
Guesthouse holiday rentals in Upstate South Carolina
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Top-rated Guesthouses in Upstate South Carolina
Guests agree: These guesthouses are highly rated for location, cleanliness and more.

Scenic Loft in the Woods
Come relax for a getaway in our elegant guest loft! Located near the end of a quiet road with lots of wide open fields and beautiful tree lines! Our loft features a cute kitchenette, plenty of closet space, TV(YoutubeTV & Roku), an extremely comfortable bed! The loft is kept very clean and neat and will be stocked with all the essentials. Access to a beautiful 33' above ground pool! We are conveniently located about 5 miles from downtown Abbeville, and only a 10 minute drive to Erskine/Due West!
FamilyLocationQuiet
4.97 out of 5 average rating, 381 reviews
The Spring Valley Retreat
Newly renovated in 2021, very comfortable guesthouse located in a quiet neighborhood just 10 minutes from downtown Greenville. Created by highly experienced bed and breakfast owners, this space is carefully crafted to be a relaxing, restful place for travelers. Two bedrooms, a kitchen with brand-new appliances, dining area, smart TV, a desktop space, WiFi, and an outdoor porch spot to enjoy nice weather days. Note that if you search the address on Google, it will pull up photos before renovation
FamilyValueWi-Fi
4.97 out of 5 average rating, 135 reviews
Campus Cottage
Upstairs two bedroom apartment located in College View area just a short walk across the street to Presbyterian College. Perfect for campus visits, tours, and sporting events. Short driving distance to local restaurants (less than one mile). Unit has two bedrooms (3 twin mattresses available upon request), one full bath, living room, dining room, and kitchen with full fridge, stove, and microwave. Coffee maker provided with coffee, creamer, and sugar during your stay. Plenty of room to relax!
LocationValueCondition
4.98 out of 5 average rating, 123 reviews
Private-Lake getaway-7 mile view from dock
Spacious two story guest house on a private road situated on Lake Hartwell. Use the double deck dock with 7 mile view for all day fishing, swimming or just relaxing. The guest house with central heating and air is fully furnished and has a fully equipped kitchen, wifi, 3 streaming flat screen tvs, two full baths, washer/dryer combo and a large attached deck. Owners live on property but in different residence. Outdoor cameras overlook parking area. Only reserved guests have property access.
ValueLocationShared spaces
4.94 out of 5 average rating, 218 reviews
Historic 19th Century Cabin/Guest House
This 19th century cabin is your perfect cozy getaway. This guest house is located on a 3.5 acre property, secluded from the historic neighborhood, though it's just 3 miles from downtown Greenville and the Bon Secours Wellness Arena. Less than a mile to the Swamp Rabbit Trail, this cottage is perfect for jaunts to downtown Greenville, Furman University, Paris Mountain, Travelers Rest and Unity Park! Micro weddings and events are available upon request and approval with applicable fees applied.
FamilyValueAccess
4.93 out of 5 average rating, 754 reviews
Mountain Cabin on Creek at Jocassee Gorge.
Welcome to Laurel Valley. A tiny, sleepy neighborhood at the top of a mountain, hidden from the hustle of civilization. This adorable cabin is nestled in beautiful Jocassee Gorge. Minutes away from multiple attractions including Sassafras Mountain and Twin Falls. Property borders thousands of acres of protected land with 5 star trails . This mountain cabin is in a unique setting that time forgot. The rushing creek outside helps you to peel off the world and get a great night's sleep.
FamilyValueCondition
4.91 out of 5 average rating, 453 reviews
The Cottage at Old Oaks Farm
Built in the early 1900's, this serene cottage is located approximately one mile from Furman University at the base of Paris Mt. It has been lovingly improved, but the floors are a bit slanted and no corner is exactly square. Located in a neighborhood on a five acre farm, it consists of three large rooms, comfortably furnished and lots of natural light. The cottage is convenient to downtown Greenville(5 miles),Travelers Rest, Furman, and the Swamp Rabbit Trail. No pet fee or cleaning fee.
ValueFamilyQuiet
4.99 out of 5 average rating, 468 reviews
Warrior Hall Cottage 1
Alpine look cottage is at the end of private road. Pretty place to walk and enjoy the outdoors. Several hosting vineyards, hiking and kayaking nearby. Convenient to nearby towns of Tryon, Landrum, Columbus and 1 Saluda. 15 minutes to the Tryon International Equestrian Center and other event venues. Less than an hour to Asheville, Greenville, Spartanburg, BMW Plant, and 3 major airports. A great gateway to western Carolina. Sofa bed and loft add to sleeping space for families.
LocationValueBackyard
4.97 out of 5 average rating, 169 reviews
The Lodge at Pythian Park
Situated in a 3+ acre gated compound surrounded on three sides by Fairforest Creek, our guest house feels like a mountain hideaway yet it's only a 3 minute drive to downtown Spartanburg. Enjoy the private patio overlooking the creek to relax or prepare a meal on the gas grill. Dogs are welcome, and we have 2 very social dogs that you will probably encounter during your stay. There's ample parking for vehicles and room to roam and enjoy the park-like setting.
FamilyLocationWi-Fi
5.0 out of 5 average rating, 151 reviews
The Dwelling Place: Just a mile from downtown TR
The Dwelling Place was created for guests to enjoy Travelers Rest and the beautiful surrounding areas. It is a studio apartment above a detached garage with a private entrance and driveway. We are a one minute walk from the Swamp Rabbit Trail, a 1.2 mile walk from the idyllic downtown Travelers Rest, 20 min. from Greenville, 8 min. from Furman, 15 min. from North Greenville University, and close to numerous hikes, waterfalls, and outdoor adventures!
FamilyValueDecor
4.99 out of 5 average rating, 121 reviews
Home on the farm
aprox. 4 miles to Erskine College and aprox. 15 miles to Greenwood sc. You’ll love the farm setting, good for couples, solo adventurers, business travelers, families (with kids), and furry friends (pets).we are aprox. 11 miles from Abbeville SC birth place of the confederacy. aprox. 60 miles to Augusta GA the masters golf tour. aprox. 40 miles to CLEMSON U. The Diamond Hill Mine in Abbeville is about 17 miles from here.
LocationFamilyBackyard
4.99 out of 5 average rating, 411 reviews
Shou-Sugi-Ban Retreat on the Saluda River
The Shou-Sugi-Ban Guest House is 5 miles from Greenville city center and West Greenville, yet you'll feel like you've escaped it all with the rush of the river and surrounding trees. This cozy, custom space has a king-size bed, and two sets of French doors leading out to a private deck. No matter where you are in the space, you'll have views of the 700 ft of Saluda river frontage.
LocationFamilyBathroom
4.97 out of 5 average rating, 146 reviewsPopular amenities for Upstate South Carolina guesthouses
Family-Friendly guesthouses

