiday rentals
- Charleston Holiday rentals
- Hilton Head Island Holiday rentals
- North Myrtle Beach Holiday rentals
- Asheville Holiday rentals
- Raleigh Holiday rentals
- Rentals with a sauna Upstate South Carolina
- Tiny house rentals Upstate South Carolina
- Nature eco lodge rentals Upstate South Carolina
- Townhouse rentals Upstate South Carolina
- Chalet rentals Upstate South Carolina
- Rentals with breakfast Upstate South Carolina
- Rentals with an accessible height toilet Upstate South Carolina
- Rentals with beach access Upstate South Carolina
- Rentals with a kayak Upstate South Carolina
- Apartment rentals Upstate South Carolina
- Rentals with a hot tub Upstate South Carolina
- Barn rentals Upstate South Carolina
- Private suite rentals Upstate South Carolina
- Waterfront rentals Upstate South Carolina
- Villa rentals Upstate South Carolina
- Ski-in/ski-out rentals Upstate South Carolina
- Hotel rooms Upstate South Carolina
- Luxury rentals Upstate South Carolina
- Serviced apartment rentals Upstate South Carolina
- House rentals Upstate South Carolina
- Beachfront rentals Upstate South Carolina
- Condo rentals Upstate South Carolina
- Resort rentals Upstate South Carolina
- Holiday home rentals Upstate South Carolina
- Family-friendly rentals Upstate South Carolina
- Tent rentals Upstate South Carolina
- Rentals with pools Upstate South Carolina
- Cottage rentals Upstate South Carolina
- Pet-friendly rentals Upstate South Carolina
- Boutique hotels Upstate South Carolina
- Dome rentals Upstate South Carolina
- Farmstay rentals Upstate South Carolina
- RV rentals Upstate South Carolina
- Bed and breakfasts Upstate South Carolina
- Cabin rentals Upstate South Carolina
- Loft rentals Upstate South Carolina
- Campsite rentals Upstate South Carolina
- Tree house rentals Upstate South Carolina
- Rentals with lake access Upstate South Carolina
- Guesthouse rentals South Carolina
- Guesthouse rentals United States
- Clemson University
- Blue Ridge Parkway
- Tryon International Equestrian Center
- Table Rock State Park
- The North Carolina Arboretum
- Chimney Rock State Park
- Gorges State Park
- Devils Fork State Park
- Lake Lure Beach and Water Park
- DuPont State Forest
- Bon Secours Wellness Arena
- Saint Paul Mountain Vineyards
- Jump Off Rock
- Fred W Symmes Chapel
- Falls Park On The Reedy
- Jones Gap State Park
- Fluor Field at the West End
- Peace Center
- Whitewater Falls
- Carl Sandburg Home National Historic Site
- Overmountain Vineyards
- Oconee State Park
- Furman University
- Memorial Stadium, Clemson
- Things to do Upstate South Carolina
- Art workshops Upstate South Carolina
- Things to do South Carolina
- Wildlife South Carolina
- Food tours South Carolina
- Cultural tours South Carolina
- Cooking South Carolina
- Outdoors South Carolina
- Landmarks South Carolina
- Tastings South Carolina
- Art workshops South Carolina
- Water sports South Carolina
- Things to do United States
- Shopping and fashion United States
- Dining United States
- Museums United States
- Cultural tours United States
- Architecture United States
- Art workshops United States
- Flying United States
- Food tours United States
- Wildlife United States
- Landmarks United States
- Workouts United States
- Performances United States
- Tastings United States
- Water sports United States
- Beauty United States
- Outdoors United States
- Cooking United States
- Wellness United States
- Galleries United States