Finished Room over Garage (FROG) on Reedy River
ValueLocationHeating
4.98 out of 5 average rating, 192 reviews
Greenville With A View!
LocationFamilyParks
4.98 out of 5 average rating, 291 reviews
1-bedroom guesthouse in Abbeville, SC
LocationFamilyAir conditioning
4.96 out of 5 average rating, 185 reviews
Lakefront Mountain Cabin on Lake Glenville, NC
ValueLocationGetting around
4.86 out of 5 average rating, 103 reviews
Lisa's Lodge
LocationValueAir conditioning
4.86 out of 5 average rating, 291 reviews
Wolf Lake Escape - lake & mountain retreat
ValueLocationCleanliness
4.99 out of 5 average rating, 273 reviews
Holly Hideaway! 10 Highway miles to Clemson U!
FamilyLocationAmenities
4.93 out of 5 average rating, 217 reviews
Modern Loft in the Mountains
ValueLocationAmenities
4.98 out of 5 average rating, 776 reviewsGuesthouses with a patio

Blessed Haven - king bed guest house
LocationValueWi-Fi
4.94 out of 5 average rating, 131 reviews
Modern guesthouse in downtown TR
LocationFamilyHeating
4.95 out of 5 average rating, 150 reviews
Cozy Cottage - 5 miles from TIEC
LocationFamilyBarbecue
4.98 out of 5 average rating, 133 reviews
Sally's Cottage
LocationValueLayout
5.0 out of 5 average rating, 196 reviews
Cozy guest cottage at The Black Walnut Chateau
ValueFamilySleep quality
4.98 out of 5 average rating, 317 reviews
Starswept Studio–Near GSMNP, BRP, walk to Joey’s.
FamilyValueTV
5.0 out of 5 average rating, 495 reviews
Fletcher NC Getaway
ValueFamilyIndoor spaces
4.96 out of 5 average rating, 100 reviews
Carriage House in the Woods
ValueLocationDecor
5.0 out of 5 average rating, 110 reviewsGuest house rentals with a washing machine and dryer

Gorgeous Downtown Studio & Dog Friendly!
FamilyLocationQuiet
4.95 out of 5 average rating, 258 reviews
Upscale cottage in Downtown Fountain Inn
ValueLocationCheck-in
4.98 out of 5 average rating, 133 reviews
Farmhouse by the lake - Private guest house
ValueLocationView
4.87 out of 5 average rating, 218 reviews
White Squirrel Bungalow
FamilyValueSleep quality
5.0 out of 5 average rating, 228 reviews
Carolina Cottage Guest House
LocationValueAccuracy
4.98 out of 5 average rating, 326 reviews
Lake front Lake Murray in the Heart of Lexington
ValueFamilyBeach
4.97 out of 5 average rating, 176 reviews
Modern Carriage House
LocationFamilyCheck-in
4.97 out of 5 average rating, 206 reviews
Newly renovated guesthouse!
FamilyLocationHeating
4.97 out of 5 average rating, 184 reviewsDestinations to explore
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- Clemson University
- Blue Ridge Parkway
- Tryon International Equestrian Center
- Table Rock State Park
- The North Carolina Arboretum
- Chimney Rock State Park
- Gorges State Park
- Devils Fork State Park
- Lake Lure Beach and Water Park
- DuPont State Forest
- Bon Secours Wellness Arena
- Saint Paul Mountain Vineyards
- Jump Off Rock
- Fred W Symmes Chapel
- Falls Park On The Reedy
- Jones Gap State Park
- Fluor Field at the West End
- Peace Center
- Whitewater Falls
- Carl Sandburg Home National Historic Site
- Overmountain Vineyards
- Oconee State Park
- Furman University
- Memorial Stadium, Clemson
- Things to do Upstate South Carolina
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